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Volumn 12, Issue 17, 1998, Pages 2684-2697

Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gβγ complex underlies activation of the yeast pheromone response pathway

Author keywords

Heterotrimeric G protein; MAP kinase; PAK Ste20 kinase; Rho Rac Cdc42 GTPase; Signal transduction

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHEROMONE;

EID: 0032168881     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.17.2684     Document Type: Article
Times cited : (202)

References (46)
  • 1
    • 0025294640 scopus 로고
    • CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae
    • Adams, A.E., D.I. Johnson, R.M. Longnecker, B.F. Sloat, and J.R. Pringle. 1990. CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J. Cell Biol. 111: 131-142.
    • (1990) J. Cell Biol. , vol.111 , pp. 131-142
    • Adams, A.E.1    Johnson, D.I.2    Longnecker, R.M.3    Sloat, B.F.4    Pringle, J.R.5
  • 2
    • 0029960339 scopus 로고    scopus 로고
    • Genetic relationships between the G protein βγcomplex, Ste5p, Ste20p and Cdc42p: Investigation of effector roles in the yeast pheromone response pathway
    • Akada, R., L. Kallal, D.I. Johnson, and J. Kurjan. 1996. Genetic relationships between the G protein βγcomplex, Ste5p, Ste20p and Cdc42p: Investigation of effector roles in the yeast pheromone response pathway. Genetics 143: 103-117.
    • (1996) Genetics , vol.143 , pp. 103-117
    • Akada, R.1    Kallal, L.2    Johnson, D.I.3    Kurjan, J.4
  • 3
    • 0029240366 scopus 로고
    • Signaling, mitogenesis and the cytoskeleton: Where the action is
    • Carraway, K.L. and C.A. Carraway. 1995. Signaling, mitogenesis and the cytoskeleton: Where the action is. Bioessays 17: 171-175.
    • (1995) Bioessays , vol.17 , pp. 171-175
    • Carraway, K.L.1    Carraway, C.A.2
  • 4
    • 0028915743 scopus 로고
    • GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more
    • Chant, J. and L. Stowers. 1995. GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more. Cell 81: 1-4.
    • (1995) Cell , vol.81 , pp. 1-4
    • Chant, J.1    Stowers, L.2
  • 5
    • 0027983908 scopus 로고
    • Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
    • Choi, K.Y., B. Satterberg, D.M. Lyons, and E.A. Elion. 1994. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78: 499-512.
    • (1994) Cell , vol.78 , pp. 499-512
    • Choi, K.Y.1    Satterberg, B.2    Lyons, D.M.3    Elion, E.A.4
  • 6
    • 0029973636 scopus 로고    scopus 로고
    • FACS-optimized mutants of the green fluorescent protein (GFP)
    • Cormack, B.P., R.H. Valdivia, and S. Falkow. 1996. FACS-optimized mutants of the green fluorescent protein (GFP). Gene 173: 33-38.
    • (1996) Gene , vol.173 , pp. 33-38
    • Cormack, B.P.1    Valdivia, R.H.2    Falkow, S.3
  • 7
    • 0029042360 scopus 로고
    • Yeast synaptobrevin homologs are modified posttranslationally by the addition of palmitate
    • Couve, A., V. Protopopov, and J.E. Gerst. 1995. Yeast synaptobrevin homologs are modified posttranslationally by the addition of palmitate. Proc. Natl. Acad. Sci. 92: 5987-5991.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 5987-5991
    • Couve, A.1    Protopopov, V.2    Gerst, J.E.3
  • 8
    • 0029091498 scopus 로고
    • Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast
    • Cvrckova, F., C. DeVirgilio, E. Manser, J.R. Pringle, and K. Nasmyth. 1995. Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes & Dev. 9: 1817-1830.
    • (1995) Genes & Dev. , vol.9 , pp. 1817-1830
    • Cvrckova, F.1    DeVirgilio, C.2    Manser, E.3    Pringle, J.R.4    Nasmyth, K.5
  • 9
    • 0032567815 scopus 로고    scopus 로고
    • Functional binding between Gβ and the LIM domain of Ste5 is required to activate the MEKK Ste11
    • Feng, Y., L.Y. Song, E. Kincaid, S.K. Mahanty, and E.A. Elion. 1998. Functional binding between Gβ and the LIM domain of Ste5 is required to activate the MEKK Ste11. Curr. Biol. 8: 267-278.
