Remodeling of asthmatic airways by glucocorticosteroids

Journal of Allergy and Clinical Immunology

Volumn 97, Issue 1 II, 1996, Pages 153-158

  Laitinen, L A ^a   Laitinen, A ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE DIPROPIONATE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; COLLAGEN; CORTICOSTEROID; DEXAMETHASONE; ELASTIN; FIBRONECTIN; GLUCOCORTICOID; GLYCOSAMINOGLYCAN; LAMININ; PROTEOGLYCAN; TENASCIN; TERBUTALINE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BASEMENT MEMBRANE; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; INFLAMMATION; INHALATIONAL DRUG ADMINISTRATION; MICROSCOPY; MORPHOGENESIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0030040329     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(96)80215-6     Document Type: Article

References (22)

1. Lundgren R. Söderberg M. Horstedt P. Stenling R. Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids Eur Respir J 1 1988 883 889
2. Laitinen L.A. Heino M. Laitinen A. Kava T. Haahtela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma Am Rev Respir Dis 131 1985 599 606
3. Beasley R. Roche W.R. Roberts J.A. Holgate S.T. Cellular events in the bronchi in mild asthma and after bronchial provocation Am Rev Respir Dis 139 1989 806 817
4. Jeffery P.K. Wardlaw A.J. Nelson Fiona C. Collins J.V. Kay A.B. Bronchial biopsies in asthma Am Rev Respir Dis 140 1990 1745 1753
5. Azzawi M. Bradley B. Jeffery P.K. Identification of activated T-lymphocytes and eosinophils in bronchial biopsies in stable atopic asthmatics Am Rev Respir Dis 142 1990 1407 1413
6. Bousquet J. Chanez P. Lacoste J.Y. Eosinophilic inflammation in asthma N Engl J Med 323 1990 1033 1039
7. Djukanovic R. Wilson J.W. Britten K.M. Quantification of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry Am Rev Respir Dis 142 1990 863 871
8. Jeffery P.K. Godfrey R.W. Adelroth E. Nelson F. Rogers A. Johansson S.-A. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma: a quantitative light and electron microscopic study Am Rev Respir Dis 145 1992 890 899
9. 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial J Allergy Clin Immunol 90 1992 32 42
10. Laitinen A. Laitinen L.A. Airway morphology: epithelium/basement membrane Am Rev Respir Dis 150 1994 S14 S17
11. McGowan S.E. Extracellular matrix and the regulation of lung development and repair FASEB J 6 1992 2895 2904
12. Adams J.C. Watt F.M. Regulation of development and differentiation by the extracellular matrix Development 117 1993 1183 1198
13. Raghow R. The role of extracellular matrix in postinflammatory wound healing and fibrosis FASEB J 8 1994 823 831
14. Stoner G.D. Katoh Y. Foidart J.M. Trump B.F. Steinert P.M. Harris C.C. Cultured human bronchial epithelial cells: blood group antigens, keratin, collagens, and fibronectin In Vitro Cell Dev Biol 17 1981 877 887
15. Paulsson M. Basement membrane proteins: structure, assembly, and cellular interactions Crit Rev Biochem Mol Biol 27 1992 93 127
16. Dunnill M.S. Massarella G.R. Anderson G.A. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema Thorax 24 1989 175 179
17. Albelda S.M. Endothelial and epithelial cell adhesion molecules Am J Respir Cell Mol Biol 1 1989 483 489
18. 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma N Engl J Med 325 1991 388 392
19. Haahtela T. Järvinen M. Kava T. Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma N Engl J Med 331 1994 700 705
20. Laitinen A. Altraja A. Linden M. Treatment with inhaled budesonide and tenascin expression in bronchial mucosa of allergic asthmatics Am J Crit Care Med 149 1994 A942
21. Trigg C.J. Manolitsas N.D. Wang J. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma Am J Respir Crit Care Med 150 1994 17 22
22. Ekblom M. Fassler R. Tomasini-Johansson B. Nilsson K. Ekblom P. Downregulation of tenascin expression by glucocorticoids in bone marrow stromal cells and in fibroblasts J Cell Biol 4 1993 1037 1045