Hyperpermeability of pulmonary endothelial monolayer: Protective role of phosphodiesterase isoenzymes 3 and 4

Lung

Volumn 174, Issue 3, 1996, Pages 181-194

  Suttorp, N ^a   Ehreiser, P ^a   Hippenstiel, S ^a   Fuhrmann, M ^a   Krull M ^a   Tenor, H ^b   Schudt, C ^c  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c ALTANA PHARMA AG   (Germany)

Author keywords

Adult respiratory distress syndrome; Endothelial permeability; Escherichia coli hemolysin; Human endothelial cells; Phosphodiesterases; Rolipram; Thrombin

Indexed keywords

PHOSPHODIESTERASE;

ANIMAL CELL; ARTICLE; BLOOD VESSEL PERMEABILITY; ENZYME ACTIVITY; LUNG BLOOD FLOW; LUNG EDEMA; NONHUMAN; PRIORITY JOURNAL; SWINE; VASCULAR ENDOTHELIUM;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADENYLATE CYCLASE; ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ESCHERICHIA COLI PROTEINS; HEMOLYSIN PROTEINS; HUMANS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PULMONARY ARTERY; SWINE; THROMBIN; UMBILICAL VEINS;

EID: 0029979610     PISSN: 03412040     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Barnard JW, Seibert AF, Prasad VR, Smart DA, Strada SJ, Taylor AE, Thompson WJ (1994) Reversal of pulmonary capillary ischemia-reperfusion injury by rolipram, a cAMP phosphodiesterase inhibitor. J Appl Physiol 77:774-781
2. Barnes PJ (1944) Cyclic nucleotides and phosphodiesterase inhibitors. In: Keller A, Tenor H, Schudt C (eds) Phosphodiesterases. Schnetztor-Verlag, Konstanz, pp 10-18
3. Beavo JA, Conti M, Heaslip J (1994) Multiple cyclic nucleotide phosphodiesterases. Mol Pharmacol 46:399-405
4. Beutin L (1991) The different hemolysins of Escherichia coli. Med Microbiol Immunol 180:167-174
5. Bhakdi S, Greulich S, Muhly M. Eberspächer B, Becker H, Thiele A, Hugo F (1989) Potent leukocidal action of E. coli hemolysin mediated by permeabilization of target cell membranes. J Exp Med 169: 737-754
6. Bhakdi S, Martin E (1991) Superoxide generation by human neutrophils induced by low doses of E. coli hemolysin. Infect Immun 59:2955-2962
7. Bhakdi S, Muhly M, Korom S, Schmidt G (1990) Effects of E. coli hemolysin on human monocytes: cytocidal action and stimulation of interleukin 1 release. J Clin Invest 85:1746-1753
8. Dent G, Magnussen H, Rabe KF (1994) Cyclic nucleotide phosphodiesterases in human lung. Lung 172:129-146
9. Devenish J, Rosendal S, Johnson R, Hubler S (1989) Immunological comparison of 104-kilodalton proteins associated with hemolysis and cytolysis in Actinobacillus pleuropneumonia, Actinobacillus suis, Pasteurella haemolytica, and Escherichia coli. Infect Immun 57:3210-3214
10. Dunn OJ, Clark VA (1974) Applied Statistics: Analysis of Variance and Regression. John Wiley and Sons, New York
11. Grimminger F, Sibelius U, Bhakdi S, Suttorp N, Seeger W (1991) Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils. J Clin Invest 88:1531-1539
12. Jaffe EA, Nachman RL, Becker CG, Minick CR (1973) Culture of human endothelial cells derived from umbilical veins: identification by morphologic and immunologic criteria. J Clin Invest 52:2745-2756
13. Kolodney M, Wysolmerski R (1992) Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study. J Cell Biol 117:73-82
14. Koronakis V, Cross M, Senior B, Koronakis E, Hughes C (1987) The secreted hemolysins of Proteus mirabilis, Proteus vulgaris, and Morganella morganii are genetically related to each other and to the α-hemolysin of Escherichia coli. J Bacteriol 169:1509-1515
15. Lugnier C, Schini VB (1990) Characterization of cyclic nucleotide phosphodiesterases from cultured bovine aortic endothelial cells. Biochem Pharmacol 39:75-84
16. 2+, and inositol polyphosphates. Am J Physiol 253:L219-L225
