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Volumn 162, Issue 12, 1999, Pages 7002-7009

Cytokine-induced protein kinase B activation and bad phosphorylation do not correlate with cell survival of hemopoietic cells

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE B;

EID: 0033564734     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (81)

References (48)
  • 2
    • 0027992342 scopus 로고
    • Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells: Association of the enzyme with various tyrosine-phosphorylated proteins
    • Gold, M. R., V. Duronio, S. P. Saxena, J. W. Schrader, and R. Aebersold. 1994. Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells: association of the enzyme with various tyrosine-phosphorylated proteins. J. Biol. Chem. 269:5403.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5403
    • Gold, M.R.1    Duronio, V.2    Saxena, S.P.3    Schrader, J.W.4    Aebersold, R.5
  • 5
    • 0030612144 scopus 로고    scopus 로고
    • p110δ, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
    • Chantry, D., A. Vojtek, A. Kashishian, D. A. Holtzman, C. Wood, P. W. Gray, J. A. Cooper, and M. F. Hoekstra. 1997. p110δ, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J. Biol. Chem. 272:19236.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19236
    • Chantry, D.1    Vojtek, A.2    Kashishian, A.3    Holtzman, D.A.4    Wood, C.5    Gray, P.W.6    Cooper, J.A.7    Hoekstra, M.F.8
  • 8
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
    • Khwaja, A., P. Rodriguez Viciana, S. Wennstrom, P. H. Warne, and J. Downward. 1997. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16:2783.
    • (1997) EMBO J. , vol.16 , pp. 2783
    • Khwaja, A.1    Viciana, P.R.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 9
    • 0030026693 scopus 로고    scopus 로고
    • Requirement for phosphatidylinositol 3′-kinase to protect hematopoietic progenitors against apoptosis depends upon the extracellular survival factor
    • Minshall, C., S. Arkins, G. G. Freund, and K. W. Kelly 1996. Requirement for phosphatidylinositol 3′-kinase to protect hematopoietic progenitors against apoptosis depends upon the extracellular survival factor. J. Immunol. 156:939.
    • (1996) J. Immunol. , vol.156 , pp. 939
    • Minshall, C.1    Arkins, S.2    Freund, G.G.3    Kelly, K.W.4
  • 10
    • 0028834557 scopus 로고
    • Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in hematopoietic-cells: Phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signaling between interleukin-3 and granulocyte-macrophage colony-stimulating factor
    • Scheid, M. P., R. W. Lauener, and V. Duronio. 1995. Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in hematopoietic-cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signaling between interleukin-3 and granulocyte-macrophage colony-stimulating factor. Biochem. J. 312:159.
    • (1995) Biochem. J. , vol.312 , pp. 159
    • Scheid, M.P.1    Lauener, R.W.2    Duronio, V.3
  • 11
    • 0032560514 scopus 로고    scopus 로고
    • Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation
    • Scheid, M. P., and V. Duronio. 1998. Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation. Proc. Natl. Acad. Sci. USA 95:7439.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7439
    • Scheid, M.P.1    Duronio, V.2
  • 12
    • 0030884103 scopus 로고    scopus 로고
    • PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
    • Marte, B. M., and J. Downward. 1997. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci. 22:355.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 355
    • Marte, B.M.1    Downward, J.2
  • 13
    • 0026095665 scopus 로고
    • A retroviral oncogene, Akt, encoding a serine-threonine kinase containing an SH2-like region
    • Bellacosa, A., J. R. Testa, S. P. Staal, and P. N. Tsichlis. 1991. A retroviral oncogene, Akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254:274.
    • (1991) Science , vol.254 , pp. 274
    • Bellacosa, A.1    Testa, J.R.2    Staal, S.P.3    Tsichlis, P.N.4
  • 14
    • 0026006501 scopus 로고
    • Molecular-cloning and characterization of a novel putative protein-serine kinase related to the cAMP-dependent and protein-kinase-C families
    • Coffer, P. J., and J. R. Woodgett. 1991. Molecular-cloning and characterization of a novel putative protein-serine kinase related to the cAMP-dependent and protein-kinase-C families. Eur. J. Biochem. 201:475.
    • (1991) Eur. J. Biochem. , vol.201 , pp. 475
    • Coffer, P.J.1    Woodgett, J.R.2
  • 15
    • 0029079275 scopus 로고
    • The protein-kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke, T. F., S. I. Yang, T. O. Chan, K. Datta, A. Kazlauskas, D. K. Morrison, D. R. Kaplan, and P. N. Tsichlis. 1995. The protein-kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727.
