Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitized guinea-pigs and airway leukocyte infiltration

British Journal of Pharmacology

Volumn 120, Issue 2, 1997, Pages 289-297

  Danahay, Henry ^a   Broadley, Kenneth J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Airway hyperreactivity; Aminophylline; Conscious guinea pigs; Leukocyte infiltration; Ovalbumin challenge; Ovalbumin sensitization; Phosphodiesterase inhibitors; Ro 20 1724; Rolipram; Siguazodan; SKF 95654; U46619 bronchoconstriction

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; 6 [4 (1,4 DIHYDRO 4 OXO 1 PYRIDYL)PHENYL] 4,5 DIHYDRO 5 METHYL 3(2H) PYRIDAZINONE; AMINOPHYLLINE; ANTIGEN; BRONCHODILATING AGENT; OVALBUMIN; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; ROLIPRAM; SIGUAZODAN; THROMBOXANE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHODILATING ACTIVITY; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; EOSINOPHIL; GUINEA PIG; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKOCYTE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; TRACHEOBRONCHIAL TOILET;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; 4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE; AMINOPHYLLINE; ANIMALS; BRONCHIAL HYPERREACTIVITY; GUINEA PIGS; LEUKOCYTES; MALE; OVALBUMIN; PHOSPHODIESTERASE INHIBITORS; PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC; PYRROLIDINONES; ROLIPRAM; THROMBOXANE A2;

EID: 0031036056     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700901     Document Type: Article

References (63)

