Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: Association with an up-regulation of the cyclic AMP pathway

Neuroscience

Volumn 95, Issue 2, 1999, Pages 433-443

  Jolas, T ^a   Nestler, E J ^a   Aghajanian, G K ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Adenylyl cyclase; Dorsal raphe; GABAergic interneurons; I(h); Opioids; Periaqueductal gray

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; ADENYLATE CYCLASE; BICUCULLINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; MORPHINE; 6 (2 (1H TETRAZOL 5 YL)ETHYL) 1,2,3,4,4A,5,6,7,8,8A DECAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 6-(2-(1H-TETRAZOL-5-YL)ETHYL)-1,2,3,4,4A,5,6,7,8,8A-DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID; ADENOSINE 3',5' PHOSPHOROTHIOATE; ADENOSINE-3',5'-CYCLIC PHOSPHOROTHIOATE; ADRENERGIC RECEPTOR STIMULATING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; CARDIOVASCULAR AGENT; DRUG DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENZYME INHIBITOR; FORSKOLIN; ICI D2788; ISOQUINOLINE DERIVATIVE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N METHYLASPARTIC ACID; NARCOTIC ANALGESIC AGENT; NUCLEOTIDE; PHENYLEPHRINE; PYRIMIDINE DERIVATIVE; SEROTONIN; SULFONAMIDE; TETRAZOLE DERIVATIVE; TETRODOTOXIN;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG WITHDRAWAL; ELECTROPHYSIOLOGY; IMMUNOREACTIVITY; LONG TERM EXPOSURE; MALE; MORPHINE ADDICTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC NERVE CELL; WESTERN BLOTTING; ANIMAL; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; INTERNEURON; METABOLISM; NERVE CELL INHIBITION; PATHOPHYSIOLOGY; PERIAQUEDUCTAL GRAY MATTER; PHYSIOLOGY; RAPHE NUCLEUS; SPRAGUE DAWLEY RAT; WITHDRAWAL SYNDROME;

ADENYLATE CYCLASE; ANALGESICS, OPIOID; ANIMALS; CARDIOVASCULAR AGENTS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTROPHYSIOLOGY; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; FORSKOLIN; GAMMA-AMINOBUTYRIC ACID; INTERNEURONS; ISOQUINOLINES; MALE; MEMBRANE POTENTIALS; MORPHINE; N-METHYLASPARTATE; NEURAL INHIBITION; PERIAQUEDUCTAL GRAY; PHENYLEPHRINE; PYRIMIDINES; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SUBSTANCE WITHDRAWAL SYNDROME; SULFONAMIDES; SYMPATHOMIMETICS; TETRAZOLES; TETRODOTOXIN; THIONUCLEOTIDES;

EID: 0033629748     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(99)00436-4     Document Type: Article

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