Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD)

Progress in Drug Research

Volumn 53, Issue , 1999, Pages 193-229

  Barnette, Mary S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Airway airway obstruction; Asthma; Basophils; Bronchoconstriction; Edema; Eosinophils; Inflammation; Macrophages; Monocytes; Neutrophils; Phosphodiesterase; T cells

Indexed keywords

4 [2 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 2 PHENYLETHYL]PYRIDINE; BENZAFENTRINE; CILOMILAST; INDOMETACIN; MIFEPRISTONE; NADOLOL; NAPROXEN; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; THEOPHYLLINE; TIBENELAST; ZARDAVERINE;

AIRWAY OBSTRUCTION; ANTIINFLAMMATORY ACTIVITY; ASTHMA; BASOPHIL; BRONCHITIS; BRONCHUS HYPERREACTIVITY; BRONCHUS MUCOSA; BRONCHUS MUSCLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; DRUG MECHANISM; EDEMA; EOSINOPHIL; GASTROINTESTINAL SYMPTOM; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LYMPHOCYTE; MAST CELL; MUCUS SECRETION; NAUSEA; NEUROTOXICITY; NEUTROPHIL; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; VOMITING;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; HUMANS; LUNG DISEASES, OBSTRUCTIVE; PHOSPHODIESTERASE INHIBITORS;

EID: 0032699082     PISSN: 0071786X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (310)

1. Torphy T.J.: Am. J. Respir, Crit. Care Med. 157, 351-370 (1998).
2. Torphy T.J., Murray K.J. and Arch J.R., in: C.P. Page and W.J. Metzger (eds.): Drugs and the Lung, Raven Press, New York 1994, 397-447.
3. Burns F., Zhao A.Z. and Beavo J.A.: Adv. Pharmacol. 36, 29-48 (1996).
4. Beavo J.A., Conti M. and Heaslip R.J.: Mol. Pharmacol. 46, 399-405 (1994).
5. Milatovich A., Bolger G., Michaeli T. and Francke U.: Somat. Cell Mol. Genet. 20, 75-86 (1994).
6. Szpirer C., Szpirer J., Riviere M., Swinnen J., Vicini E. and Conti M.: Cytogenet. Cell Genet. 69, 11-14 (1995).
7. Bolger G., Michaeli T., Martins T., St. John T., Steiner B., Rodgers L., Riggs M., Wigler M. and Ferguson K.: Mol. Cell. Biol. 13, 6558-6571 (1993).
8. Houslay M.D., Sullivan M. and Bolger G.B.: Adv. Pharmacol. 44, 225-342 (1998).
9. Teixeria M., Gristwood R.W., Cooper N. and Hellewell P.G.: TIPS 18, 164-170 (1997).
10. Cavalla D. and Frith R.: Curr. Med. Chem. 2, 561-572 (1995).
11. Stafford J.A. and Feldman P.L.: Ann. Rep. Med. Chem. 31, 71-80 (1996).
12. Karlsson J.A. and Aldous D.: Exp. Opin. Ther. Patents 7, 989-1003 (1997).
13. Muller T., Engels P. and Fozard J.R.: TIPS 17, 294-298 (1996).
14. Morley J.: Immunol. Today 14, 317-322 (1993).
15. Busse W.W. and, Parry D.E., in: A.P. Fishman, J.A. Elias, J.A. Fishman, M.A. Grippi, L.R. Kaiser and R.M. Senior (eds.): Fishman's Pulmonary Diseases and Disorders, McGraw-Hill, New York 1998, 721-733.
16. Beasley R., Burgess C., Crane J., Pearce N. and Roche W.: J. Allergy Clin. Immunol. 93, 148-154 (199).
17. Senior R.M. and Shapiro S.D., in: A.P. Fishman, J.A. Elias, J.A. Fishman, M.A. Grippi, L.R. Kaiser and R.M. Senior (eds.): Fishman's Pulmonary Diseases and Disorders, McGraw-Hill, New York 1998, 659-681.
18. Pueringer R.J. and Hunninghake G.W.: Am. J. Med. 92, 6A-32S-6A-38S (1992).
19. Hamid Q., Song Y., Kotsimbos T.C., Minshall E., Bai T.R., Hegele R.G. and Hogg J.C.: J. Allergy Clin. Immunol. 100, 44-51 (1997).
20. Roche W.R.: Am. J. Respir. Crit. Care Med. 15, S191-S194 (1998).
21. Poulter L.W., Janossy G.J., Power C., Sreenan S. and Burke C.: Immunol. Today 15, 258-261 (1994).
22. Holgate S.T.: Clin. Rev. Asthma 12, 65-78 (1994).
23. Church M.K., Okayama Y. and Bradding P.: N.Y. Acad. Sci. 725, 13-21 (1994).
24. Holgate S.T., Djukanovic R., Howarth P.H., Montefort S. and Roche W.: Chest 103, 125S-128S (1993).
25. Aebischer I. and Stadler B.M.: Adv. Immunol. 61, 341-403 (1996).
26. Rennard S.I.: Am. J. Respir. Crit. Care Med. 153, S14-S15 (1996).
27. Rennard S.I.: Eur. Respir. Rev. 7, 206-210 (1997).
28. Postma D.S. and Kerstjens H.A.M.: Am. J. Respir. Crit. Care Med. 158, S187-S192 (1998).
29. Hiemstra P.S., van Wetering S. and Stolk J.: Eur. Respir. J. 12, 1200-1208 (1998).
30. Pesci A., Majori M., Cuomo A., Borciani N., Bertacco S., Cacciani G. and Gabrielli M.: Respir. Med. 92, 863-870 (1998).
