Effects of phosphodiesterase inhibitors and salbutamol on microvascular leakage in guinea-pig trachea

European Journal of Pharmacology

Volumn 344, Issue 1, 1998, Pages 59-66

  Planquois, Jean Michel ^a   Mottin, Geneviève ^a   Artola, Myriam ^a   Vincent Lagente, ^b   Payne, Adrian ^a   Dahl, Svein ^a  

^a Institut de Recherche Jouveinal   (France)

^b INSERM   (France)

Author keywords

2 adrenoceptor agonist; Guinea pig; Microvascular leakage; Phosphodiesterase inhibitor; Trachea

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; HISTAMINE; MILRINONE; OVALBUMIN; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; SALBUTAMOL; SUBSTANCE P; THEOPHYLLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; DRUG EFFECT; DRUG POTENTIATION; EXTRAVASATION; GUINEA PIG; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TRACHEA;

4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE; ADRENERGIC BETA-AGONISTS; ALBUTEROL; ANIMALS; CAPILLARY PERMEABILITY; GUINEA PIGS; HISTAMINE; MALE; OVALBUMIN; PHOSPHODIESTERASE INHIBITORS; SUBSTANCE P; THEOPHYLLINE; TRACHEA;

EID: 0032567981     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01536-7     Document Type: Article

References (42)

