Function of WW domains as phosphoserine- or phosphothreonine-binding modules

Science

Volumn 283, Issue 5406, 1999, Pages 1325-1328

  Lu, Pei Jung ^a   Zhou, Xiao Zhen ^a   Shen, Minhui ^a   Lu, Kun Ping ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOSERINE; PHOSPHOTHREONINE;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CALCIUM-BINDING PROTEINS; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; HELA CELLS; HUMANS; LIGASES; PEPTIDYLPROLYL ISOMERASE; PHOSPHOPEPTIDES; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; POINT MUTATION; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

EID: 0040017910     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.283.5406.1325     Document Type: Article

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61. We thank two anonymous reviewers, T. Hunter, B. Neel, and L. Cantley for constructive comments, D. Parker and M. Montony for help with fluorescence polarization assay, and T. Stukenberg, M. W. Kirschner, M. Sudol, J. Kunag, J. Hani, H. Domdey, M. Schutkowski, and G. Fischer for providing reagents. K.P.L. is a Leukemia Society of America Scholar. The work was supported by NIH grants R01GM56230 and R01GM58556 to K.P.L.