31. Sandford A.J., Weir T.D. and Pare P.D.: Eur. Respir. J. 10, 1380-1391 (1997).
32. O'Shaoughnessy T.C., Ansari T.W., Barnes N.C. and Jeffery P.K.: Am. J. Respir. Crit. Care Med. 155, 852-857 (1997).
33. Lams B.E., Sousa A.R., Rees P.J. and Lee T.H.: Am. J. Respir. Crit. Care Med. 158, 1518-1523 (1998).
34. Peleman R.A., Kips J.C. and Pauwels R.A.: Clin. Exp. Allergy 28 (Suppl. 3), 53-56 (1998).
35. Folkerts G. and Nijkamp F.P.: TIPS 19, 334-341 (1998).
36. Barnes P.J.: Chest 107, 119S-125S (1995).
37. Verleden G.M.: Biochem. Pharmacol. 51, 1247-1257 (1996).
38. Halayko A.J. and Stephens N.L.: Can. J. Physiol. Pharmacol. 72, 1448-1457 (1994).
39. Halayko A.J., Salari H., Ma X. and Stephens N.L.: Am. J. Physiol. 270, L1040-L1051 (1996).
40. Laitinen L.A. and Laitinen A.: J. Allergy Clin, Immunol. 97, 153-158 (1996).
41. Pare P.D. and Bai T.R.: Eur. Respir. Rev. 6, 259-263 (1996).
42. Jeffery P.K.: Am. J. Respir. Crit. Care Med. 150, S6-S13 (1994).
43. Harris A.L., Connell M.J., Ferguson E.W., Wallace A.M., Gordon R.J., Pagani E.D. and Silver P.J.: J. Pharmacol. Exp. Ther. 251, 199-206 (1989).
44. Torphy T.J. and Cielinski L.B.: Mol. Pharmacol. 37, 206-214 (1990).
45. Cortijo J., Bou J., Beleta J., Cardelus I., Llenas J., Morcillo E. and Gristwood R.W.: Br. J. Pharmacol. 108, 562-568 (1993).
46. Qian Y., Naline E., Karlsson J.-A., Raeburn D. and Advenier C.: Br. J. Pharmacol. 109, 774-778 (1993).
47. Torphy T.J., Undem B.J., Cieslinski L.B., Luttman M.A., Reeves M.L. and Hay D.W.P.: J. Pharmacol. Exp. Ther. 265, 1213-1223 (1993).
48. Torphy T.J., Zhou H.-L., Burman M. and Huang B.F.: Mol. Pharmacol. 39, 376-384 (1991).
49. Small R.C., Boyle J.P., Duty S., Elliott K.R.F., Foster R.W. and Watt A.J.: Br. J. Pharmacol. 97, 1165-1173 (1989).
50. Small R.C., Berry J.L., Boyle J.P., Chapman I.D., Elliott K.R.F., Foster R.W. and Watt A.J.: Eur. J. Pharmacol. 192, 417-126 (1991).
51. Tomkinson A., Karlsson J.-A. and Raeburn D.: Br. J. Pharmacol. 108, 57-61 (1993).
52. Underwood D.C., Osborn R.R., Novak L.B., Matthews J.K., Newsholme S.J., Undem B.J., Hand J.M. and Torphy T.J.: J. Pharmacol. Exp. Ther. 266, 306-313 (1993).
53. Ortiz J.L., Valles J.M., Marti-Cabrera M., Cortijo J. and Morcillo E.J.: Nauyn-Schmiedeberg's Arch. Pharmacol. 353, 200-206 (1996).
54. Heaslip R.J., Buckley S.K., Sickels B.D. and Grimes D.: J. Pharmacol. Exp. Ther. 257, 741-747 (1991).
55. Held H.-D., Wendel A. and Uhlig S.: Biochem. Biophys. Res. Commun. 231, 22-25 (1997).
56. Underwood D.C., Kotzer C.J., Bochnowicz S., Osborn R.R., Luttman M.A., Hay D.W.P. and Torphy T.J.: J. Pharmacol. Exp. Ther. 270, 250-259 (1994).
57. Turner C.R., Andresen C.J., Smith W.B. and Watson J.W.: Am. J. Respir. Crit. Care Med. 149, 1153-1159 (1994).
58. Elwood W., Sun J., Bames P.J., Giembycz M.A. and Chung K.F.: Inflamm. Res. 44, 83-86 (1995).
59. Gozzard N., Herd C.M., Blake S.M., Holbrook M., Hughes B., Higgs G.A. and Page C.P.: Br. J. Pharmacol. 117, 1405-1412 (1996).
60. Lugnier C. and Schini V.B.: Biochem. Pharmacol. 39, 75-84 (1990).
61. Kishi Y., Ashikaga T. and Numano F.: Adv. Second Messengers Phosphoprotein Res. 25, 201-213 (1992).
62. Suttorp N., Weber U., Welsch T. and Schudt C.: J. Clin. Invest. 91, 1421-1428 (1993).
63. Suttorp N., Ehreiser P., Hippenstiel S., Fuhrmann M., Krull M., Tenor H. and Schudt C.: Lung 174, 181-194 (1996).
64. Ashikaga T., Strada S.J. and Thompson W.J.: Biochem. Pharmacol. 54, 1071-1079 (1997).
65. Ortiz J.L. Cortijo J., Valles J.M., Bou J. and Morcillo E.J.: Fundam. Clin. Pharmacol. 6, 247-249 (1992).
66. Raeburn D. and Karlsson J.-A.: J. Pharmacol. Exp. Ther. 267, 1147-1152 (1993).
67. Turner C.R., Esser K.M. and Wheeldon E.B.: Circulatory Shock 39, 237-245 (1993).
68. Underwood D.C., Osborn R.R., Bochnowicz S., Hay D.W.P. and Torphy T.J.: Am. J. Respir. Crit. Care Med. 157, A827 (abstract) (1998).
69. Planquois J.-M., Mottin G., Artola M., Lagente V., Payne A. and Dahl S.: Eur. J. Pharmacol. 344, 59-66 (1998).
70. Barnard J.W., Seibert A.F., Prasad V.R., Smart D.A., Strada S.J., Taylor A.E. and Thompson W.J.: J. Appl. Physiol. 77, 774-781 (1994).
71. Svensjo E., Andersson K.E., Bouskela E., Cyrino F.Z.G.A. and Lindgren S.: Agents Actions 39, 35-41 (1993).
72. Howell R.E., Jenkins L.P. and Howell D.E.: J. Pharmacol. Exp. Ther. 275, 703-709 (1995).
73. Knight D.A., Stewart G.A. and Thompson P.J.: Clin. Exp. Allergy 24, 698-706 (1994).
74. Polito A.J. and Proud D.: J. Allergy Clin, Immunol. 102, 714-718 (1998).
75. Rousseau E., Gagnon J. and Lugnier C.: Mol. Cell Biochem. 140, 171-175 (1994).
76. Wright L.C., Seybold J., Robichaud A., Adcock I.M. and Barnes P.J.: Am. J. Physiol. 275, L694-L700 (1998).
77. Fuhrmann M., Jahn H.-U., Seybold J., Neurohr C., Barnes P.J., Hippenstiel S., Kraemer J. and Suttorp N.: Am. J. Respir. Cell Mol. Biol. 20, 292-302 (1999).
