메뉴 건너뛰기




Volumn 28, Issue 2-3, 1998, Pages 161-185

Upregulation of cAMP-Specific PDE-4 Activity Following Ligation of the TCR Complex on Thymocytes Is Blocked by Selective Inhibitors of Protein Kinase C and Tyrosyl Kinases

Author keywords

[No Author keywords available]

Indexed keywords

3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ADENYLATE CYCLASE; ALKALOID; BENZOPHENANTHRIDINE DERIVATIVE; CD3 ANTIGEN; CHELERYTHRINE; CYCLIC AMP; CYCLOHEXIMIDE; DACTINOMYCIN; ENZYME INHIBITOR; LYMPHOCYTE ANTIGEN RECEPTOR; NUCLEIC ACID SYNTHESIS INHIBITOR; PHENANTHRIDINE DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHODIESTERASE IV; PROTEIN KINASE C; PROTEIN SYNTHESIS INHIBITOR; PROTEIN TYROSINE KINASE; STAUROSPORINE;

EID: 0031607084     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02737810     Document Type: Article
Times cited : (10)

References (83)
  • 1
    • 0347378799 scopus 로고    scopus 로고
    • Cyclic nucleotide signalling throughout T cell maturation
    • Harnett, M. M. and Rigley, K. P., eds., John Wiley, Chichester, in press
    • Michie, A. M., Harnett, M. M., and Houslay, M. D. (1997) Cyclic nucleotide signalling throughout T cell maturation, in Lymphocyte Signalling: Mechanism, Subversion and Manipulation (Harnett, M. M. and Rigley, K. P., eds.), John Wiley, Chichester, in press.
    • (1997) Lymphocyte Signalling: Mechanism, Subversion and Manipulation
    • Michie, A.M.1    Harnett, M.M.2    Houslay, M.D.3
  • 2
    • 0023938335 scopus 로고
    • The adenylate cyclase-cAMP-protein kinase pathway and regulation of the immune response
    • Kammer, G. M. (1988) The adenylate cyclase-cAMP-protein kinase pathway and regulation of the immune response. Immunol. Today 9, 222-229.
    • (1988) Immunol. Today , vol.9 , pp. 222-229
    • Kammer, G.M.1
  • 3
    • 0019357892 scopus 로고
    • Cyclic nucleotides and calcium in human lymphocytes induced to divide
    • Rochette-Egly, C. and Kempf, J. (1981) Cyclic nucleotides and calcium in human lymphocytes induced to divide. J. Physiol. (Paris) 77, 721-725.
    • (1981) J. Physiol. (Paris) , vol.77 , pp. 721-725
    • Rochette-Egly, C.1    Kempf, J.2
  • 4
    • 0018100334 scopus 로고
    • Rise and fall of cyclic AMP required for onset of lymphocyte DNA synthesis
    • Wang, T., Sheppard, J. R., and Foker, J. E. (1978) Rise and fall of cyclic AMP required for onset of lymphocyte DNA synthesis. Science 201, 155-157.
    • (1978) Science , vol.201 , pp. 155-157
    • Wang, T.1    Sheppard, J.R.2    Foker, J.E.3
  • 5
    • 0016592390 scopus 로고
    • Regulation of Θ-antigen expression by agents altering cyclic AMP level and by thymic factor
    • Bach, M.-A., Fournier, C., and Bach, J.-F. (1975) Regulation of Θ-antigen expression by agents altering cyclic AMP level and by thymic factor. Ann. NY Acad. Sci. 249, 316-327.
    • (1975) Ann. NY Acad. Sci. , vol.249 , pp. 316-327
    • Bach, M.-A.1    Fournier, C.2    Bach, J.-F.3
  • 7
    • 0026494774 scopus 로고
    • Differentiation of an immature T cell line: A model of thymic positive selection
    • Kaye, J. and Ellenberger, D. L. (1992) Differentiation of an immature T cell line: A model of thymic positive selection. Cell 71, 423-435.
    • (1992) Cell , vol.71 , pp. 423-435
    • Kaye, J.1    Ellenberger, D.L.2
  • 8
    • 0025024913 scopus 로고
    • Agents that elevate cAMP stimulate DNA fragmentation in thymocytes
    • McConkey, D. J., Orrenius, S., and Jondal, M. (1990) Agents that elevate cAMP stimulate DNA fragmentation in thymocytes. J. Immunol. 145, 1227-1230.
    • (1990) J. Immunol. , vol.145 , pp. 1227-1230
    • McConkey, D.J.1    Orrenius, S.2    Jondal, M.3
  • 10
    • 33847612208 scopus 로고
    • Adenosine 3′5′-phosphate in biological materials
    • Butcher, R. W. and Sutherland, E. W. (1962) Adenosine 3′5′-phosphate in biological materials. J. Biol. Chem. 237, 1244-1250.
