Inflammation of small airways in asthma

Journal of Allergy and Clinical Immunology

Volumn 100, Issue 1, 1997, Pages 44-51

  Hamid, Qutayba ^a   Song, Yunling ^a   Kotsimbos, Thomas C ^a   Minshall, Eleanor ^a   Bai, Tony R ^b   Hegele, Richard G ^b   Hogg, James C ^b  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Airway wall; Asthma; Eosinophils; Inflammation; Small airways

Indexed keywords

ADULT; AGED; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; CONTROLLED STUDY; EOSINOPHIL; FEMALE; HUMAN; HUMAN TISSUE; LEUKOCYTE ACTIVATION; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SMALL AIRWAY DISEASE; T LYMPHOCYTE;

EID: 0030856376     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(97)70193-3     Document Type: Article

References (32)

1. McFadden ER Jr, Gilbert IA. Asthma. N Engl J Med 1992;327:1928-37.
2. Sterk PJ, Bell EH. Bronchial hyperresponsiveness: the need for a distinction between hypersensitivity and excessive airway narrowing. Eur Respir J 1989;2:267-74.
3. Curschmann H. Ueber bronchiolitis exsudativa und ihr Verhaltniss zum asthma nervosum. Dtsch Arch Klin Med 1882;32:1-34.
4. Huber HL, Koessler KK. The pathology of bronchial asthma. Arch Intern Med 1922;30:689-760.
5. Dunnill MS. The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol 1960;13:27-33.
6. Dunnill MS, Massarella GR, Anderson JA. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis and in emphysema. Thorax 1969;24:176-9.
7. Djukanovic R, Wilson JW, Lai CK, Holgate ST, Howarth PH. The safety aspects of fiberoptic bronchoscopy, bronchoalveolar lavage, and endobronchial biopsy in asthma. Am Rev Respir Dis 1991;143:772-7.
8. Azzawi M, Bradley B, Jeffery PK, Frew AJ, Wardlaw AJ, Assoufi B, et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990;142:1407-13.
9. Bentley AM, Meng Q, Robinson DS, Hamid Q, Kay AB, Durham SR. Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression in interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen challenge in atopic asthmatics. Am J Respir Cell Mol Biol 1993;8:35-42.
10. Yanai M, Sekizawa K, Ohrui T, Sasaki H, Takishima T. Site of airway obstruction in pulmonary disease: direct measurements of intrabronchial pressure. J Appl Physiol 1992;72:1016-23.
11. Wiggs BR, Bosken C, Paré PD, Hogg JC. A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992;145:1251-8.
12. Kuwano K, Bosken CH, Paré PD, Bai TR, Wiggs BR, Hogg JC. Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1993;148:1220-5.
13. Hamid Q, Azzawi M, Ying S, Moqbel R, Wardlaw AJ, Corrigan CJ, et al. Expression of m-RNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 1991;87:1541-6.
14. Robinson DS, Ying S, Bentley AM, Meng Q, North J, Durham SR, et al. Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. J Allergy Clin Immunol 1993;92:397-402.
15. Robinson DS, Hamid Q, Bentley A, Ying S, Kay AB, Durham SR. Activation of CD4+ T cells increased Th2-type cytokine mRNA expression and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 1993;92:313-24.
16. Kay AB. "Helper" (CD4+) T cells and eosinophils in allergy and asthma. Am Rev Respir Dis 1992;145:S22-S26.
17. James AL, Pare PD, Hogg JC. The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989;139:242-6.
18. Gonzalez S, Hards J, Vaneeden S, Hogg JC. The expression of adhesion molecules in cigarette smoke-induced airways obstruction Eur Respir J 1996;9:1995-2001.
19. Laitinen LA, Laitinen A, Haahtela T. Airway mucosal inflammation even in patients with newly diagnosed asthma. Am Rev Respir Dis 1993;147:697-704.
20. Wilson JW, Djukanovic R, Howarth PH, Holgate ST. Inhaled beclomethasone dipropionate downregulates airway lymphocyte activation in atopic asthma. Am J Respir Crit Care Med 1994;149:86-90.
21. Djukanovic R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR, et al. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 1992;145:669-74.
22. Walker C, Virchow J-C Jr, Bruijnzeel PLB, Blaser K. T cell subsets and their soluble products regulate eosinophilia in allergic and non-allergic asthma. J Immunol 1991;146:1829-35.
23. Wilson JW, Djukanovic R, Howarth PH, Holgate ST. Lymphocyte activation in bronchoalveolar lavage and peripheral blood in atopic asthma. Am Rev Respir Dis 1992;135:958-60.
24. Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB. Eosinophils and mast cells in bronchoalveolar lavage in mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis 1988;137:62-9.
25. De Monchy JG, Kauffman HF, Venge P, Koeter GH, Jansen HM, Sluiter HJ, et al. Bronchoalveolar eosinophils during allergen-induced late asthmatic reactions. Am Rev Respir Dis 1985;131:373-6.
26. Gleich GJ, Frigas E, Loegering DA, Wassom DL, Steinmuller D. Cytotoxic properties of the eosinophil major basic protein. J Imrnunol 1979;123:2925-7.
27. Durham SR, Kay AB. Eosinophils, bronchial hyperreactivity and late-phase asthmatic reactions. Clin Allergy 1985;15:411-8.
28. Bosken CH, Hards J, Gatter K, Hogg JC. Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocytochemistry. Am Rev Respir Dis 1992;145:911-7.
29. Lopez AF, Sanderson CJ, Gamble JR, Campbell HR, Young IG, Davas MA. Recombinant human interleukin-5 is a selective activator of human eosinophil function. J Exp Med 1988;167:219-24.
30. Yamaguchi Y, Hayashi Y, Sugama Y, Miura Y, Kasahara T, Kitamura S, et al. Highly purified murine interleukin-5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. J Exp Med 1988;167:1737-42.
31. Romagnani S. Human Th1 and Th2 doubt no more. Immunol Today 1992;12:256-7.
32. Macklem FT, Proctor DF, Hogg JC. The stability of peripheral airways. Respir Physiol 1970;8:191-203.