Modulation of cellular apoptotic potential: Contributions to oncogenesis

Oncogene

Volumn 18, Issue 45, 1999, Pages 6094-6103

  Stambolic, Vuk ^a,b   Mak, Tak W ^a,b   Woodgett, James R ^b  

^a AMGEN INSTITUTE   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Apoptosis; Cell survival; PI3'K; PTEN

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPID; PROTEIN SERINE KINASE; WORTMANNIN;

ANGIOSARCOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CANCER GENETICS; CARCINOGENESIS; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; ENZYME ACTIVATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; LYMPHOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALIA;

EID: 0033231188     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203126     Document Type: Review

References (141)

1. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P and Hemmings BA. (1996). EMBO J., 15, 6541-6551.
2. Alessi DR, Deak M, Casamayor A, Caudwell F, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A and Bownes M. (1997a). Curr. Biol., 7, 776-789.
3. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB and Cohen P. (1997b). Curr. Biol., 7, 261-269.
4. Alessi DR, Kozlowski MT, Weng QP, Morrice N and Avruch J. (1998). Curr. Biol., 8, 69-81.
5. Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M, Cron P, Cohen P, Lucocq JM and Hemmings BA. (1997). J. Biol. Chem., 272, 31515-31524.
6. Baker SJ and Reddy EP. (1998). Oncogene, 17, 3261-3270.
7. Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Dowries CP and Alessi DR. (1999). Curr. Biol., 9, 393-404.
8. Basu S and Kolesnick R. (1998). Oncogene, 17, 3277-3285.
9. Belham C, Wu S and Avruch J. (1999). Curr. Biol., 9, R93-R96.
10. Bellacosa A, de Feo D, Godwin AK, Bell DW, Cheng JQ, Altomare DA, Wan M, Dubeau L, Scambia G, Masciullo V, Ferrandina G, Benedetti Panici P, Mancuso S, Neri G and Testa JR (1995). Int. J. Cancer, 64, 280-285.
11. Bellacosa A, Testa JR, Staal SP and Tsichlis PN. (1991). Science, 254, 274-277.
12. Biggs WH III, Meisenhelder J, Hunter T, Cavenee WK and Arden KC. (1999). Proc. Natl. Acad. Sci. USA, 96, 7421-7426.
13. Bostrom J, Cobbers JM, Wolter M, Tabatabai G, Weber RG, Lichter P, Collins VP and Reifenberger G. (1998). Cancer Res., 58, 29-33.
14. Brodbeck D, Cron P and Hemmings BA. (1999). J. Biol. Chem., 274, 9133-9136.
15. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME. (1999). Cell, 96, 857-868.
16. Burgering BM and Coffer PJ. (1995). Nature, 376, 599-602.
17. Cairns P, Okami K, Halachmi S, Halachmi N, Esteller M, Herman JG, Jen J, Isaacs WB, Bova GS and Sidransky D. (1997). Cancer Res., 57, 4997-5000.
18. Cardone MH, Roy N, Stennicke HR, Salvesen, GS, Franke TF, Stanbridge E, Frisch S and Reed JC. (1998). Science, 282, 1318-1321.
19. Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS and Cantley LC. (1990). J. Biol. Chem., 265, 19704-19711.
20. Chaffanet M, Chauvin C, Laine M, Berger F, Chedin M, Rost N, Nissou MF and Benabid AL. (1992). Eur. J. Cancer, 28, 11-17.
21. Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM and Vogt PK. (1997). Science, 276, 1848-1850.