    • (1962) J. Biol. Chem. , vol.237 , pp. 1244-1250
    • Butcher, R.W.1    Sutherland, E.W.2
  • 11
    • 0028136159 scopus 로고
    • Multiple cyclic nucleotide phosphodiesterases
    • Beavo, J. A., Conti, M., and Heaslip, R. J. (1994) Multiple cyclic nucleotide phosphodiesterases. Mol. Pharmacol. 46, 399-405.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 399-405
    • Beavo, J.A.1    Conti, M.2    Heaslip, R.J.3
  • 12
    • 0028574848 scopus 로고
    • Molecular biology of the cAMP-specific cyclic nucleotide phosphodiesterases
    • Bolger, G. B. (1994) Molecular biology of the cAMP-specific cyclic nucleotide phosphodiesterases. Cell Signaling 6, 851-859.
    • (1994) Cell Signaling , vol.6 , pp. 851-859
    • Bolger, G.B.1
  • 13
    • 0029009878 scopus 로고
    • Recent progress in understanding the hormonal regulation of phosphodiesterases
    • Conti, M., Nemoz, G., Sette, C., and Vincini, E. (1995) Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocr. Rev. 16, 370-389.
    • (1995) Endocr. Rev. , vol.16 , pp. 370-389
    • Conti, M.1    Nemoz, G.2    Sette, C.3    Vincini, E.4
  • 14
    • 0001227355 scopus 로고
    • Cyclic nucleotide phosphodiesterases in liver - A review of their characterisation, regulation by insulin and glucagon and their role in controlling cyclic AMP concentrations
    • Beavo, J. A. and Houslay, M. D., eds., John Wiley, Chichester
    • Houslay, M. D. and Kilgour, E. (1990) Cyclic nucleotide phosphodiesterases in liver - a review of their characterisation, regulation by insulin and glucagon and their role in controlling cyclic AMP concentrations, in Molecular Pharmacology of Cell Regulation (Beavo, J. A. and Houslay, M. D., eds.), John Wiley, Chichester, pp. 299-316.
    • (1990) Molecular Pharmacology of Cell Regulation , pp. 299-316
    • Houslay, M.D.1    Kilgour, E.2
  • 15
    • 0001227355 scopus 로고
    • Cardiac phosphodiesterases and the functional effects of selective inhibitors
    • Beavo, J. A. and Houslay, M. D., eds., John Wiley, Chichester
    • Reeves, M. L. and England, P. J. (1990) Cardiac phosphodiesterases and the functional effects of selective inhibitors, in Molecular Pharmacology of Cell Regulation (Beavo, J. A. and Houslay, M. D., eds.), John Wiley, Chichester, pp. 299-316.
    • (1990) Molecular Pharmacology of Cell Regulation , pp. 299-316
    • Reeves, M.L.1    England, P.J.2
  • 16
    • 0018881270 scopus 로고
    • Activation of cyclic nucleotide PDE from isolated human peripheral blood lymphocytes by mitogenic agents
    • Epstein, P. M., Mills, J. S., Hersh, E. M., Strada, S. J., and Thompson, W. J. (1980) Activation of cyclic nucleotide PDE from isolated human peripheral blood lymphocytes by mitogenic agents. Cancer Res. 40, 379-386.
    • (1980) Cancer Res. , vol.40 , pp. 379-386
    • Epstein, P.M.1    Mills, J.S.2    Hersh, E.M.3    Strada, S.J.4    Thompson, W.J.5
  • 17
    • 0025284702 scopus 로고
    • Induction of a Ca/CaM PDE during PHA stimulated lymphocyte mitogenesis
    • Hurwitz, R. L., Hirsch, K. M., Clark, D. J., Holcombe, V. N., and Hurwitz, M. Y. (1990) Induction of a Ca/CaM PDE during PHA stimulated lymphocyte mitogenesis. J. Biol. Chem. 265, 8901-8907.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8901-8907
    • Hurwitz, R.L.1    Hirsch, K.M.2    Clark, D.J.3    Holcombe, V.N.4    Hurwitz, M.Y.5
  • 18
    • 0027448876 scopus 로고
    • Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents
    • Marcoz, P., Prigent, A. F., Lagarde, M., and Nemoz, G. (1993) Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents. Mol. Pharmacol. 44, 1027-1035.
    • (1993) Mol. Pharmacol. , vol.44 , pp. 1027-1035
    • Marcoz, P.1    Prigent, A.F.2    Lagarde, M.3    Nemoz, G.4
  • 19
    • 0026533929 scopus 로고
    • Early increase in lymphocyte cyclic nucleotide phosphodiesterase activity upon mitogenic activation of human peripheral blood mononuclear cells
    • Meskini, N., Hosni, M., Nemoz, G., Lagarde, M., and Pringent, A.-F. (1992) Early increase in lymphocyte cyclic nucleotide phosphodiesterase activity upon mitogenic activation of human peripheral blood mononuclear cells. J. Cell. Physiol. 150, 140-148.