17. Moy AB, Shasby SS, Scott BD, Shasby DM (1993) The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells. J Clin Invest 92:1198-1206
18. Persson CGA (1994) Airway epithelium and microcirculation. Eur Respir Rev 4:352-362
19. Podzuweit T, Müller A, Opie LH (1993) Antiarrhythmic effects of selective inhibition of myocardial phosphodiesterase II. Lancet 341:760
20. Prop G, Borbe HO, Hilboll G (1986) Motapizone. Drugs of the Future 11:24-25
21. Schnittler H, Wilke A, Gress T, Suttorp N, Drenckhahn D (1990) Role of endothelial actin and myosin in the control of paracellular permeability. J Physiol (Lond) 431:379-401
22. Schudt C, Winder S, Müller B, Ukena D (1991) Zardaverine as a selective inhibitor of phosphodiesterase isoenzymes. Biochem Pharmacol 42:153-162
23. Seeger W, Hansen T, Rössing R, Schmehl T, Schütte H, Krämer HJ, Walmrath D, Weissmann N, Grimminger F, Suttorp N (1995) Hydrogen peroxide-induced increase in lung endothelial and epithelial permeability: effect of adenylate cyclase stimulation and phosphodiesterase inhibition. Microvasc Res 50:1-17
24. Seeger W, Walter H, Suttorp N, Muhly M, Bhakdi S (1989) Thromboxane-mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs. J Clin Invest 84:220-227
25. Shasby DM, Yorek M, Shasby SS (1988) Exogenous oxidants initiate hydrolysis of endothelial cell inositol phospholipids. Blood 72:491-499
26. Souness JE, Diocee BK, Martin W, Moodie SA (1990) Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Biochem J 266:127-132
27. Stelzner TJ, Weil JV, O'Brien RF (1989) Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties. J Cell Physiol 139:157-166
28. Suttorp N, Flöer B, Schnittler H, Seeger W, Bhakdi S (1990) Effect of E. coli hemolysin on endothelial cell function. Infect Immun 58:3796-3801
29. Sultorp N, Fuhrmann M, Tannert-Otto S, Grimminger F, Bhakdi S (1993) Pore-forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells. J Exp Med 178:337-341
30. Suttorp N, Galanos C, Neuhof H (1987) Endotoxin alters arachidonate metabolism in endothelial cells. Am J Physiol 253:C384-C390
31. 2+ in polymorphonuclear leukocytes. Infect Immun 56:2228-2234
32. Suttorp N, Hessz T, Seeger W, Wilke A, Lutz F, Drenckhahn D (1988) Bacterial exotoxins and endothelial permeability for water and albumin. Am J Physiol 255:C369-C376
33. Suttorp N, Hippenstiel S, Fuhrmann M, Krüll M, Podzuweit T (1996) Reduction of endothelial monolayer hyperpermeability by cGMP-dependent mechanisms: special role of nitric oxide and phosphodiesterase isoenzyme II. Am J Physiol (Cell), 270: in press
34. Suttorp N, Policy M, Seybold J, Schnittler H, Seeger W, Grimminger F, Aktories K (1991) ADP-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro. J Clin Invest 87:1575-1584
35. 2 production in endothelial cells: role of calcium. Am J Physiol 248:C127-C134
36. 2 formation in cultured endothelial cells. Am J Physiol 253:C13-C22
37. Suttorp N, Weber U, Welsch T, Schudt C (1993) Role of phosphodiesterases in the regulation of endothelial permeability in vitro. J Clin Invest 91:1421-1428
38. Torphy TJ, Undem BJ (1991) Phosphodiesterase inhibitors: new opportunities for the treatment of asthma. Thorax 46:512-523
39. Turner MR (1992) Flows of liquid and electrical current through monolayers of cultured bovine arterial endothelium. J Physiol 449:1-20
40. Vagts D, Dienes HP, Earth PJ, Ronneberger H, Hungerer KD, Bhakdi S (1993) In vivo effects of intravascularly applied E. coli hemolysin: dissociation between induction of granulocytopenia and lethality in monkeys. Med Microbiol Immunol 182:1-12
41. Wysolmerski R, Lagunoff D (1990) Involvement of myosin light chain kinase in endothelial cell retraction. Proc Natl Acad Sci USA 87:16-20