Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC

Current Biology

Volumn 8, Issue 21, 1998, Pages 1195-1198

  Haas Kogan, Daphne ^a   Shalev, Noga ^a   Wong, Michelle ^b   Mills, Gordon ^c   Yount, Garret ^a   Stokoe, David ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0032558822     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0960-9822(07)00493-9     Document Type: Article

References (19)

1. Leibel SA, Sheline GE: Radiation therapy for neoplasms of the brain. J Neurosurg 1987, 66:1-22.
2. Franke TF, Kaplan DR, Cantley LC: PI3K: Downstream AKTion blocks apoptosis. Cell 1997, 88:435-437.
3. Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, et al.: Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science 1997, 276:1848-1850.
4. Staal SP: Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA 1987, 84:5034-5037.
5. Bellacosa A, de Feo D, Godwin AK, Bell DW, Cheng JQ, Altomare DA, et al.: Molecular alterations of the Akt2 oncogene in ovarian and breast carcinomas. Int J Cancer 1995, 64:280-285.
6. Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK, et al.: Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci USA 1996, 93:3636-3641.
7. Haas-Kogan DA, Dazin P, Hu L, Deen DF, Israel MA: p53-independent apoptosis: a mechanism of radiation-induced cell death of glioblastomas cells. Cancer J 1996, 2:114-121.
8. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, et al.: Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996, 15:6541-6551.
9. Vlahos CJ, Matter WF, Hui KY, Brown RF: A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 1994, 269:5241-5248.
10. Smith A, Ashworth A: Cancer predisposition: where's the phosphate? Curr Biol 1998, 8:R241-R243.
11. Maehama T, Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998, 273:13375-13378.
12. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al.: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275:1943-1947.
13. Steck PA, Pershouse MA, Jasser SA, Yung WKA, Lin H, Ligon AH, et al.: Identification of a candidate tumour supressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997, 15:356-362.
14. Furnari FB, Lin H, Huang HS, Cavanee WK: Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc Natl Acad Sci USA 1997, 94:12479-12484.
15. Myers MP, Stolarov JP, Eno C, Li J, Wang SI, Wigler MH, et al.: P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci USA 1997, 94:9052-9057.
16. Cheney IW, Johnson DE, Vaillancourt M-T, Avanzi J, Morimoto A, Demers GW, et al.: Supression of tumoriginicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. Cancer Res 1998, 58:2331-2334.
17. Stokoe D, Stephens LR, Copeland T, Gaffney PRJ, Reese CB, Painter GF, et al.: Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 1997, 277:567-570.
18. Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, et al.: 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol 1997, 7:776-789.
19. Downward J: Mechanisms and consequences of activation of protein kinase B/akt. Curr Opin Cell Biol 1998, 10:262-267.