Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by three selective type-4 phosphodiesterase inhibitors: In vitro and in vivo studies

British Journal of Pharmacology

Volumn 121, Issue 3, 1997, Pages 459-468

  Kumari, Meena ^b   Cover, Patricia O ^b   Poyser, Robert H ^a   Buckingham, Julia C ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

ACTH; BRL 61063; CRH; Denbufylline; HPA axis; Hypothalamus; Pituitary; Rolipram; Type 4 phosphodiesterase

Indexed keywords

1,3 DICYCLOPROPYLMETHYL 8 AMINOXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ADENOSINE DEAMINASE; ARGIPRESSIN; BRL 61063; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP; CYCLOHEXYLADENOSINE; DENBUFYLLINE; FORSKOLIN; LUTEINIZING HORMONE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; ROLIPRAM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN RELEASE; DRUG POTENCY; ENZYME INHIBITION; HIPPOCAMPUS; HORMONE RELEASE; HYPOPHYSIS; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LIGAND BINDING; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PHOSPHODIESTERASE INHIBITORS; PITUITARY-ADRENAL SYSTEM; PYRROLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; ROLIPRAM; XANTHINES;

EID: 0030962340     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701158     Document Type: Article

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