    • (1998) Curr. Biol. , vol.8 , pp. 267-278
    • Feng, Y.1    Song, L.Y.2    Kincaid, E.3    Mahanty, S.K.4    Elion, E.A.5
  • 10
    • 0028070987 scopus 로고
    • Vesicle fusion from yeast to man
    • Ferro-Novick, S. and R. Jahn. 1994. Vesicle fusion from yeast to man. Nature 370: 191-193.
    • (1994) Nature , vol.370 , pp. 191-193
    • Ferro-Novick, S.1    Jahn, R.2
  • 11
    • 0028284596 scopus 로고
    • Biochemical and genetic analysis of dominant-negative mutations affecting a yeast G-protein γ subunit
    • Grishin, A.V., J.L. Weiner, and K.J. Blumer. 1994. Biochemical and genetic analysis of dominant-negative mutations affecting a yeast G-protein γ subunit. Mol. Cell. Biol. 14: 4571-4578.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4571-4578
    • Grishin, A.V.1    Weiner, J.L.2    Blumer, K.J.3
  • 12
    • 0027982807 scopus 로고
    • Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway
    • Hasson, M.S., D. Blinder, J. Thorner, and D.D. Jenness. 1994. Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway. Mol. Cell. Biol. 14: 1054-1065.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1054-1065
    • Hasson, M.S.1    Blinder, D.2    Thorner, J.3    Jenness, D.D.4
  • 13
    • 0028985079 scopus 로고
    • MAP kinase pathways in yeast: For mating and more
    • Herskowitz, I. 1995. MAP kinase pathways in yeast: For mating and more. Cell 80: 187-197.
    • (1995) Cell , vol.80 , pp. 187-197
    • Herskowitz, I.1
  • 14
    • 0030614451 scopus 로고    scopus 로고
    • The Gβγ complex of the yeast pheromone response pathway: Subcellular fractionation and protein-protein interactions
    • Hirschman, J., G. DeZutter, W. Simonds, and D.D. Jenness. 1996. The Gβγ complex of the yeast pheromone response pathway: Subcellular fractionation and protein-protein interactions. J. Biol. Chem. 272: 240-248.
    • (1996) J. Biol. Chem. , vol.272 , pp. 240-248
    • Hirschman, J.1    DeZutter, G.2    Simonds, W.3    Jenness, D.D.4
  • 15
    • 0030815533 scopus 로고    scopus 로고
    • Ste5 RING-H2 domain: Role in Ste4-promoted oligomerization for yeast pheromone signaling
    • Inouye, C., N. Dhillon, and J. Thorner. 1997. Ste5 RING-H2 domain: Role in Ste4-promoted oligomerization for yeast pheromone signaling. Science 278: 103-106.
    • (1997) Science , vol.278 , pp. 103-106
    • Inouye, C.1    Dhillon, N.2    Thorner, J.3
  • 16
    • 0027048684 scopus 로고
    • The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein βγ subunits to downstream signalling components
    • Leberer, E., D. Dignard, D. Harcus, D.Y. Thomas, and M. Whiteway. 1992. The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein βγ subunits to downstream signalling components. EMBO J. 11: 4815-4824.
    • (1992) EMBO J. , vol.11 , pp. 4815-4824
    • Leberer, E.1    Dignard, D.2    Harcus, D.3    Thomas, D.Y.4    Whiteway, M.5
  • 17
    • 0031058930 scopus 로고    scopus 로고
    • Pheromone signalling and polarized morphogenesis in yeast
    • Leberer, E., D.Y. Thomas, and M. Whiteway. 1997a. Pheromone signalling and polarized morphogenesis in yeast. Curr. Opin. Genet. Dev. 7: 59-66.
