Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway

Cell

Volumn 86, Issue 3, 1996, Pages 453-463

  Willems, Andrew R ^a,b   Lanker, Stefan ^c   Patton, E Elizabeth ^a,b   Craig, Karen L ^a   Nason, Timothy F ^d,g   Mathias, Neal ^e   Kobayashi, Ryuji ^f   Wittenberg, Curt ^c   Tyers, Mike ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^g ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLINE; PROTEASOME; PROTEIN KINASE; UBIQUITIN;

AMINO ACID SEQUENCE; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL DIVISION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN ISOLATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RNA ANALYSIS; YEAST CELL;

SACCHAROMYCETALES;

EID: 0030576515     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80118-X     Document Type: Article

References (59)

1. Amon, A., Irniger, S., and Nasmyth, K. (1994). Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. Cell 77, 1037-1050.
2. Bai, C., Sen, P., Hofmann, K., Ma, L., Goebl, M., Harper, J.W., and Elledge, S.J. (1996). SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274.
3. Baroni, M.D., Monti, P., and Alberghina, L. (1994). Repression of growth-regulated G1 cyclin expression by cyclic AMP in budding yeast. Nature 371, 339-342.
4. Barral, Y., Jentsch, S., and Mann, C. (1995). G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev. 9, 399-409.
5. Chau, V., Tobias, J.W., Bachmair, A., Marriott, D., Ecker, D.J., Gonda, D.K., and Varshavsky, A. (1989). A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science 243, 1576-1583.
6. Cross, F.R. (1988). DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae. Mol. Cell. Biol. 8, 4675-4684.
7. Cross, F.R. (1995). Starting the cell cycle: what's the point? Curr. Opin. Cell Biol. 7, 790-797.
8. Deshaies, R.J., Chau, V., and Kirschner, M. (1995). Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway. EMBO J. 14, 303-312.
9. Dirick, L., Bohm, T., and Nasmyth, K. (1995). Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. EMBO J. 14, 4803-4813.
10. Evans, T., Rosenthal, E.T., Youngblom, J., Distel, D., and Hunt, T. (1983). Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 33, 389-396.
11. Fitch, I., Dahmann, C., Surana, U., Amon, A., Nasmyth, K., Goetsch, L, Byers, B., and Futcher, B. (1992). Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae. Mol. Biol. Cell 3, 805-818.
12. Glotzer, M., Murray, A.W., and Kirschner, M.W. (1991). Cyclin is degraded by the ubiquitin pathway. Nature 349, 132-138.
13. Goebl, M.G., Yochem, J., Jentsch, S., McGrath, J.P., Varshavsky, A., and Byers, B. (1988). The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science 241, 1331-1335.
14. + gene, encodes a subunit of the Cdc28 protein kinase complex. Mol. Cell. Biol. 9, 2034-2041.
15. Hadwiger, J.A., Wittenberg, C., Richardson, H.E., De Barros Lopes, M., and Reed, S.I. (1989b). A family of cyclin homologs that control the G1 phase in yeast. Proc. Natl. Acad. Sci. USA 86, 6255-6259.
16. Harlow, E., and Lane, D.P. (1988). Antibodies: A Laboratory Manual (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press).
17. Hershko, A., Ganoth, D., Sudakin, V., Dahan, A., Cohen, L.H., Luca, F.C., Ruderman, J.V., and Eytan, E. (1994). Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase Cdc2. J. Biol. Chem. 269, 4940-4946.
18. Hochstrasser, M. (1995). Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Opin. Cell Biol. 7, 215-223.
19. Hodgins, R.R.W., Ellison, K.S., and Ellison, M.J. (1992). Expression of a ubiquitin derivative that conjugates to protein irreversibly produces phenotypes consistent with a ubiquitin deficiency. J. Biol. Chem. 267, 8807-8812.
20. Huibregtse, J.M., Scheffner, M., Beaudenon, S., and Howley, P.M. (1995). A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. USA 92, 2563-2567.
21. Hunter, T., and Pines, J. (1994). Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age. Cell 79, 573-582.
22. Irniger, S., Piatti, S., Michaelis, C., and Nasmyth, K. (1995). Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 81, 269-278.
23. Kaiser, C., Michaelis, S., and Mitchell, A. (1994). Methods in Yeast Genetics (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press).
24. King, R.W., Peters, J.M., Tugendreich, S., Rolfe, M., Hieter, P., and Kirschner, M.W. (1995). A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81, 279-288.
