The mouse Fused locus encodes axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

Cell

Volumn 90, Issue 1, 1997, Pages 181-192

  Zeng, Li ^a   Fagotto, François ^b   Zhang, Tong ^a   Hsu, Wei ^a   Vasicek, Thomas J ^c,d   Perry III, William L ^a,e   Lee, James J ^a,f   Tilghman, Shirley M ^c   Gumbiner, Barry M ^b   Costantini, Frank ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c PRINCETON UNIVERSITY   (United States)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

^e Utah   (United States)

^f MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ALLELE; AMPHIBIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DNA FLANKING REGION; EMBRYO DEVELOPMENT; GENE DUPLICATION; GENE LOCUS; GENE MUTATION; MAMMAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; XENOPUS;

AMPHIBIA; ANIMALIA; MAMMALIA; RODENTIA; VERTEBRATA;

EID: 0031457978     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80324-4     Document Type: Article

References (56)

1. Bachvarova, R.F. (1996). Anterior-posterior polarization and mesoderm inducing factors in the pregastrula mouse embryo. Comparison to chick and frog embryos. Adv. Dev. Biol. 4, 147-191.
2. Beddington, R.S.P. (1994). Induction of a second neural axis by the mouse node. Development 120, 613-620.
3. i subfamily of G protein α subunits. Cell 86, 445-452.
4. Carnac, G., Kodjabachian, L., Gurdon, J.B., and Lemaire, P. (1996). The homeobox gene Siamois is a target of the Wnt dorsalization pathway and triggers organizer activity in the absence of mesoderm. Development 722, 3055-3065.
5. Chenchik, A., Moqadam, J., and Siebert, P. (1995). Marathon cDNA amplification: a new method for cloning full-length cDNAs. CLONE-TECHniques 10, 5-8.
6. Christian, J.L., and Moon, R.T. (1993). Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus. Genes Dev. 7, 13-28.
7. Conlon, F., and Beddington, R. (1995). Mouse gastrulation from a frog's perspective. Semin. Dev. Biol. 6, 249-256.
8. Cooke, J. (1972). Properties of the primary organization field in the embryo of Xenopus laevis. II. Positional information for axial organization in embryos with two head organizers. J. Embryol. Exp. Morphol. 28, 27-46.
9. De Vries, L., Mousli, M., Wurmser, A., and Farquhar, M.G. (1995). GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. Proc. Natl. Acad. Sci. USA 92, 11916-11920.
10. Dingwall, C., and Laskey, R.A. (1991). Nuclear targeting sequences - a consensus? Trends Biochem. Sci. 16, 478-481.
11. Dohlman, H.G., and Thorners, J. (1997). RSG proteins and signaling by heterotrimeric G proteins. J. Biol. Chem. 272, 3871-3874.
12. Dohlman, H.G., Song, J., Ma, D., Courchesne, W.E., and Thorners, J. (1996). Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein α subunit). Mol. Cell. Biol. 16, 5194-5209.
13. Druey, K.M., Blumer, K.J., Kang, V.H., and Kehrl, J.H. (1996). Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature 379, 742-746.
14. Fagotto, F., and Gumbiner, B.M. (1994). Beta-catenin localization during Xenopus embryogenesis: accumulation at tissue and somite boundaries. Development 120, 3667-3679.
15. Fagotto, F., Funayama, N., Gluck, U., and Gumbiner, B.M. (1996). Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus. J. Cell Biol. 132, 1105-1114.
16. Fagotto, F., Guger, K., and Gumbiner, B.M. (1997). Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/β-catenin signaling pathway, but not by Vg1, Activin, or Noggin. Development 124, 453-460.
17. Funayama, N., Fagotto, F., McCrea, P., and Gumbiner, B.M. (1995). Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling. J. Cell Biol. 128, 959-968.
18. Gardner, R.L., Meredith, M.R., and Altman, D.G. (1992). Is the anterior-posterior axis of the fetus specified before implantation in the mouse? J. Exp. Zool. 264, 437-443.
19. Gluecksohn-Schoenheimer, S. (1949). The effects of a lethal mutation responsible for duplications and twinning in mouse embryos. J. Exp. Zool. 110, 47-76.
20. Greenspan, R.J., and O'Brien, M.C. (1986). Genetic analysis of mutations at the fused locus in the mouse. Proc. Natl. Acad. Sci. USA 83, 4413-4417.
21. Haegel, H., Larue, L, Ohsugi, M., Fedorov, L, Herrenknecht, K., and Kemler, R. (1995). Lack of beta-catenin affects mouse development at gastrulation. Development 121, 3529-3537.
22. Heasman, J., Crawford, A., Goldstone, K., Garner-Hamrick, P., Gumbiner, B., McCrea, P., Kintner, C., Noro, C.Y., and Wylie, C. (1994). Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell 79, 791-803.
23. Hogan, B.L. (1996). Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10, 1580-1594.
24. Hoppler, S., Brown, J.D., and Moon, R.T. (1996). Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos. Genes Dev. 10, 2805-2817.