    • (1992) J. Cell. Physiol. , vol.150 , pp. 140-148
    • Meskini, N.1    Hosni, M.2    Nemoz, G.3    Lagarde, M.4    Pringent, A.-F.5
  • 20
    • 18144445994 scopus 로고
    • The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases
    • Beltman, J., Sonnenberg, W. K., and Beavo, J. A. (1993) The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases. Mol. Cell. Biol. 127/128, 239-253.
    • (1993) Mol. Cell. Biol. , vol.127-128 , pp. 239-253
    • Beltman, J.1    Sonnenberg, W.K.2    Beavo, J.A.3
  • 22
    • 0024323112 scopus 로고
    • Activation and phosphorylation of the "dense-vesicle" high-affinity cyclic AMP phosphodiesterase by cyclic AMP-dependent protein kinase
    • Kilgour, E., Anderson, N. G., and Houslay, M. D. (1989) Activation and phosphorylation of the "dense-vesicle" high-affinity cyclic AMP phosphodiesterase by cyclic AMP-dependent protein kinase. Biochem. J. 260, 27-39.
    • (1989) Biochem. J. , vol.260 , pp. 27-39
    • Kilgour, E.1    Anderson, N.G.2    Houslay, M.D.3
  • 24
    • 0024382619 scopus 로고
    • Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes
    • Pyne, N. J., Cushley, W., Nimmo, H. G., and Houslay, M. D. (1989) Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes. Biochem. J. 261, 897-901.
    • (1989) Biochem. J. , vol.261 , pp. 897-901
    • Pyne, N.J.1    Cushley, W.2    Nimmo, H.G.3    Houslay, M.D.4
  • 25
    • 0344531201 scopus 로고
    • The mRNA encoding a high affinity cAMP phosphodiesterase is regulated by hormones and cAMP
    • Swinnen, J. V., Joseph, D. R., and Conti, M. (1989) The mRNA encoding a high affinity cAMP phosphodiesterase is regulated by hormones and cAMP. Proc. Natl. Acad. Sci. USA 86, 8197-8201.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 8197-8201
    • Swinnen, J.V.1    Joseph, D.R.2    Conti, M.3
  • 26
    • 0026543522 scopus 로고
    • Effects of isozyme selective phosphodiesterase inhibitors on bovine tracheal smooth muscle tone
    • Hall, I. P. and Hill, S. J. (1992) Effects of isozyme selective phosphodiesterase inhibitors on bovine tracheal smooth muscle tone. Biochem. Pharmacol. 43, 15-17.
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 15-17
    • Hall, I.P.1    Hill, S.J.2
  • 27
    • 0025773585 scopus 로고
    • Bemoradan - A novel inhibitor of rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue
    • Moore, J. B., Combs, D. W., and Tobia, A. J. (1991) Bemoradan - a novel inhibitor of rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue. Biochem. Pharmacol. 42, 679-683.
    • (1991) Biochem. Pharmacol. , vol.42 , pp. 679-683
    • Moore, J.B.1    Combs, D.W.2    Tobia, A.J.3
  • 28
    • 0028243837 scopus 로고
    • The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation
    • Sette, C., Iona, S., and Conti, M. (1994) The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation. J. Biol. Chem. 269, 9245-9252.
    • (1994) J. Biol. Chem. , vol.269 , pp. 9245-9252
    • Sette, C.1    Iona, S.2    Conti, M.3
  • 29
    • 0026010201 scopus 로고
    • Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from rat sertoli cell
    • Swinnen, J. V., Tsikalas, K. E., and Conti, M. (1991) Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from rat sertoli cell. J. Biol. Chem. 266, 18,370-18,377.
    • (1991) J. Biol. Chem. , vol.266 , pp. 18370-18377
    • Swinnen, J.V.1    Tsikalas, K.E.2    Conti, M.3
  • 30
    • 0028145823 scopus 로고
    • Expression and regulation of human and rat phosphodiesterase type IV isogene
    • Engels, P., Fichtel, K., and Lubbert, H. (1994) Expression and regulation of human and rat phosphodiesterase type IV isogene. FEBS Lett. 350, 291-295.
    • (1994) FEBS Lett , vol.350 , pp. 291-295
    • Engels, P.1    Fichtel, K.2    Lubbert, H.3
  • 31
    • 0029033752 scopus 로고
    • Brain distribution of four rat homologues of the drosphila dunce phosphodiesterase
    • Engels, P., Abdel'Al, S., Hulley, P., and Lubbert, H. (1995) Brain distribution of four rat homologues of the drosphila dunce phosphodiesterase. J. Neurosci. Res. 41, 169-178.
