Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies

Cancer Research

Volumn 57, Issue 18, 1997, Pages 3935-3940

  Tashiro, Hironori ^a   Blazes, Marian S ^a   Wu, Rong ^a   Cho, Kathleen R ^a   Bose, Shikha ^b   Wang, Steven I ^b   Li, Jing ^b   Parsons, Ramon ^b   Ellenson, Lora Hedrick ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b The New York Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER RISK; CHROMOSOME 10Q; ENDOMETRIUM CARCINOMA; GENE DELETION; GENE FREQUENCY; GENE LOCATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GYNECOLOGIC DISEASE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

CARCINOMA; CHROMOSOMES, HUMAN, PAIR 10; DNA, NEOPLASM; ENDOMETRIAL NEOPLASMS; EXONS; FEMALE; GENE DELETION; GENES, TUMOR SUPPRESSOR; HETEROZYGOTE; HUMANS; MICROFILAMENT PROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-TYROSINE-PHOSPHATASE; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEINS;

EID: 0030761409     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Parker, S. L., Tong, T., Bolden, S., and Wingo, P. A. Cancer Statistics. CA Cancer J. Clin., 46: 5-27, 1996.
2. Bokhman, J. V. Two pathogenetic types of endometrial carcinoma. Gynecol. Oncol., 15: 10-17, 1983.
3. Imamura, T., Arima, T., Kato, H., Miyamoto, S., Sasazuki, T., and Wake, N. Chromosomal deletions and K-ras gene mutations in human endometrial carcinomas. Int. J. Cancer, 51: 47-52, 1992.
4. Enomoto, T., Fujita, M., Inoue, M., Nomura, T., and Shroyer, K. R. Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado. Am. J. Clin. Pathol., 103: 224-230, 1995.
5. Risinger, J. I., Dent, G. A., Ignar-Trowbridge, D., McLachlan, J. A., Tsao, M. S., Senterman, M., and Boyd, J. p53 gene mutations in human endometrial carcinoma. Mol. Carcinog., 5: 250-253, 1992.
6. Tashiro, H., Isacson, C., Levine, R., Kurman, R. J., Cho, K. R., and Hedrick, L. p53 gene mutations are common in uterine serous carcinoma and occur as an early event in their pathogenesis. Am. J. Pathol., 150: 177-185, 1997.
7. Burks, R. T., Kessis, T. D., Cho, K. R., and Hedrick, L. Microsatellite instability in endometrial carcinoma. Oncogene, 9: 1163-1166, 1994.
8. Duggan, B. D., Felix, J. C., Muderspach, L. I., Tourgeman, D., Zheng, J., and Shibata, D. Microsatellite instability in sporadic endometrial carcinoma. J. Natl. Cancer Inst., 86: 1216-1221, 1994.
9. Risinger, J. I., Berchuck, A., Kohler, M. F., Watson, P., Lynch, H. T., and Boyd, J. Genetic instability of microsatellite in endometrial carcinoma. Cancer Res., 53: 5100-5103, 1993.
10. Jones, M. H., Koi, S., Fujimoto, I., Hasumi, K., Kato, K., and Nakamura, Y. Allelotype of uterine cancer by analysis of RFLP and microsatellite polymorphisms: frequent loss of heterozygosity on chromosome arms 3p, 9q, 10q, 17p. Genes Chromosomes Cancer, 9: 119-123, 1994.
11. Nagase, S., Sato, S., Tezuka, F., Wada, Y., Yajima, A., and Horii, A. Deletion mapping on chromosome 10q25-q26 in human endometrial cancer. Br. J. Cancer, 74: 1979-1983, 1996.
12. Peiffer, S. L., Herzog, T. J., Tribune, D. J., Mutch, D. G., Gersell, D. J., and Goodfellow, P. J. Allelic loss of sequences from the long arm of chromosomes 10 and replication errors in endometrial cancers. Cancer Res., 55: 1922-1926, 1995.
13. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittman, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parson, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Washington DC), 275: 1943-1947, 1997.
14. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K. A., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H. F., and Tavtigian, S. V. Identification of a candidate tumour suppressor gene, MMACl, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997.
15. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L. M., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., Eng, C., and Parsons, R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16: 64-67, 1997.
16. Fearon, E. R., Hamilton, S. R., and Vogelstein, B. Clonal analysis of human colorectal tumors. Science (Washington DC), 238: 193-197, 1987.
17. Katabuchi, H., van Rees, B., Lambers, A. R., Ronnett, B. M., Blazes, M. S., Leach, F. S., Cho, K. R., and Hedrick, L. Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas. Cancer Res., 55: 5556-5560, 1995.
18. Fults, D., and Pedone, C. Deletion mapping of the long arm of chromosome 10 in glioblastoma multiforme. Genes Chromosomes Cancer, 7: 173-177, 1993.
19. Gray, I. C., Phillips, S. M., Lee, S. J., Neoptolemos, J. P., Weissenbach, J., and Spurr, N. K. Loss of the chromosomal region 10q23-25 in prostate cancer. Cancer Res., 55: 4800-4803, 1995.
20. Trybus, T. M., Burgess, A. C., Wojno, K. J., Glover, T. W., and Macoska, J. A. Distinct areas of allelic loss on chromosomal regions 10p and 10q in human prostate cancer. Cancer Res., 56: 2263-2267, 1996.
21. Huang, J., Papadopoulos, N., McKinley, A. J., Farrington, S. M., Curtis, L. J., Wyllie, A. H., Zheng, S., Willson, J. K. V., Markowitz, S. D., Morin, P., Kinzler, K. W., Vogelstein, B., and Dunlop, M. G. APC mutations in colorectal tumors with mismatch repair deficiency. Proc. Natl. Acad. Sci. USA. 93: 9049-9054, 1996.
22. Ouyang, H., Shiwaku, H. O., Hagiwara, H., Miura, K., Abe, T., Kato, Y., Ohtani, H., Shiiba, K., Souza, R. F., Meltzer, S. J., and Horii, A. The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium stomach, and colorectum. Cancer Res., 57: 1851-1854, 1997.
23. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., Brattain, M., and Willson, J. K. V. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science (Washington DC), 268: 1336-1338, 1995.