78. Dowling R.B., Johnson M., Cole P.J. and Wilson R.: J. Pharmacol. Exp. Ther 282, 1565-1571 (1997).
79. Wagner U., Bredenbroker D., Fehmann H.-C., Schwarz F., Schudt C. and von Wichert P.: Eur. J. Pharmacol. 298, 265-270 (1996).
80. Torphy T.J. and Undem B.J.: Thorax 46, 512-523 (1991).
81. Giembycz M.A: Biochem. Pharmacol. 43, 2041-2051 (1992).
82. Bamette M.S., Christensen S.B., Underwood D.C. and Torphy T.J.: Pharmacol. Rev. Commun. 8, 65-73 (1996).
83. Torphy T.J., DeWolf W.E., Green D.W. and Livi G.P.: Agents Actions 43S, 51-71 (1993).
84. Peachell P.T., Undem B.J., Schleimer R.P., MacGlashan D.W., Lichtenstein L.M., Cieslinski L.B. and Torphy T.J.: J. Immunol. 148, 2503-2510 (1992).
85. Torphy T.J., Livi G.P., Balcarek J.M., White J.R., Chilton F.H. and Undem B.J.: Adv. Second Messengers Phosphoprotein Res. 25, 289-305 (1992).
86. Weston M.C., Anderson N. and Peachell P.T.: Br. J. Pharmacol. 121, 287-295 (1997).
87. Kleine-Tebbe J., Wicht L., Gagne H., Friese A., Schunack W., Schudt C. and Kunkel G.: Agents Actions 36, 200-206 (1992).
88. Louis R., Bury T.H., Corhay J.L. and Radermecker M.: Int. J. Immunopharmac. 14, 191-194 (1992).
89. Weston M.C. and Peachell P.T.: Gen. Pharmac. 31, 715-719 (1998).
90. Shichijo M., Shimizu Y., Hiramatsu K., Inagaki N., Tagaki K. and Nagai H.: Int. Arch. Allergy Immunol. 114, 348-353 (1997).
91. Frossard N., Landry Y., Pauli G. and Rucksruhl M.: Br. J. Pharmacol. 73, 933-938 (1981).
92. Banner K.H., Moriggi E., Da Ros B., Schioppacassi G., Semeraro C. and Page C.P.: Br. J. Pharmacol. 119, 1255-1261 (1996).
93. Shichijo M., Inagaki N., Nakai N., Kimata M., Nakahata T., Serizawa I., Iikura Y., Saito H. and Nagai H.: Clin. Exp. Allergy 28, 1228-1236 (1998).
94. Nagai H., Takeda H., Iwama T., Yamaguchi S. and Mori H.: Jpn. J. Pharmacol. 67, 149-156 (1995).
95. Poulter L.W. and Burke C.M.: Immunobiol. 195, 574-587 (1996).
96. Elliott K.R.F. and Leonard E.J.: FEBS Letters 254, 94-98 (1989).
97. Torphy T.J., Stadel J.M., Burman M., Cieslinski L.B., McLaughlin M.M., White J.R. and Livi G.P.: J. Biol. Chem. 267, 1798-1804 (1992).
98. Seldon P.M., Barnes P.J., Meja K. and Giembycz M.A.: Mol. Pharmacol. 48, 747-757 (1995).
99. Manning C.D., McLaughlin M.M., Livi G.M., Cieslinski L.B., Torphy T.J. and Bamette M.S.: J. Pharmacol. Exp. Ther. 276, 810-818 (1996).
100. Tenor H., Hatzelmann A., Kupferschmidt R., Stanciu L., Djukanovic R., Schudt C., Wendel A., Church M.K. and Shute J.K.: Clin. Exp. Allergy 25, 625-633 (1995).
101. Kelly J.J., Barnes P.J. and Giembycz M.A.: Biochem. J. 318, 425-436 (1996).
102. Ganter F., Kuperschmidt R., Schudt C., Wendel A. and Hatzelmann A.: Br. J. Pharmacol. 121, 221-231 (1997).
103. Germain N., Bertin B., Legendre A., Martin B., Lagente V., Payne A. and Boichot E.: Eur. Respir. J. 12, 1334-1339 (1998).
104. Engels P., Fichtel K. and Lubbert H.: FEBS Letters 350, 291-295 (1994).
105. Verghese M.W., McConnell R.T., Lenhard J.M., Harnacher L., Jin S.-L.C.: Mol. Pharmacol. 47, 1164-1171 (1995).
106. Souness J.E., Griffin M., Maslen C., Ebsworth K., Scott L.C., Pollock K., Palfreyman M.N. and Karlsson J.-A.: Br. J. Pharmacol. 118, 649-658 (1996).
107. Molnar-Kimber K.L., Yonno L., Heaslip R.J. and Weichman B.M.: Mediators Inflamm, 1, 411-417 (1992).
108. Molnar-Kimber K., Yonno L., Heaslip R. and Weichman B.: Agents Actions 39, C77-C79 (1993).
109. Semmler J., Wachtel. and Endres S.: Int. J. Immunopharmacol. 15, 409-413 (1993).
110. Prabhakar U., Lipshutz D., O'Leary Bartus J., Slivjak M.J., Smith E.F., Lee J.C. and Esser K.M.: Int. J. Immunopharmacol. 16, 805-816 (1994).
111. Barnette M.S., O'Leary Bartus J., Burman M., Christensen S.B., Cielslinski L.B., Esser K.M., Prabhakar U.S., Rush J.A. and Torphy T.J.: Biochem. Pharmacol. 51, 949-956 (1996).
112. Brideau C., van Staden C., Styhler A., Rodger I.W. and Chan C.-C.: Br. J. Pharmacol. 126, 979-988 (1999).
113. Verghese M.W., McConnell R.T., Strickland A.B., Gooding R.C., Stimpson S.A., Yarnall D.P., Taylor J.D. and Furdon P.J.: J. Pharmacol. Exp. Ther. 272, 1313-1320 (1995).