    • (1995) J. Neurosci. Res. , vol.41 , pp. 169-178
    • Engels, P.1    Abdel'Al, S.2    Hulley, P.3    Lubbert, H.4
  • 32
    • 0028036970 scopus 로고
    • Identification of two splice variant forms of type IVb cyclic AMP phosphodiesterase, DPD rPDE-IVb1 and PDE-4rPDE-IVB2 in brain: Selective localisation in membrane and cytosolic compartments and differential expression in various brain regions
    • Lobban, M., Shakur, Y., Beattie, J., and Houslay, M. D. (1994) Identification of two splice variant forms of type IVb cyclic AMP phosphodiesterase, DPD (rPDE-IVb1 and PDE-4(rPDE-IVB2 in brain: selective localisation in membrane and cytosolic compartments and differential expression in various brain regions. Biochem. J. 304, 399-406.
    • (1994) Biochem. J. , vol.304 , pp. 399-406
    • Lobban, M.1    Shakur, Y.2    Beattie, J.3    Houslay, M.D.4
  • 33
    • 0027295333 scopus 로고
    • Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram
    • Shakur, Y., Pryde, J. G., and Houslay, M. D. (1993) Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram. Biochem. J. 292, 677-686.
    • (1993) Biochem. J. , vol.292 , pp. 677-686
    • Shakur, Y.1    Pryde, J.G.2    Houslay, M.D.3
  • 34
    • 0029962380 scopus 로고    scopus 로고
    • Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: Analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram
    • Michie, A. M., Lobban, M. D., Mueller, T., and Harnett, M. M., Houslay, M. D. (1996) Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell. Signalling 8, 97-110.
    • (1996) Cell. Signalling , vol.8 , pp. 97-110
    • Michie, A.M.1    Lobban, M.D.2    Mueller, T.3    Harnett, M.M.4    Houslay, M.D.5
  • 35
    • 0025285280 scopus 로고
    • Increases in tyrosine phosphorylation are detectable before phospholiase C activation after T cell receptor stimulation
    • June, C. H., Fletcher, M. C., Ledbetter, J. A., and Samelson, L. E. (1990) Increases in tyrosine phosphorylation are detectable before phospholiase C activation after T cell receptor stimulation. J. Immunol. 144, 1591-1599.
    • (1990) J. Immunol. , vol.144 , pp. 1591-1599
    • June, C.H.1    Fletcher, M.C.2    Ledbetter, J.A.3    Samelson, L.E.4
  • 36
    • 0025114471 scopus 로고
    • T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf- Associated kinase activity via a protein kinase C-dependent pathway
    • Siegel, J. N., Klausner, R. D., Rapp, U. R., and Samelson, L. E. (1990) T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf- associated kinase activity via a protein kinase C-dependent pathway. J. Biol. Chem. 265, 18,472-18,480.
    • (1990) J. Biol. Chem. , vol.265 , pp. 18472-18480
    • Siegel, J.N.1    Klausner, R.D.2    Rapp, U.R.3    Samelson, L.E.4
  • 37
    • 0028014460 scopus 로고
    • Signal transduction by lymphocyte antigen receptors
    • Weiss, A. and Littman, D. R. (1994) Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274.
    • (1994) Cell , vol.76 , pp. 263-274
    • Weiss, A.1    Littman, D.R.2
  • 38
    • 0028181498 scopus 로고
    • Two step TCRζ/CD3-CD4 and CD28 signalling in T cells: SH2/SH3 domains, protein tyrosine and lipid kinases
    • Rudd, C. E., Janssen, O., Cai, Y.-C., da Silva, A. J., and Raab, M., et al. (1994) Two step TCRζ/CD3-CD4 and CD28 signalling in T cells: SH2/SH3 domains, protein tyrosine and lipid kinases. Immunol. Today 15, 225-234.
    • (1994) Immunol. Today , vol.15 , pp. 225-234
    • Rudd, C.E.1    Janssen, O.2    Cai, Y.-C.3    Da Silva, A.J.4    Raab, M.5
  • 40
    • 0025764018 scopus 로고
    • Activation of MAP-2 kinase activity by the CD2 receptor in Jurkat T cells can be reversed by CD45 phosphatase
    • Nel, A. E., Ledbetter, J. A., Ho, P., Akerley, B., Franklin, K., et al. (1991) Activation of MAP-2 kinase activity by the CD2 receptor in Jurkat T cells can be reversed by CD45 phosphatase. Immunology 73, 129-133.
    • (1991) Immunology , vol.73 , pp. 129-133
    • Nel, A.E.1    Ledbetter, J.A.2    Ho, P.3    Akerley, B.4    Franklin, K.5
  • 41
    • 0025740389 scopus 로고
    • Antigen receptor-mediated phosphoinositide hydrolysis in murine T cells is not initiated via G-protein activation
    • Phillips, R. J., Harnett, M. M., and Klaus, G. G. (1991) Antigen receptor-mediated phosphoinositide hydrolysis in murine T cells is not initiated via G-protein activation. Int. Immunol. 3, 617-621.
