Agonist-induced desensitization of the μ opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail

Journal of Biological Chemistry

Volumn 272, Issue 40, 1997, Pages 24961-24965

  Pak, Youngshil ^a   O'Dowd, Brian F ^a,b   George, Susan R ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; FORSKOLIN; GLUTAMIC ACID; GLUTAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NALOXONE; PHOSPHOTRANSFERASE; THREONINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME ACTIVITY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DOWN REGULATION;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NALOXONE; POINT MUTATION; RATS; RECEPTORS, OPIOID, MU; RECOMBINANT PROTEINS; SERINE; THREONINE; TRANSFECTION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0030875721     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.40.24961     Document Type: Article

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