22. Cheng JQ. Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN and Testa JR. (1992). Proc. Natl. Acad. Sci. USA, 89, 9267-9271.
23. Cheng JQ. Ruggeri B, Klein WM, Sonoda, G, Altomare DA, Watson DK and Testa JR. (1996). Proc. Natl. Acad. Sci. USA, 93, 3636-3641.
24. Cheng X, Ma Y, Moore M, Hemmings BA and Taylor SS. (1998). Proc. Natl. Acad. Sci. USA, 95, 9849-9854.
25. Coffer PJ, Jin J and Woodgett JR. (1998). Biochem. J., 335, 1-13.
26. Craddock BL, Orchiston EA, Hinton, HJ and Welham MJ. (1999). J. Biol. Chem., 274, 10633-10640.
27. Cross DA, Alessi DR, Cohen P, Andjelkovich M and Hemmings BA. (1995). Nature, 378, 785-789.
28. Dahia PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman A, Stiles C and Eng C. (1999). Hum. Mol. Genet., 8, 185-193.
29. Dahia PL, Marsh DJ, Zheng Z, Zedenius J, Komminoth P, Frisk T, Wallin G, Parsons R, Longy M, Larsson C and Eng C. (1997). Cancer Res., 57, 4710-4713.
30. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y and Greenberg ME. (1997). Cell, 91, 231-241.
31. Davies MA, Koul D, Dhesi H, Berman R, McDonnell TJ, McConkey D, Yung WK and Steck PA. (1999). Cancer Res., 59, 2551-2556.
32. del Peso L, Gonzalez-Garcia M, Page C, Herrera R and Nunez G. (1997). Science, 278, 687-689.
33. Delcommenne M, Tan C, Gray V, Ruel L, Woodgett J and Dedhar S. (1998). Proc. Natl. Acad. Sci. USA, 95, 11211-11216.
34. Di Cristofano A, Pesce B, Cordon-Cardo C and Pandolfi PP. (1998). Nat. Genet., 19, 348-355.
35. Dong LQ, Zhang RB, Langlais P, He H, Clark M, Zhu L and Liu F. (1999). J. Biol. Chem., 274, 8117-8122.
36. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR and Greenberg ME. (1997). Science, 275, 661-665.
37. Eng C. (1998). Int. J. Oncol., 12, 701-710.
38. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ and Hancock DC. (1992). Cell, 69, 119-128.
39. Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR and Tsichlis PN. (1995). Cell, 81, 727-736.
40. Frisch SM and Francis H. (1994). J. Cell. Biol., 124, 619-626.
41. Frumann DA, Meyers RE and Cantley LC. (1998) Annu. Rev. Biochem., 67, 481-507.
42. Fujio Y and Walsh K. (1999). J. Biol. Chem., 274, 16349-16354.
43. Furnari FB, Huang HJ and Cavenee WK. (1998). Cancer Res., 58, 5002-5008.
44. Furnari FB, Lin H, Huang HS and Cavenee WK. (1997). Proc. Natl. Acad. Sci. USA, 94, 12479-12484.
45. Gajewski TF and Thompson CB. (1996). Cell, 87, 589-592.
46. Gil EB, Malone Link E, Liu LX, Johnson CD and Lees JA. (1999). Proc. Natl. Acad. Sci. USA, 96, 2925-2930.
47. Guldberg P, thor Straten P, Birck A, Ahrenkiel V, Kirkin AF and Zeuthen J. (1997). Cancer Res., 57, 3660-3663.
48. Guo S, Rena G, Cichy S, He X, Cohen P and Unterman T. (1999). J. Biol. Chem., 274, 17184-17192.
49. Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G and Stokoe D. (1998). Curr. Biol., 8, 1195-1198.
50. Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M and Rubin LL. (1995). Neuron., 14, 927-939.
51. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC and Dedhar S. (1996). Nature, 379, 91-96.
52. Harrington EA, Bennett MR, Fanidi A and Evan GI. (1994). EMBO J., 13, 3286-3295.