    • (1991) Int. Immunol. , vol.3 , pp. 617-621
    • Phillips, R.J.1    Harnett, M.M.2    Klaus, G.G.3
  • 42
    • 0026567962 scopus 로고
    • Developmental regulation of transmembrane signalling via the T cell antigen receptor/CD3 complex in human T lymphocytes
    • Sancho, J., Silverman, L. B., Castigli, E., Ahern, D., and Laudano, A. P., et al. (1992) Developmental regulation of transmembrane signalling via the T cell antigen receptor/CD3 complex in human T lymphocytes. J. Immunol. 148, 1315-1321.
    • (1992) J. Immunol. , vol.148 , pp. 1315-1321
    • Sancho, J.1    Silverman, L.B.2    Castigli, E.3    Ahern, D.4    Laudano, A.P.5
  • 43
    • 0025876073 scopus 로고
    • IL-4 promotes anti-Ig-mediated protein kinase C translocation and reverses phorbol ester-mediated protein kinase C regulation in murine B cells
    • Harnett, M. M., Holman, M. J., and Klaus, G. G. B. (1991) IL-4 promotes anti-Ig-mediated protein kinase C translocation and reverses phorbol ester-mediated protein kinase C regulation in murine B cells. J. Immunol. 147, 3831-3836.
    • (1991) J. Immunol. , vol.147 , pp. 3831-3836
    • Harnett, M.M.1    Holman, M.J.2    Klaus, G.G.B.3
  • 44
    • 0015231739 scopus 로고
    • Multiple cyclic nucleotide phosphodiesterase activities in rat brain
    • Thompson, W. J. and Appleman, M. M. (1971) Multiple cyclic nucleotide phosphodiesterase activities in rat brain. Biochemistry 10, 311-316.
    • (1971) Biochemistry , vol.10 , pp. 311-316
    • Thompson, W.J.1    Appleman, M.M.2
  • 45
    • 0015831183 scopus 로고
    • Adenosine 3′,5′-monophosphate phosphodiesterase assay in tissue homogenates
    • Rutten, W. J., Shoot, B. M., and De Pont, J. J. H. H. M. (1973) Adenosine 3′,5′-monophosphate phosphodiesterase assay in tissue homogenates. Biochim. Biophys. Acta 315, 378-383.
    • (1973) Biochim. Biophys. Acta , vol.315 , pp. 378-383
    • Rutten, W.J.1    Shoot, B.M.2    De Pont, J.J.H.H.M.3
  • 46
    • 0019015257 scopus 로고
    • A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes
    • Marchmont, R. J. and Houslay, M. D. (1980) A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes. Biochem. J. 187, 381-392.
    • (1980) Biochem. J. , vol.187 , pp. 381-392
    • Marchmont, R.J.1    Houslay, M.D.2
  • 47
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 48
    • 0020620230 scopus 로고
    • Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes
    • Heyworth, C. M., Wallace, A. V., and Houslay, M. D. (1983) Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes. Biochem. J. 214, 99-110.
    • (1983) Biochem. J. , vol.214 , pp. 99-110
    • Heyworth, C.M.1    Wallace, A.V.2    Houslay, M.D.3
  • 49
    • 0028941914 scopus 로고
    • A role for protein kinase C-mediated phosphorylation in eliciting glucagon desensitization in rat hepatocytes
    • Savage, A., Zeng, L., and Houslay, M. D. (1995) A role for protein kinase C-mediated phosphorylation in eliciting glucagon desensitization in rat hepatocytes. Bio. J. 307, 281-285.
    • (1995) Bio. J. , vol.307 , pp. 281-285
    • Savage, A.1    Zeng, L.2    Houslay, M.D.3
  • 50
    • 0029613794 scopus 로고
    • Insulin and vasopressin elicit inhibition of cholera-toxin-stimulated adenylate cyclase activity in both hepatocytes and the P9 immortalized hepatocyte cell line through an action involving protein kinase C
    • Zeng, L. and Houslay, M. D. (1995) Insulin and vasopressin elicit inhibition of cholera-toxin-stimulated adenylate cyclase activity in both hepatocytes and the P9 immortalized hepatocyte cell line through an action involving protein kinase C. Biochem. J. 312, 769-774.
    • (1995) Biochem. J. , vol.312 , pp. 769-774
    • Zeng, L.1    Houslay, M.D.2
  • 51
    • 0024851293 scopus 로고
    • The local anaesthetic benzl alcohol attenuates the a2-adrenoceptor-mediated inhibition of human platelet adenylyl cyclase activity when stimulated by prostaglandin E1, but not that stimulated by forskolin
    • Spence, S. and Houslay, M. D. (1989) The local anaesthetic benzl alcohol attenuates the a2-adrenoceptor-mediated inhibition of human platelet adenylyl cyclase activity when stimulated by prostaglandin E1, but not that stimulated by forskolin. Biochem. J. 264, 483-488.
    • (1989) Biochem. J. , vol.264 , pp. 483-488
    • Spence, S.1    Houslay, M.D.2
  • 52
    • 0025633236 scopus 로고
    • Indentification of the MAP-2 and P75-binding domain in the regulatory subunit of RII cAMP dependent protein kinase
    • Luo, Z., Shafit-Zagardo, B., and Erlichman, J. (1990) Indentification of the MAP-2 and P75-binding domain in the regulatory subunit of RII cAMP dependent protein kinase. J. Biol.Chem. 265, 21,804-21,810.
