PTEN gene mutations are seen in high-grade but not in low-grade gliomas

Cancer Research

Volumn 57, Issue 19, 1997, Pages 4187-4190

  Rasheed, B K Ahmed ^a   Stenzel, Timothy T ^a   McLendon, Roger E ^a   Parsons, Ramon ^b   Friedman, Allan H ^a   Friedman, Henry S ^a   Bigner, Darell D ^a   Bigner, Sandra H ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; ASTROCYTOMA; CANCER GRADING; CARCINOGENESIS; CHROMOSOME 10Q; FEMALE; GENE LOCATION; GENE MUTATION; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; BRAIN NEOPLASMS; CHILD; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENES, P53; GENES, TUMOR SUPPRESSOR; GLIOMA; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MEDULLOBLASTOMA; MIDDLE AGED; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SEQUENCE DELETION;

EID: 0030817576     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Bigner, S. H., Mark, J., Burger, P. C., Mahaley, M. S., Bullard, D. E., Muhlbaier, L. H., and Bigner, D. D. Specific chromosomal abnormalities in malignant human gliomas. Cancer Res., 48: 405-411, 1988.
2. James, C. D., Carlbom, E., Dumanski, J. P., Hamsen, M., Nordenskjold, M., Colliins, V. P. and Cavenee, W. K. Clonal genomic alterations in glioma malignancy stages Cancer Res., 48: 5546-5551, 1988.
3. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc. J., Miliaresis. G., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittman, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer. Science (Washington DC), 275: 1943-1947, 1997.
4. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K. A., Lin, H., Lignon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Swedlund, B., Teng, D. H. F., and Tavtigian, S. V. Identification of a candidate tumour suppressor gene. MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997.
5. von Deimling, A., von Ammon, K., Schoenfeld, D., Wiestler, O. D., Seizinger, B. R., and Louis, D. N. Subsets of glioblastoma multiforme defined by molecular genetic analyses. Brain Pathol., 3: 19-26, 1993.
6. Lang, F. P., Miller, D. C., Koslow, M., and Newcomb, E. W. Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors. J. Neurosurg., 81: 427-436, 1994.
7. Burger, P. C., Scheithauer, B. W., and Vogel, F. S. Surgical Pathology of the Nervous System and the Coverings, Ed. 3. New York: Churchill Livingston, 1991.
8. Rasheed, B. K. A., Fuller, G. N., Friedman, A. H., Bigner, D. D., and Bigner, S. H. Loss of heterozygosity for 10q loci in human gliomas. Genes Chromosomes & Cancer, 5: 75-82, 1992.
9. Rasheed, B. K. A., McLendon, R. E., Herndon, J. E., Friedman, H. S., Freidman, A. H., Bigner, D. D., and Bigner, S. H. Alterations of the TP53 gene in human gliomas. Cancer Res., 54: 1324-1330, 1994.
10. Rasheed, B. K. A., McLendon, R. E., Friedman, H. S., Friedman, A. H., Fuchs, H. E., Bigner, D. D., and Bigner, S. H. Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. Oncogene, 10: 2243-2246, 1995.
11. Batra, S. K., McLendon, R. E., Koo, J. S., Castelino-Prabhu, S., Fuchs, H. E., Krischer, J. P., Friedman, H. S., Bigner, D. D., and Bigner, S. H. Prognostic implications of chromosome 17p deletions in human medulloblastomas. J. Neurol. Oncol., 24: 39-45. 1995.
12. Blacker, H. Rasheed, B. K. A., McLendon, R. E., Friedman, H. S., Batra, S. K., Fuchs, H. E., and Bigner, S. H. Microsatellite analysis of childhood brain tumors. Genes Chromosomes & Cancer, 15: 54-63, 1996.
13. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L. M., Wang, S. I., Zheng, Z. M., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., Eng, C., and Parsons R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16: 64-67, 1997.
14. Spinardi, L., Mazars, R., and Theillet, C. Protocols for an improved detection of point mutations by SSCP. Nucleic Acids Res., 19: 4009, 1991.
15. Fults, D., Pedone, C. A., Thomas, G. A., and White, R. Allelotype of human malignant astrocytoma. Cancer Res., 50: 5784-5789, 1990.
16. Ransom, D. T., Ritland, S. R., Moertel, C. A., Dahl, R. J., O'Fallon, J. R., Scheithauer, B. W., Kimmel, D. W., Kelly, P. J., Olopade, O. I., Diaz, M. O., and Jenkins, R. B. Correlation of cytogenetic analysis and loss of heterozygosity studies in human diffuse astrocytomas and mixed oligo-astrocytomas. Genes Chromosomes & Cancer. 5: 357-374, 1992.
17. Karlbom, A. E., James, C. D., Boethius, J., Cavenee, W. K., Collins, V. P., Nordenskjold, M., and Larsson, C. Hum. Genet., 92: 169-174, 1993.
18. Albarosa, R., Colombo, B. M., Roz, L., Magnani, I., Pollo, B., Cirenei, N., Giani, C., Conti, A. M. F., DiDonato, S., and Finocchiaro. G. Deletion mapping of gliomas suggests the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q. Am J. Hum. Genet. 58: 1260-1267, 1996.