114. Kambayashi T., Jacob C.O., Zhou D., Mazurek N., Fong M. and Strassmann G.: J. Immunol. 155, 4909-4916 (1995).
115. Siegmund B., Eigler A., Moeller J., Greten T.F., Hartmann G. and Endres S.: Eur, J. Pharmacol. 321, 231-239 (1997).
116. Hichami A., Boichot E., Germain N., Legrand A., Moodley I. and Lagente V.: Eur. J. Pharmacol. 291, 91-97 (1995).
117. Hichami A., Boichot E., Germain N., Coqueret O. and Lagente V.: Life Sci, 59, 255-261 (1996).
118. Sinha B., Semmler J., Eisenhut T., Eigler A. and Endres S.: Eur. J. Immunol. 25, 147-153 (1995).
119. Greten T.F., Sinha B., Haslberger C., Eigler A. and Endres S.: Eur. J. Pharmacol. 299, 229-233 (1996).
120. Schade U.F. and Schudt C.: Eur. J. Pharmacol. 230, 9-14 (1993).
121. Gonclaves de Moraes V.L., Singer M., Vargaftig B.B. and Chignard M.: Br. J. Pharmacol. 123, 631-636 (1998).
122. Turner N.C., Wood L.J., Burns F.M., Gueremy T. and Souness J.E.: Br. J. Pharmacol. 108, 876-883 (1993).
123. Turner N.C. and Wood L.J.: Cell Signal 6, 923-931 (1994).
124. Conti M., Jin S.-L.C., Monaco L., Repaske D.R. and Swinnen J.V.: Endocrine Rev. 12, 218-234 (1991).
125. Sette C., Vicini E. and Conti M.: Mol. Cell Endocrinol. 100, 75-79 (1994).
126. Conti M., Nemoz G., Sette C. and Vicini E.: Endocrine Rev. 16, 370-389 (1995).
127. Holden C.A., Chan S.C., Norris S. and Hanifin J.M.: Agents Actions 22, 36-42 (1987).
128. Torphy T.J., Zhou H.-L. and Cieslinski L.B.: J. Pharmacol. Exp. Ther. 263, 1195-1205 (1992).
129. Torphy T.J., Zhou H.-L., Foley J.J., Sarau H.M., Manning C.D. and Barnette M.S.: J. Biol. Chem. 270, 23598-23604 (1995).
130. Bates M.D., Olsen C.L., Becker B.N., Alber F.J., Middleton J.P., Mulheron J.G., Jin S.-L.C., Conti M. and Raymond J.R.: J. Biol. Chem. 268, 14757-14763 (1993).
131. Sette C., Iona S. and Conti M.: J. Biol. Chem. 269, 9245-9252 (1994).
132. Sette C., Vicini E. and Conti M.: J. Biol. Chem. 269, 18271-18274 (1994).
133. Nemoz G., Sette C., Hess M., Muca C., Vallar L. and Conti M.: Mol. Endocrinol. 9 1279-1287 (1995).
134. Sette C. and Conti M.: J. Biol. Chem. 271, 16526-16534 (1996).
135. Alvarez R., Sette C., Yang D., Eglen R.M., Wilhelm R., Shelton E.R, and Conti M.: Mol. Pharmacol. 48, 616-622 (1995).
136. Saldou N., Obernolte R., Huber A., Baecker P.A., Wilhem R., Alvarez R., Li B., Xia L., Callan O., Su C. et al.: Cell Signal 10, 427-440 (1998).
137. Lenhard J.M., Kassel D.B., Rocque W.J., Harnacher L., Holmes W.D., Patel I, Hoffman C. and Luther M.: Biochem. J. 316, 751-758 (1996).
138. Chan S.C., Reifsnyder D., Beavo J.A. and Hanifin J.M.: J. Allergy Clin. Immunol. 91, 1179-1188 (1993).
139. Hanifin J.M. and Chan S.C.: J. Invest. Dermatol. 105, 84S-88S (1995).
140. Gantner F., Tenor H., Gekeler V., Schudt C., Wendel A. and Hatzelmann A.: J. Allergy Clin. Immunol. 100, 527-535 (1997).
141. Martin L.B., Kita H., Leiferman K.M. and Gleich G.J.: Int. Arch. Allergy Immunol. 109, 207-215 (1996).
142. Walsh G.M.: Br J. Haematol. 97, 701-709 (1997).
143. Souness J.E., Carter C.M., Diocee B.K., Hassall G.A., Wood L.J. and Turner N.C.: Biochem. Pharmacol. 42, 937-945 (1991).
144. Dent G., Giembycz M.A., Rabe K.F. and Barnes P.J.: Br. J. Pharmacol. 103, 1339-1346 (1991).
145. Souness J.E., Malsen C. and Scott L.C.: FEBS Letters 302, 181-184 (1992).
146. Souness J.E. and Scott L.C.: Biochem. J. 291, 389-395 (1993).
147. Dent G., Giembycz M.A., Evans P.M., Rabe K.F. and Barnes P.J.: J. Pharmacol. Exp. Ther. 271, 1167-1174 (1994).
148. Hatzelmann A., Tenor H. and Schudt C.: Br. J. Pharmacol. 114, 821-831 (1995).
149. Souness J.E., Malsen C., Webber S., Foster M., Raebum D., Palfreyman M.N., Ashton M.J. and Karlsson J.-A.: Br. J. Pharmacol. 115, 39-46 (1995).
150. Essayan D.M., Huang S.-K., Kagey-Sobotka A. and Lichtenstein L.M.: Am. J. Respir. Cell Mol. Biol. 13, 692-702 (1995).
151. Barnette M.S., Christensen S.B. Essayan D.M., Grous M., Prabhakar U., Rush J.A., Kagey-Sobotka A. and Torphy T.J.: J. Pharmacol. Exp. Ther. 284, 420-426 (1998).
152. Kaneko T., Alvarez R., Ueki I.F. and Nadel J.A.: Cell Signal 7, 527-534 (1998).
153. Alves A.C., Pires A.L.A., Cruz H.N., Serra M.F., Diaz B.L., Cordeiro R.S.B., Lagente V., Martins M.A. and Silva P.M.R.: Eur. J. Pharmacol. 312, 89-96 (1996).
154. Tenor H., Hatzelmann A., Church M.K., Schudt C. and Shute J.K.: Br. J. Pharmacol. 118, 1727-1735 (1996).
155. Santamaria L.F., Palacios J.M. and Beleta J.: Br. J. Pharmacol. 121, 1150-1154 (1997).
156. Cohan V.L., Showell H.J., Fisher D.A., Pazoles C.J., Watson J.W., Turner C.R. and Cheng J.B.: J. Pharmacol. Exp. Ther. 278, 1356-1361 (1996).