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 59-66
    • Leberer, E.1    Thomas, D.Y.2    Whiteway, M.3
  • 18
    • 0031015562 scopus 로고    scopus 로고
    • Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase
    • Leberer, E., C. Wu, T. Leeuw, A. Fourest-Lieuvin, J.E. Segall, and D.Y. Thomas. 1997b. Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase. EMBO J. 16: 83-97.
    • (1997) EMBO J. , vol.16 , pp. 83-97
    • Leberer, E.1    Wu, C.2    Leeuw, T.3    Fourest-Lieuvin, A.4    Segall, J.E.5    Thomas, D.Y.6
  • 20
    • 0032495478 scopus 로고    scopus 로고
    • Interaction of a G-protein β-subunit with a conserved sequence in Ste20/PAK family protein kinases
    • Leeuw, T., C. Wu, J.D. Schrag, M. Whiteway, D.Y. Thomas, and E. Leberer. 1998. Interaction of a G-protein β-subunit with a conserved sequence in Ste20/PAK family protein kinases. Nature 391: 191-195.
    • (1998) Nature , vol.391 , pp. 191-195
    • Leeuw, T.1    Wu, C.2    Schrag, J.D.3    Whiteway, M.4    Thomas, D.Y.5    Leberer, E.6
  • 21
    • 0028978605 scopus 로고
    • Chemoattractant and GTPγS-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes
    • Lilly, P.J. and P.N. Devreotes. 1995. Chemoattractant and GTPγS-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes. J. Cell Biol. 129: 1659-1665.
    • (1995) J. Cell Biol. , vol.129 , pp. 1659-1665
    • Lilly, P.J.1    Devreotes, P.N.2
  • 22
    • 0027077607 scopus 로고
    • Specification of sites for polarized growth in Saccharomyces cerevisiae and the influence of external factors on site selection
    • Madden, K. and M. Snyder. 1992. Specification of sites for polarized growth in Saccharomyces cerevisiae and the influence of external factors on site selection. Mol. Biol. Cell 3: 1025-1035.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 1025-1035
    • Madden, K.1    Snyder, M.2
  • 23
    • 0031977016 scopus 로고    scopus 로고
    • The riddle of MAP kinase signaling specificity
    • Madhani, H.D. and G.R. Fink. 1998. The riddle of MAP kinase signaling specificity. Trends Genet. 14: 151-155.
    • (1998) Trends Genet. , vol.14 , pp. 151-155
    • Madhani, H.D.1    Fink, G.R.2
  • 24
    • 0029002374 scopus 로고
    • Characterization of protein prenylation in Saccharomyces cerevisiae
    • Mitchell, D.A. and R.J. Deschenes. 1995. Characterization of protein prenylation in Saccharomyces cerevisiae. Methods Enzymol. 250: 68-78.
    • (1995) Methods Enzymol. , vol.250 , pp. 68-78
    • Mitchell, D.A.1    Deschenes, R.J.2
  • 25
    • 0028261404 scopus 로고
    • Reconstitution of a yeast protein kinase cascade in vitro: Activation of the yeast MEK homologue STE7 by STE11
    • Neiman, A.M. and I. Herskowitz. 1994. Reconstitution of a yeast protein kinase cascade in vitro: Activation of the yeast MEK homologue STE7 by STE11. Proc. Natl. Acad. Sci. 91: 3398-3402.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 3398-3402
    • Neiman, A.M.1    Herskowitz, I.2
  • 26
    • 0032495489 scopus 로고    scopus 로고
    • A GTP-exchange factor required for cell orientation
    • Nern, A. and R.A. Arkowitz. 1998. A GTP-exchange factor required for cell orientation. Nature 391: 195-198.
    • (1998) Nature , vol.391 , pp. 195-198
    • Nern, A.1    Arkowitz, R.A.2
  • 27
    • 0030465534 scopus 로고    scopus 로고
    • Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast
    • Peter, M., A.M. Neiman, H.-O. Park, M. van Lohuizen, and I. Herskowitz. 1996. Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J. 15: 7046-7059.
