-
1
-
-
0027931640
-
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the ras signaling pathway
-
Aronheim, A., Engelberg, D., Li, N., Al-Alawi, N., Schlessinger, J., and Karin, M. (1994). Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the ras signaling pathway. Cell 78, 949-961.
-
(1994)
Cell
, vol.78
, pp. 949-961
-
-
Aronheim, A.1
Engelberg, D.2
Li, N.3
Al-Alawi, N.4
Schlessinger, J.5
Karin, M.6
-
3
-
-
0029911521
-
Interaction of the nek adapter protein with p21-activated kinase (PAK1)
-
Bokoch, G.M., Wang, Y., Bohl, B.P., Sells, M.A., Quilliam, L.A., and Knaus, U.G. (1996). Interaction of the Nek adapter protein with p21-activated kinase (PAK1). J. Biol. Chem. 271, 25746-25749.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 25746-25749
-
-
Bokoch, G.M.1
Wang, Y.2
Bohl, B.P.3
Sells, M.A.4
Quilliam, L.A.5
Knaus, U.G.6
-
4
-
-
0028786020
-
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
-
Burbello, P.D., Drechsel, D., and Hall, A. (1995). A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem. 270, 29071-29074.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 29071-29074
-
-
Burbello, P.D.1
Drechsel, D.2
Hall, A.3
-
5
-
-
0029849810
-
P21 ras activation by the guanine nucleotide exchange factor sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus
-
Byrne, J.L., Paterson, H.F., and Marshall, C.J. (1996). p21 Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus. Oncogene 13, 2055-2065.
-
(1996)
Oncogene
, vol.13
, pp. 2055-2065
-
-
Byrne, J.L.1
Paterson, H.F.2
Marshall, C.J.3
-
7
-
-
0028862890
-
Abr and bcr are multifunctional regulators of the Rho GTP-binding protein family
-
Chuang, T.-H., Xu, X., Kaartinen, V., Heisterkamp, N., Groffen, J., and Bokoch, G.M. (1995). Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc. Natl. Acad. Sci. USA 92, 10282-10286.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 10282-10286
-
-
Chuang, T.-H.1
Xu, X.2
Kaartinen, V.3
Heisterkamp, N.4
Groffen, J.5
Bokoch, G.M.6
-
8
-
-
0029830139
-
The adaptor protein nck links receptor tyrosine kinases with the serine-threonine kinase pak1
-
Galisteo, M.L., Chernoff, J., Su, Y-C., Skolnik, E.Y., and Schlessinger, J. (1996). The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J. Biol. Chem. 277, 20997-21000.
-
(1996)
J. Biol. Chem.
, vol.277
, pp. 20997-21000
-
-
Galisteo, M.L.1
Chernoff, J.2
Su, Y.-C.3
Skolnik, E.Y.4
Schlessinger, J.5
-
9
-
-
0028225439
-
Identification of an invasion-inducing gene, tiam-1, that encodes a protein with homology to GDP-GTP exchangers for rho-like proteins
-
Habets, G.G.M., Scholtes, E.H.M., Zuydgeest, D., van der Kammen, R.A., Stam, J.C., Berns, A., and Collard, J.G. (1994). Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell 77, 537-549.
-
(1994)
Cell
, vol.77
, pp. 537-549
-
-
Habets, G.G.M.1
Scholtes, E.H.M.2
Zuydgeest, D.3
Van Der Kammen, R.A.4
Stam, J.C.5
Berns, A.6
Collard, J.G.7
-
10
-
-
0029963547
-
A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that co-localizes with dynamic actin structures
-
Harden, N., Lee, J., Loh, H.-Y., Ong, Y.-M., Tan, I., Leung, T., Manser, E., and Lim, L. (1996). A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that co-localizes with dynamic actin structures. Mol. Cell. Biol. 16, 1896-1908.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1896-1908
-
-
Harden, N.1
Lee, J.2
Loh, H.-Y.3
Ong, Y.-M.4
Tan, I.5
Leung, T.6
Manser, E.7
Lim, L.8
-
11
-
-
0029891491
-
IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for Cdc42Hs
-
Hart, M.J., Callow, M.G., Souza, B., and Polakis, P. (1996). IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for Cdc42Hs. EMBO J. 15, 2997-3005.
-
(1996)
EMBO J.
, vol.15
, pp. 2997-3005
-
-
Hart, M.J.1
Callow, M.G.2
Souza, B.3
Polakis, P.4
-
12
-
-
0026044409
-
Catalysis of guanine nucleotide exchange on Cdc42Hs protein by the dbl oncogene product
-
Hart, M.J., Eva, A., Evans, T., Aaronson, S.A., and Cerione, R.A. (1991). Catalysis of guanine nucleotide exchange on Cdc42Hs protein by the dbl oncogene product. Nature 354, 311-314.