25. Hume, C.R., and Dodd, J. (1993). Cwnt-8C: a novel Wnt gene with a potential role in primitive streak formation and hindbrain organization. Development 119, 1147-1160.
26. i GTPase activity. Nature 383, 175-177.
27. Jacobs-Cohen, R.J., Spiegelman, M., Cookingham, J.C., and Bennett, D. (1984). Knobbly, anew dominant mutation in the mouse that affects embryonic ectoderm organization. Genet. Res. 43, 43-50.
28. Kao, K.R., and Elinson, R.P. (1988). The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos. Dev. Biol. 127, 64-77.
29. Khaner, O., and Eyal-Giladi, H. (1989). The chick's marginal zone and primitive streak formation. I. Coordinative effect of induction and inhibition. Dev. Biol. 134, 206-214.
30. Klingensmith, J., Nusse, R., and Perrimon, N. (1994). The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev. 8, 118-130.
31. Koelle, M.R., and Horvitz, H.R. (1996). EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell 84, 115-125.
32. Kozak, M. (1986). Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44, 283-292.
33. Lawson, K.A., Meneses, J.J.,and Pedersen, R.A. (1991).Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113, 891-911.
34. Lemaire, P., Garrett, N., and Gurdon, J.B. (1995). Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis. Cell 81, 85-94.
35. Lyon, M.F., Rastan, S., and Brown, S.D.M. (1996). Genetic Variants and Strains of the Laboratory Mouse (Oxford: Oxford University Press).
36. Miller, J.R., and Moon, R.T. (1996). Signal transduction through β-catenin and specification of cell fate during embryogenesis. Genes Dev. 10, 2527-2539.
37. Moon, R.T., Brown, J.D., and Torres, M. (1997). WNTs modulate cell fate and behavior during vertebrate development. Trends Genet. 13, 157-162.
38. Parr, B.A., and McMahon, A.P. (1994). Wnt genes and vertebrate development. Curr. Opin. Genet. Dev. 4, 523-528.
39. Perry, W.L.I., Vasicek, T.J., Lee, J.J., Rossi, J.M., Zeng, L., Zhang, T., Tilghman, S.M., and Costantini, F. (1995). Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus. Genetics 141, 321-332.
40. Pierce, S.B., and Kimelman, D. (1995). Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3. Development 121, 755-765.
41. Rupp, R.A., Snider, L., and Weintraub, H. (1994). Xenopus embryos regulate the nuclear localization of XMyoD. Genes Dev. 8, 1311-1323.
42. Sasaki, H., and Hogan, B.L. (1993). Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118, 47-59.
43. Sasaki, H., and Hogan, B.L. (1994). HNF-3β as a regulator of floor plate development. Cell 76, 103-115.
44. Slack, J.M. (1994). Inducing factors in Xenopus early embryos. Curr. Biol. 4, 116-126.
45. Sokol, S.Y. (1996). Analysis of Dishevelled signaling pathways during Xenopus development. Curr. Biol. 6, 1456-1467.
46. St-Jacques, B., and McMahon, A.P. (1996). Early mouse development: lessons from gene targeting. Curr. Opin. Genet. Dev. 6, 439-444.
47. Sussman, D.J., Klingensmith, J., Salinas, P., Adams, P.S., Nusse, R., and Perrimon, N. (1994). Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. Dev. Biol. 766, 73-86.
48. Suzuki, A., Thies, R.S.,Yamaji, N., Song, J.J., Wozney, J.M., Murakami, K., and Ueno, N. (1994). A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. Proc. Natl. Acad. Sci. USA 91, 10255-10259.
49. Tilghman, S.M. (1996). Lessons learned, promises kept: a biologist's eye view of the Genome Project. Genome Res. 6, 773-780.
50. Watabe, T., Kim, S., Candia, A., Rothbacher, U., Hashimoto, C., Inoue, K., and Cho, K.W. (1995). Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes Dev. 9, 3038-3050.
51. Watson, N., Linder, M.E., Druey, K.M., Kehrl, J.H., and Blumer, K.J. (1996). RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits. Nature 383, 172-175.
52. Wilkinson, D.G. (1992). Whole mount in situ hybridization of vertebrate embryos. In In Situ Hybridization: a Practical Approach, D.G. Wilkinson, ed. (Oxford: IRL Press), pp. 75-83.
53. Wylie, C., Kofron, M., Payne, C., Anderson, R., Hosobuchi, M., Joseph, E., and Heasman, J. (1996). Maternal beta-catenin establishes a 'dorsal signal' in early Xenopus embryos. Development 122, 2987-2996.
54. Yanagawa, S., van Leeuwen, F., Wodarz, A., Klingensmith, J., and Nusse, R. (1995). The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev. 9, 1087-1097.
55. Yost, C., Torres, M., Miller, J.R., Huang, E., Kimelman, D., and Moon, R.T. (1996). The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev. 10, 1443-1454.
56. Ziv, T., Shimoni, Y., and Mitrani, E. (1992). Activin can generate ectopic axial structures in chick blastoderm explants. Development 115, 689-694.