Human eosinophils: Their accumulation, activation and fate

British Journal of Haematology

Volumn 97, Issue 4, 1997, Pages 701-709

  Walsh, Garry M ^a,b  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Activation; Adhesion; Apoptosis; Eosinophils; Mediators

Indexed keywords

CELL SPECIFICITY; CELL SURVIVAL; EOSINOPHIL; HUMAN; IMMUNOMODULATION; IMMUNOREGULATION; LEUKOCYTE ACTIVATION; LEUKOPOIESIS; PRIORITY JOURNAL; REVIEW;

EID: 0030750488     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.00125.x     Document Type: Review

References (99)

1. Alam, R., Forsythe, P., Stafford, S. & Fukuda, Y. (1994) Transforming growth factor-β abrogates the effects of hematopoietins on eosinophils and induces their apoptosis. Journal of Experimental Medicine, 179, 1041-1045.
2. Anwar, A.R.E., Moqbel, R., Walsh, G.M., Kay, A.B. & Wardlaw, A.J. (1993) Adhesion of fibronectin prolongs eosinophil survival. Journal of Experimental Medicine, 177, 839-843.
3. Anwar, A.R.E., Walsh, G.M., Cromwell, O., Kay, A.B. & Wardlaw, A.J. (1994) Adhesion to fibronectin primes eosinophils via α4β1 (VLA-4). Immunology, 82, 222-228.
4. Azzawi, M., Bradley, B., Jeffery, P.K., Frew, A.J., Wardlaw, A.J., Knowles, G., Assoufi, B., Collins, J.V., Durham, S.R. & Kay, A.B. (1990) Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. American Review of Respiratory Diseases, 142, 1407-1413.
5. Baggiolini, M. & Dahinden, C.A. (1994) CC chemikines in allergic inflammation. Immunology Today, 15, 127-133.
6. + channels. Journal of Leukemia Biology, 57, 851-855.
7. Bentley, A.M., Durham, S.R., Robinson, D.S., Menz, G., Storz, C., Cromwell, O., Kay, A.B. & Warlaw, A.J. (1993) Expression of the endothelial and leukocyte adhesion molecules ICAM-1. E-selectin and VCAM-1 in the bronchial mucosa in steady state and allergen induced asthma. Journal of Allergy and Clinical Immunology, 92, 857-868.
8. Bentley, A.M., Menz, G., Storz, C., Robinson, D.S., Bradley, B., Jeffery, P.K., Durham, S.R. & Kay, A.B. (1992) Identification of T lymphocytes, macrophages and activated eosinophils in the bronchial mucosa in intrinsic asthma: relationship to symptoms and bronchial hyper-responsiveness. American Review of Respiratory Diseases, 146, 500-506.
9. Berlin, C., Berg, E.L., Briskin, M.J., Andrew, D.P., Kilshaw, P.J., Holzmann, B., Weissman, I.L., Hamann, A. & Butcher, E.C. (1993) α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-I. Cell, 74, 185-95.
10. Bochner, B.S. & Schleimer, R.P. (1995) The role of adhesion molecules in human eosinophil and basophil recruitment. Journal of Allergy and Clinical Immunology, 94, 427-438.
11. Bousquet, J., Chanez, P., Lacoste, J.Y., Barneon, G., Gavanian, N., Enander, I., Venge, P., Ahlstedt, S., Simony-Lafontaine, J., Godard, P. & Michel, F-P. (1990) Eosinophilic inflammation in asthma. New England Journal of Medicine, 323, 1033-1035.
12. Briskin, M.J., McEvoy, L.M. & Butcher, E.C. (1993) MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgAl. Nature, 331, 461-464.
13. Carlos, T.M. & Harlan, J.M. (1994) Leukocyte-endothelial adhesion molecules. Blood, 84, 2068-2101.
14. Chan, B.M.C., Elices, M.J., Murphy, E. & Hemler, M.E. (1992) Adhesion to vascular cell adhesion molecule 1 and fibronectin: comparison of α4β1 (VLA-4) and α4β7 on the human cell line JY. Journal of Biological Chemistry, 267, 8366-8370.
