Suppression of tumor necrosis factor-α production by interleukin-10 is enhanced by cAMP-elevating agents

European Journal of Pharmacology

Volumn 321, Issue 2, 1997, Pages 231-239

  Siegmund, Britta ^a   Eigler, Andreas ^a   Moeller, Jochen ^a   Greten, Tim F ^a   Hartmann, Gunther ^a   Endres, Stefan ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

cAMP elevating agent; Interleukin 10; TNF (tumor necrosis factor )

Indexed keywords

CICAPROST; INTERLEUKIN 10; MESSENGER RNA; ROLIPRAM; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BLOOD; CELL STIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MONONUCLEAR CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BLOTTING, NORTHERN; CELLS, CULTURED; CYCLIC AMP; DRUG SYNERGISM; EPOPROSTENOL; HUMANS; INTERLEUKIN-10; KINETICS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; PHOSPHODIESTERASE INHIBITORS; PYRROLIDINONES; RNA, MESSENGER; ROLIPRAM; STAPHYLOCOCCUS EPIDERMIDIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031058155     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00947-8     Document Type: Article

References (42)

1. Beavo, J.A., 1995, Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms, Physiol. Rev. 75, 725.
2. Bogdan, C., Y. Vodovotz and C. Nathan, 1991, Macrophage deactivation by interleukin 10, J. Exp. Med. 174, 1549.
3. Böyum, A., 1968, Isolation of mononuclear cells and granulocytes from human blood (paper IV), Scand. J. Clin. Lab. Invest. 21, 77.
4. Broudy, V.C., K. Kaushensky, G.M. Segal, J.M. Harlan and J.W. Adamson, 1996, Tumor necrosis factor type α stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor, Proc. Natl. Acad. Sci. USA 83, 7467.
5. Chen, W.-F. and A. Zlotnik, 1991, IL-10: a novel cytotoxic T cell differentiation factor, J. Immunol. 147, 528.
6. Chernoff, A.E., E.V. Granowitz, L. Shapiro, E. Vannier, G. Lonnemann, J.B. Angel, J.S. Kennedy, A.R. Rabson, S.M. Wolff and C.A. Dinarello, 1995, A randomized, controlled trial of IL-10 in humans, J. Immunol. 154, 5492.
7. Chomczynski, P. and N. Sacchi, 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem. 162, 156.
8. De Waal Malefyt, R., J. Abrams, B. Bennett, C.G. Figdor and J.E. De Vries, 1991, Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes, J. Exp. Med. 174, 1209.
9. Dinarello, C.A., J.G. Cannon, S.M. Wolff, H.A. Bernheim and B. Beutler, 1986, Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1, J. Exp. Med. 163, 1433.
10. Eigler, A., T.F. Greten, B. Sinha, C. Haslberger, G.W. Sullivan and S. Endres, 1996, Endogenous adenosine curtails lipopolysaccharide-stimulated tumor necrosis factor synthesis, Scand. J. Immunol. (in press).
11. Eisenhut, T., B. Sinha, E. Göttrup-Wolfers, J. Semmler, W. Siess and S. Endres, 1993, Prostacyclin analogs suppress the synthesis of tumor necrosis factor-α in LPS-stimulated human peripheral blood mononuclear cells, Immunopharmacology 26, 259.
12. Elliott, M.J., R.N. Maini, M. Feldmann, A. Long-Fox, P. Charles, H. Bijl and J.N. Woody, 1994, Repeated therapy with monoclonal antibody to tumour necrosis factor α (cA2) in patients with rheumatoid arthritis, Lancet 344, 1125.
13. Endres, S., R. Ghorbani, G. Lonnemann, J.W.M. Van der Meer and C.A. Dinarello, 1988, Measurement of immunoreactive interleukin-1β from human mononuclear cells: optimization of recovery, intrasubject consistency and comparison with interleukin-1α and tumor necrosis factor, Clin. Immunol. Immunopathol. 49, 424.
14. Endres, S., H.-J. Fülle, B. Sinha, D. Stoll, C.A. Dinarello, R. Gerzer and P.C. Weber, 1991, Cyclic nucleotides differentially regulate the synthesis of tumor necrosis factor-α and interleukin-β by human mononuclear cells, Immunology 72, 56.
15. Enk, A.H. and S.I. Katz, 1992, Identification and induction of keratinocyte-derived IL-10, J. Immunol. 149, 92.
16. Fiorentino, D.F., M.W. Bond and T.R. Mosmann, 1989, Two types of mouse T helper cell IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones, J. Exp. Med. 170, 2081.
17. Fiorentino, D.F., A. Zlotnik, T.R. Mosmann, M. Howard and A. O'Garra, 1991, IL-10 inhibits cytokine production by activated macrophages, J. Immunol. 147, 3815.
18. Greten, T.F., B. Sinha, C. Haslberger and A. Eigler, 1996, Cicaprost and the specific type IV phosphodiesterase inhibitor rolipram synergize in suppression of tumor necrosis factor-α synthesis, Eur. J. Pharmacol. 299, 229.
