Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses

Oncogene

Volumn 19, Issue 2, 2000, Pages 177-187

  Zisch, Andreas H ^a   Pazzagli, Claudia ^a   Freeman, Andrew L ^a   Schneller, Maximilian ^a,b   Hadman, Martin ^a,c   Smith, Jeffrey W ^a   Ruoslahti, Erkki ^a   Pasquale, Elena B ^a  

^a BURNHAM INSTITUTE   (United States)

^b Sect of Connective Tissue Biology   (Sweden)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Actin cytoskeleton; Cell adhesion; Mitogen activated protein kinases; Signaling pathways; Tyrosine phosphorylation

Indexed keywords

GLUTAMIC ACID; MUTANT PROTEIN; PHENYLALANINE; PROTEIN TYROSINE KINASE; RECEPTOR PROTEIN; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL ADHESION; CONTROLLED STUDY; CYTOSKELETON; DNA TRANSFECTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STRUCTURE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 0034642564     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203304     Document Type: Article

References (74)

1. Adams JC. (1995). J. Cell. Sci., 108, 1977-1990.
2. Adams JC. (1997). Mol. Biol. Cell., 8, 2345-2363.
3. Boguski MS and McCormick F. (1993). Nature, 366, 643-654.
4. Bruckner K and Klein R. (1998). Curr. Opin. Neurobiol., 8, 375-382.
5. Buchert M, Schneider S, Meskenaite V, Adams MT, Canaani E, Baechi T, Moelling K and Hovens CM. (1999). J. Cell. Biol., 2, 361-371.
6. Cavigelli M, Dolfi F, Claret FX and Karin M. (1995). EMBO J., 14, 5957-5964.
7. Courtneidge SA, Kypta RM, Cooper JA and Kazlauskas A. (1991). Cell. Growth Differ., 2, 483-486.
8. Courtneidge SA, Dhand R, Pilat D, Twamley GM, Waterfield MD and Roussel MF. (1993). EMBO J., 12, 943-950.
9. Davis RJ. (1988). J. Biol. Chem., 263, 9462-9469.
10. Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M and Yancopoulos GD. (1994). Science, 266, 816-819.
11. Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M and Davis RJ. (1994). Cell, 76, 1025-1037.
12. Drescher U. (1997). Curr. Biol., 7, R799-R807.
13. Drescher U, Kremoser C, Handwerker C, Loschinger J, Noda M and Bonhoeffer F. (1995). Cell, 82, 359-370.
14. Ellis C, Kasmi F, Ganju P, Walls E, Panayotou G and Reith AD. (1996). Oncogene, 12, 1727-1736.
15. Escobedo JA, Kaplan DR, Kavanaugh WM, Turck CW and Williams LT. (1991). Mol. Cell. Biol., 11, 1125-1132.
16. Fantl WJ, Escobedo JA, Martin GA, Turck CW, del Rosario M, McCormick F and Williams LT. (1992). Cell, 69, 413-423.
17. Flanagan JG and Vanderhaeghen P. (1998). Annu. Rev. Neurosci., 21, 309-345.
18. Gandino L, Longati P, Medico E, Prat M and Comoglio PM. (1994). Mol. Cell. Biol., 269, 1815-1820.
19. Giasson BI and Mushynski WE. (1996). Mol. Cell. Biol., 271, 30404-30409.
20. Giasson BI and Mushynski WE. (1997). J. Neurosci., 17, 9466-9472.
21. Hock B, Bohme B, Karn T, Feller S, Rubsamen-Waigmann H and Strebhardt K. (1998a). Oncogene, 17, 255-260.
22. Hock B, Bohme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rubsamen-Waigmann H and Strebhardt K. (1998b). Proc. Nat. Acad. Sci. USA, 95, 9779-9784.
23. Holash JA and Pasquale EB. (1995). Devel. Biol., 172, 683-693.
24. Holash JA, Soans C, Chong LD, Shao H, Dixit VM and Pasquale EB. (1997). Devel. Biol., 182, 256-269.
25. Holland SJ, Gale NW, Gish GD, Roth RA, Zhou SY, Cantley LC, Henkemeyer M, Yancopoulos GD and Pawson T. (1997). EMBO J., 16, 3877-3888.
26. Huang W and Erikson RL. (1994). Proc. Nat. Acad. Sci. USA, 91, 8960-8963.
27. Hubbard SR. (1997). EMBO J., 16, 5572-5581.
28. Hubbard SR, Mohammadi M and Schlessinger J. (1998). J. Biol. Chem., 273, 11987-11990.
29. Hughes PE, Renshaw MW, Pfaff M, Forsyth J, Keivens VM, Schwarte MA and Ginsberg MH. (1997). Cell, 88, 521-530.
30. Kalo MS, and Pasquale EB. (1999). Biochemistry, 38, 14396-14408.
31. Kaufman RJ, Davies MV, Pathak VK and Hershey JW. (1989). Mol. Cell. Biol., 9, 946-958.