-
(1991)
Nature
, vol.354
, pp. 311-314
-
-
Hart, M.J.1
Eva, A.2
Evans, T.3
Aaronson, S.A.4
Cerione, R.A.5
-
13
-
-
0027958423
-
Cellular transformation and guanine nucleotide exchange activity are catalysed by a common domain on the dbl oncogene product
-
Hart, M.J., Eva, A., Zangrilla, D., Aaronson, S.A., Evans, T., Cerione, R.A., and Zheng, Y. (1994). Cellular transformation and guanine nucleotide exchange activity are catalysed by a common domain on the dbl oncogene product. J. Biol. Chem. 269, 62-65.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 62-65
-
-
Hart, M.J.1
Eva, A.2
Zangrilla, D.3
Aaronson, S.A.4
Evans, T.5
Cerione, R.A.6
Zheng, Y.7
-
14
-
-
0029802561
-
Rac regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase
-
Joneson, T., McDonough, M., Bar-Sagi, D., and Van Aelst, L. (1996). RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science 274, 1374-1376.
-
(1996)
Science
, vol.274
, pp. 1374-1376
-
-
Joneson, T.1
McDonough, M.2
Bar-Sagi, D.3
Van Aelst, L.4
-
15
-
-
0028998794
-
Regulation of human leukocyte p21-activated kinases through G-protein-coupled receptors
-
Knaus, U.G., Morris, S., Dong, H.-J., Chernoff, J., and Bokoch, G.M. (1995). Regulation of human leukocyte p21-activated kinases through G-protein-coupled receptors. Science 269, 221-223.
-
(1995)
Science
, vol.269
, pp. 221-223
-
-
Knaus, U.G.1
Morris, S.2
Dong, H.-J.3
Chernoff, J.4
Bokoch, G.M.5
-
16
-
-
0028986034
-
The ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
-
Kozma, R., Ahmed, S., Best, A., and Lim, L. (1995). The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 15, 1942-1952.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 1942-1952
-
-
Kozma, R.1
Ahmed, S.2
Best, A.3
Lim, L.4
-
17
-
-
0031027205
-
Rho family GTPases and neuronal growth cone remodelling: Relationship between increased complexity induced by Cdc42Hs, Rac1 and acetylcholine, and collapse induced by RhoA and lysophosphatidic acid
-
Kozma, R., Sarner, S., Ahmed, S., and Lim, L. (1997). Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1 and acetylcholine, and collapse induced by RhoA and lysophosphatidic acid. Mol. Cell. Biol. 17, 1201-1211.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1201-1211
-
-
Kozma, R.1
Sarner, S.2
Ahmed, S.3
Lim, L.4
-
18
-
-
0030298138
-
PAK and the JNK/SAPK MAP kinase cascade
-
PAK and the JNK/SAPK MAP kinase cascade. Cell 87, 519-529.
-
(1996)
Cell
, vol.87
, pp. 519-529
-
-
Lamarche, N.1
Tapon, N.2
Stowers, L.3
Burbelo, P.D.4
Aspenstrom, P.5
Bridges, T.6
Chant, J.7
Hall, A.8
-
19
-
-
0028805516
-
A single amino acid in the SH3 domain of hck determines its high affinity and specificity in binding to hIV-1 nef protein
-
Lee, C.-H., Leung, B., Lemmon, M.A., Zheng, J., Cowburn, D., Kuriyan, J., and Saksela, K. (1995). A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J. 14, 5006-5015.
-
(1995)
EMBO J.
, vol.14
, pp. 5006-5015
-
-
Lee, C.-H.1
Leung, B.2
Lemmon, M.A.3
Zheng, J.4
Cowburn, D.5
Kuriyan, J.6
Saksela, K.7
-
20
-
-
0029789678
-
The p160 RhoA-binding kinase ROKa is a member of a kinase family and is involved in the reorganization of the cytoskeleton
-
Leung, T., Chen, X.-Q., Manser, E., and Lim, L. (1996). The p160 RhoA-binding kinase ROKa is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell. Biol. 16, 5313-5327.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5313-5327
-
-
Leung, T.1
Chen, X.-Q.2
Manser, E.3
Lim, L.4
-
21
-
-
0031962372
-
The myotinic dystophy kinase-related Cdc42-binding kinase (MRCK) acts as a Cdc42 effector in promoting cytoskeletal reorganization
-
in press
-
Leung, T., Chen, X.-Q., Tan, I., Manser, E., and Lim, L. (1998). The myotinic dystophy kinase-related Cdc42-binding kinase (MRCK) acts as a Cdc42 effector in promoting cytoskeletal reorganization. Mol. Cell. Biol., in press.