53. Hayashi K, Takahashi M, Kimura K, Nishida W, Saga H and Sobue K. (1999). J. Cell. Biol., 145, 727-740.
54. Hekimi S, Lakowski B, Barnes TM and Ewbank JJ. (1998). Trends Genet., 14, 14-20.
55. Hengartner MO and Horvitz HR. (1994). Curr. Opin. Genet. Dev., 4, 581-586.
56. Hinton HJ and Welham MJ. (1999). J. Immunol., 162, 7002-7009.
57. James SR, Downes CP, Gigg R, Grove SJ, Holmes AB and Alessi DR. (1996). Biochem J., 315, 709-713.
58. Jimenez C, Jones, DR, Rodriguez-Viciana P, Gonzalez-Garcia A, Leonardo E, Wennstrom S, von Kobbe C, Toran JL, Calvo V, Copin SG, Albar JP, Gaspar ML, Diez E, Marcos MA, Downward J, Martinez AC, Merida I and Carrera AC. (1998). EMBO J., 17, 743-753.
59. Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley L and Roberts TM. (1987). Cell, 50, 1021-1029.
60. Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J and Evan G. (1997). Nature, 385, 544-548.
61. Kenyon C, Chang J, Gensch E, Rudner A and Tabtiang R. (1993). Nature, 366, 461-464.
62. Khwaja A, Rodriguez-Viciana P, Wennstrom S, Warne PH and Downward J. (1997). EMBO J., 16, 2783-2793.
63. Kimura KD, Tissenbaum HA, Lin Y and Ruvkun G. (1997). Science, 211, 942-946.
64. Klippel A, Kavanaugh WM, Pot D and Williams LT. (1997). Mol. Cell. Biol., 17, 338-344.
65. Kohn AD, Kovacina KS and Roth RA. (1995). EMBO J., 14, 4288-4295.
66. Konishi H, Kuroda S, Tanaka M, Matsuzaki H, Ono Y, Kameyama K, Haga T and Kikkawa U. (1995). Biochem. Biophys. Res. Commun., 216, 526-534.
67. Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL and Burgering BM. (1999). Nature, 398, 630-634.
68. Korsmeyer SJ. (1999). Cancer Res., 59, 1693s-1700s.
69. Kulik G, Klippel A and Weber MJ. (1997). Mol. Cell. Biol., 17, 1595-1606.
70. Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P and Parker PJ. (1998). Science, 281, 2042-2045.
71. Leevers SJ, Vanhaesebroek B and Waterfield MD. (1999) Curr. Opin. Cell. Biol., 11, 219-225.
72. Li DM and Sun H. (1997). Cancer Res., 57, 2124-2129.
73. Li H and Yuan J. (1999). Curr. Opin. Cell. Biol., 11, 261-266.
74. Li J, Simpson L, Takahashi M, Miliaresis C, Myers MP, Tonks N and Parsons R. (1998). Cancer Res., 58, 5667-5672.
75. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH and Parsons R. (1997). Science, 275, 1943-1947.
76. Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C and Parsons R. (1997). Nat. Genet., 16, 64-67.
77. Lin K, Dorman, JB, Rodan A and Kenyon, C. (1997). Science, 278, 1319-1322.
78. Liu W, James CD, Frederick L, Alderete BE and Jenkins RB. (1997). Cancer Res., 57, 5254-5257.
79. Lo SH, An Q, Bao S, Wong WK, Liu Y, Janmey PA, Hartwig JH and Chen LB. (1994). J. Biol. Chem., 269, 22310-22319.
80. Maehama T and Dixon JE. (1998). J. Biol. Chem., 273, 13375-13378.
81. Marsh DJ, Coulon V, Lunetta KL, Rocca-Serra P, Dahia PL, Zheng Z, Liaw D, Caron S, Duboue B, Lin AY, Richardson AL, Bonnetblanc JM, Bressieux JM, Cabarrot-Moreau A, Chompret A, Demange L, Eeles RA, Yahanda AM, Fearon ER, Fricker JP, Gorlin RJ, Hodgson SV, Huson S, Lacombe D, LePrat F, Odent S, Toulouse C, Olopade OI, Sobol H, Tishler S, Woods CG, Robinson BG, Weber HC, Parsons R, Peacocke M, Longy M and Eng C. (1998a). Hum. Mol. Genet., 7, 507-515.