32. Kundra V, Escobedo JA, Kazlauskas A, Kim HK, Rhee SG, Williams LT and Zetter BR. (1994). Nature, 367, 474-476.
33. Lauffenburger DA and Horwitz AF. (1996). Cell, 84, 359-369.
34. Lin XH, Grako KA, Burg MA and Stallcup WB. (1996). Mol. Biol. Cell., 7, 1977-1993.
35. Luo L, Jan LY and Jan YN. (1997). Curr. Opin. Neurobiol., 7, 81-86.
36. Mackay DJ, Nobes CD and Hall A. (1995). Trends Neurosci., 18, 496-501.
37. Meima L, Kljavin IJ, Moran P, Shih A, Winslow JW and Caras IW. (1997a). Eur. J. Neurosci., 9, 177-188.
38. Meima L, Moran P, Matthews W and Caras IW. (1997b). Mol. Cell. Neurosci., 9, 314-328.
39. Minden A, Lin A, McMahon M, Lange-Carter C, Derijard B, Davis RJ, Johnson GL and Karin M. (1994). Science., 266, 1719-1723.
40. Mitchison TJ and Cramer LP. (1996). Cell, 84, 371-379.
41. Mori S, Ronnstrand L, Yokote K, Engstrom A, Courtneidge SA, Claesson-Welsh L and Heldin CH. (1993). EMBO J., 12, 2257-2264.
42. Myles GM, Brandt CS, Carlberg K and Rohrschneider LR. (1994). Mol. Cell. Biol., 14, 4843-4854.
43. Nakamoto M, Cheng HJ, Friedman GC, McLaughlin T, Hansen MJ, Yoon CH, O'Leary DD and Flanagan JG. (1996). Cell, 86, 755-766.
44. Pandey A, Lazar DF, Saltiel AR and Dixit VM. (1994). J. Biol. Chem., 269, 30154-30157.
45. Pasquale EB. (1991). Cell. Regulation, 2, 523-534.
46. Pasquale EB. (1997). Curr. Opin. Cell. Biol., 9, 608-615.
47. Pawson T and Scott JD. (1997). Science, 278, 2075-2080.
48. Peters KG, Marie J, Wilson E, Ives HE, Escobedo J, Del Rosario M, Mirda D and Williams LT. (1992). Nature, 358, 678-681.
49. Potempa S and Ridley AJ. (1998). Mol. Biol. Cell., 9, 2185-2200.
50. Quilliam LA, Khosravi-Far R, Huff SY and Der CJ. (1995). Bioessays, 17, 395-404.
51. Reszka AA, Seger R, Diltz CD, Krebs EG and Fischer EH. (1995). Proc. Nat. Acad. Sci. USA, 92, 8881-8885.
52. Shao H, Lou L, Pandey A, Pasquale EB and Dixit VM. (1994). J. Biol. Chem., 269, 26606-26609.
53. Spivak-Kroizman T, Mohammadi M, Hu P, Jaye M, Schlessinger J and Lax I. (1994). J. Biol. Chem., 269, 14419-14423.
54. Stein EDP, Cerretti DP and Daniel TO. (1996). J. Biol. Chem., 271, 23588-23593.
55. Stein E, Huynh-Do U, Lane AA, Cerretti DP and Daniel TO. (1998a). J. Biol. Chem., 273, 1303-1308.
56. Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL and Daniel TO. (1998b). Gen. Dev., 12, 667-678.
57. Stephens RM, Loeb DM, Copeland TD, Pawson T, Greene LA and Kaplan DR. (1994). Neuron, 12, 691-705.
58. Tapon N and Hall A. (1997). Curr. Opin. Cell. Biol., 9, 86-92.
59. Thomas SM, Soriano P and Imamoto A. (1995). Nature, 376, 267-271.
60. Thorsness PE and Koshland Jr DE. (1987). J. Biol. Chem., 262, 10422-10425.
61. Torres R, Finestein BL, Dong H, Standinger J, Olson EN, Huganin RL, Bredt DS, Gale NW and Yancopoulos D. (1998). Neuron, 21, 1453-1463.
62. Treisman R. (1996). Curr. Opin. Cell. Biol., 8, 205-215.
63. van der Geer P, Hunter T and Lindberg RA. (1994). Annu. Rev. Cell. Biol., 10, 251-337.
64. Veeranna, Amin ND, Ahn NG, Jaffe H, Winters CA, Grant P and Pant HC. (1998). J. Neurosci., 18, 4008-4021.
65. Waldmann R, Hanson PI and Schulman H. (1990). Biochemistry, 29, 1679-1684.
66. Wang HU and Anderson DJ. (1997). Neuron. 18, 383-396.
67. Wittekind M, Reizer J, Deutscher J, Saier MH and Klevit RE. (1989). Biochemistry, 28, 9908-9912.
68. Yamaguchi H and Hendrickson WA. (1996). Nature, 384, 484-489.
69. Yamashiro S, Yamakita Y, Ono S and Matsumura F. (1998). Mol. Biol. Cell., 9, 993-1006.
70. Zhang Z, Vuori K, Wang H, Reed JC and Ruoslahti E. (1996). Cell, 85, 61-69.
71. Zisch AH and Pasquale EB. (1997). Cell. Tissue Res., 290, 217-226.
72. Zisch AH, Stallcup WB, Chong LD, Dahlin-Huppe K, Voshol J, Schachner M and Pasquale EB. (1997). J. Neurosci. Res., 47, 655-665.
73. Zisch AH, Kalo MS, Chong LD and Pasquale EB. (1998). Oncogene, 16, 2657-2670.
74. Zou JX, Wang B, Zisch AH, Pasquale EB and Ruoslahti E. Proc. Nat. Acad. Sci. USA, (in press).