1. ABRAHAM, W.M., AHMED, A., CORTES, A., SIELCZAK, M.W., HINZ, W., BOUSKA, J., LANNI, C. & BELL, R.L. (1992). The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep. Eur. J. Pharmacol., 217, 119-126.
2. AVERILL, L.E. & KAMMER, G.M. (1985). Inhibition of Interleukin-2 production is mediated by a cyclic adenosine monophosphate (cAMP)-dependent pathway. Clin. Res., 33, 839A.
3. BANNER, K.H. & PAGE, C.P. (1995). Acute versus chronic administration of phosphodiesterase inhibitors on allergen-induced pulmonary cell influx in sensitized guinea-pigs. Br. J. Pharmacol., 114, 93-98.
4. BARNES, P.J. (1986). Asthma as an axon reflex. Lancet, 2, 242-244.
5. BARNES, P.J., CHUNG, K.F. & PAGE, C.P. (1988). Inflammatory mediators and asthma. Pharmacol. Rev., 40, 49-84.
6. BAZZONI, F., CASSATELLA, M.A., ROSSI, F., CESKA, M., DEWALD, B. & BAGGIOLINI, M. (1991). Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/ interleukin 8. J. Exp. Med., 173, 771-774.
7. BEAVO, J.A., CONTl, M. & HEASLIP, R.J. (1994). Multiple cyclic nucleotide phosphodiesterases. Mol. Pharmacol., 46, 399-405.
8. BEAVO, J.A. & REIFSNYDER, D.H. (1990). Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol. Sci., 11, 150-155.
9. BRADDING, P., ROBERTS, J.A., BRITTEN, K.M., MONTEFORTE, S., DJUKANOVIC, R., MUELLER, R., HEUSSER, C.H., HOWARTH, P.H. & HOLGATE, S.T. (1994). Interleukin-4, -5 and -6 and tumor necrosis factor-α in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am. J. Resp. Cell Mol. Biol., 10, 471-480.
10. BRADDING, P., OKAYAMA, Y., HOWARTH, P.H., CHURCH, M.K. & HOLGATE, S.T. (1995). Heterogeneity of human mast cells based on cytokine content. J. Immunol., 155, 297-307.
11. BRITISH THORACIC SOCIETY GUIDELINES ON THE MANAGEMENT OF ASTHMA. (1993). Thorax, 48, S1-24.
12. CHURCH, M.K., HUTSON, P.A. & HOLGATE, S.T. (1993). Nedocromil sodium blocks the early and late phases of allergen challenge in a guinea pig model of asthma. J. Allergy Clin. Immunol., 92, 177-182.
13. COYLE, A.J., UCHIDA, D., ACKERMAN, S.J., MITZNER, W. & IRVIN, C.G. (1994). Role of cationic proteins in the airway: Hyperresponsiveness due to airway inflammation. Am. J. Respir. Crit. Care Med., 150, S63-S71.
14. DANAHAY, H. & BROADLEY, K.J. (1995). Effects of Ro 20-1724, a selective inhibitor of phosphodiesterase4, on a long lasting bronchoconstriction and eosinophilia in chronically antigen challenged guinea pigs. Br. J. Pharmacol., 116, 89P.
15. DEBRITO, F.B., EBSWORTH, K.E. & LAWRENCE, C.E. (1991). Regulation of eosinophilia by cAMP. Proceedings of the International Congress of Inflammation Meeting, 1991, Rome, Italy.
16. DENT, G., GIEMBYCZ, M.A., RABE, K.F., & BARNES, P.J. (1991). Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by type4-selective PDE inhibitors. Br. J. Pharmacol., 103, 1339-1346.
17. DJUKANOVIK, R., WILSON, J.W., BRITTEN, K.M., WILSON, S.J., WALLS, A.F., ROCHE, W.R., HOWARTH, P.H. & HOLGATE, S.T. (1992). Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am. Rev. Resp. Dis., 145, 669-674.
18. FLAVAHAN, N.A., SLIFMAN, N.R., GLEICH, G.J. & VANHOUTTE, P.M. (1988). Human eosinophil major basic protein causes hyperreactivity of respiratory smooth muscle. Am. Rev. Resp. Dis., 138, 685-688.
19. FRIGAS, E. & GLEICH, G.J. (1986). The eosinophil and the pathophysiology of asthma. J. Allergy Clin. Immunol., 77, 527-537.
20. FRIGAS, E., LOEGERING, D.A., SOLLEY, G.O., FARROW, G.M. & GLEICH, G.J. (1981). Elevated levels of the eosinophil granule Major Basic Protein in the sputum of patients with bronchial asthma. Mayo Clin. Proc., 56, 345-353.
21. FROSSARD, N., LANDRY, Y., PAULI, G. & RUCKSTUHL, M. (1981). Effects of cyclic AMP and cyclic GMP-phosphodiesterase inhibitors on immunological release of histamine and on lung contraction. Br. J. Pharmacol., 73, 933-938.
22. GENTILINI, G., DI BELLO, M., RASPANTI, S., BINDI, D., MUGNAI, S. & ZILLETTI, L. (1993). Salmeterol inhibits anaphylactic histamine release from guinea-pig isolated mast cells. J. Pharm. Pharmacol., 46, 76-77.