25. Kipreos, E.T., Lander, L.E., Wing, J.P., He, W.W., and Hedgecock, E.M. (1996). cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85, 829-839.
26. Kolodziej, P.A., and Young, R.A. (1991). Epitope tagging and protein surveillance. Meth. Enzymol. 194, 508-519.
27. Kornitzer, D., Raboy, B., Kulka, R.G., and Fink, G.R. (1994). Regulated degradation of the transcription factor Gcn4. EMBO J. 13, 6021-6030.
28. Lanker, S., Valdivieso, M.H., and Wittenberg, C. (1996). Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation. Science 271, 1597-1601.
29. Lew, D.J., Dulic, V., and Reed, S.I. (1991). Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 66, 1197-1206.
30. Madura, K., Dohmen, J.R., and Varshavsky, A. (1993). N-recognin/ Ubc2 interactions in the N-end rule pathway. J. Biol. Chem. 268, 12046-12054.
31. McKinney, J.D., Chang, F., Heintz, N., and Cross, F.R. (1993). Negative regulation of FAR1 at the Start of the yeast cell cycle. Genes Dev. 7, 833-843.
32. CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259, 216-219.
33. Murray, A. (1995). Cyclin ubiquitination: the destructive end of mitosis. Cell 87, 149-152.
34. + gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog. EMBO J. 7, 4335-4346.
35. Nasmyth, K. (1993). Control of the yeast cell cycle by the Cdc28 protein kinase. Curr. Opin. Cell Biol. 5, 166-179.
36. Nugroho, T.T., and Mendenhall, M.D. (1994). An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol. Cell. Biol. 14, 3320-3328.
37. Pines, J. (1995). Cyclins and cyclin-dependent kinases: theme and variations. Adv. Cancer Res. 66, 181-212.
38. Richardson, H., Lew, D.J., Henze, M., Sugimoto, K., and Reed, S.I. (1992). Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2. Genes Dev. 6, 2021-2034.
39. Rogers, S.W., Wells, R., and Rechsteiner, M. (1986). Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 234, 364-368.
40. Salama, S.R., Hendricks, K.B., and Thorner, J. (1994). G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover. Mol. Cell. Biol. 14, 7953-7966.
41. Scheffner, M., Nuber, U., and Huibregtse, J.M. (1995). Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature 373, 81-83.
42. Schneider, B.L., Seufert, W., Steiner, B., Yang, Q.H., and Futcher, A.B. (1995). Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae. Yeast 11, 1265-1274.
43. Schneider, B.L., Yang, Q.-H., and Futcher, A.B. (1996). Linkage of replication to Start by the Cdk inhibitor Sic1. Science, 272, 560-562.
44. Schultz, M.C., Choe, S.Y., and Reeder, R.H. (1991). Specific initiation by RNA polymerase I in a whole-cell extract from yeast. Proc. Natl. Acad. Sci. USA 88, 1004-1008.
45. Schwob, E., and Nasmyth, K. (1993). CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes Dev. 7, 1160-1175.
46. SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79, 233-244.
47. Sherr, C.J. (1994). G1 phase progression: cycling on cue. Cell 79, 551-555.
48. Sikorski, R.S., and Hieter, P. (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
49. Sopta, M., Carthew, R.W., and Greenblatt, J. (1985). Isolation of three proteins that bind to mammalian RNA polymerase II. J. Biol. Chem. 260, 10353-10360.
50. Stuart, D., and Wittenberg, C. (1995). CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells. Genes Dev. 9, 2780-2794.
51. Sudakin, V., Ganoth, D., Dahan, A., Heller, H., Hershko, J., Luca, F.C., Ruderman, J.V., and Hershko, A. (1995). The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185-197.
52. Tokiwa, G., Tyers, M., Volpe, T., and Futcher, B. (1994). Inhibition of G1 cyclin activity by the Ras/cAMP pathway in yeast. Nature 371, 342-345.
53. SIC1 imposes the requirement for CLN G1 cyclin function at Start. Proc. Natl. Acad. Sci. USA, in press.
54. Tyers, M., Tokiwa, G., Nash, R., and Futcher, B. (1992). The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation. EMBO J. 11, 1773-1784.
55. Tyers, M., Tokiwa, G., and Futcher, B. (1993). Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins. EMBO J. 12, 1955-1968.
56. CDC28 protein kinase. Cell 62, 225-237.
57. CDC28-mediated control of Cln3 cyclin degradation. Mol. Cell. Biol. 15, 731-741.
58. Yochem, J., and Byers, B. (1987). Structural comparison of the yeast cell division cycle gene CDC4 and a related pseudogene. J. Mol. Biol. 195, 233-245.
59. Yoon, H.J., and Carbon, J. (1995). Genetic and biochemical interactions between an essential kinetochore protein, Cbf2p/Ndc10p, and the CDC34 ubiquitin-conjugating enzyme. Mol. Cell. Biol. 15, 4835-4842.