15. Cox, C., Ohtoshi, T., Vancheri, C., Denburg, J.A., Dolovich, J., Gauldie, J. & Jordana, M. (1991) Promotion of eosinophil survival by human bronchial epithelial cells and its modulation by steroids. American Journal of Respiratory Cell Molecular Biology, 4, 525-531.
16. Dent, L.A., Strath, M., Mellor, A.L. & Sanderson, C.J. (1990) Eosinophilia in transgenic mice expressing interleukin-5. Journal of Experimental Medicine, 172, 1425-1431.
17. Desremaux, P., Janin, A., Colombel, J.F., Prin, L., Plumas, J., Emilie, D., Torpier, D.G., Capron, A. & Capron, M. (1992) Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease. Journal of Experimental Medicine, 175, 293-296.
18. 2 in response to physiologic soluble stimuli is differentially modulated by extracellular matrix components and endothelial cells. Journal of Immunology, 147, 613-620.
19. Druilhe, A., Cai, Z., Haile, S., Chouaib, S. & Pretolani, M. (1996) Fas-mediated apoptosis in cultured human eosinophils. Blood, 87, 2822-2830.
20. Erle, D.J., Briskin, M.J., Butcher, E.C., Garcia-Pardo, A., Lazarovits, A.I. & Tidswell, M. (1994) Expression and function of the MAdCAM-1 receptor α4β7 on human leukocytes. Journal of Immunology, 153, 517-528.
21. Evans, R. (1993) Epidemiology and natural history of asthma, allergic rhinitis and atopic dermatitis. Allergy: Principles and Practice, 4th edn (ed. by E. Middleton, Jr. C. E. Reed, E. F. Ellis, N. F. Adkinson, Jr. J. W. Yunginger and W. W. Busse), pp. 1109-1136. Mosby, St Louis.
22. Foster, P.S., Hogan, S.P., Ramsay, A.J., Matthaei, K.I. & Young, I.G. (1996) Interleukin-5 deficiency abolishes eosinophilia, airway hyperreactivity and lung damage in a mouse asthma model. Journal of Experimental Medicine, 183, 195-201.
23. Frigas, E., Loegering, D.A., Solley, G., Farrow, G. & Gleich, G.J. (1981) Elevated levels of the eosinophil major basic protein in the sputum of patients with bronchial asthma. Mayo Clinic Proceedings, 56, 345-353.
24. Fukuda, T., Fukushima, Y., Numao, T., Ando, N., Arima, M., Nakajima, H., Sagara, H., Adachi, T., Motojima, S. & Makino, S. (1996) Role of interleukin-4 and vascular cell adhesion molecule-1 in selective eosinophil migration into the airways in allergic asthma. American Journal of Respiratory Cell Molecular Biology, 14, 84-94.
25. Georas, S.N., McIntyre, B.W., Ebisawa, M., Bednarczyk, J.L., Sterbinsky, S.A., Schleimer, R.P. & Bochner, B.S. (1993) Expression of a functional laminin receptor (α6β1, very late activation antigen-6) on human eosinophils. Blood, 82, 2872-2879.
26. Gleich, G.J. (1990) The eosinophil and bronchial asthma: current understanding. Journal of Allergy and Clinical Immunology, 85, 422-436.
27. Gleich, G.J. (1993) The biology of the eosinophilic leukocyte. Annual Review of Medicine, 44, 85-101.
28. Hartnell, A., Moqbel, R., Walsh, G.M., Bradley, B. & Kay, A.B. (1990) Fc-γ and CD11/18 receptor expression on normal density and low density human eosinophils. Immunology, 69, 264-270.
29. Hartnell, A., Robinson, D.S., Kay, A.B. & Warlaw, A.J. (1993) CD69 is expressed hy human eosinophils activated in vivo in asthma and in vitro by cytokines. Immunology, 80, 281-286.
30. Her, E., Frazer, J., Austen, K.F. & Owen, W.F. (1991) Eosinophil hematopoietins antagonize the programmed cell death of eosinophils. Journal of Clinical Investigation, 88, 1982-1987.
31. Horie, S. & Kita, H. (1994) CD11b/CD18 (Mac-1) is required for degranulation of human eosinophils induced by human recombinant granulocyte-macrophage colony stimulating factor and platelet activating factor. Journal of Immunology, 152, 5457-5467.