    • (1990) J. Biol.Chem. , vol.265 , pp. 21804-21810
    • Luo, Z.1    Shafit-Zagardo, B.2    Erlichman, J.3
  • 54
    • 0025248571 scopus 로고
    • Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesised inhibitor of cyclic AMP dependent protein kinase, H89, in PC12D Pheochromocytoma cells
    • Chijiwa, T., Mishima, A., Hagiwara, M., Sano, M., and Hayashi, K., et al. (1990) Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesised inhibitor of cyclic AMP dependent protein kinase, H89, in PC12D Pheochromocytoma cells. J. Biol. Chem. 265, 5267-5272.
    • (1990) J. Biol. Chem. , vol.265 , pp. 5267-5272
    • Chijiwa, T.1    Mishima, A.2    Hagiwara, M.3    Sano, M.4    Hayashi, K.5
  • 55
    • 0023691731 scopus 로고
    • Inhibitor effect of a marine-sponge toxin, okadaic acid, on protein phosphatases
    • Bialojan, C. and Takai, A. (1988) Inhibitor effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem. J. 256, 283-290.
    • (1988) Biochem. J. , vol.256 , pp. 283-290
    • Bialojan, C.1    Takai, A.2
  • 56
    • 0024385914 scopus 로고
    • Tyrophostins inhibit epidermal growth factor (EGF) receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation
    • Lyall, R. M., Zilberstein, A., Gazit, A., Gilon, C., Levitzki, A., et al. (1989) Tyrophostins inhibit epidermal growth factor (EGF) receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J. Biol. Chem. 264, 14,503.
    • (1989) J. Biol. Chem. , vol.264 , pp. 14503
    • Lyall, R.M.1    Zilberstein, A.2    Gazit, A.3    Gilon, C.4    Levitzki, A.5
  • 57
    • 0024345772 scopus 로고
    • EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signalling
    • Margolis, B., Rhee, S. G., Felder, S., Mervic, M., Lyall, R., et al. (1989) EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signalling. Cell 57, 1101-1107.
    • (1989) Cell , vol.57 , pp. 1101-1107
    • Margolis, B.1    Rhee, S.G.2    Felder, S.3    Mervic, M.4    Lyall, R.5
  • 58
    • 0028340177 scopus 로고
    • Activation of novel protein kinase C upon mitogenic stimulation of quiescent rat 3Y1 fibroblasts
    • Ohno, S., Mizuna, K., Adachi, Y., Hata, A., Akita, Y., et al. (1994) Activation of novel protein kinase C upon mitogenic stimulation of quiescent rat 3Y1 fibroblasts. J. Biol. Chem. 269, 17,495-17,501.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17495-17501
    • Ohno, S.1    Mizuna, K.2    Adachi, Y.3    Hata, A.4    Akita, Y.5
  • 59
    • 0025094356 scopus 로고
    • Inhibition of tyrosone phosphorylation prevents T-cell receptor-mediated signal transduction
    • June, C. H., Fletcher, M. C., Ledbetter, J. A., Schieven, G. L., Siegel, J. N., et al. (1990) Inhibition of tyrosone phosphorylation prevents T-cell receptor-mediated signal transduction. Proc. Natl. Acad. Sxi. USA 87, 7722-7726.
    • (1990) Proc. Natl. Acad. Sxi. USA , vol.87 , pp. 7722-7726
    • June, C.H.1    Fletcher, M.C.2    Ledbetter, J.A.3    Schieven, G.L.4    Siegel, J.N.5
  • 60
    • 0021213870 scopus 로고
    • Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
    • Greenberg, M. E. and Ziff, E. B. (1984) Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 311, 433-438.
    • (1984) Nature , vol.311 , pp. 433-438
    • Greenberg, M.E.1    Ziff, E.B.2
  • 61
    • 0027529149 scopus 로고
    • Functional divergence of protein kinase C family members
    • Hata, A., Akita, Y., Suzuki, K., and Ohno, S. (1993) Functional divergence of protein kinase C family members. J. Biol. Chem. 268, 9122-9129.
    • (1993) J. Biol. Chem. , vol.268 , pp. 9122-9129
    • Hata, A.1    Akita, Y.2    Suzuki, K.3    Ohno, S.4
  • 62
    • 0028979317 scopus 로고
    • Induction of Ca2+/calmodulin-stimulated cyclic AMP phosphodiesterase (PDE-1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selctive overexpression of protein kinase C isoforms
    • Spence, S., Rena, G., Sweeney, G., and Houslay, M. D. (1995) Induction of Ca2+/calmodulin-stimulated cyclic AMP phosphodiesterase (PDE-1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selctive overexpression of protein kinase C isoforms. Biochem. J. 310, 975-982.