-
(1998)
Mol. Cell. Biol.
-
-
Leung, T.1
Chen, X.-Q.2
Tan, I.3
Manser, E.4
Lim, L.5
-
22
-
-
0029805324
-
Regulation of phosphorylation pathways by p21 GTPases
-
Lim, L., Manser, E., Leung, T., and Hall, C. (1996). Regulation of phosphorylation pathways by p21 GTPases. Eur. J. Biochem. 242, 171-185.
-
(1996)
Eur. J. Biochem.
, vol.242
, pp. 171-185
-
-
Lim, L.1
Manser, E.2
Leung, T.3
Hall, C.4
-
23
-
-
0031080595
-
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nek
-
Lu, W., Katz, S., Gupta, R., and Mayer, B.J. (1997). Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nek. Curr. Biol. 7, 85-94.
-
(1997)
Curr. Biol.
, vol.7
, pp. 85-94
-
-
Lu, W.1
Katz, S.2
Gupta, R.3
Mayer, B.J.4
-
24
-
-
0028078824
-
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
-
Manser, E., Leung, T., Salihuddin, H., Zhao, Z.-S., and Lim, L. (1994). A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367, 40-46.
-
(1994)
Nature
, vol.367
, pp. 40-46
-
-
Manser, E.1
Leung, T.2
Salihuddin, H.3
Zhao, Z.-S.4
Lim, L.5
-
25
-
-
0028862297
-
Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family
-
Manser, E., Chong, C., Zhao, Z.-S., Leung, T., Michael, G., Hall, C., and Lim, L. (1995). Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. J. Biol. Chem. 270, 25070-25078.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 25070-25078
-
-
Manser, E.1
Chong, C.2
Zhao, Z.-S.3
Leung, T.4
Michael, G.5
Hall, C.6
Lim, L.7
-
26
-
-
0031036626
-
Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes
-
Manser, E., Huang, H.-Y., Loo, T.-H., Chen, X.-Q., Dong, J.-M., Leung, T., and Lim, L. (1997). Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes. Mol. Cell. Biol. 17, 1129-1143.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1129-1143
-
-
Manser, E.1
Huang, H.-Y.2
Loo, T.-H.3
Chen, X.-Q.4
Dong, J.-M.5
Leung, T.6
Lim, L.7
-
27
-
-
0029056399
-
A novel serine kinase activated by Rac/Cdc42Hs-dependent autophosphorylation is related to PAK65 and Ste20
-
Martin, G.A., Bollag, G., McCormick, F.A., and Abo, A. (1995). A novel serine kinase activated by Rac/Cdc42Hs-dependent autophosphorylation is related to PAK65 and Ste20. EMBO J. 14, 1970-1978.
-
(1995)
EMBO J.
, vol.14
, pp. 1970-1978
-
-
Martin, G.A.1
Bollag, G.2
McCormick, F.A.3
Abo, A.4
-
28
-
-
0029079431
-
A role for rac in tiam1 induced membrane ruffling and invasion
-
Michiels, F., Habets, G.G.M., Stam, J.C., Van der Kammen, R.A., and Collard, J.G. (1995). A role for Rac in Tiam1 induced membrane ruffling and invasion. Nature 375, 338-340.
-
(1995)
Nature
, vol.375
, pp. 338-340
-
-
Michiels, F.1
Habets, G.G.M.2
Stam, J.C.3
Van Der Kammen, R.A.4
Collard, J.G.5
-
29
-
-
0030931216
-
Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for rac-dependent membrane ruffling and c-Jun NH2-terminal kinase activation
-
Michiels, F., Stam, J.C., Hordijk, P.L., Van der Kammen, R.A., Ruuls-Van Stalle, L., Feltkamp, C.A., and Collard, J.G. (1997). Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for rac-dependent membrane ruffling and c-Jun NH2-terminal kinase activation. J. Cell. Biol. 127, 387-398.
-
(1997)
J. Cell. Biol.
, vol.127
, pp. 387-398
-
-
Michiels, F.1
Stam, J.C.2
Hordijk, P.L.3
Van Der Kammen, R.A.4
Ruuls-Van Stalle, L.5
Feltkamp, C.A.6
Collard, J.G.7
-
30
-
-
0028961293
-
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
-
Nobes, C.D., and Hall, A. (1995). Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.
-
(1995)
Cell
, vol.81
, pp. 53-62
-
-
Nobes, C.D.1
Hall, A.2
-
31
-
-
0030466893
-
Facio-genital dysplasia protein (FGD1) and vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases
-
Olson, M.F., Pasteris, N.G., Gorski, J.L., and Hall, A. (1996). Facio-genital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. Curr. Biol. 6, 1628-1633.
-
(1996)
Curr. Biol.