157. Barnette M.S., Manning C.D., Cieslinski L.B., Burman M., Christensen S.B. and Torphy T.J.: J. Pharmacol. Exp. Ther. 273, 674-679 (1995).
158. Ezeamuzie C.I. and Al-Hage M.: Int. Arch. Allergy Immunol. 118, 162-168 (1998).
159. Souness J.E., Villamil M.E., Scott L.C., Tomkinson A., Giembycz M.A. and Raeburn D.: Br. J. Pharmacol. 111, 1081-1088 (1994).
160. Teixeira M.M., Rossi A.G., Giembycz M.A. and Hellewell P.G.: Br. J. Pharmacol. 118, 2099-2106 (1996).
161. Momose T., Okubo Y., Horie S., Suzuki J., Isobe M. and Sekiguchi M.: Int. Arch. Allergy Immunol. 117, 138-145 (1998).
162. Lagente V., Moodley I., Perrin S., Mottin G., Junien J.-L.: Eur. J. Pharmacol. 255, 253-256 (1994).
163. Lagente V., Pruniaux M.-P., Junien J.-L. and Moodley I.: Am. J. Respir. Crit. Care Med. 151, 1720-1724 (1995).
164. Hughes B., Howat D., Lisle H., Holbrook M., James T., Gozzard N., Blease K., Hughes P, Kingaby R., Warrellow G. et al.: Br. J. Pharmacol. 118, 1183-1191 (1996).
165. Newsholme S.J. and Schwartz L.: Inflammtion 17, 25-31 (1993).
166. Underwood D.C., Bochnowicz S., Osborn R.R., Kotzer C.J., Luttmann M.A., Hay D.W.P., Gorycki P.D., Christensen S.B. and Torphy T.J.: J. Pharmacol. Exp. Ther. 287, 988-995 (1998).
167. Banner K.H. and Page C.P.: Br. J. Pharmacol. 114, 93-98 (1995).
168. Danahay H. and Broadley K.J.: Br J. Phamacol 120, 289-297 (1997).
169. Cortijo J., Pons R., Dasi R., Marin N., Martinez-Losa M., Advenier C. and Morcillo E.J.: Naunyn-Schmiedeberg's Arch. Pharmacol. 356, 806-814 (1997).
170. Kaminuma O., Kikkawa H., Matsubara S. and Ikezawa K.: Int. Arch. Allergy Immunol. 112, 406-411 (1997).
171. Danahay H. and Broadley K.J.: Clin. Exp. Allergy 28, 513-522 (1998).
172. Gozzard N-, El-Hashim A., Herd C.M., Blake S.M., Holbrook M., Hughes B., Higgs G.A. and Page C.P.: Br. J. Pharmacol. 118, 1201-1208 (1996).
173. Turner C.R., Cohan V.L., Cheng, J.B., Showell H.J., Pazoles C.J. and Watson J.W.: J. Pharmacol. Exp. Ther. 278, 1349-1355 (1996).
174. Teixeira M.M., Rossi A.G., Williams T.J. and Hellewell P.G.: Br. J. Pharmacol. 112, 332-340 (1994).
175. Smith G.P. and Peter T.J.: Clinica Chimica Acta 103, 193-201 (1980).
176. Grady P.G. and Thomas L.L.: Biochim. Biophys. Acta 885, 282-293 (1986).
177. Wright C.D., Kuipers P.J., Kobylarz-Singer D., Devall L.J., Klinkefus B.A. and Weishaar R.E.: Biochem. Pharmacol. 40, 699-707 (1990).
178. Schudt C., Winder S., Forderkunz S., Hatzelmann A. and Ullrich V.: Naunyn-Schmiedeberg's Arch. Pharmacol. 344, 682-690 (1991).
179. Pryzwansky K.B., Kidao S. and Merricks E.P.: Cell Biochem. Biophys. 28, 251-275 (1998).
180. Au B.-T., Teixeira M.M., Collins P.D. and Williams T.J.: Br. J. Pharmacol. 123,1260-1266 (1998).
181. Nielson C.P., Vestal R.E., Sturm R.J. and Heaslip R.: J. Allergy Clin. Immunol. 86, 801-808 (1990).
182. Ottonello L., Morone M.P., Dapino P. and Dallegn F.: Br. J. Haematol. 91, 566-570 (1995).
183. Sullivan G.W., Carper H.T. and Mandell G.L.: Int. J. Immunopharmacol. 17, 793-803 (1995).
184. Denis D. and Riendeau D.: Eur. J. Pharmacol. 367, 343-350 (1999).
185. Derian C., Santulli R.J., Rao P.E., Solomon H.F. and Barrett J.A.: J. Immunol. 154, 308-317 (1995).
186. Currie M.S., Rao M.K., Padmanabhan J., Jones A., Crawford J. and Cohen H.J.: J. Leukocyte Biol. 47, 244-250 (1990).
187. Berends C., Dijkhuizen B., de Monchy J.G.R., Dubois A.E.J., Gerritsen J. and Kauffman H.F.: Eur. Respir. J. 10, 1000-1007 (1997).
188. Ottonello L., Morone M.P., Dapino P. and Dallegri F.: Clin. Exp. Immunol. 101, 502-506 (1995).
189. Nourshargh S. and Hoult J.R.S.: Eur. J. Pharmacol. 122, 205-212 (1986).
190. Griswold D.E., Webb E.F., Breton J., White J.R., Marshall P.J. and Torphy T.J.: Inflammation 17, 333-344 (1993).
191. Griswold D.E., Martin L.D. and Torphy T.J.: Am. J. Respir. Crit. Care Med. 159, A90 (abstract) (1999).
192. Kips J.C., Joos G.F., Peleman R.A. and Pauwels R.A.: Clin. Exp. Allergy 23, 518-523 (1993).
193. Klemm P., Harris H.J. and Perretti M.: Eur. J. Pharmacol. 281, 69-74 (1995).
194. Duplantier A.J., Andresen C.J., Cheng J.B., Cohan V.L., Decker C., DiCapua F.M., Kraus K.G., Johnson K.L., Turner C.R., UmLand J.P. et al.: J. Med. Chem. 41, 2268-2277 (1998).