    • (1995) Biochem. J. , vol.310 , pp. 975-982
    • Spence, S.1    Rena, G.2    Sweeney, G.3    Houslay, M.D.4
  • 63
    • 0031033008 scopus 로고    scopus 로고
    • Receptor-mediated stimulation of protein kinase C in CHO cells elicits the rapid transient induction of the PDE-1B isoform of calcium/calmodulin-stimulated phosphodiesterase
    • Spence, S., Rena, G., Sullivan, M., Erdogan, S., and Houslay, M. D. (1997) Receptor-mediated stimulation of protein kinase C in CHO cells elicits the rapid transient induction of the PDE-1B isoform of calcium/calmodulin-stimulated phosphodiesterase. Biochem. J. 321, 157-163.
    • (1997) Biochem. J. , vol.321 , pp. 157-163
    • Spence, S.1    Rena, G.2    Sullivan, M.3    Erdogan, S.4    Houslay, M.D.5
  • 64
    • 0031016064 scopus 로고    scopus 로고
    • Intracellular localisation of the PDE-4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE-4A1A) in transfected human thyroid carcinoma FTC cell lines
    • Pooley, L., Shakur, Y., Rena, G., and Houslay, M. D. (1997) Intracellular localisation of the PDE-4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE-4A1A) in transfected human thyroid carcinoma FTC cell lines. Biochem. J. 271, 177-185.
    • (1997) Biochem. J. , vol.271 , pp. 177-185
    • Pooley, L.1    Shakur, Y.2    Rena, G.3    Houslay, M.D.4
  • 65
    • 0029151222 scopus 로고
    • Identification, characterisation and regional distribution in brain of RPDE-6 (RNPDE-4A5), a novel splice variant of the PDE-4A cyclic AMP phosphodiestase family
    • McPhee, I., Pooley, L., Lobban, M., Bolger, G., and Houslay, M. D. (1995) Identification, characterisation and regional distribution in brain of RPDE-6 (RNPDE-4A5), a novel splice variant of the PDE-4A cyclic AMP phosphodiestase family. Biochem. J. 310, 965-974.
    • (1995) Biochem. J. , vol.310 , pp. 965-974
    • McPhee, I.1    Pooley, L.2    Lobban, M.3    Bolger, G.4    Houslay, M.D.5
  • 66
    • 0029812555 scopus 로고    scopus 로고
    • The cyclic AMP phosphodiesterase RPDE-6 (RNPDE-4A5) binds to the SH3 domain of v-src through its N-terminal splice region
    • O'Connell, J. C., McCallum, J. F., McPhee, I., Bolger, G., and Frame, M., et al. (1996) The cyclic AMP phosphodiesterase RPDE-6 (RNPDE-4A5) binds to the SH3 domain of v-src through its N-terminal splice region. Biochem. J. 318, 255-262.
    • (1996) Biochem. J. , vol.318 , pp. 255-262
    • O'Connell, J.C.1    McCallum, J.F.2    McPhee, I.3    Bolger, G.4    Frame, M.5
  • 67
    • 0025752347 scopus 로고
    • Regulation of T cell receptor signalling by a src family protein-tyrosine kinase (p59 fyn)
    • Cooke, M. P., Abraham, K. M., Forbush, K. A., and Perlmutter, R. M. (1991) Regulation of T cell receptor signalling by a src family protein-tyrosine kinase (p59 fyn). Cell 65, 281-291.
    • (1991) Cell , vol.65 , pp. 281-291
    • Cooke, M.P.1    Abraham, K.M.2    Forbush, K.A.3    Perlmutter, R.M.4
  • 68
    • 0028177590 scopus 로고
    • P561ck via its src homology 2 (SH2) domain with the ZAP-70 kinase
    • Duplay, P., Thome, M., Herve, F., and Acuto, O. (1994) p561ck via its src homology 2 (SH2) domain with the ZAP-70 kinase. J. Exp. Med. 179, 1163-1172.
    • (1994) J. Exp. Med. , vol.179 , pp. 1163-1172
    • Duplay, P.1    Thome, M.2    Herve, F.3    Acuto, O.4
  • 69
    • 0027263368 scopus 로고
    • Regulation of src family tyrosine kinases in lymphocytes
    • Mustelin, T. and Burn, P. (1993) Regulation of src family tyrosine kinases in lymphocytes. TIBS 18, 215-220.
    • (1993) TIBS , vol.18 , pp. 215-220
    • Mustelin, T.1    Burn, P.2
  • 70
    • 0026355723 scopus 로고
    • CSK: A protein-tyrosine kinase involved in the regulation of src family kinases
    • Okada, M., Nada, S., Yamanashi, N. Y., Yamamoto, T., and Nakagawa, H. (1991) CSK: a protein-tyrosine kinase involved in the regulation of src family kinases. J. Biol. Chem. 266, 24,249-24,252.
