Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q

Cancer Research

Volumn 58, Issue 1, 1998, Pages 29-33

  Boström, Jan ^a   Ludwig Cobbers, J M J ^a   Wolter, Marietta ^a   Tabatabai, Ghazaleh ^a   Weber, Ruthild G ^b   Lichter, Peter ^b   Peter Collins, V ^c   Reifenberger, Guido ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CELL SUBPOPULATION; CHILD; CHROMOSOME 10Q; CHROMOSOME LOSS; CLINICAL ARTICLE; FEMALE; GENE MUTATION; GLIOBLASTOMA; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MALE; MENINGIOMA; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BRAIN NEOPLASMS; CHILD; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 10; FEMALE; GENES, TUMOR SUPPRESSOR; GLIOBLASTOMA; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MENINGEAL NEOPLASMS; MENINGIOMA; MIDDLE AGED; PHOSPHORIC MONOESTER HYDROLASES; POLYMERASE CHAIN REACTION; PROTEIN-TYROSINE-PHOSPHATASE; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEINS;

EID: 2642705040     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Lantos, P. L., Vandenberg, S. R., and Kleihues, P. Tumours of the nervous system. In: D. I. Graham and P. L. Lantos (eds.). Greenfield's Neuropathology, Ed. 6, Vol. 2, pp. 583-879. London: E. Arnold, 1996.
2. Collins, V. P., and James, C. D. Gene and chromosomal alterations associated with the development of human gliomas. FASEB J., 7: 926-930, 1993.
3. von Deimling, A., Louis, D. N., and Wiestler, O. D. Molecular pathways in the formation of gliomas. Glia, 15: 328-338, 1995.
4. Bigner, S. H., and Vogelstein, B. Cytogenetics and molecular genetics of malignant gliomas and medulloblastomas. Brain Pathol., 1: 12-18, 1990.
5. Karlbom, A. E., James, C. D., Boethius, J., Cavenee, W. K., Collins, V. P., Nordenskjold, M., and Larsson, C. Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10. Hum. Genet., 92: 169-174, 1993.
6. Sonoda, Y., Murakami, Y., Tominaga, T., Kayama, T., Yoshimoto, T., and Sekiya, T. Deletion mapping of chromosome 10 in human glioma. Jpn. J. Cancer Res., 87: 363-367, 1996.
7. Rempel, S. A., Schwechheimer, K., Davis, R. L., Cavenee, W. K., and Rosenblum, M. L. Loss of heterozygosity for loci on chromosome 10 is associated with morphologically malignant meningoma progression. Cancer Res., 53: 2386-2392, 1993.
8. Simon, M., von Deimling, A., Larson, J. J., Wellenreuther, R., Kaskel, P., Waha, A., Warnich, R. E., Tew, J. M., Jr., and Menon, A. G. Allelic losses on chromosome 14, 10, and 1 in atypical and malignant meningiomas. A genetic model of meningioma progression. Cancer Res., 55: 4696-4701, 1995.
9. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. PTEN, a putative tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Washington DC), 275: 1943-1947, 1997.
10. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K. A., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H. F., and Tavtigian, S. V. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997.
11. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L. M., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., Eng, C., and Parsons, R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16: 64-67, 1997.
12. Lyons, C. J., Wilson, C. B., and Horton, J. C. Association between meningioma and Cowden's disease. Neurology, 43: 1436-1437, 1993.
13. Kleihues, P., Burger, P. C., and Scheithauer, B. Histological typing of tumours of the central nervous system, pp. 16-19. Berlin: Springer-Verlag, 1993.
14. INK4a, MTS1) and CDK4 gene have frequent mutations of the retinoblastoma gene. Oncogene, 13: 1065-1072, 1996.
15. Gyapay, G., Morisette, J., Vignal, A., Dib, C., Fizames, C., Millasseau, P., Marc, S., Bernardi, G., Lathrop, M., and Weissenbach, J. The 1993-94 Généthon human genetic linkage map. Nat. Genet., 7: 250-255, 1994.