32. Hossain, M., Okubo, Y. & Sekiguchi, M. (1994) Effects of various drugs (staurosporin, herbimycin A, ketotifen, theophyline. FK506 and cyclosporin A) on eosinophil viability. Japanese Journal of Allergology, 43, 711-717.
33. Humbert, M., Durham, S.R., Ying, S., Kimmit, P., Barkans, J., Assoufi, B., Pfister, R., Menx, G., Robinson, D.S., Kay, A.B. & Corrigan, C.J. (1996) IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and non-atopic asthma: evidence against intrinsic asthma being a distinct immunopathologic entity. American Journal of Respiratory Critical Care Medicine, 154, 1497-1504.
34. Hynes, R.O. (1992) Integrins: versatility, modulation and signaling in cell adhesion. Cell, 69, 11-25.
35. Jahnsen, F.L., Haraldsen, G., Aanesen, J.P., Haye, R. & Brandtzaeg, P. (1995) Eosinophil infiltration is related to increased expression of vascular cell adhesion molecule-1 in nasal polyps. American Journal of Respiratory Cell Molecular Biology, 12, 624-632.
36. Kaneko, M., Horie, S., Kato, M., Gleich, G.J. & Kita, H. (1995) A crucial role for β2 integrin in the activation of eosinophils stimulated by IgG. Journal of Immunology, 155, 2631-2641.
37. Kawabori, S., Soda, K., Perdue, M.H. & Bienenstock, J. (1991) The dynamics of intestinal eosinophil depletion in rats treated with doxamethasone. Laboratory Investigation, 64, 224-233.
38. Kita, H. & Gleich, G.J. (1996) Chemokines active on eosinophils: potential roles in allergic inflammation. Journal of Experimental Medicine, 183, 2421-2426.
39. Kita, H., Horie, S. & Gleich, G.J. (1996) Extracellular matrix proteins attenuate activation and degranulation of stimulated eosinophils. Journal of Immunology, 156, 1174-1181.
40. Kuijpers, T.W., Mul, E.P.J., Blom, M., Kovach, N.L., Gaeta, C.A., Tollefson, V., Elices, M.J. & Harlan, J.M. (1993) Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration. Journal of Experimental Medicine, 178, 279-284.
41. Kyan-Aung, U., Haskard, D.O., Poston, R.N., Thornhill, M.H. & Lee, T.H. (1991) Endothelial leukocyte adhesion molecule-1 and intercellular adhesion molecule-1 mediate adhesion of eosinophils to endothelial cells in vitro and are expressed by endothelium in allergic cutaneous inflammation in vivo. Journal of Immunology, 146, 521-528.
42. Laudanna, C., Melotti, P., Bonizzato, C., Piacentini, G., Boner, A., Serra, M.C. & Berton, G. (1993) Ligation of the members of the β1 or β2 subfamilies of integrins by antibodies triggers eosinophil respiratory burst and spreading. Immunology, 80, 273-280.
43. Matsumoto, K., Schleimer, R.P., Saito, H., Iikura, Y. & Bochner, B.S. (1995) Induction of apoptosis in human eosinophils by anti-Fas antibody treatment in vitro. Blood, 86, 1437-1443.
44. Mauser, P.J., Pitman, A.M., Fernandez, X., Foran, S.K., Adams, G.K., Kreutner, W., Egan, R.W. & Chapman, R.W. (1995) Effects of an antibody to interleukin-5 in a monkey model of asthma. American Journal of Critical Care Medicine, 153, 467-472.
45. Meagher, L.C., Cousin, J.M., Seckl, J.R. & Haslett, C. (1996) Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. Journal of Immunology, 156, 4422-4428.
46. Metzger, W.J., Rider, V., Tollefson, V., Arrheius, T., Gaeta, F.C.A. & Elices, M. (1994) Anti-VLA-1 antibody and CS-1 peptide inhibitor modify airway inflammation and bronchial airway hyperresponsiveness (BHR) in the allergic rabbit. (Abstract). Journal of Allergy and Clinical Immunology, 93, 183.