195. Miotla J.M., Teixeira M.M. and Hellewell P.G.: Am. J. Respir. Cell Mol. Biol. 18, 411-420 (1998).
196. Salgame P., Abrams J.S., Clayberger C., Goldstein H., Convit J., Modlin R.L. and Bloom B.R.: Science 254, 279-282 (1991).
197. Robicsek S.A., Krzanowski J.J., Szentivanyi A. and Poison J.B.: Biochem. Biophys. Res. Commun. 163, 554-560 (1989).
198. Robicsek S.A., Blanchard D.K., Djeu J.Y., Krzanowski J.J., Szentivanyi A. and Poison J.B.: Biochem. Pharmacol. 42, 869-877 (1991).
199. Essayan D.M., Huang S.-K., Undem B.J., Kagey-Sobotka A. and Lichtenstein L.M.: J. Immunol. 153, 3408-3416 (1994).
200. Sheth S.B., Chaganti K., Bastepe M., Ajuria J., Brennan K., Biradavolu R. and Colman R.W.: Br. J. Haematol 99, 784-789 (1997).
201. Giembycz M.A., Corrigan C.J., Seybold J., Newton R. and Barnes P.J.: Br. J. Pharmacol. 118, 1945-1958 (1996).
202. Tenor H., Staniciu L., Schudt C., Hatzelmann A., Wendel A., Djukanovic R., Church M.K. and Shute J.K.: Clin. Exp. Allergy 25, 616-624 (1995).
203. Ekholm D., Hemmer B., Gao G., Vergelli M., Martin R. and Manganiello V.: J. Immunol. 159, 1520-1529 (1997).
204. Essayan D.M., Kagey-Sobotka A., Lichtenstein L.M. and Huang S.-K.: J. Pharmacol. Exp. Ther. 282, 505-512 (1997).
205. Epstein P.M., Mills J.S., Hersh E.M., Strada S.J. and Thompson W.J.: Cancer Res. 40, 379-386 (1980).
206. Valette L., Prigent A.F., Nemoz G., Anker G., Macovschi O. and Lagarde M.: Biochem. Biophys. Res. Commun. 169, 864-872 (1990).
207. Meskini N., Hosni M., Nemoz G., Lagarde M. and Prigent A.-F.: J. Cell Physiol. 150, 140-148 (1992).
208. Jiang X., Paskin M., Weltzien R. and Epstein P.M.: Cell Biochem. Biophys. 28, 135-160 (1998).
209. Michie A.M., Rena G., Harnett M.M. and Houslay M.D.: Cell Biochem. Biophys. 28, 161-185 (1998).
210. Savany A., Abriat C., Nemoz G., Lagarde M. and Prigent A,-F.: Cell Signal 8, 511-516 (1996).
211. DiSanto M.E. and Heaslip R.J.: Eur. J. Pharmacol. 290, 169-172 (1995).
212. DiSanto M.E., Glaser K.B. and Heaslip R.J.: Cell Signal 7, 827-835 (1995).
213. El Bawab S., Macovschi O., Sette C., Conti M., Lagarde M., Nemoz G. and Prigent A.-F.: Eur J. Biochem. 247, 1151-1157 (1997).
214. Nemoz G., Sette C. and Conti M.: Mol. Pharmacol. 51, 242-249 (1997).
215. Baroja M.L., Cieslinski L.B., Torphy T.J., Wange R.L. and Madrenas J.: J. Immunol. 162, 2016-2023 (1999).
216. Seybold J., Newton R., Wright L., Finney P.A., Suttorp N., Barnes P.J., Adcock I.M. and Giembycz M.A.: J. Biol. Chem. 273, 20575-20588 (1998).
217. Erdogan S. and Housaly M.D.: Biochem J. 324, 165-175 (1997).
218. Ostlere L.S., Mallett R.B., Kaminski A., Kaminski E.R., Pereira R.S. and Holden C.A.: Br. J. Dermatol. 133, 1-5 (1995).
219. Gantner F., Gozt C., Gekeler V., Schudt C., Wendel A. and Hatzelmann A.: Br. J. Pharmacol. 123, 1031-1038 (1998).
220. Marcoz P., Prigent A.-F., Lagarde M. and Nemoz G.: Mol. Pharmacol. 44, 1027-1035 (1993).
221. Banner K.H., Roberts N.M. and Page C.P.: Br. J. Pharmacol. 116, 3169-3174 (1995).
222. Crocker I.C., Townely R.G. and Khan M.M.: Immunopharmacology 31, 223-235 (1996).
223. Foissier L., Lonchampt M., Coge F. and Cante E.: J. Pharmacol. Exp. Ther. 278, 1484-1490 (1996).
224. Kaminuma O., Mori A., Suko M., Kikkawa H., Ikezawa K. and Okudaira H.: J. Pharmacol. Exp. Ther. 279, 240-246 (1996).
225. vanWauve J., Aerts F., Walter H. and de Boer M.: Inflamm. Res. 44, 400-405 (1995).
226. Yoshimura T., Nagao T., Nakao T., Watanabe S., Usami E., Kabayashi J., Yamazaki F., Tanaka H., Inagaki N. and Nagai H.: Gen. Pharmacol. 30, 175-180 (1998).
227. Essayan D.M., Kagey-Sobotka A., Lichtenstein L.M. and Huang S.-K.: Biochem. Pharmacol. 53, 1055-1060 (1997).
228. Grunig G., Wamock M., Wakil A.E., Venkayya R., Brombacher F., Rennick D.M., Sheppard D., Mohrs M., Donaldson D.D., Locksley R.M. et al.: Science 282, 2261-2263 (1998).
229. Li Y., Simons F.E. and HayGlass K.T.: J. Immunol. 161, 7007-7014 (1998).
230. Lidington E., Nohammer C., Dominguez M., Ferry B. and Rose M.L: Clin. Exp. Immunol. 104, 66-71 (1996).
231. Sommer N., Loschmann P.-A., Northoff G.H., Weller M., Steinbrecher A., Steinbach J.P., Lichtenfels R., Meyermann R., Riethmuller A., Fontana A. et al.: Nature Med. 1, 244-248 (1995).
232. Genain C.R., Roberts T., Davis R.L., Nguyen M.-H., Uccelli A., Faulds D., Li Y., Hedgpeth J. and Hauser S.L.: Proc. Nat. Acad. Sci. 92, 3601-3605 (1995).