82. Marsh DJ, Dahia PL, Caron S, Kum JB, Frayling IM, Tomlinson IP, Hughes KS, Eeles RA, Hodgson SV, Murday VA, Houlston R and Eng C. (1998b). J. Med. Genet., 35, 881-885.
83. Marsh DJ, Dahia PL, Zheng Z, Liaw D. Parsons R, Gorlin RJ and Eng C. (1997). Nat. Genet., 16, 333-334.
84. Meier R, Alessi DR, Cron P, Andjelkovic M and Hemmings BA. (1997). J. Biol. Chem., 272, 30491-30497.
85. Metzstein MM, Stanfield GM and Horvitz HR. (1998). Trends Genet., 14, 410-416.
86. Mihaylova VT, Borland CZ, Manjarrez L., Stern MJ and Sun H. (1999). Proc. Natl. Acad. Sci. USA, 96, 7427-7432.
87. Morris JZ, Tissenbaum HA and Ruvkun G. (1996). Nature, 382, 536-539.
88. Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP and Tonks NK. (1998). Proc. Natl. Acad. Sci. USA, 95, 13513-13518.
89. Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R and Tonks NK. (1997). Proc. Natl. Acad. Sci. USA, 94, 9052-9057.
90. Nakae J, Park BC and Accili D. (1999). J. Biol. Chem., 274, 15982-15985.
91. Nakatani K, Sakaue H, Thompson DA, Weigel RJ and Roth RA. (1999). Biochem. Biophys. Res. Commun., 257, 906-910.
92. Nunez G, Benedict MA, Hu Y and Inohara N. (1998). Oncogene, 17, 3237-3245.
93. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA and Ruvkun G. (1997). Nature, 389, 994-999.
94. Ogg S and Ruvkun G. (1998). Mol. Cell., 2, 887-893.
95. Pap M and Cooper GM. (1998). J. Biol. Chem., 273, 19929-19932.
96. Paradis S, Ailion M, Toker A, Thomas JH and Ruvkun G. (1999). Genes Dev, 13, 1438-1452.
97. Paradis S and Ruvkun G. (1998). Genes Dev., 12, 2488-2498.
98. Pastorino JG, Tafani M and Farber JL. (1999). J. Biol. Chem., 274, 19411-19416.
99. Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM, Cordon-Cardo C, Catoretti G, Fisher PE and Parsons R. (1999). Proc. Natl. Acad. Sci. USA, 96, 1563-1568.
100. Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC., Hemmings BA and Thomas G. (1998). Science, 279, 707-710.
101. Rameh E and Cantley LC. (1999) J. Biol. Chem., 274, 8347-8350.
102. Rasheed BK, Stenzel TT, McLendon RE, Parsons R, Friedman AH, Friedman HS, Bigner DD and Bigner SH. (1997). Cancer Res., 57, 4187-4190.
103. Reed JC. (1998). Oncogene, 17, 3225-3236.
104. Rena G, Guo S, Cichy SC, Unterman TG and Cohen P. (1999). J. Biol. Chem., 274, 17179-17183.
105. Risinger JI, Hayes, AK, Berchuck A and Barrett JC. (1997). Cancer Res., 57, 4736-4738.
106. Risinger JI, Hayes K, Maxwell GL, Carney ME, Dodge RK, Barrett JC and Berchuck A. (1998). Clin. Cancer Res., 4, 3005-3010.
107. Rouault JP, Kuwabara PE, Sinilnikova OM, Durel L, Thierry-Mieg D and Billaud M. (1999). Curr. Biol., 9, 329-332.
108. Roush W. (1997). Science, 277, 897-898.
109. Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE and Abraham RT. (1998). Cancer Res., 58, 4375-4382.
110. Scheid MP and Duronio V. (1998). Proc. Natl. Acad. Sci, USA, 95, 7439-7444.
111. Scrunian LA, Auger KR, Roberts TM and Cantley LC. (1990). J. Virol., 64, 4718-4725.
112. Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB and Gray JW. (1999). Nat. Genet., 21, 99-102.