47. Moqbel, R., Nevi-Schaffer, F. & Kay, A.B. (1994) Cytokine generation by eosinophils. Journal of Allergy and Clinical Immunology, 94, 1183-1188.
48. Moser, R., Fehr, J. & Bruijnzeel, P.B. (1992) IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals. Journal of Immunology, 149, 1432-1438.
49. Motojima, S., Frigas, E., Loegering, D.A. & Gleich, G.J. (1989) Toxicity of eosinophil cationic protein for guinea pig tracheal epithelium. American Review of Respiratory Disease, 139, 801-805.
50. Mould, A.P., Wheldon, A., Komoriya, E., Wayner, H.A., Yamada, K.M. & Humphries, M.J. (1990) Affinity chromatic isolation of the melanoma adhesion receptor for the HICS region of fibronectin and its identification as the integrin α4β1. Journal of Biological Chemistry, 265, 4020-4024.
51. Nagata, M., Sedgwick, J.B., Bates, M.E., Kita, H. & Busse, W.W. (1995) Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide generation. Journal of Immunology, 155, 2194-2202.
52. Nagata, S. & Goldstein, P. (1995) The Fas death factor. Science, 267, 1449-1455.
53. Nakajima, H., Sano, H., Nishimura, T., Yoshida, S. & Iwamoto, I. (1994) Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/ lymphocyte function-associated antigen 1 interactions in antigen induced eosinophil and T cell recruitment into the tissue. Journal of Experimental Medicine, 179, 1145-1154
54. Neeley, S., Hamann, K.J., Dowling, T.L., McAllister, K.T., White, S.R. & Leff, A.R. (1994) Augmentation of stimulated eosinophil degranulation by VLA-4 (CD49d)-mediated adhesion to fibronectin. American Journal of Respiratory Cell Molecular Biology, 11, 206-213.
55. Nishikawa, K., Morii, T., Ako, H., Hamada, K., Saito, S. & Narita, N. (1992) In vivo expression of CD69 on lung eosinophils in eosinophilic pneumonia: CD69 as a possible activation marker for eosinophils. Journal of Allergy and Clinical Immunology, 90, 169-174.
56. Ohkawara, Y., Yamauchi, K., Maruyama, N., Hoshi, H., Ohno, I., Honma, M., Tanno, Y., Tamura, G., Shirato, K. & Ohtani, H. (1995) In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with airflow limitation: in vivo evidence of VCAM-1/VLA-4 interaction in selective eosinophil infiltration. American Journal of Respiratory Cell Molecular Biology, 12, 4-12.
57. Ohnishi, T., Kita, H., Weiler, D., Sur, S., Sedgwick, J.B., Calhoun, W.J., Busse, W.W., Abrahams, J.S. & Gleich, G.J. (1993) IL-5 is the predominant eosinophil-active cytokine in the antigen-induced pulmonary late-phase reaction. American Review of Respiratory Disease, 147, 901-907.
58. Oppenheim, J.J., Zachariae, C.O., Mukaida, N. & Matsushima, K. (1991) Properties of the novel proinflammatory supergene intercrine cytokine family. Annual Review of Immunology, 9, 617-648.
59. Owen, W.F., Rothenburg, M.E., Silberstein, D.S., Gasson, J.C., Stevens, R.L., Austin, K.F. & Soberman, R.J. (1987) Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony stimulating factor in the presence of 3T5 fibroblasts. Journal of Experimental Medicine, 166, 129-141.
60. Postigo, A.A., Sanchez-Mateos, P., Lazarovits, A.I., Sanchez-Madrid, F. & de Landazuri, M.O. (1993) α4β7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Journal of Immunology, 151, 2471-2483.
61. Pretolani, M., Ruffie, C., Lopa e Silva, J.M., Lobb, R. & Vargaftig, B.B. (1994) Antibody to very late activation antigen 4 prevents antigen-induced bronchial hyperreactivity and cellular infiltration in the guinea pig airway. Journal of Experimental Medicine, 180, 795-805.
62. Richards, I.M., Kolbasa, K.P., Hatfield, C.A., Winterrowd, G.E., Vonderfecht, S.L., Fidler, S.F., Griffin, R.L., Brashler, J.R., Staite, N.D. & En Chin, J. (1996) Role of very late activation antigen-4 in the antigen-induced accumulation of eosinophils and lymphocytes in the lungs and airway lumen of sensitised brown Norway rats. American Journal of Respiratory Cell Molecular Biology, 15, 172-183.