    • (1991) J. Biol. Chem. , vol.266 , pp. 24249-24252
    • Okada, M.1    Nada, S.2    Yamanashi, N.Y.3    Yamamoto, T.4    Nakagawa, H.5
  • 71
    • 0025781203 scopus 로고
    • Coordinate interactions of protein tyrosine kinases and protein tyrosine phosphatases in T-cell receptor-mediated signalling
    • Shaw, A. and Thomas, M. L. (1991) Coordinate interactions of protein tyrosine kinases and protein tyrosine phosphatases in T-cell receptor-mediated signalling. Curr. Opinion Cell. Biol. 3, 862-868.
    • (1991) Curr. Opinion Cell. Biol. , vol.3 , pp. 862-868
    • Shaw, A.1    Thomas, M.L.2
  • 72
    • 0026095639 scopus 로고
    • Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1
    • Weiss, A., Koretzky, G., Schatzman, R. C., and Kadlecek, T. (1991) Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1. Proc. Natl. Acad. Sci. USA 88, 5484-5488.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5484-5488
    • Weiss, A.1    Koretzky, G.2    Schatzman, R.C.3    Kadlecek, T.4
  • 74
    • 0030974622 scopus 로고    scopus 로고
    • Tailoring cAMP signalling responses through isoform multiplicity
    • Houslay, M. D. and Milligan, G. (1997) Tailoring cAMP signalling responses through isoform multiplicity. Trends in Biochem. Sc. 22, 217-224.
    • (1997) Trends in Biochem. Sc. , vol.22 , pp. 217-224
    • Houslay, M.D.1    Milligan, G.2
  • 75
    • 0028009991 scopus 로고
    • Localization of A-kinase through anchoring proteins
    • Scott, J. D. and McCartney, S. (1994) Localization of A-kinase through anchoring proteins. Mol. Endocrinol. 8, 5-11.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 5-11
    • Scott, J.D.1    McCartney, S.2
  • 76
    • 0000209835 scopus 로고
    • Subcellular localisation of type II cAMP-dependent protein kinase
    • Scott, J. D. and Carr, D. W. (1992) Subcellular localisation of type II cAMP-dependent protein kinase. NIPS 7, 143-148.
    • (1992) NIPS , vol.7 , pp. 143-148
    • Scott, J.D.1    Carr, D.W.2
  • 77
    • 0028360098 scopus 로고
    • The rat PDE-3/IVD phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase
    • Sette, C., Vincini, E., and Conti, M. (1994) The rat PDE-3/IVD phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase. J. Biol. Chem. 269, 18,271-18,274.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18271-18274
    • Sette, C.1    Vincini, E.2    Conti, M.3
  • 78
    • 0027716596 scopus 로고
    • Inhibition by cAMP of rasdependent activation of Raf
    • Cook, S. J. and McCormick, F. (1993) Inhibition by cAMP of rasdependent activation of Raf. Science 262, 1069-1072.
    • (1993) Science , vol.262 , pp. 1069-1072
    • Cook, S.J.1    McCormick, F.2
  • 80
    • 0028302767 scopus 로고
    • The T cell antigen receptor utilises lck, raf-1, MEK-1 for activating mitogen-activated protein kinase
    • Gupta, S., Weiss, A., Kumar, G., Wang, S., and Nel, A. (1994) The T cell antigen receptor utilises lck, raf-1, MEK-1 for activating mitogen-activated protein kinase. J. Biol. Chem. 269, 17,349-17,357.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17349-17357
    • Gupta, S.1    Weiss, A.2    Kumar, G.3    Wang, S.4    Nel, A.5
  • 81
    • 0027772672 scopus 로고
    • Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine-3′,5′-Monophosphate
    • Wu, J., Dent, P., Jelinek, T., Wolfman, A., Weber, M. J., et al. (1993) Inhibition Of the EGF-Activated MAP Kinase Signaling Pathway By Adenosine-3′,5′-Monophosphate. Science 262, 1065-1069.
    • (1993) Science , vol.262 , pp. 1065-1069
    • Wu, J.1    Dent, P.2    Jelinek, T.3    Wolfman, A.4    Weber, M.J.5
  • 82
    • 0028239542 scopus 로고
    • Association of raf with the CD3 d and g chains of the T cell receptor-CD3 complex
    • Loh, C., Romeo, C., Seed, B., Bruder, J. T., Rapp, U., et al. (1994) Association of raf with the CD3 d and g chains of the T cell receptor-CD3 complex. J. Biol. Chem. 269, 8817-8825.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8817-8825
    • Loh, C.1    Romeo, C.2    Seed, B.3    Bruder, J.T.4    Rapp, U.5
  • 83
    • 0028328869 scopus 로고
    • Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex
    • Skalhegg, B. S., Tasken, K., Hansson, V., Huitfeldt, H. S., Jahnsen, T., et al. (1994) Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex. Science 263, 84-87.
    • (1994) Science , vol.263 , pp. 84-87
    • Skalhegg, B.S.1    Tasken, K.2    Hansson, V.3    Huitfeldt, H.S.4    Jahnsen, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.