    • (1996) EMBO J. , vol.15 , pp. 7046-7059
    • Peter, M.1    Neiman, A.M.2    Park, H.-O.3    Van Lohuizen, M.4    Herskowitz, I.5
  • 29
    • 0029954765 scopus 로고    scopus 로고
    • AKR1 encodes a candidate effector of the Gβγ complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction
    • Pryciak, P.M. and L.H. Hartwell. 1996. AKR1 encodes a candidate effector of the Gβγ complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction. Mol. Cell. Biol. 16: 2614-2626.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2614-2626
    • Pryciak, P.M.1    Hartwell, L.H.2
  • 30
    • 0030945486 scopus 로고    scopus 로고
    • Transmembrane domain-dependent sorting of proteins to the ER and plasma membrane in yeast
    • Rayner, J.C. and H.R.B. Pelham. 1997. Transmembrane domain-dependent sorting of proteins to the ER and plasma membrane in yeast. EMBO J. 16: 1832-1841.
    • (1997) EMBO J. , vol.16 , pp. 1832-1841
    • Rayner, J.C.1    Pelham, H.R.B.2
  • 31
    • 0030884623 scopus 로고    scopus 로고
    • Mating in Saccharomyces cerevisiae: The role of the pheromone signal transduction pathway in the chemotropic response to pheromone
    • Schrick, K., B. Garvik, and L.H. Hartwell. 1997. Mating in Saccharomyces cerevisiae: The role of the pheromone signal transduction pathway in the chemotropic response to pheromone. Genetics 147: 19-32.
    • (1997) Genetics , vol.147 , pp. 19-32
    • Schrick, K.1    Garvik, B.2    Hartwell, L.H.3
  • 32
    • 0031127255 scopus 로고    scopus 로고
    • Emerging from the Pak: The p21-activated protein kinase family
    • Sells, M.A. and J. Chernoff. 1997. Emerging from the Pak: The p21-activated protein kinase family. Trends Cell Biol. 7: 162-167.
    • (1997) Trends Cell Biol. , vol.7 , pp. 162-167
    • Sells, M.A.1    Chernoff, J.2
  • 33
    • 0025978949 scopus 로고
    • Getting started with yeast
    • Sherman, F. 1991. Getting started with yeast. Methods Enzymol. 194: 3-21.
    • (1991) Methods Enzymol. , vol.194 , pp. 3-21
    • Sherman, F.1
  • 34
    • 0024669291 scopus 로고
    • A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
    • Sikorski, R.S. and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
    • (1989) Genetics , vol.122 , pp. 19-27
    • Sikorski, R.S.1    Hieter, P.2
  • 35
    • 0029157469 scopus 로고
    • Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway
    • Simon, M.-N., C. DeVirgilio, B. Souza, J.R. Pringle, A. Abo, and S.I. Reed. 1995. Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway. Nature 376: 702-705.
    • (1995) Nature , vol.376 , pp. 702-705
    • Simon, M.-N.1    DeVirgilio, C.2    Souza, B.3    Pringle, J.R.4    Abo, A.5    Reed, S.I.6
  • 36
    • 0001134626 scopus 로고
    • Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae
    • (ed. E.W. Jones, J.R. Pringle, and J.R. Broach), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Sprague, G.F. and J.W. Thorner. 1992. Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae. In The molecular and cellular biology of the yeast Saccharomyces, Vol. 2 (ed. E.W. Jones, J.R. Pringle, and J.R. Broach), pp. 657-744. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1992) The Molecular and Cellular Biology of the Yeast Saccharomyces , vol.2 , pp. 657-744
    • Sprague, G.F.1    Thorner, J.W.2
  • 37
    • 0031128205 scopus 로고    scopus 로고
    • Regulation of the mating pheromone and invasive growth responses in yeast by two MAP kinase substrates
    • Tedford, K., S. Kim, D. Sa, K. Stevens, and M. Tyers. 1997. Regulation of the mating pheromone and invasive growth responses in yeast by two MAP kinase substrates. Curr. Biol. 7: 228-238.