1. Advenier C., Qian Y., Law Koune J.D., Molimard M., Candenas M.L., Naline E. Formoterol and salbutamol inhibit bradykinin- and histamine-induced airway microvascular leakage in guinea-pig. Br. J. Pharmacol. 105:1992;792-798.
2. Barnes P.J., Boschetto P., Rogers D.F., Belvisi M., Roberts N., Chung K.F., Evans T.W. Effects of treatment on airway microvascular leakage. Eur. Respir. J. 3 (Suppl. 12):1990;663s-670s.
3. Beavo J.A., Conti M., Heaslip R.J. Multiple cyclic nucleotide phosphodiseterases. Mol. Pharmacol. 46:1994;399-405.
4. Bertrand C., Geppetti P., Graf P.D., Foresi A., Nadel J.D. Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea-pigs. Am. J. Physiol. 265:1993;L507-L511.
5. Boschetto P., Roberts N.M., Rogers D.F., Barnes P.J. Effects of anti-asthma drugs on microvascular leakage in guinea-pig airways. Am. Rev. Respir. Dis. 139:1989;416-421.
6. Coleman R.A., Knowles I.D., Ball D.I., Nials A.T. A comparison of the relaxant activity of phosphodiesterase inhibitors on human bronchus, ferret trachea and guinea-pig trachea and bronchus. Am. J. Respir. Crit. Care Med. 151:1995;A289. (Absract).
7. Djukanovic R., Roche W.R., Wilson J.W., Beasley C.R.W., Twentyman O.P., Howarth P.H., Holgate S.T. Mucosal inflammation in asthma. Am. Rev. Respir. Dis. 142:1990;434-457.
8. Erjefält I., Persson C.G.A. Pharmacologic control of plasma exudation into tracheaobronchial airways. Am. Rev. Respir. Dis. 143:1991;1008-1014.
9. Erjefält I., G-Wagner Z., Strand S.E., Persson C.G.A. A method for studies of tracheobronchial microvascular permeability to macromolecules. J. Pharmacol. Methods. 14:1985;275-284.
10. Erjefält I., Greiff L., Alkner U., Persson C.G.A. Allergen-induced biphasic plasma exudation responses in guinea pig large airways. Am. Rev. Respir. Dis. 148:1993;695-701.
11. Fullerton D.A., Hahn A.R., Banerjee A., Harken A.H. Pulmonary vascular smooth muscle relaxation by cGMP- versus cAMP-mediated mechanisms. J. Surg. Res. 57:1994;259-263.
12. Gray D.W., Marshall I. Novel signal transduction pathway mediating endothelium-dependent β-adrenoceptor vasorelaxation in rat thoracic aorta. Br. J. Pharmacol. 107:1992;684-690.
13. Heaslip R.J., Buckley S.K., Sickels B.D., Grimes D. Bronchial versus cardiovascular activities of selective phosphodiesterase inhibitors in the anaesthetized beta-blocked dog. J. Pharmacol. Exp. Ther. 257:1991;741-747.
14. Howell R.E., Sickels B.D., Woeppel S.L. Pulmonary antiallergic and bronchodilator effects of isoenzyme-selective phosphodiesterase inhibitors in guinea-pigs. J. Pharmacol. Exp. Ther. 264:1992;609-615.
15. Howell R.E., Jenkins L.P., Howell D.E. Inhibition of lipopolysaccharide-induced pulmonary edema by isozyme-selective phosphodiesterase inhibitors in guinea pigs. J. Pharmacol. Exp. Ther. 275:1995;703-709.
16. Hui K.P., Lötvall J., Chung K.F., Barnes P.J. Attenuation of allergen-induced airway microvascular leakage and airflow obstruction in guinea-pigs by a 5-lipoxygenase inhibitor (A-63162). Am. Rev. Respir. Dis. 143:1991;1015-1019.
17. Jang E.K., Davidson M.M.L., Crankshaw D., Haslam R.J. Synergistic inhibitory effects of atriopeptin II and isoproterenol on contraction of rat smooth muscle: Roles of cGMP and cAMP. Eur. J. Pharmacol. 250:1993;477-481.
18. Kelly L.J., Undem B.J., Adams G.K. Antigen-induced contraction of guinea-pig isolated pulmonary arteries and lung parenchyma. J. Appl. Physiol. 74:1993;1563-1569.
19. Komas N., Le Bec A., Stoclet J.C., Lugnier C. Cardiac cGMP-stimulated cyclic nucleotide phosphodiesterases: Effects of cGMP analogues and drugs. Eur. J. Pharmacol. 206:1991;5-13.
20. Lagente V., Moodley I., Perrin S., Mottin G., Junien J.-L. Effects of isoenzyme-selective phosphodiesterase inhibitors on eosinophil infiltration in the guinea-pig lung. Eur. J. Pharmacol. 255:1994;253-256.
21. Lagente V., Pruniaux M.-P., Junien J.-L., Moodley I. Modulation of cytokine-induced eosinophil infiltration in guinea-pig airways by selective phosphodiesterase inhibitors. Am. J. Respir. Crit. Care. Med. 151:1995;1720-1724.
22. Lincoln T.M., Cornwell T.L. Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth muscle relaxation. Blood Vessels. 28:1991;129-256.
23. Lugnier C., Komas N. Modulation of vascular cyclic nucleotide phosphodiesterases by cyclic GMP: Role in vasodilatation. Eur. Heart J. 14:1993;141-148.
24. Lugnier C., Schini V.B. Characterization of cyclic nucleotide phosphodiesterases from cultured bovine aortic endothelial cells. Biochem. Pharmacol. 39:1990;75-84.
25. Maurice D.H., Haslam R.J. Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: Inhibition of cyclic AMP breakdown by cyclic GMP. Mol. Pharmacol. 37:1990;671-681.
26. Maurice D.H., Crankshaw D., Haslam R.J. Synergistic actions of nitrovasodilators and isoprenaline on rat aortic smooth muscle. Eur. J. Pharmacol. 192:1991;235-242.
27. Muller B., Stoclet J.-C., Lugnier C. Cytosolic and membrane-bound cyclic nucleotide phosphodiesterases from guinea-pig cardiac ventricles. Eur. J. Pharmacol. 225:1992;263-272.
28. Nicholson C.D., Shahid M. Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes: Their potential utility in the therapy of asthma. Pulm. Pharmacol. 7:1994;1-17.
29. Ortiz J.L., Cortijo J., Vallés J.M., Bou J., Morcillo E.J. Rolipram inhibits PAF-induced airway microvascular leakage in guinea-pig: A comparison with milrinone and theophylline. Fund. Clin. Pharmacol. 6:1992;247-249.
30. Ortiz J.L., Cortijo J., Vallés J.M., Bou J., Morcillo E.J. Rolipram inhibits airway microvascular leakage induced by platelet-activating factor, histamine and bradykinin in guinea-pigs. J. Pharm. Pharmacol. 45:1992;1090-1092.
31. Person C.G.A. Role of plasma exudation in asthmatic airways. Lancet. ii:1986;1126-1128.
32. Persson C.G.A., Erjefält I., Andersson P. Leakage of macromolecules from guinea-pig tracheobronchial microcirculation. Effects of allergen, leukotrienes, tachykinins, and anti-asthma drugs. Acta Physiol. Scand. 127:1986;95-105.
33. Planquois J.-M., Ruffin-Morin Y., Lagente V., Payne A.N., Dahl S.G. Salbutamol potentiates the relaxant effects of selective phosphodiesterase inhibitors on guinea-pig isolated trachea. Fund. Clin. Pharmacol. 10:1996;356-367.
34. Quian Y., Naline E., Karlsson J.-A., Raeburn D., Advenier C. Effect of rolipram and siguazodan on the human isolated bronchus and their interaction with isoprenaline and sodium nitroprusside. Br. J. Pharmacol. 109:1993;774-778.
35. Raeburn D., Karlsson J.A. Effects of isozyme-selective inhibitors of cyclic nucleotide phosphodiesterase on microvascular leak in guinea-pig airways in vivo. J. Pharmacol. Exp. Ther. 267:1993;1147-1152.
36. Raeburn D., Underwood S.L., Lewis S.A., Woodman V.R., Battram C.H., Tomkinson A., Sharma S., Jordan R., Souness J.E., Webber S.E., Karlsson J.A. Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor. Br. J. Pharmacol. 113:1994;1423-1431.
37. Rogers D.F., Boschetto P., Barnes P.J. Plasma exudation: Correlation between Evans blue dye and radiolabelled albumin in guinea-pig airways in vivo. J. Pharmacol. Methods. 21:1989;309-315.
38. Tomkinson A., Karlsson J.-A., Raeburn D. Comparison of the selective inhibitors of phosphodiesterase types III and IV in airway smooth muscle with different β-adrenoceptor subtypes. Br. J. Pharmacol. 108:1993;57-61.
39. Underwood D.C., Osborn R.R., Novak L.B., Matthews J.K., Newsholme S.J., Undem B.J., Hand J.M., Torphy T.J. Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram. J. Pharmacol. Exp. Ther. 266:1993;306-313.
40. Widdicombe J. The tracheobronchial vasculature: A possible role in asthma. Microcirculation. 3:1996;129-141.
41. Wright I.K., Amirchetty-Rao S., Kendal D.A. Potentiation by forskolin of both SNP- and ANP-stimulated cyclic GMP accumulation in porcine isolated palmar lateral vein. Br. J. Pharmacol. 112:1994;1146-1150.
42. Zhou H.-L., Torphy T.J. Relationship between cyclic guanosine monophosphate accumulation and relaxation of canine trachealis induced by nitrovasodilators. J. Pharmacol. Exp. Ther. 258:1991;972-978.