Aryl sulfonamides as selective PDE4 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 19, 1998, Pages 2635-2640

  Montana, John G ^a   Buckley, George M ^a   Cooper, Nicola ^a   Dyke, Hazel J ^a   Gowers, Lewis ^a   Gregory, Joanna P ^a   Hellewell, Paul G ^b   Kendall, Hannah J ^a   Lowe, Christopher ^a   Maxey, Robert ^a   Miotla, Jadwiga ^b   Naylor, Robert J ^c   Runcie, Karen A ^a   Tuladhar, Bishwa ^c   Warneck, Julie B H ^a  

^a Chiroscience Ltd   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EOSINOPHILIA; FERRET; GUINEA PIG; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; VOMITING;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; ANTI-ASTHMATIC AGENTS; EOSINOPHILIA; GUINEA PIGS; PHOSPHODIESTERASE INHIBITORS; PYRROLIDINONES; ROLIPRAM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

ANIMALIA; CAVIA PORCELLUS; MUSTELA PUTORIUS FURO; SUS SCROFA;

EID: 0032491265     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00491-0     Document Type: Article

References (20)

1. 1. Giembycz, M. A. Trends Pharmacol. Sci. 1996, 17, 331-336.
2. 2. Stafford, J.A.; Feldman, P.L. Ann. Rep. Med. Chem., 1996, 31, 71 and references therein; Hughes, B.; Owens, R.; Perry, M.; Warrellow, G.; Allen, R. Drug Discovery Today, 1997, 2, 89.
3. 2. Stafford, J.A.; Feldman, P.L. Ann. Rep. Med. Chem., 1996, 31, 71 and references therein; Hughes, B.; Owens, R.; Perry, M.; Warrellow, G.; Allen, R. Drug Discovery Today, 1997, 2, 89.
4. 3. Nicholson, C.D.; Shahid, M. Pulmon. Pharmacol. 1994, 7, 1; Palacios, J.M.; Beleta, J.; Segarra, V. Il Farmaco 1995, 50, 819; Torphy, T.J.; Murray, K.J.; Arch, J.R.S. in Drugs and the Lung; Page, C.P.; Metzger, W.J., Eds.; Raven Press: New York, 1994; pp 397-447.
5. 3. Nicholson, C.D.; Shahid, M. Pulmon. Pharmacol. 1994, 7, 1; Palacios, J.M.; Beleta, J.; Segarra, V. Il Farmaco 1995, 50, 819; Torphy, T.J.; Murray, K.J.; Arch, J.R.S. in Drugs and the Lung; Page, C.P.; Metzger, W.J., Eds.; Raven Press: New York, 1994; pp 397-447.
6. 3. Nicholson, C.D.; Shahid, M. Pulmon. Pharmacol. 1994, 7, 1; Palacios, J.M.; Beleta, J.; Segarra, V. Il Farmaco 1995, 50, 819; Torphy, T.J.; Murray, K.J.; Arch, J.R.S. in Drugs and the Lung; Page, C.P.; Metzger, W.J., Eds.; Raven Press: New York, 1994; pp 397-447.
7. 4. Demoliou-Mason, C.D. Exp. Opin. Ther. Patents 1995, 5, 417.
8. 5. Teixeira, M.M.; Gristwood, R.W.; Cooper, N.; Hellewell, P.G. TIPS 1997, 18, 164; Banner, K.H.; Page, C.P. Clin. Exp. Allergy 1996, 26(Supplement 2), 2.
9. 5. Teixeira, M.M.; Gristwood, R.W.; Cooper, N.; Hellewell, P.G. TIPS 1997, 18, 164; Banner, K.H.; Page, C.P. Clin. Exp. Allergy 1996, 26(Supplement 2), 2.
10. 6. Schwabe, U.; Miyake, M.; Ohga, Y.; Daly, J. J. Mol. Pharmacol. 1976, 900.
11. 7. Muller, T.; Engels, P.; Fozard, J.R. Trends Pharmacol. Sci. 1996, 17, 294; Kelly, J.J.; Barnes, P.J.; Giembycz, M.A. Biochem. 1996, 318, 425; Jacobitz, S.; McLaughlin, M.M.; Livi, G.P.; Burman, M.; Torphy, T.J. Mol. Pharmacol. 1996, 50, 891.
12. 7. Muller, T.; Engels, P.; Fozard, J.R. Trends Pharmacol. Sci. 1996, 17, 294; Kelly, J.J.; Barnes, P.J.; Giembycz, M.A. Biochem. 1996, 318, 425; Jacobitz, S.; McLaughlin, M.M.; Livi, G.P.; Burman, M.; Torphy, T.J. Mol. Pharmacol. 1996, 50, 891.
13. 7. Muller, T.; Engels, P.; Fozard, J.R. Trends Pharmacol. Sci. 1996, 17, 294; Kelly, J.J.; Barnes, P.J.; Giembycz, M.A. Biochem. 1996, 318, 425; Jacobitz, S.; McLaughlin, M.M.; Livi, G.P.; Burman, M.; Torphy, T.J. Mol. Pharmacol. 1996, 50, 891.
14. 8. Duplantier, A.J.; Biggers, M.S.; Chambers, R.J.; Cheng, J.B.; Cooper, K.; Damon, D.B.; Eggler, J.F.; Kraus, K.G.; Marfat, A.; Masamune, H.; Pillar, J.S.; Shirley, J.T.; Umland, J.P.; Watson, J.W. J. Med. Chem. 1996, 39, 120.
15. 9. Thompson, W.J.; Terasaki, W.L.; Epstein, P.M.; Strada, S. J. Adv. Cyc. Nuc. Res. 1979, 10, 69.
16. 10. Schneider, H.H.; Schmeichen, R.; Brezinski, M.; Seidler, J. Eur. J. Pharmacol. 1997, 127, 105.
17. 11. Ames, D.E.; Dodds, W.D. J. Chem. Soc., Perkin Trans, 1, 1972, 705.
18. 12. Teixeira, M.M.; Reynia, S.; Robinson, M.; Shock, A.; Williams, T.J.; Williams, F.M.; Rossi, A.G.; Hellewell, P.G. Br. J. Pharmacol. 1994, 111, 811; Teixeira, M.M.; Williams, T.J.; Hellewell, P.G.; Br. J. Pharmacol. 1993, 110, 416.
19. 12. Teixeira, M.M.; Reynia, S.; Robinson, M.; Shock, A.; Williams, T.J.; Williams, F.M.; Rossi, A.G.; Hellewell, P.G. Br. J. Pharmacol. 1994, 111, 811; Teixeira, M.M.; Williams, T.J.; Hellewell, P.G.; Br. J. Pharmacol. 1993, 110, 416.
20. 13. Costall, B.; Domeney, A.M.; Naylor, R.J.; Tattersall, F.D. Neuropharmacology 1987, 26, 1321.