    • (1997) Curr. Biol. , vol.7 , pp. 228-238
    • Tedford, K.1    Kim, S.2    Sa, D.3    Stevens, K.4    Tyers, M.5
  • 38
    • 0028065397 scopus 로고
    • Site-directed mutations altering the CAAX box of Ste18, the yeast pheromone-responsive pathway Gγ subunit
    • Whiteway, M.S. and D.Y. Thomas. 1994. Site-directed mutations altering the CAAX box of Ste18, the yeast pheromone-responsive pathway Gγ subunit. Genetics 137: 967-976.
    • (1994) Genetics , vol.137 , pp. 967-976
    • Whiteway, M.S.1    Thomas, D.Y.2
  • 39
    • 0025191033 scopus 로고
    • Overexpression of the STE4 gene leads to mating response in haploid Saccharomyces cerevisiae
    • Whiteway, M., L. Hougan, and D.Y. Thomas. 1990. Overexpression of the STE4 gene leads to mating response in haploid Saccharomyces cerevisiae. Mol. Cell. Biol. 10: 217-222.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 217-222
    • Whiteway, M.1    Hougan, L.2    Thomas, D.Y.3
  • 40
    • 0029146796 scopus 로고
    • Association of the yeast pheromone response G protein βγ subunits with the MAP kinase scaffold Ste5p
    • Whiteway, M.S., C. Wu, T. Leeuw, K. Clark, A. Fourest-Lieuvin, D.Y. Thomas, and E. Leberer. 1995. Association of the yeast pheromone response G protein βγ subunits with the MAP kinase scaffold Ste5p. Science 269: 1572-1575.
    • (1995) Science , vol.269 , pp. 1572-1575
    • Whiteway, M.S.1    Wu, C.2    Leeuw, T.3    Clark, K.4    Fourest-Lieuvin, A.5    Thomas, D.Y.6    Leberer, E.7
  • 41
    • 0029066439 scopus 로고
    • Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) kinase kinase from Saccharomyces cerevisiae
    • Wu, C., M. Whiteway, D.Y. Thomas, and E. Leberer. 1995. Molecular characterization of Ste20p, a potential mitogen-activated protein or extracellular signal-regulated kinase kinase (MEK) kinase kinase from Saccharomyces cerevisiae. J. Biol. Chem. 270: 15984-15992.
    • (1995) J. Biol. Chem. , vol.270 , pp. 15984-15992
    • Wu, C.1    Whiteway, M.2    Thomas, D.Y.3    Leberer, E.4
  • 42
    • 0030450397 scopus 로고    scopus 로고
    • Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction
    • Yablonski, D., I. Marbach, and A. Levitzki. 1996. Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction. Proc. Natl. Acad. Sci. 93: 13864-13869.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 13864-13869
    • Yablonski, D.1    Marbach, I.2    Levitzki, A.3
  • 43
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: Molecular mechanisms and functional consequences
    • Zhang, F.L. and P.J. Casey. 1996. Protein prenylation: Molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65: 241-269.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2
  • 44
    • 0029118202 scopus 로고
    • Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24
    • Zhao, Z.-S., T. Leung, E. Manser, and L. Lim. 1995. Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24. Mol. Cell. Biol. 15: 5246-5257.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5246-5257
    • Zhao, Z.-S.1    Leung, T.2    Manser, E.3    Lim, L.4
  • 45
    • 0025847665 scopus 로고
    • Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity
    • Ziman, M., J.M. O'Brien, L.A. Ouellette, W.R. Church, and D.I. Johnson. 1991. Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity. Mol. Cell. Biol. 11: 3537-3544.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3537-3544
    • Ziman, M.1    O'Brien, J.M.2    Ouellette, L.A.3    Church, W.R.4    Johnson, D.I.5
  • 46
    • 0027744475 scopus 로고
    • Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity
    • Ziman, M., D. Preuss, J. Mulholland, J.M. O'Brien, D. Botstein, and D.I. Johnson. 1993. Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol. Biol. Cell 4: 1307-1316.
    • (1993) Mol. Biol. Cell , vol.4 , pp. 1307-1316
    • Ziman, M.1    Preuss, D.2    Mulholland, J.3    O'Brien, J.M.4    Botstein, D.5    Johnson, D.I.6


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