113. Shepherd PR, Withers DJ and Siddle K. (1998). Biochem. J., 333, 471-490.
114. Smits A and Funa K. (1998). Histol. Histopathol., 13, 511-520.
115. Songyang Z, Baltimore D, Cantley LC, Kaplan DR and Franke TF. (1997). Proc. Natl. Acad. Sci. USA, 94, 11345-11350.
116. Staal SP and Hartley JW. (1988). J. Exp. Med., 167, 1259-1264.
117. Stambolic V, Ruel L and Woodgett JR. (1996). Curr. Biol., 6, 1664-1668.
118. Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP and Mak TW. (1998). Cell, 95, 29-39.
119. Staveley BE, Ruel L, Jin J, Stambolic V, Mastronardi FG, Heitzler P, Woodgett JR and Manoukian AS. (1998). Curr. Biol., 8, 599-602.
120. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH and Tavtigian SV, (1997). Nat. Genet., 15, 356-362.
121. Steller H. (1995). Science, 267, 1445-1449.
122. Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F and Hawkins, PT. (1997). Science, 277, 567-570.
123. Sugimoto Y, Whitman M, Cantley LC and Erikson RL. (1984). Proc. Natl. Acad. Sci. USA, 81, 2117-2121.
124. Summers SA, Garza LA, Zhou H and Birnbaum MJ. (1998). Mol. Cell. Biol., 18, 5457-5464.
125. Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X and Wu H. (1999). Proc. Natl. Acad. Sci. USA, 96, 6199-6204.
126. Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M and Mak TW. (1998). Curr. Biol., 8, 1169-1178.
127. Takeuchi H, Kanematsu T, Misumi Y, Sakane F, Konishi H, Kikkawa U, Watanabe Y, Katan M and Hirata M. (1997). Biochim. Biophys. Acta, 1359, 275-285.
128. Tamura M, Gu J, Matsumoto K, Aota S, Parsons R and Yamada KM. (1998). Science. 280, 1614-1617.
129. Tashiro H, Blazes MS, Wu R, Cho KR, Bose S. Wang SI, Li J, Parsons R and Ellenson LH. (1997). Cancer Res., 57, 3935-3940.
130. Teng DH-F, Hu R, Lin H, Davis T, Hiev D, Frye C. Swedlund B, Hansen KL, Vinson VL, Gumpper KL, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford LA, Lee J, Mills GB, Pershouse MA, Pollack RE, Tornos C, Troncoso P, Yung WKA, Fujii G, Berson A, Steck PA, Bookstein R and Bolen JB. (1997). Cancer Res.,57, 5221-5225.
131. Thomas JH and Inoue T. (1998). Bioessays, 20, 113-115.
132. Vanhaesebroeck B, Levers SJ, Panayotou G and Waterfield MD. (1997). Trends Biochem. Sci., 22, 267-272.
133. Wang SI, Pue J, Li J, Bruce JN, Cairns P, Sidransky D and Parsons R. (1997). Cancer Res., 57, 4183-4186.
134. Whitman M, Kaplan DR, Schaffhausen B, Cantley L and Roberts TM. (1985). Nature, 315, 239-242.
135. Wu C, Keightley SY, Leung-Hagesteijn C, Radeva G, Coppolino M, Goicoechca S, McDonald JA and Dedhar S. (1998). J. Biol. Chem., 273, 528-536.
136. Wymann MP, Bulgarelli-Leva G, Zvelebil MJ, Pirola L, Vanhaesebroeck B, Waterfield MD and Panayotou G. (1996). Mol. Cell. Biol., 16, 1722-1733.
137. Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ and Cantley LC. (1997). Cell, 91, 961-971.
138. Yao R and Cooper GM. (1996). Oncogene, 13, 343-351.
139. Zha J, Harada H, Yang E, Jockel J and Korsmeyer SJ. (1996). Cell. 87, 619-628.
140. Zhou H, Summers SA, Birnbaum MJ and Pittman RN. (1998). J. Biol. Chem., 273, 16568-16575.
141. Zundel W and Giaccia A. (1998). Genes Dev., 12, 1941-1946.