-
5
-
-
0031911575
-
-
284:420-426.
-
Barnette MS, Christensen SB, Essayan DM, Grous M, Prabhakar U, Rush JA, Kagey-Sobotka A and Torphy TJ (1998) SB 207499, a potent and selective second generation phosphodiesterase 4 inhibitor: In vitro anti-inflammatory actions. J Pharmacol Exp Ther 284:420-426.
-
Christensen SB, Essayan DM, Grous M, Prabhakar U, Rush JA, Kagey-Sobotka A and Torphy TJ (1998) SB 207499, A Potent and Selective Second Generation Phosphodiesterase 4 Inhibitor: in Vitro Anti-inflammatory Actions. J Pharmacol Exp Ther
-
-
Barnette, M.S.1
-
6
-
-
0024045691
-
-
3:245-253.
-
Bertolino A, Crippa D, Di-Dio S, Fichte K, Musmeci G, Porro V, Rapisarda V, Sastre-Y-Hernandez M and Schratzer M (1988) Rolipram versus imipramine in inpatients with major, "minor" or atypical depressive disorder: A double-blind double-dummy study aimed at testing a novel therapeutic approach. Int Clin Psychopharmacol 3:245-253.
-
Crippa D, Di-Dio S, Fichte K, Musmeci G, Porro V, Rapisarda V, Sastre-Y-Hernandez M and Schratzer M (1988) Rolipram Versus Imipramine in Inpatients with Major, "Minor" or Atypical Depressive Disorder: A Double-blind Double-dummy Study Aimed at Testing A Novel Therapeutic Approach. Int Clin Psychopharmacol
-
-
Bertolino, A.1
-
8
-
-
14444268769
-
-
41:821-835.
-
Christensen SB, Guider .AM, Forster CJ, Gleason JG, Bender PB, Karpinski JM, De Wolf WE Jr, Barnette MS, Underwood DC, Griswold DE, Cieslinski LB, Burman M, Bochnowicz S, Osborn RR, Manning CD, Grous M, Hillegas LM, Bartus JO, Ryan MD, Eggleston DS, Haltiwanger RC and Torphy TJ (1998) 1,4Cyclohexane carboxylates: Potent and selective inhibitors of phosphodiesterase 4 for the treatment of asthma. J Med Chem 41:821-835.
-
Guider.AM, Forster CJ, Gleason JG, Bender PB, Karpinski JM, de Wolf WE Jr, Barnette MS, Underwood DC, Griswold DE, Cieslinski LB, Burman M, Bochnowicz S, Osborn RR, Manning CD, Grous M, Hillegas LM, Bartus JO, Ryan MD, Eggleston DS, Haltiwanger RC and Torphy TJ (1998) 1,4Cyclohexane Carboxylates: Potent and Selective Inhibitors of Phosphodiesterase 4 for the Treatment of Asthma. J Med Chem
-
-
Christensen, S.B.1
-
9
-
-
0030438705
-
-
278:1356-1361.
-
Cohan VL, Showell HJ, Fisher DA, Pazoles CJ, Watson JW, Turner CR and Cheng JB (1996) In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633. J Pharmacol Exp Ther 278:1356-1361.
-
Showell HJ, Fisher DA, Pazoles CJ, Watson JW, Turner CR and Cheng JB (1996) in Vitro Pharmacology of the Novel Phosphodiesterase Type 4 Inhibitor, CP-80633. J Pharmacol Exp Ther
-
-
Cohan, V.L.1
-
13
-
-
0032469469
-
-
287:705-711.
-
Griswold DE, Webb EF, Badger AM, Gorycki PD, Lavandoski PA, Barnette MA, Grous M, Christensen S and Torphy TJ (1998) SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor a and interleukin-4 production in vivo. J Pharmacol Exp Ther 287:705-711.
-
Webb EF, Badger AM, Gorycki PD, Lavandoski PA, Barnette MA, Grous M, Christensen S and Torphy TJ (1998) SB 207499 (Ariflo), A Second Generation Phosphodiesterase 4 Inhibitor, Reduces Tumor Necrosis Factor A and Interleukin-4 Production in Vivo. J Pharmacol Exp Ther
-
-
Griswold, D.E.1
-
14
-
-
0024743190
-
-
251:199-206.
-
Harris AL, Connell MJ, Ferguson EW, Wallace AM, Gordon RJ, Pagani ED and Silver PJ (1989) Role of low-K, cyclic AMP phophodiesterase in trachéal relaxation and bronchodilation in the guinea pig. J Pharmacol Exp Ther 251:199-206.