63. Rothenberg, M.E., Owen, W.F., Silberstein, D.S., Woods, J., Soberman, R.J., Austen, K.F. & Stevens, R.L. (1988) Human eosinophils have prolonged survival, enhanced functional properties and become hypodense when exposed to human interleukin 3. Journal of Clinical Investigation, 81, 1986-1992.
64. Rothenberg, M.E., Petersen, J., Stevens, R.L., Silberstein, D.S., McKenzie, D.T., Austin, K.F. & Owen, W.F. (1989) IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype used 3T3 fibroblasts for enhanced viability, accelerated hypodensity and sustained antibody-dependent cytotoxicity. Journal of Immunology, 145, 2311-2316.
65. Ruegg, C., Postigo, A.A., Sikorski, E.E., Butcher, E.C., Pytela, R. & Erle, D.J. (1992) Role of α4β7/α4βp in lymphocyte adherence to fibronectin and VCAM-I in homotypic cell clustering. Journal of Cell Biology, 117, 179-189.
66. Sanderson, C.J. (1992) Interleukin-5, eosinophils and disease. Blood 79, 3101-3109.
67. Schleimer, R.P. (1990) Effects of glucocorticoids on inflammalory cells relevant to their therapeutic applications in asthma. American Review of Respiratory Diseases, 141, S59-S69.
68. Schubert, D. (1992) Collaborative interactions between growth factors and the extracellular matrix. Trends in Cell Biology, 2, 63.
69. Springer, T.A. (1990) Adhesion receptors of the immune system. Nature, 346, 425-434.
70. Spry, C.J.F. (1993) The natural history of eosinophils. The Immunopharmacology of Eosinophils (ed. by H. Smith and R. M. Cook), pp. 1-9. Academic Press, London.
71. Sriramarao, P., von Andrian, U.H., Butcher, E.C., Bourdon, M.A. & Broide, D.H. (1994) L-selectin and very late antigen-4 promote eosinophil rolling at physiological shear rates in vivo. Journal of Immunology, 153, 4238-4246.
72. Stern, M., Meagher, H., Savill, J. & Haslett, C. (1992) Apoptosis in human eosinophils: programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5. Journal of Immunology, 148, 3543-3549.
73. Stern, M., Savill, J. & Haslett, C. (1996) Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis. American Journal of Pathology, 149, 911-921.
74. Symon, F.A., Walsh, G.M., Watson, S. & Wardlaw, A.J. (1994). Eosinophil adhesion to nasal polyp endothelium is P-selectin dependent. Journal of Experimental Medicine, 180, 371-376.
75. Symon, F.A., Lawrence, M.B., Wiliamson, M.L., Walsh, G.M., Watson, S.R. & Wardlaw, A.J. (1996) Functional and structural characterisation of the eosinophil P-selectin ligand. Journal of Immunology, 157, 1711-1719.
76. Takafuji, S., Ohtoshi, T., Takizawa, H., Tadokoro, K. & Ito, K. (1996) Eosinophil degranulation in the presence of epithelial cells: effect of cytokines and role of adhesion. Journal of Immunology, 156, 3980-3985.
77. 2+ mobilisation, actin reorganisation and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein. Blood, 88, 3195-3199.
78. Testi, R., D'Ambrosio, D., De Maria, R. & Santoni, A. (1994) The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunology Today, 15, 479-483.
79. Thornhill, M.H., Kyan-Aung, U. & Haskard, D.O. (1990) IL-4 increases human endothelial cell adhesiveness for T cells but not neutrophils. Journal of Immunology, 144, 3060.
80. Tourkin, A., Anderson, T., LeRoy, E.C. & Hoffman, S. (1993) Eosinophil adhesion and maturation is modulated by laminin. Cell Adhesion Communications, 1, 161-176.
81. Tsuyuki, S., Bertrand, C., Erard, F., Trifilieff, A., Tsuyuki, J., Wesp, M., Andersen, G.P. & Coyle, A.J. (1995) Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways. Journal of Clinical Investigation, 96, 2924-2931.