233. Jung S., Zielasek J., Kollner G., Donhauser T., Toyka K. and Hartung H.-R: J. Neuroimmunol. 68, 1-11 (1996).
234. Moodley I., Sotsios Y. and Bertin B.: Mediators Inflamm. 4, 112-116 (1995).
235. Griswold D.E., Webb E.F., Badger A.M., Gorycki P.D., Levandoski P.A., Barnette M.S., Grous M., Christensen S.B. and Torphy T.J.: J. Pharmacol. Exp. Ther. 387, 705-711 (1998).
236. Webb E.F., Tzimas M.N., Newsholme S.J. and Griswold G.E.: J. Invest Dermatol. 111, 86-92 (1998).
237. Sekut L., Yarnall D., Stimpson S.A., Noel L.S., Bateman-Fite R., Clark R.L., Brackeen M.F., Menius J.A. and Connolly K.M.: Clin. Exp. Immunol. 100, 126-132 (1995).
238. Nyman U., Mussener A., Larsson E., Lorentzen J. and Klareskog L.: Clin. Exp. Immunol. 108, 415-419 (1997).
239. Ross S.E., Wiliams R.O., Mason L.J., Mauri C., Marinova-Mutafchieva L., Malfait A.-M., Maini R.N. and Feldmann M.: J. Immunol. 159, 6253-6259 (1997).
240. Liang L., Beshay E. and Prud'homme G.J.: Diabetes 47, 570-575 (1998).
241. Underwood D.C., Matthew J.K., Osbom R.R., Bochnowicz S. and Torphy T.J.: J. Pharmacol. Exp. Ther. 280, 21-219 (1997).
242. Fischer W., Schudt C. and Wendel A.: Biochem. Pharmacol. 45, 2399-2404 (1993).
243. Badger A.M., Olivera D.L. and Esser K.M.: Circulatory Shock 44, 188-195 (1994).
244. Griswold D.E., Hillegass L.M., O'Leary-Bartus J., Lee J.C., Laydon J.T. and Torphy T.J.: J. Immunol. Methods 195, 1-5 (1996).
245. Cheng J.B., Watson J.W., Pazoles C.J., Eskra J.D., Griffiths R.J., Cohan V.L., Turner C.R., Showell H.J. and Pettipher E.R.: J. Pharmacol. Exp. Ther. 280, 621-626 (1997).
246. Pettipher E.R., Labasi J.M., Salter E.D., Stam E.J., Cheng J.B, and Griffiths R.J.: Br. J. Pharmacol. 117, 1530-1534 (1996).
247. Hadley A.J., Kumari M.K., Cover P.O., Osborne J., Poyser R., Flack J.D. and Buckingham J.C.: Br. J. Pharmacol. 119, 463-470 (1996).
248. Kumari M., Cover P.O., Poyser R.H. and Buckingham J.C.: Br. J. Pharmacol. 121, 459-468 (1997).
249. Holbrook M., Gozzard N., James T., Higgs G. and Hughers B.: Br. J. Pharmacol. 118, 1192-1200 (1996).
250. Uno T., Tanaka H. and Nagai H.: Gen, Pharmac. 30, 167-173 (1998).
251. Santig R.E., Olymulder C.G., Van der Molen K., Meurs H. and Zaagsma J.: Eur. J. Pharmacol. 275, 75-82 (1995).
252. Planquois J.M.S., Bonnet S. and Payne A.N.: Am. J. Respir. Crit. Care Med. 157, A843 (abstract) (1998).
253. Qian Y., Girard V., Martin C.A.E., Molimard M. and Advenier C.: Eur J. Respir 7, 306-310 (1994).
254. Undem B.J., Meeker S.N. and Chen J.: J. Pharmacol. Exp. Ther. 271, 811-817 (1994).
255. Imoto A., Yoshida M., Takahashi N. and Ito Y.: J. Auton Nervous System 68, 1-13 (1998).
256. Ellis J.L. and Conanan D.N.: J. Pharmacol. Exp. Ther. 272, 997-1004 (1995).
257. Fernandes L.B., Ellis J.L. and Undem B.J.: Am. J. Respir. Crit. Care Med. 150, 1384-1390 (1994).
258. Palmer D., Tsoi K. and Maurice D.H.: Circ. Res. 82, 852-861 (1998).
259. Rose R.J., Liu H., Palmer D. and Maurice D.H.: Br. J. Pharmacol. 122, 233-240 (1997).
260. Tomlinson P.R., Wilson J.W. and Stewart A.G.: Biochem. Pharmacol. 49, 1809-1819 (1995).
261. Maruno K., Absood A. and Said S.I.: Am. J. Physiol. 268, L1047-L1051 (1995).
262. Florio C., Martin J.G., Styhler A. and Heisler S.: Am. J. Physiol. 266, L131-L137 (1994).
263. Noveral J.P. and Grunstein M.M.: Am. J. Physiol. 267, L291-L299 (1994).
264. Johnson-Mills K., Arauz E., Coffey R.G., Krzanowski J.J. and Poison J.B.: Biochem. Pharmacol. 56, 1065-1073 (1998).
265. Pan X., Arauz E., Krzanowski J.J., Fitzpatrick D.F. and Poison J.B.: Biochem. Pharmacol. 48, 827-835 (1994).
266. Souness J.E., Hassall G.A. and Parrott D.P.: Biochem. Pharmacol. 44, 857-866 (1992).
267. Billington CK, Joseph S.K., Swan C., Scott M.G.H., Jobson T.M. and Hall I.P.: Am. J. Physiol. 276, L412-L419 (1999).
268. Duttagupta C., Rifas L. and Makman M.H.: Biochim. Biophys. Acta 523, 385-394 (1978).
269. Saltzman L.E., Moss J., Berg R.A., Horn B. and Crystal R.G.: Biochem. J. 204, 25-30 (1982).
270. Magnaldo I. and Pouyssegur P.S.: FEBS Lett. 245, 65-69 (1989).
271. Zitnik R.J., Zheng T. and Elias J.A.: Am. J. Physiol. 264, L253-L260 (1993).
272. Lindenschmidt R.C. and Witschi H.: Biochem. Pharmacol. 34, 4269-4273 (1985).
273. Wagner R.S., Smith C.J., Taylor A.M. and Rhoades R.A.: J. Pharmacol. Exp. Ther. 282, 1650-1657 (1997).
274. Pauwels R.: Clin. Exp. Allergy 26 (Suppl. 2), 55-59 (1996).
275. Spina D., Landells L.J. and Page C.P.: Clin. Exp. Allergy 28 (Suppl. 3), 24-34 (1998).
276. Foster R.W., Rakshi K., Carpenter J.R. and Small R.C.: Br. J. Clin. Pharmac. 34, 527-534 (1992).
277. Brunnee T., Engelstatter R., Steinijans V.W. and Kunkel G.: Eur. Respir. J. 5, 982-985 (1992).
278. Ukena D., Rentz K., Reiber C. and Sybrecht G.W.: Respir. Med. 89, 441-444 (1995).
279. Harbinson P.L., MacLeod D., Hawksworth R., OToole S., Sullivan P.J., Heath P., Kilfeather S., Page C.P., Costello J., Holgate S.T. et al.: Eur. Respir. J. 10, 1008-1014 (1997).