, vol.6
, pp. 1628-1633
-
-
Olson, M.F.1
Pasteris, N.G.2
Gorski, J.L.3
Hall, A.4
-
32
-
-
0026778133
-
The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
-
Ridley, A.J., and Hall, A. (1992). The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
-
(1992)
Cell
, vol.70
, pp. 389-399
-
-
Ridley, A.J.1
Hall, A.2
-
33
-
-
0026654125
-
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
-
Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D., and Hall, A. (1992). The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
-
(1992)
Cell
, vol.70
, pp. 401-410
-
-
Ridley, A.J.1
Paterson, H.F.2
Johnston, C.L.3
Diekmann, D.4
Hall, A.5
-
34
-
-
0030911052
-
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
-
Rodriguez-Viciana, P., Warne, P.H., Khwaja, A., Marte, B.M., Pappin, D., Das, P., Waterfield, M.D., Ridley, A., and Downward, J. (1997). Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89, 457-467.
-
(1997)
Cell
, vol.89
, pp. 457-467
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Khwaja, A.3
Marte, B.M.4
Pappin, D.5
Das, P.6
Waterfield, M.D.7
Ridley, A.8
Downward, J.9
-
35
-
-
0031055415
-
Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras
-
de Rooij, J., and Bos, J.L. (1997). Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 14, 623-625.
-
(1997)
Oncogene
, vol.14
, pp. 623-625
-
-
De Rooij, J.A.1
Bos, J.L.2
-
36
-
-
0028825182
-
Quantitative analysis of Grb2-sos1 interaction: The N-terminal SH3 domain of Grb2 mediates affinity
-
Sastry, L., Lin, W., Wong, W.T., Di-Fiore, P.P., Scoppa, C.A., and King, C.R. (1995). Quantitative analysis of Grb2-Sos1 interaction: the N-terminal SH3 domain of Grb2 mediates affinity. Oncogene 11, 1107-1112.
-
(1995)
Oncogene
, vol.11
, pp. 1107-1112
-
-
Sastry, L.1
Lin, W.2
Wong, W.T.3
Di-Fiore, P.P.4
Scoppa, C.A.5
King, C.R.6
-
37
-
-
0031105660
-
Human p21-activated kinase (pak1) regulates actin organization in mammalian cells
-
Sells, M.A., Knaus, U.G., Bagrodia, S., Ambrose, D.M., Bokoch, G.M., and Chernoff, J. (1997). Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7, 202-210.
-
(1997)
Curr. Biol.
, vol.7
, pp. 202-210
-
-
Sells, M.A.1
Knaus, U.G.2
Bagrodia, S.3
Ambrose, D.M.4
Bokoch, G.M.5
Chernoff, J.6
-
38
-
-
0031557311
-
Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers
-
Sone, M., Hoshino, M., Suzuki, E., Kuroda, S., Kaibuchi, K., Nakagoshi, H., Saigo, K., Nabeshima, Y., and Hama, C. (1997). Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers. Science 275, 543-547.
-
(1997)
Science
, vol.275
, pp. 543-547
-
-
Sone, M.1
Hoshino, M.2
Suzuki, E.3
Kuroda, S.4
Kaibuchi, K.5
Nakagoshi, H.6
Saigo, K.7
Nabeshima, Y.8
Hama, C.9
-
39
-
-
0028842508
-
cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets
-
cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets. J. Biol. Chem. 270, 26690-26697.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 26690-26697
-
-
Teo, M.1
Manser, E.2
Lim, L.3
-
40
-
-
0031038716
-
A Drosophila gene with predicted rhoGEF, pleckstrin homology and SH3 domains is highly expressed in morphogenic tissue
-
Werner, L.A., and Manseau, L.J. (1997). A Drosophila gene with predicted rhoGEF, pleckstrin homology and SH3 domains is highly expressed in morphogenic tissue. Gene 187, 107-114.
-
(1997)
Gene
, vol.187
, pp. 107-114
-
-
Werner, L.A.1
Manseau, L.J.2
-
41
-
-
0031026132
-
Rac regulation of transformation, gene expression and actin organization by multiple, PAK-independent pathways
-
Westwick, J.K., Lambert, Q.T., Clarke, G.J., Symons, M., Van Aelst, L., Pestell, R.G., and Der, C.J. (1997). Rac regulation of transformation, gene expression and actin organization by multiple, PAK-independent pathways. Mol. Cell Biol. 17, 1324-1335.
-
(1997)
Mol. Cell Biol.
, vol.17
, pp. 1324-1335
-
-
Westwick, J.K.1
Lambert, Q.T.2
Clarke, G.J.3
Symons, M.4
Van Aelst, L.5
Pestell, R.G.6
Der, C.J.7
|