UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues

Cell

Volumn 87, Issue 2, 1996, Pages 187-195

  Chan, S S Y ^a,b   Zheng, H ^a   Su, M W ^a   Wilk, R ^a,b   Killeen, M T ^a   Hedgecock, E M ^c   Culotti, J G ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CELL SURFACE PROTEIN; DELETED IN COLORECTAL CANCER PROTEIN; MESSENGER RNA; NETRIN; RECEPTOR; UNC 40; UNC 5; UNC 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL MIGRATION; CELL MOTILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; EPIDERMIS; GASTRULA; NERVE FIBER; NEURULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

ANIMALIA; CAENORHABDITIS ELEGANS; VERTEBRATA;

EID: 0030592485     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81337-9     Document Type: Article

References (41)

1. Bieber, A.J., Snow, P.M., Hortsch, M., Patel, N.H., Jacobs, J.R., Traquina, Z.R., Schilling, J., and Goodman, C.S., (1989). Drosophila neuroglian: a member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1. Cell 59, 447-460.
2. Burden-Gulley, S.M., and Lemmon, V. (1995). Ig superfamily adhesion molecules in the vertebrate nervous system: binding partners and signal transduction during axon growth. Semin. Dev. Biol. 6, 79-87.
3. Chuong C.-M., Jiang, T.-X., Yin, E., and Widelitz, R.B. (1994). cDCC (chicken homolog to a gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelial-mesenchymal interactions. Dev. Biol. 164, 383-397.
4. Colamarino, S.A., and Tessier-Lavigne, M. (1995). The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81, 621-629.
5. Culotti, J.G. (1994). Axon guidance mechanisms in Caenorhabditis elegans. Curr. Opin. Gen. Dev. 4, 587-595.
6. Cunningham, B.A. (1995). Cell adhesion molecules as morphoregulators. Curr. Opin. Cell Biol. 7, 628-633.
7. Durbin, R.M. (1987). Studies on the development and organisation of the nervous system of Caenorhabditis elegans. Ph.D. Thesis, University of Cambridge, England.
8. Fearon, E.R., Cho, K.R., Nigro, J.M., Kern, S.E., Simons, J.W., Ruppert, J.M., Hamilton, S.R., Preisinger, A.C., Thomas, G., Kinzler, K.W., and Vogelstein, B. (1990). Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247, 49-56.
9. Hamelin, M., Zhou, Y., Su, M.-W., Scott, I.M., and Culotti, J.G. (1993). Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature 364, 327-330.
10. Harrelson, A.L., and Goodman, C.S. (1988). Growth cone guidance in insects: fasciclin II is a member of immunoglobulin superfamily. Science 242, 700-708.
11. Hedgecock, E.M., Culotti, J.G., Hall, D.H., and Stern, B.D. (1987). Genetics of cell and axon migrations in Caenorhabditis elegans. Development 100, 365-382.
12. Hedgecock, E.M., Culotti, J.G., and Hall, D.H. (1990). The unc-5, unc-6 and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4, 61-85.
13. Hedrick, L., Cho, K.R., Boyd, J., Risinger, J., and Vogelstein, B. (1992). DCC, a tumor suppressor gene expressed on the cell surface. Cold Spring Harbor Symp. Quant. Biol. LVII, 345-351.
14. Hedrick, L., Cho, K.R., Fearon, E.R., Wu, T.-C., Kinzler, K.W., and Vogelstein, B. (1994). The DCC gene product in cellular differentiation and colorectal tumorogenesis. Genes Dev. 8, 1174-1183.
15. Heim, R., Cubitt, A., and Tsien, R. (1995). Improved green fluorescence. Nature 373, 663-664.
16. Ishii, N., Wadsworth, W.G., Stern, B.D., Culotti, J.G., and Hedgecock, E.M. (1992). UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9, 873-881.
17. Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E.D., Chan, S.S.-Y., Culotti, J.G., and Tessier-Lavigne, M. (1996). Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell, this issue.
18. Kennedy, T.E., Serafini, T., de la Torre, J.R., and Tessier-Lavigne, M. (1994). Netrinsare diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78, 425-435.