16. Wechsler, D. S., Shelly, C. A., and Dang, C. V. Genomic organization of human MXI1, a putative tumor suppressor gene. Genomics, 32: 466-470, 1996.
17. Boström, J., Mühlbauer, A., and Reifenberger, G. Deletion mapping of the short arm of chromosome 1 identifies a common region of deletion distal to D1S496 in human meningiomas. Acta Neuropathol., 94: 479-485, 1997.
18. Lichter, P., Bentz, M., and Joos, S. Detection of chromosomal aberrations by means of molecular cytogenetics: painting of chromosomes and chromosomal subregions and comparative genomic hybridization. Methods Enzymol., 254: 334-359, 1995.
19. Weber, R. G., Sabel, M., Reifenberger, J., Sommer, C., Oberstrass, J., Reifenberger, G., Kiessling M., and Cremer, T. Characterization of genomic alterations associated with glioma progression by comparative genomic hybridization. Oncogene, 13: 983-994, 1996.
20. Oberstrass, J., Reifenberger, G., Reifenberger, J., Wechsler, W., and Collins, V. P. Mutation of the von Hippel-Lindau tumour suppressor gene in capillary haemangioblastomas of the central nervous system. J. Pathol., 179: 151-156, 1996.
21. Wolter, M., Reifenberger, J., Sommer, C., Ruzicka, T., and Reifenberger, G. Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res., 57: 2581-2585, 1997.
22. Schmidt, E. E., Ichimura, K., Messerle, K. R., Goike, H. M., and Collins, V. P. Infrequent methylation of CDKN2A (MTS1/p16) and rare mutation of both CDKN2A and CDKN2B (MTS2/p15) in primary astrocytic tumours. Br. J. Cancer, 75: 2-8, 1997.
23. Sheffield, V. C., Beck, J. S., Kwitek, A. E., Sandstrom, D. W., and Stone, E. M. The sensitivity of single-strand conformation polymorphism analysis for the detection of single base substitutions. Genomics, 16: 325-332, 1993.
24. Fults, D., and Pedone, C. Deletion mapping of the long arm of chromosome 10 in glioblastoma multiforme. Genes Chromosomes Cancer, 7: 173-177, 1993.
25. Albarosa, R., Colombo, B. M., Roz, L., Magnani, I., Polio, B., Cirenei, N., Giani, C., Conti, A. M., DiDonato, S., and Finocchiaro, G. Deletion mapping of gliomas suggest the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q. Am. J. Hum. Genet., 58: 1260-1267, 1996.
26. Rasheed, B. K. A., McLendon, R. E., Friedman, H. S., Friedman, A. H., Fuchs, H. E., Bigner, D. D., and Bigner, S. H. Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. Oncogene, 10: 2243-2246, 1995.
27. Albarosa, R., Finocchiaro, G., Chiariello, E., Russo, G., Susani, L., Vezzoni, P., and Zucchi, I. Construction of a 5-Mb YAC contig from the putative 10q25 tumor-suppressor region for glioblastomas. Genomics, 41: 345-349, 1997.
28. Nagase, S., Yamakawa, H., Sato, S., Yajima, A., and Horii, A. Identification of a 790-kilobase region of common allelic loss in chromosome 10q25-q26 in human endometrial cancer. Cancer Res., 57: 1630-1633, 1997.
29. Zervos, A. S., Gyuris, J., and Brent, R. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell, 72: 223-232, 1993.
30. Eagle, L. R., Yin, X., Brothman, A. R., Williams, B. J., Atkin, N. B., and Prochownik, E. V. Mutation of the MXI1 gene in prostate cancer. Nat. Genet., 9: 249-255, 1995.
31. Gray, I. C., Phillips, S. M., Lee, S. J., Neoptolemos, J. P., Weissenbach, J., and Spurr, N. K. Loss of the chromosomal region 10q23-q25 in prostate cancer. Cancer Res., 55: 4800-4803, 1995.
32. Kawamata, N., Park, D., Wilczynski, S., Yokota, J., and Koeffler, H. P. Point mutations of the MXI1 gene are rare in prostate cancers. Prostate, 29: 191-193, 1996.
33. Mollenhauer, J., Wiemann, S., Scheuerlen, W., Korn, B., Hayashi, Y., Wilgenbus, K. K., von Deimling, A., and Poustka, A. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumors. Nat. Genet., 17: 32-39, 1997.