    • (1995) Cell , vol.81 , pp. 727
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3    Datta, K.4    Kazlauskas, A.5    Morrison, D.K.6    Kaplan, D.R.7    Tsichlis, P.N.8
  • 16
    • 0029587224 scopus 로고
    • Inhibition of glycogen-synthase kinase-3 by insulin-mediated by protein-kinase-B
    • Cross, D. A. E., D. R. Alessi, P. Cohen, M. Andjelkovich, and B. A. Hemmings. 1995. Inhibition of glycogen-synthase kinase-3 by insulin-mediated by protein-kinase-B. Nature 378:785.
    • (1995) Nature , vol.378 , pp. 785
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 17
    • 0029143388 scopus 로고
    • Insulin stimulates the kinase-activity of Rac-Pk, a pleckstrin homology domain-containing Ser/Thr kinase
    • Kohn, A. D., K. S. Kovacina, and R. A. Roth. 1995. Insulin stimulates the kinase-activity of Rac-Pk, a pleckstrin homology domain-containing Ser/Thr kinase. EMBO J. 14:4288.
    • (1995) EMBO J. , vol.14 , pp. 4288
    • Kohn, A.D.1    Kovacina, K.S.2    Roth, R.A.3
  • 18
    • 0029160069 scopus 로고
    • Protein-Kinase-B (C-Akt) in phosphatidylinositol-3-OH kinase signal-transduction
    • Burgering, B. M. T., and P. J. Coffer. 1995. Protein-Kinase-B (C-Akt) In phosphatidylinositol-3-OH kinase signal-transduction. Nature 376:599.
    • (1995) Nature , vol.376 , pp. 599
    • Burgering, B.M.T.1    Coffer, P.J.2
  • 19
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • del Peso, L., M. Gonzalez Garcia, C. Page, R. Herrera, and G. Nunez. 1997. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687.
    • (1997) Science , vol.278 , pp. 687
    • Del Peso, L.1    Gonzalez Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 20
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta, S. R., H. Dudek, X. Tao, S. Masters, H. A. Fu, Y. Gotoh, and M. E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231.
    • (1997) Cell , vol.91 , pp. 231
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.A.5    Gotoh, Y.6    Greenberg, M.E.7
  • 22
    • 0029810181 scopus 로고    scopus 로고
    • Akt, a pleckstrin homology domain-containing kinase, is activated primarily by phosphorylation
    • Kohn, A. D., F. Takeuchi, and R. A. Roth. 1996. Akt, a pleckstrin homology domain-containing kinase, is activated primarily by phosphorylation. J. Biol. Chem. 271:21920.
    • (1996) J. Biol. Chem. , vol.271 , pp. 21920
    • Kohn, A.D.1    Takeuchi, F.2    Roth, R.A.3
  • 23
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinosital-3,4-bisphosphate
    • Franke, T. F., D. R. Kaplan, L. C. Cantley, and A. Toker. 1997. Direct regulation of the Akt proto-oncogene product by phosphatidylinosital-3,4-bisphosphate. Science 275:665.
    • (1997) Science , vol.275 , pp. 665
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 24
    • 0029807471 scopus 로고    scopus 로고
    • Akt is a direct target of the phosphatidylinositol 3-kinase: Activation by growth-factors, v-Src and v-Ha-Ras, in sf9 and mammalian-cells
    • Datta, K., A. Bellacosa, T. O. Chan, and P. N. Tsichlis. 1996. Akt is a direct target of the phosphatidylinositol 3-kinase: activation by growth-factors, v-Src and v-Ha-Ras, in Sf9 and mammalian-cells. J. Biol. Chem. 271:30835.
    • (1996) J. Biol. Chem. , vol.271 , pp. 30835
    • Datta, K.1    Bellacosa, A.2    Chan, T.O.3    Tsichlis, P.N.4
  • 26
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B α
    • Alessi, D. R., S. R. James, C. P. Downes, A. B. Holmes, P. R. J. Gaffney, C. B. Reese, and P. Cohen. 1997. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B α. Curr. Biol. 7:261.
    • (1997) Curr. Biol. , vol.7 , pp. 261
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.J.5    Reese, C.B.6    Cohen, P.7
  • 27
    • 0031918223 scopus 로고    scopus 로고
    • BCL-2 family: Regulators of cell death
    • Chao, D. T., and S. J. Korsmeyer. 1998. BCL-2 family: regulators of cell death. Annu. Rev. Immunol. 16:395.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 395
    • Chao, D.T.1    Korsmeyer, S.J.2
  • 28
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • Adams, J. M., and S. Cory. 1998. The Bcl-2 protein family: arbiters of cell survival. Science 281:1322.