23. GIEMBYCZ, M.A. (1992). Could isoenzyme-selective phosphodiesterase inhibitors render bronchodilator therapy redundant in the treatment of bronchial asthma? Biochem. Pharmacol., 43, 2041-2051.
24. GRIFFITHS-JOHNSON, D.A., NICHOLLS, P.J. & MCDERMOTT, M. (1988). Measurement of specific airway conductance in guinea pigs. A noninvasive method. J. Pharmacol. Methods, 19, 233-242.
25. GRISTWOOD, R.W., LLUPIÁ, J., FERNÁNDEZ, A.G. & BERGA, P. (1991). Effects of theophylline compared with prednisolone on late phase airway leukocyte infiltration in guinea pigs. Int. Arch. Appl. Immunol., 94, 293-294.
26. HARGREAVE, F. (1989). Late-phase asthmatic responses and airway inflammation. J. Allergy Clin. Immunol., 83, 525-527.
27. HATZELMANN, A., TENOR, H. & SCHUDT, C. (1995). Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions. Br. J. Pharmacol., 114, 821-831.
28. HOWELL, R.E., SICKELS, B.D. & WOEPPEL, S.L. (1993). Pulmonary antiallergic and broncbodilator effects of isozyme-selective phosphodiesterase inhibitors. J. Pharmacol. Exp. Ther., 264, 609-615.
29. HOWELL, R.E., JENKINS, L.P. & HOWELL, D.E. (1995). Inhibition of lipopolysaccharide-induced pulmonary edema by isozyme-selective phosphodiesterase inhibitors in guniea pigs. J. Pharmacol. Exp. Ther., 257, 703-709.
30. HUTSON, P.A., HOLGATE, S.T. & CHURCH, M.K. (1988). Inhibition by nedocromil sodium of early and late phase bronchoconstriction and airway cellular infiltration provoked by ovalbumin inhalation in conscious sensitized guinea-pigs. Br. J. Pharmacol., 94, 6-8.
31. KAY, A.B. (1991). Asthma and inflammation. J. Allergy Clin. Immunol., 87, 893-910.
32. LEWIS, C.A. & BROADLEY, K.J. (1995a). Inflammatory cell infiltration associated with an early and late phase bronchoconstriction after allergen challenge in conscious sensitized guinea-pigs. Br. J. Pharmacol., 114, 52P.
33. LEWIS, C.A. & BROADLEY, K.J. (1995b). Airway hyper- or hyporeactivity to inhaled spasmogens 24h after ovalbumin challenge of sensitised guinea-pigs. Br. J. Pharmacol., 116, 2351-2358.
34. LOUGHNEY, K. & FERGUSON, K.M. (1994). The human cyclic nucleotide phosphodiesterases. In Methylxanthines and Phosphodiesterase Inhibitors in the Treatment of Airway Disease, ed. Costello, J.F. & Piper P.J. pp. 81-100. London: Parthenon.
35. LUGNIER, C. & SCHINI, V.B. (1990). Characterization of cyclic nucleotide phosphodiesterases from cultured bovine aortic cells. Biochem. Pharmacol., 39, 75-84.
36. MARY, D., AUSSEL, C., FERRUA, B. & FEHLMANN, M. (1987). Regulation of interleukin 2 synthesis by cAMP in human T cells. J. Immunol., 139, 1179-1184.
37. METZGER, W.J., RICHERSON, H.B. & WASSERMAN, S.I. (1986). Generation and partial characterization of eosinophil chemotactic activity and neutrophil achemotactic activity during early and late-phase asthmatic responses. J. Allergy Clin. Immunol., 78, 282-290.
38. + T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am. Rev. Resp. Dis., 146, 374-377.
39. NICHOLSON, C.D., CHALLISS, R.A.J. & SHAHID, M. (1991). Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol. Sci., 12, 19-27.
40. NOURSHARGH, S. (1993). Mechanism of neutrophil and eosinophil accumulation in vivo. Am. Rev. Resp. Dis., 148, S60-S64.
41. O'BYRNE, P., DOLOVICH, J. & HARGREAVE, F. (1987). Late asthmatic responses. Am. Rev. Resp. Dis., 136, 740-751.
42. PEACHELL, P.T., UNDEM, B.J., SCHLEIMER, R.P., LICHTENSTEIN, L.M. & TORPHY, T.J. (1980). Action of isozyme-selective phosphodiesterase inhibitors on human basophils. FASEB J., 4, A639.
43. PERSSON, C.G.A. (1986). Overview of the effects of theophylline. J. Allergy Clin. Immunol., 78, 780-787.
44. POSER, J.S., SLOWIK, M., DELUCA, L. & RITCHIE, A.J. (1992). Elevated cAMP inhibits endothelial expression of ELAM-1 and VCAM-1 but not ICAM-1. FASEB J., 6, A1592.
45. PRETOLANI, M., LEFORT, J. & VARGAFTIG, B.B. (1993). Inhibition by nedocromil sodium of recombinant human interleukin-5 induced lung hyperresponsiveness to platelet-activating factor in actively sensitised guinea pigs. J. Allergy Clin. Immunol., 91, 809-816.
