Effects of selective and non-selective phosphodiesterase inhibitors on tracheal mucus secretion in the rat

European Journal of Pharmacology

Volumn 298, Issue 3, 1996, Pages 265-270

  Wagner, Ulrich ^a,c   Bredenbröker, Dirk ^a   Fehmann, Hans Christoph ^a   Schwarz, Friederike ^a   Schudt, Christian ^b   Von Wiehert, Peter ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b ALTANA PHARMA AG   (Germany)

^c Medizinische Poliklinik   (Germany)

Author keywords

3 Isobutyl methylxanthine; 8 Phenyltheophylline; Enprofylline; Motapizone; Mucus secretion; Rolipram; Theophylline; Trachea; Zaprinast; Zardaverine

Indexed keywords

8 PHENYLTHEOPHYLLINE; ADENOSINE; ADENOSINE RECEPTOR BLOCKING AGENT; ENPROFYLLINE; ISOBUTYLMETHYLXANTHINE; ISOENZYME; MOTAPIZONE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE V INHIBITOR; ROLIPRAM; SULFUR 35; THEOPHYLLINE; UNCLASSIFIED DRUG; ZAPRINAST; ZARDAVERINE;

ANIMAL TISSUE; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELECTIVITY; MALE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; RAT; TRACHEA;

EID: 18344405245     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00794-6     Document Type: Article

References (21)

1. Adler, K.B., D.H. Hardwick and J.E. Craighead, 1981, Effect of cholera toxin on secretion of mucin by explants of guinea pig trachea, Lab. Invest. 45, 372.
2. Barbieri, E.J. and C. Barsigia, 1985, Cyclic nucleotides fail to affect mucus glycoconjugate secretion from canine tracheal explants, J. Pharm. Pharmacol. 37, 748.
3. Barnes, P.J. and R.A. Pauwels, 1994, Theophylline in the management of asthma: time for reappraisal?, Eur. Respir. J. 7, 579.
4. Borson, D.B., A.A. Gashi and J.A. Nadel, 1988, Methods for studying secretions from airways, in: Methods in Bronchial Mucology, eds. P.C. Braga and L. Allegra (Raven Press, New York) p. 303.
5. Dent, G., H. Magnussen and K.F. Rabe, 1994, Cyclic nucleotide phosphodiesterases in the human lung, Lung 172, 129.
6. Finkbeiner, W.E., J.H. Widdicombe, L. Hu and C.B. Basbaum, 1992, Bovine tracheal serous cell secretion: role of cAMP and cAMP-dependent protein kinase, Am. J. Physiol. 262, L574.
7. Hoymann, H.G., U. Heinrich, R. Beume and U. Kilian, 1994, Comparative investigation of the effects of zardaverine and theophylline on pulmonary function in rats, Exp. Lung Res. 20, 235.
8. Johnson, H.G. and M. McNee, 1985, Adenosine-induced secretion in the canine trachea: modification by methylxanthines and adenosine derivates, Br. J. Pharmacol. 86, 63.
9. Konrad, F., T. Schreiber, J. Haehnel, J. Kilian and M. Georgieff, 1994, Effect of theophylline on mucociliary transport in ventilated intensive-care patients, Anaesthesist 43, 101.
10. Miyamoto, K.-I., M. Kurita, R. Sakai, F. Sanae, S. Wakusawa and K. Takagi, 1994, Cyclic nucleotide phosphodiesterase isoenzymes in guinea-pig tracheal muscle and bronchorelaxation by alkylxanthines, Biochem. Pharmacol. 48, 1219.
11. Quian, Y., V. Girard, C.A.E. Martin, M. Molimard and C. Advenier, 1994, Rolipram, but not siguazodan or zaprinast, inhibits the excitatory noncholinergic neurotransmission in guinea-pig bronchi, Eur. Respir. J. 7, 306.
12. Raeburn, D. and J.-A. Karlsson, 1993, Effects of isoenzyme-selective inhibitors of cyclic nucleotide phosphodiesterase on microvascular leak in guinea pig airways, J. Pharmacol. Exp. Ther. 267, 1147.
13. Richter, G., O. Feddersen, U. Wagner, P.J. Barth, R. Göke and B. Göke, 1993. Glucagon-like peptide-1 stimulates the secretion of macro-molecules from airways and relaxes the pulmonary artery, Am. J. Physiol. 265, L374.
14. Serafini, S.M., A. Wanner and E.D. Michaelson, 1976, Mucociliary transport in central and intermediate size airways: effect of aminophyllin, Bull. Eur. Physiopathol. Respir. 12, 415.
15. Tokuyama, K., T. Yokoyama, H. Arakawa, H. Morikawa and T. Kuroume, 1994, Effects of cilostazol, a cyclic nucleotide phoshodiesterase III inhibitor, on substance P-induced airflow obstruction and airway microvascular leakage in guinea pigs, Pharmacology 48, 301.
16. Torphy, T.J. and B.J. Undem, 1991, Phosphodiesterse inhibitors: new opportunities for treatment of asthma, Thorax 46, 512.
17. Underwood, D.C., C.J. Kotzer, S. Bochnowicz, R.R. Osborn, M.A. Luttmann, D.W.P. Hay and T.J. Torphy, 1994, Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs, J. Pharmacol. Exp. Ther. 270, 250.
18. Wagner, U., H.-C. Fehmann, D. Bredenbröker, F. Yu, P.J. Barth, P. Von Wiehert and B. Göke, 1993, Amylin stimulates airway secretion in the rat, Res. Exp. Med. 193, 347.
19. Wagner, U., H.-C. Fehmann, D. Bredenbröker, F. Yu, P.J. Barth and P. Von Wiehert, 1995a, Galanin and somatostatin inhibition of substance P-induced airway mucus secretion in the rat, Neuropeptides 28, 59.
20. Wagner, U., H.-C. Fehmann, D. Bredenbröker, F. Yu, P.J. Barth and P. Von Wiehert, 1995b, Galanin and somatostatin inhibition of neurokinin A and B induced airway mucus secretion in the rat, Life Sci. 57, 283.
21. Wanner, A., 1985, Effects of methylxanthines on airway mucociliary function, Am. J. Med. 79, 16.