19. Kennedy, T.E., and Tessier-Lavigne, M. (1995). Guidance and induction of branch formation in developing axons by target-derived diffusible factors. Curr. Opin. Neurobiol. 5, 83-90.
20. Klingensmith, J., and Nusse, R. (1994). Signaling by wingless in Drosophila. Dev. Biol. 166, 396-414.
21. Kolodziej, P.A., Timpe, L.C., Mitchell, K.J., Fried, S.A., Goodman, C.S., Jan, L.Y., and Jan, Y.N. (1996). frazzled encodes a Drosophila member of the Deleted in Colorectal Cancer (DCC) immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell, this issue.
22. Krause, M., and Hirsh, D. (1987). A trans-spliced leader sequence on actin mRNA in C. elegans. Cell 49, 753-761.
23. Lawlor, K.G., and Narayanan, R. (1992). Persistent expression of the tumor suppressor gene DCC is essential for neuronal differentiation. Cell Growth Differ. 3, 609-616.
24. Leung-Hagesteijn, C., Spence, A.M., Stern, B.D., Zhou, Y., Su, M.-W., Hedgecock, E.M., and Culotti, J.G. (1992). UNC-5, atransmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell 71, 289-299.
25. Maniatis, T., Fritsch, E.F., and Sambrook, J. (1982). Molecular Cloning: A Laboratory Manual (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory).
26. Mello, C., and Fire, A. (1995). DNA transformation in Caenorhabditis elegans: modern biological analysis of an organism, H.F. Epstein and D.C. Shakes, eds. Methods in Cell Biology 48, 452-482.
27. Nathke, I.S., Adams, C.L., Polakis, P., Stellin, J.H., and Nelson, W.J. (1996). The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J. Cell Biol. 134, 165-179.
28. Orita, M., Suzuki, Y., Sekiya, T. and Hayashi, K. (1989). Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5, 874-879.
29. Pierceall, W.E., Reale, M.A., Candia, A.F., Wright, C.V.E., Cho, K.R., and Fearon, E.R. (1994a). Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos. Dev. Biol. 166, 654-665.
30. Pierceall, W.E., Cho, K.R., Getzenberg, R.H., Reale, M.A., Hedrick, L., Vogelstein, B., and Fearon, E.R. (1994b). NIH3T3 cells expressing the deleted in colorectal cancer tumor suppressor gene product stimulate neurite outgrowth in rat PC12 pheochromocytoma cells. J. Cell Biol. 124, 1017-1027.
31. Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C., Munemitsu, S. and Polakis, P. (1996). Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272 1023-1026.
32. Sanger, F., Nicklen, S., and Coulson, A.R. (1977). DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463-5467.
33. Serafini, T., Kennedy, T.E., Galko, M.J., Mirzayan, C., Jessel, T.M., and Tessier-Lavigne, M. (1994). The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424.
34. Spinardi, L., Mazars, R., and Theillet, C. (1991). Protocols for an improved detection of point mutations by SSCP. Nucleic Acids Res. 19, 4009.
35. Sulston, J., and Hodgkin, J. (1988). Methods. In The Nematode Caenorhabditis elegans, W.B. Wood, ed. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory), pp. 587-606.
36. Vaughn, D.E., and Bjorkman, P.J. (1996). The (Greek) key to structures of neural cell adhesion molecules. Neuron 16, 261-273.
37. Vielmetter, J., Kayyem, J.F., Roman, J.M., and Dreyer, W.J. (1994). Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. J. Cell Biol. 727, 2009-2020.
38. Wadsworth, W.G., and Hedgecock, E.M. (1992). Guidance of neuroblast migrations and axonal projections in Caenorhabditis elegans. Curr. Opin. Neurobiol. 2, 36-41.
39. Wadsworth, W.G., Bhatt, H., and Hedgecock, E.M. (1996). Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron 16, 35-46.
40. White, J.G., Southgate, E., Thomson, J.N., and Brenner, S., (1986). The structure of the nervous system of the nematode Caenorhabditis elegans. Philos. Trans. R. Soc. Lond. (B) 314, 1-340.
41. Zinn, K. (1993). Drosophila protein tyrosine phosphatases. Semin. Cell Biol. 4, 397-401.