82. Van Oosterhout, A.J., Ladenius, A.R., Savelkoul, H.L., Van Ark, I., Delsman, K.C. & Nijkamp, F.P. (1993) Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs. American Review of Respiratory Diseases, 147, 548-552.
83. Walker, C., Rihs, S., Braun, R.K., Betz, S. & Bruijnzeel, P.J. (1993) Increased expression of CD11b and functional changes in eosinophils after migration across endothelial cell monolayers. Journal of Immunology, 150, 4061-4071.
84. Walsh, G.M. (1997) Mechanisms of human eosinophil survival and apoptosis. Clinical and Experimental Allergy, (in press).
85. Walsh, G.M., Hartnell, A., Mermod, J-J., Kay, A.B. & Wardlaw, A.J. (1991) Human eosinophil but not neutrophil adherence to IL-1 stimulated HUVEC is α4β1 dependent. Journal of Immunology, 146, 3419-3423.
86. Walsh, G.M., Hartnell, A., Wardlaw, A.J., Kuirhara, K., Sanderson, C.J. & Kay, A.B. (1990) IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leukocyte integrin (CD11/18-dependent manner. Immunology, 71, 258-265.
87. Walsh, G.M., Symon, F.A., Lazarovits, A.I. & Wardlaw, A.J. (1996a) Integrin α4β7 mediates human eosinophil interaction with MAdCAM-1, VCAM-1 and fibronectin. Immunology, 89, 112-119.
88. Walsh, G.M., Symon, F.A. & Wardlaw, A.J. (1995) Human eosinophils preferentially survive on tissue fibronectin compared with plasma fibronectin. Clinical and Experimental Allergy, 25, 1128-1136.
89. Walsh, G.M. & Wardlaw, A.J. (1997) Dexamethasone inhibits prolonged survival and autocrine GM-CSF production by human eosinophils cultured on laminin or tissue fibronectin. Journal of Allergy and Clinical Immunology, (in press).
90. Walsh, G.M., Wardlaw, A.J. & Kay, A.B. (1993) Mechanisms of eosinophil adhesion, migration and activation. Immunopharmacology of Eosinophils (ed. by H. Smith), Chap. 6, pp. 75-89. Academic Press, London.
91. Walsh, G.M., Williamson, M.L., Symon, F.A., Wilars, G.B. & Wardlaw, A.J. (1996b) Ligation of CD69 induces apoptosis and cell death in human eosinophils cultured with GM-CSF. Blood, 87, 2815-2821.
92. Wardlaw, A.J. & Kay, A.B. (1987) The eosinophil in the pathogenesis of asthma. Allergy, 42, 321-335.
93. Wardlaw, A.J., Walsh, G.M. & Symon, F.A. (1994) Mechanisms of eosinophil and basophil migration. Allergy, 49, 797-807.
94. Weg, V.B., Williams, T.J., Lobb, R.R. & Nourshargh, S. (1993) A monoclonal antibody recognizing very late antigen-4 inhibits eosinophil accumulation in vivo. Journal of Experimental Medicine, 177, 561-566.
95. Wegner, C.D., Gundel, R.H., Reilly, J., Haynes, N., Letts, G.L. & Rothlein, R. (1990) Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma. Science, 247, 456-458.
96. Weller, P.F. (1993) Eicosanoids, cytokines and other mediators elaborated by eosinophils. Eosinophils: Biological and Clinical Aspects (ed. by S. Makino and T. Fukuda), pp. 125-154. CRC Press, Boca Raton, Florida.
97. Weller, P.F. (1994) Eosinophils: structure and functions. Current Opinion in Immunology, 6, 85-90.
98. Wooley, K.L., Gibson, P.G., Carty, K., Wilson, A.J., Twaddell, S.H. & Wooley, M.J. (1996) Eosinophil apoptosis and the resolution of airway inflammation in asthma. American Journal of Respiratory Critical Care Medicine, 154, 237-243.
99. Yousefi, S., Green, D.R., Blaser, K. & Simon, H-U. (1994) Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proceedings of the National Academy of Sciences of the United States of America, 91, 10868-10872.