280. Jones T.R., McAuliffe M., McFarlane C.S., Piechuta H., Macdonald D. and Rodger I.W.: Can. J. Physiol. Pharmacol. 76, 210-217 (1998).
281. Nieman R.B., Fisher B.D., Amit O. and Dockhorn R.J.: Am. J. Respir. Crit. Care Med. 157, A413 (abstract) (1998).
282. Murdoch R.D., Cowley H., Upward J., Webber D. and Wyld P.: Am. J. Respir. Crit. Care Med. 157, A409 (abstract) (1998).
283. Compton C., Cedar E., Nieman R.B., Amit O., Langley S.J. and Sapene M.: Am. J. Respir. Crit. Care Med. 159, A624 (abstract) (1999).
284. Torphy T.J., Barnette M-S., Underwood D.C., Griswold D.E., Christensen S.B., Murdoch R.D., Nieman R.B. and Compton C.H.: Pulmonary Pharmacol. Ther. (in press) (1999).
285. Compton C.H., Gubb, J., Cedar E., Bakst A., Nieman R.B., Amit O., Ayres J. and Brambilla C.: Am. J. Respir. Crit. Care Med. 159, A522 (abstract) (1999).
286. Compton C.H., Gubb J., Nieman R.B., Amit O., Brambilla A and Ayres J.: Am. J. Respir. Crit. Care Med. 159, A806 (abstract) (1999).
287. Souness J.E. and Rao S.: Cell Signal 9, 227-236 (1997).
288. Horowski R., Sastre Y. and Hemandez M.: Curr. Ther. Res. 38, 23-29 (1985).
289. Carpenter D.O., Briggs D.B., Knox A.P. and Strominger N.: J. Neurophysiol. 59, 358-369 (1988).
290. Heaslip R.J. and Evans D.Y.: Eur. J. Pharmacol. 286, 281-290 (1995).
291. Robichaud A., Tattersall F.D., Choudhury I. and Rodger I.W.: Neuropharmacology 38, 289-297 (1999).
292. Barnette M.S., Grous M., Cieslinski L.B., Burman M., Christensen S.B. and Torphy T.J.: J. Pharmacol. Exp. Ther. 273, 1396-1402 (1995).
293. Silver P.J., Harris A.L., Buchholz R.A., Miller M.S., Gordon R.J., Dundore R.L. and Pagani E.D., in: K.A. Jacobson, J.W. Daley and V. Manganiello (eds.): Purines in Cellular Signaling, Targets for New Drugs, Springer-Verlag, New York 1990, 358-364.
294. Barnette M.S., Manning C.D., Price W.J. and Barone F.C.: J. Pharmacol. Exp. Ther. 264, 801-812 (1993).
295. Grous M. and Barnette M.S.: Br. J. Pharmacol. 111, 259-263 (1994).
296. Izzo A.A., Mascolo N. and Capasso F.: Naunyn Schmiedeberg's Arch. Pharmacol. 357, 677-681 (1998).
297. Schneider H.H., Schmiechen R., Brezinski M. and Seidler J.: Eur. J. Pharmacol. 127, 105-115 (1986).
298. Jacobitz S., McLaughlin M.M., Livi G.P., Burman M. and Torphy T.J.: Mol. Pharmacol. 50, 891-899 (1996).
299. Rocque W.J., Tian G., Wiseman J.S., Holmes W.D., Zajac-Thompson I., Willard D.H., Patel I.R., Wisely G.B., Clay W.C., Kadwell S.H. et al.: Biochemistry 36, 14250-14261 (1997).
300. Kaulen P., Bruning G., Schneider H.H., Sarter M. and Baumgarten H.G.: Brain Res. 503, 229-245 (1989).
301. Souness J.E., Houghton C., Sardar N. and Withnall M.T.: Br. J. Pharmacol. 121, 743-750 (1997).
302. Duplantier A.J., Biggers M.S., Chambers R.J., Cheng J.B., Cooper K., Damon D.B., Eggler J.F., Kraus K.G., Marfat A., Masamune H. et al.: J. Med. Chem. 39, 120-125 (1996).
303. Koe B.K., Lebel L.A., Nielsen J.A., Russo L.L., Saccomano N.A., Vinick F.J. and Williams I.H.: Drug Dev. Res, 21, 135-142 (1990).
304. Christensen S.B., Guider A., Forster C.J., Gleason J.G., Bender P.E., Karpinski J.M., DeWolf W.E., Bamette M.S., Underwood D.C., Griswold D.E. et al.: J. Med. Chem. 41, 821-835 (1998).
305. Montana J.G., Buckley G.M., Cooper N., Dyke H.J., Cowers L., Gregory J.P., Hellewell P.G., Kendall H.J., Lowe C., Maxey R. et al.: Bioorganic Med. Chem. Lett. 8, 2635-2640 (1998).
306. Bolger G.B., Rodgers L. and Riggs M.: Gene 149, 237-244 (1993).
307. Obernolte R., Bhakta S., Alvarez R., Bach C., Zuppan P., Mulkins M., Jarnagin K. and Shelton E.R.: Gene 129, 239-247 (1993).
308. Engels P., Abdel'Al S., Hulley P. and Lubbert H.: J. Neuroscience Res. 41, 169-178 (1995).
309. Iwahashi Y., Furuyama T., Tano Y., Ishimoto I., Shimomura Y. and Inagaki S.: Mol. Brain Res. 38, 14-24 (1996).
310. Iona S., Cuomo M., Bushnik T., Naro F., Sette C., Hess M., Shelton E.R. and Conti M.: Mol. Pharmacol. 53, 23-32 (1998).