-
Connell MJ, Ferguson EW, Wallace AM, Gordon RJ, Pagani ED and Silver PJ (1989) Role of Low-K, Cyclic AMP Phophodiesterase in Trachéal Relaxation and Bronchodilation in the Guinea Pig. J Pharmacol Exp Ther
-
-
Harris, A.L.1
-
16
-
-
0024319477
-
-
22:156-160.
-
Hebenstreit GF, Feilerer K, Fichte K, Fischer G, Geyer N, Meya U, Sastre-YHernandez M, Schony W, Schratzer M, Soukop W et al. (1989) Rolipram in major depressive disorder: Results of a double-blind comparative study with imipramine. Phartnacopsychiatry 22:156-160.
-
Feilerer K, Fichte K, Fischer G, Geyer N, Meya U, Sastre-YHernandez M, Schony W, Schratzer M, Soukop W et Al. (1989) Rolipram in Major Depressive Disorder: Results of A Double-blind Comparative Study with Imipramine. Phartnacopsychiatry
-
-
Hebenstreit, G.F.1
-
18
-
-
8944247744
-
-
Owens R, Catterall C, Lumb S, Russell A, Alien R, Merriman M, Bloxham D and Higgs G (1996) The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br J Pharmacol 118:1183-1191.
-
Hughes B, Howat D, Lisle H, Holbrook M, James T, Gozzard N, Blease K, Hughes P, Kingaby R, Warrellow G, Alexander R, Head J, Boyd E, Eaton M, Perry M, Wales M, Smith B, Owens R, Catterall C, Lumb S, Russell A, Alien R, Merriman M, Bloxham D and Higgs G (1996) The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br J Pharmacol 118:1183-1191.
-
Howat D, Lisle H, Holbrook M, James T, Gozzard N, Blease K, Hughes P, Kingaby R, Warrellow G, Alexander R, Head J, Boyd E, Eaton M, Perry M, Wales M, Smith B
-
-
Hughes, B.1
-
26
-
-
33748348366
-
-
10:313s.
-
Torphy TJ, Christensen SB, Barnette MS, Burman M, Cieslinski LB and DeWolf WE Jr (1997) Molecular basis for an improved therapeutic index of SB 207499, a second generation phosphodiesterase 4 inhibitor. Eur Resp J 10:313s.
-
Christensen SB, Barnette MS, Burman M, Cieslinski LB and DeWolf WE Jr (1997) Molecular Basis for An Improved Therapeutic Index of SB 207499, A Second Generation Phosphodiesterase 4 Inhibitor. Eur Resp J
-
-
Torphy, T.J.1
-
27
-
-
33748343347
-
-
Raton.
-
Torphy TJ and Hay DWP (1990) Biochemical regulation of airway smooth muscle tone: An overview, in Airway Smooth Muscle: Modulation of Receptors and Response, (Townley RG and Agrawal DK, eds) pp 39-68, CRC Press, Boca Raton.
-
And Hay DWP (1990) Biochemical Regulation of Airway Smooth Muscle Tone: An Overview, in Airway Smooth Muscle: Modulation of Receptors and Response, (Townley RG and Agrawal DK, Eds) Pp 39-68, CRC Press, Boca
-
-
Torphy, T.J.1
-
32
-
-
0028289793
-
-
270:250-259.
-
Underwood DC, Kotzer CJ, Bochnowicz S, Osborn RR, Luttmann MA, Hay DWP and Torphy TJ (1994) Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. J Pharmacol Exp Ther 270:250-259.
-
Kotzer CJ, Bochnowicz S, Osborn RR, Luttmann MA, Hay DWP and Torphy TJ (1994) Comparison of Phosphodiesterase III, IV and Dual III/IV Inhibitors on Bronchospasm and Pulmonary Eosinophil Influx in Guinea Pigs. J Pharmacol Exp Ther
-
-
Underwood, D.C.1
-
35
-
-
0027496775
-
-
266:306-313.
-
Underwood DC, Osborn RR, Novak LB, Matthews JK, Newsholme SJ, Undem BJ, Hand JM and Torphy TJ ( 1993) Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram. J Pharmacol Exp Ther 266:306-313.
-
Osborn RR, Novak LB, Matthews JK, Newsholme SJ, Undem BJ, Hand JM and Torphy TJ ( 1993) Inhibition of Antigen-induced Bronchoconstriction and Eosinophil Infiltration in the Guinea Pig by the Cyclic AMP-specific Phosphodiesterase Inhibitor, Rolipram. J Pharmacol Exp Ther
-
-
Underwood, D.C.1
|