    • (1998) Science , vol.281 , pp. 1322
    • Adams, J.M.1    Cory, S.2
  • 30
    • 0030695837 scopus 로고    scopus 로고
    • Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL
    • Kelekar, A., B. S. Chang, J. E. Harlan, S. W. Fesik, and C. B. Thompson. 1997. Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Mol. Cell. Biol. 17:7040.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 7040
    • Kelekar, A.1    Chang, B.S.2    Harlan, J.E.3    Fesik, S.W.4    Thompson, C.B.5
  • 31
    • 0030584088 scopus 로고    scopus 로고
    • Serine phosphorylation of death agonist Bad in response to survival factor results in binding to 14-3-3 not Bcl-X(L)
    • Zha, J. P., H. Harada, E. Yang, J. Jockel, and S. J. Korsmeyer. 1996. Serine phosphorylation of death agonist Bad in response to survival factor results in binding to 14-3-3 not Bcl-X(L). Cell 87:619.
    • (1996) Cell , vol.87 , pp. 619
    • Zha, J.P.1    Harada, H.2    Yang, E.3    Jockel, J.4    Korsmeyer, S.J.5
  • 32
    • 0033537849 scopus 로고    scopus 로고
    • Dissociation of apoptosis from proliferation, protein kinase B activation and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling
    • Craddock, B. L., E. A. Orchiston, H. J. Hinton, and M. J. Welham. 1999. Dissociation of apoptosis from proliferation, protein kinase B activation and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling. J. Biol. Chem. 274:10633.
    • (1999) J. Biol. Chem. , vol.274 , pp. 10633
    • Craddock, B.L.1    Orchiston, E.A.2    Hinton, H.J.3    Welham, M.J.4
  • 33
    • 0023872192 scopus 로고
    • Establishment of mouse-cell lines which constitutively secrete large quantities of interleukin-2, interleukin-3, interleukin-4 or interleukin-5, using modified cDNA expression vectors
    • Karasuyama, H., and F. Melchers. 1988. Establishment of mouse-cell lines which constitutively secrete large quantities of interleukin-2, interleukin-3, interleukin-4 or interleukin-5, using modified cDNA expression vectors. Eur. J. Immunol. 18:97.
    • (1988) Eur. J. Immunol. , vol.18 , pp. 97
    • Karasuyama, H.1    Melchers, F.2
  • 34
    • 0026730110 scopus 로고
    • Steel factor-induced tyrosine phosphorylation in murine mast cells: Common elements with IL-3-induced signal transduction pathways
    • Welham, M. J., and J. W. Schrader. 1992. Steel factor-induced tyrosine phosphorylation in murine mast cells: common elements with IL-3-induced signal transduction pathways. J. Immunol. 149:2772.
    • (1992) J. Immunol. , vol.149 , pp. 2772
    • Welham, M.J.1    Schrader, J.W.2
  • 35
    • 0028021690 scopus 로고
    • Interleukin-4-dependent proliferation dissociates p44(erk-1 ), p42(erk-2), and p21(ras) activation from cell growth
    • Welham, M. J., V. Duronio, and J. W. Schrader. 1994. Interleukin-4-dependent proliferation dissociates p44(erk-1 ), p42(erk-2), and p21(ras) activation from cell growth J. Biol. Chem. 269:5865.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5865
    • Welham, M.J.1    Duronio, V.2    Schrader, J.W.3
  • 36
    • 0019830851 scopus 로고
    • Inducer lymphocytes-T synthesize a factor that stimulates proliferation of cloned mast cells
    • Nabel, G., S. J. Galli, A. M. Dvorak, H. F. Dvorak, and H. Cantour. 1981. Inducer lymphocytes-T synthesize a factor that stimulates proliferation of cloned mast cells. Nature 291:332.
    • (1981) Nature , vol.291 , pp. 332
    • Nabel, G.1    Galli, S.J.2    Dvorak, A.M.3    Dvorak, H.F.4    Cantour, H.5
  • 37
    • 0022274007 scopus 로고
    • IL-3-dependent mouse clones that express b220 surface antigen, contain Ig genes in germ-line configuration and generate lymphocytes-B in vivo
    • Palacios, R., and M. Steinmetz. 1985. IL-3-dependent mouse clones that express B220 surface antigen, contain Ig genes in germ-line configuration and generate lymphocytes-B in vivo. Cell 41:727.
    • (1985) Cell , vol.41 , pp. 727
    • Palacios, R.1    Steinmetz, M.2
  • 38
    • 0025799991 scopus 로고
    • An improved colorimetric assay for cell proliferation and viability utilising the tetrazolium salt XTT
    • Roehm, N. W., G. H. Rodgers, S. M. Hatfield, and A. L. Glasebrook. 1991. An improved colorimetric assay for cell proliferation and viability utilising the tetrazolium salt XTT. J. Immunol. Methods 142:257.