46. RAEBURN, D. & KARLSSON, A. (1992). Comparison of the effects of isoenzyme-selective phosphodiesterase inhibitors and theophylline on PAF-induced plasma leak in the guinea-pig airways in vivo. Am. Rev. Resp. Dis., 145, A612.
47. ROBERTSON, D.G., KERIGAN, A.T., HARGREAVE, F., CHALMERS, R. & DOLOVICH, J. (1974). Late asthmatic responses induced by ragweed pollen allergen. J. Allergy Clin. Immunol., 54, 244-254.
48. SELIG, W.M. & TOCKER, J. (1992). Effect of interleukin-1 receptor antagonist on the antigen-induced pulmonary responses in guinea-pigs. Eur. J. Pharmacol., 213, 331-336.
49. SMITH, D., WATSON, M.L., BOURNE, A.D., THOMPSON, R. & WESTWICK, J. (1992). An interleukin-2 receptor antagonist inhibits antigen-induced accumulation and bronchial hyperreactivity in guinea-pigs. Br. J. Pharmacol., 105, 128P.
50. SOUNESS, J.E., CARTER, C.M., DIOCEE, B.K., HASSALL, G.A., WOOD, L.J. & TURNER, N.C. (1991). Characterization of guinea-pig eosinophil phosphodiesterase activity: Assessment of its involvement in regulating superoxide generation. Biochem. Pharmacol., 42, 937-945.
51. SOUNESS, J.E., MASLEN, C., WEBBER, S., FOSTER, M., RAEBURN, D., PALFREYMAN, M.N., ASHTON, M.J. & KARLSSON, A. (1995). Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP-specific phosphodiesterase: comparison with rolopram. Br. J. Pharmacol., 115, 39-46.
52. SULLIVAN, P., BEKIR, S., JAFFAR, Z., PAGE, C.P., JEFFERY, P. & COSTELLO, J.F. (1994). Anti-inflammatory effects of low-dose oral theophylline in atopic asthma. Lancet, 343, 1006-1008.
53. TEIXEIRA, M.M., ROSSI, A.G., WILLIAMS, T.J. & HELLEWELL, P.G. (1994). Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig. Br. J. Pharmacol., 112, 332-340.
54. THORNHILL, M.H & HASKARD, D.O. (1990). IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-γ. J. Immunol., 145, 865-872.
55. TOWN, G.I. & HOLGATE, S.T. (1991). The role of inflammation in airways disease. In Mediators of Pulmonary Inflammation. Vol. 54. ed. Bray, M.A. & Anderson, W.H. pp. 35-79. New York: Marcel Dekker.
56. TURNER, C.R., ANDRESEN, C.J., SMITH, W.B. & WATSON, J.W. (1994), Effects of rolipram on responses to acute and chronic antigen exposure in monkeys. Am. J. Respir. Crit. Care Med., 149, 1153-1159.
57. UNDEM, B.J., PEACHELL, P.T. & LICHTENSTEIN, L.M. (1988). Isoproterenol-induced inhibition of immunoglobulin E-mediated release of histamine and arachidonic acid matabolites from the human lung mast cell. J. Pharmacol. Exp. Ther., 247, 209-217.
58. UNDERWOOD, D.C., KOTZER, C.J., BOCHNOWICZ, S., OSBORN, R.R., LUTTMANN, M.A., HAY, D.W.P. & TORPHY, T.J. (1994). Comparison of phosphodieaterase3,4 and dual3/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea-pigs. J. Pharmacol. Exp. Ther., 270, 250-259.
59. UNDERWOOD, D.C., OSBORN, R.R., NOVAK, L.B., MATHEWS, J.K., NEWSHOLME, S.J., UNDEM, B.J., HAND, J.M. & TORPHY, T.J. (1993). Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea-pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram. J. Pharmacol. Exp. Ther., 266, 306-313.
60. WARD, A.J., MCKENNIFF, M.G., EVANS, J.M., PAGE, C.P. & COSTELLO, J.F. (1993). Theophylline - an immunomodulatory role in asthma? Am. Rev. Resp. Dis., 147, 518-523.
61. WARDLAW, A.J. & KAY, A.B. (1987). The role of the eosinophil in the pathogenesis of asthma. Allergy, 42, 321-335.
62. WATSON, M.L., SMITH, D., BOURNE, A.D., THOMPSON, R. & WESTWICK, J. (1993). Cytokines contribute to airway dysfunction in antigen-challenged guinea-pigs: inhibition of airway hyperreactivity, pulmonary eosinophil accumulation, and tumour necrosis factor generation by pretreatment with an interleukin-1 receptor antagonist. Am. J. Respir. Cell Mol. Biol., 8, 365-369.
63. WELLICOME, S.W., THORNHILL, M.H., PITZALIS, C., SIAN THOMAS, D., LANCHBURY, J.S.S., PANAYI, G.S. & HASKARD, D.O. (1990). A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1 or lipopolysaccharide. J. Immunol., 144, 2558-2565.