19. Howard, M., T. Muchamuel, S. Andrade and S. Menon, 1993, Interleukin 10 protects mice from lethal endotoxemia, J. Exp. Med. 177, 1205.
20. Hsu, D.-H., K.W. Moore and H. Spits, 1992, Differential effects of interleukin-4 and interleukin-10 on interleukin-2-induced interferon-γ synthesis and lymphokine-activated killer activity, Int. Immunol. 4, 563.
21. Kambayashi, T., C.O. Jacob, D. Zhou, N. Mazurek, M. Fong and G. Strassmann, 1995, Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-α and IL-6 release by endotoxin-stimulated macrophages, J. Immunol. 155, 4909.
22. Kehrl, J.H., A. Miller and A.S. Fauci, 1987, Effects of tumor necrosis factor a on mitogen-activated B cells, J. Exp. Med. 166, 786.
23. Manié, S., A. Schmidalliana, J. Kubar, B. Ferrua and B. Rossi, 1993, Disruption of microtubule network in human monocytes induces expression of interleukin-1 but not that of interleukin-6 nor tumor necrosis factor-alpha - involvement of protein kinase-A stimulation, J. Biol. Chem. 268, 13675.
24. Moore, K.W., A. O'Garra, R. De Waal Malefyt, P. Vieira and T.R. Mosmann, 1993, Interleukin-10, Annu. Rev. Immunol. 11, 165.
25. O'Garra, A., R. Chang, N. Go, R. Hastings, G. Haughton and M. Howard, 1992, Ly-1 B (B-1) cells are the main source of B cell derived interleukin-10, Eur. J. Immunol. 22, 711.
26. Oswald, I.P., T.A. Wynn, A. Sher and S.L. James, 1992, Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor-α required as a costimulatory factor of interferon-γ-induced activation, Proc. Natl. Acad. Sci. USA 89, 8676.
27. Platzer, C., C. Meisel, K. Vogt and H.-D. Volk, 1995, Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs, Int. Immunol. 7, 517.
28. Sambrook, J., E.F. Fritsch and T. Maniatis, 1989, Molecular Cloning: A Laboratory Handbook (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY).
29. Schade, U.F., 1989, The role of prostacyclin in the protective effects of pentoxifylline and other xanthine derivatives in endotoxin action in mice, Eicosanoids 2, 183.
30. Schreiber, S., T. Heinig, H.G. Thiele and A. Raedler, 1995, Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease, Gastroenterology 108, 1434.
31. Semmler, J., H. Wachtel and S. Endres, 1992, The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor production by human mononuclear cells, Int. J. Immunopharmacol. 15, 409.
32. Semmler, J., U. Gebert, T. Eisenhut, J. Moeller, M.M. Schönharting, A. Alléra and S. Endres, 1993, Xanthine derivates: comparison between suppression of tumor necrosis factor-α production and inhibition of cAMP phosphodiesterase activity, Immunology 78, 520.
33. Sinha, B., J. Semmler, T. Eisenhut, A. Eigler and S. Endres, 1995, Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids, Eur. J. Immunol. 25, 147.
34. Smith, S.R., C. Terminelli, L. Kenworthy-Bott and J. Donkin, 1994, The cooperative effects of TNF-α and IFN-γ are determining factors in the ability of IL-10 to protect mice from lethal endotoxemia, J. Leukocyte Biol. 55, 711.
35. Sommer, N., P.-A. Löschmann, G.H. Northoff, M. Weller, A. Steinbrecher, J.P. Steinbach, R. Lichtenfels, R. Meyermann, A. Riethmüller, A. Fontana, J. Dichgans and R. Martin, 1995, The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis, Nature Med. 1, 244.
36. Suda, T., A. O'Garra, I. MacNeil, I. Fischer, M. Bond and A. Zlotnik, 1990, Identification of a novel thymocyte growth promoting factor derived from B cell lymphomas, Cell. Immunol. 129, 228.
37. Tracey, K.J. and A. Cerami, 1994, Tumor necrosis factor: a pleiotropic cytokine and therapeutic target, Annu. Rev. Med. 45, 491.
38. Turner, C.R., K.M. Esser and E.B. Wheeldon, 1993, Therapeutic intervention in a rat model of ARDS: IV. Phosphodiesterase IV inhibition, Circ. Shock 39, 237.
39. Van der Meer, J.W.M., S. Endres, G. Lonnemann, J.G. Cannon, T. Ikejima, S. Okusawa, J.A. Gelfand and C.A. Dinarello, 1988, Concentrations of immunoreactive human tumor necrosis factor alpha produced by human mononuclear cells in vitro, J. Leukocyte Biol. 43, 216.
40. Wachtel, H., 1983, Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′,5′-monophosphate phosphodiesterase inhibitors, Neuropharmacology 22, 267.
41. Wakabayashi, G., J.A. Gelfand, W.K. Jung, R.J. Connolly, J.F. Burke and C.A. Dinarello, 1991, Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli, J. Clin. Invest. 87, 1925.
42. Yokota, S., T. Geppert and P. Lipsky, 1988, Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-α, J. Immunol. 140, 531.