    • (1991) J. Immunol. Methods , vol.142 , pp. 257
    • Roehm, N.W.1    Rodgers, G.H.2    Hatfield, S.M.3    Glasebrook, A.L.4
  • 39
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55
    • Mosmann, T.1
  • 40
    • 0028963084 scopus 로고
    • Requirement for phosphatidylinositol-3 kinase in prevention of apoptosis by nerve growth factor
    • Yao, R., and G. M. Cooper. 1995. Requirement for phosphatidylinositol-3 kinase in prevention of apoptosis by nerve growth factor. Science 267:2003.
    • (1995) Science , vol.267 , pp. 2003
    • Yao, R.1    Cooper, G.M.2
  • 41
    • 0031034574 scopus 로고    scopus 로고
    • Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
    • Kulik, G., A. Klippel, and M. J. Weber. 1997. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17:1595.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1595
    • Kulik, G.1    Klippel, A.2    Weber, M.J.3
  • 42
    • 0031770827 scopus 로고    scopus 로고
    • Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I
    • Kulik, G., and M. J. Weber. 1998. Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. Mol. Cel. Biol. 18:6711.
    • (1998) Mol. Cel. Biol. , vol.18 , pp. 6711
    • Kulik, G.1    Weber, M.J.2
  • 43
    • 0030444051 scopus 로고    scopus 로고
    • IL-4 protects cells from apoptosis via the insulin-receptor substrate pathway and a 2nd independent signaling pathway
    • Zamorano, J., H. Y. Wang, L. M. Wang, J. H. Pierce, and A. D. Keegan. 1996. IL-4 protects cells from apoptosis via the insulin-receptor substrate pathway and a 2nd independent signaling pathway. J. Immunol. 157:4926.
    • (1996) J. Immunol. , vol.157 , pp. 4926
    • Zamorano, J.1    Wang, H.Y.2    Wang, L.M.3    Pierce, J.H.4    Keegan, A.D.5
  • 44
    • 0032528425 scopus 로고    scopus 로고
    • Regulation of apoptosis by tyrosine-containing domains of IL-4Rα: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis
    • Zamorano, J., and A. D. Keegan. 1998. Regulation of apoptosis by tyrosine-containing domains of IL-4Rα: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis. J. Immunol. 161:859.
    • (1998) J. Immunol. , vol.161 , pp. 859
    • Zamorano, J.1    Keegan, A.D.2
  • 45
    • 0029019017 scopus 로고
    • Interleukin-13 signal transduction in lymphohemopoietic cells: Similarities and differences in signal transduction with interleukin-4 and insulin
    • Welham, M. J., L. Learmonth, H. Bone, and J. W. Schrader. 1995. Interleukin-13 signal transduction in lymphohemopoietic cells: similarities and differences in signal transduction with interleukin-4 and insulin. J. Biol. Chem. 270:12286.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12286
    • Welham, M.J.1    Learmonth, L.2    Bone, H.3    Schrader, J.W.4
  • 46
    • 0031205542 scopus 로고    scopus 로고
    • IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors
    • Minshall, C., S. Arkins, J. Straza, J. Conners, R. Dantzer, G. G. Freund, and K. W. Kelley. 1997. IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors. J. Immunol. 159:1225.
    • (1997) J. Immunol. , vol.159 , pp. 1225
    • Minshall, C.1    Arkins, S.2    Straza, J.3    Conners, J.4    Dantzer, R.5    Freund, G.G.6    Kelley, K.W.7
  • 47
    • 0031012544 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells
    • Welham, M. J., H. Bone, M. Levings, L. Learmonth, L.-M. Wang, K. B. Leslie, J. H. Pierce, and J. W. Schrader. 1997. Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells. J. Biol. Chem. 272:1377.
    • (1997) J. Biol. Chem. , vol.272 , pp. 1377
    • Welham, M.J.1    Bone, H.2    Levings, M.3    Learmonth, L.4    Wang, L.-M.5    Leslie, K.B.6    Pierce, J.H.7    Schrader, J.W.8
  • 48
    • 0026671246 scopus 로고
    • Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members
    • Welham, M. J., V. Duronio, J. S. Sanghera, S. L. Pelech, and J. W. Schrader. 1992. Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members. J. Immunol. 149:1683.
    • (1992) J. Immunol. , vol.149 , pp. 1683
    • Welham, M.J.1    Duronio, V.2    Sanghera, J.S.3    Pelech, S.L.4    Schrader, J.W.5


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