Inhibition of bronchospasm and ozone-induced airway hyperresponsiveness in the guinea-pig by CDP840, a novel phosphodiesterase type 4 inhibitor

British Journal of Pharmacology

Volumn 118, Issue 5, 1996, Pages 1192-1200

  Holbrook, Mark ^a   Gozzard, Neil ^a   James, Tina ^a   Higgs, Gerry ^a   Hughes, Bernadette ^a  

^a UCB PHARMA   (Belgium)

Author keywords

Airway hyperresponsiveness; Bronchospasm; CDP840; Non cholinergic bronchoconstriction; Ozone; Phosphodiesterase inhibitor; Rolipram; Tachykinins; Vagal stimulation

Indexed keywords

4 [2 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 2 PHENYLETHYL]PYRIDINE; AMINOPHYLLINE; ATROPINE; CARBACHOL; HISTAMINE; OZONE; PHOSPHODIESTERASE INHIBITOR; PICLAMILAST; ROLIPRAM; SALBUTAMOL; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; GUINEA PIG; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; TRACHEA; VAGUS NERVE STIMULATION;

EID: 0030037738     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15523.x     Document Type: Article

References (27)

1. AMDUR, M.O. & MEAD, J. (1958). Mechanics of respiration in unanaesthetized guinea-pigs. Am. J. Physiol., 192, 364-368.
2. 2-adrenoceptor agonist: characterisation of pharmacological activity in vitro and in vivo. Br. J. Pharmacol., 104, 665-671.
3. BARNES, P.J. (1989). New concepts in the pathogenesis of bronchial asthma. J. Allergy Clin. Immunol., 83, 1013-1026.
4. 2-adrenoceptor agonists in asthma. Trends Pharmacol. Sci., 13, 20-23.
5. BEAVO, J.A. & REIFSNYDER, D.H. (1990). Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol. Sci., 11, 150-155.
6. CORTIJO, J., BOU, J., BELETA, J., CARDELUS, I., LIENAS, J., MORCILLO, E. & GRISTWOOD, R.W. (1993). Investigation into the role of phosphodiesterase 4 in bronchorelaxation, including studies with human bronchus. Br. J. Pharmacol., 108, 562-568.
7. GOZZARD, N., EL HASHIM, A., HERD, C.M., BLAKE, S.M., HOLBROOK, M., HUGHES, B., HIGGS, B.A. & PAGE, C.P. (1996a). Effects of the steroid budesonide and a novel phosphodiesterase type 4 inhibitor CDP840 on antigen-induced pulmonary responses in neonatally immunised rabbits. Br. J. Pharmacol., 118, 1201-1208.
8. GOZZARD, N., HERD, C.M., BLAKE, SM., HOLBROOK, M., HUGHES, B., HIGGS, G.A. & PAGE. C.P. (1996b). Effects of theophylline and rolipram on antigen-induced airway responses in neonatally immunised rabbits. Br. J. Pharmacol., 117, 1405-1412.
9. HARRIS, A.L., CONNELL, M.J., FERGUSON, E.W., WALLACE. A.M., GORDON, R.J., PAGANI, E.D. & SILVER, P.J. (1989). Role of low Km cyclic AMP phosphodiesterase inhibition in tracheal relaxation and bronchodilation in the guinea-pig. J. Pharmacol. Exp. Ther., 251, 199-206.
10. HERD, C.M., GOZZARD, N. & PAGE, C.P. (1995). Capsaicin pretreatment prevents the development of antigen-induced airway hyperresponsiveness in neonatally immunised rabbits. Eur. J. Pharmacol., 282, 111-121.
11. HOLBROOK, M., BLEASE, K. & HUGHES, B. (1995). The effect of PDE and NOS inhibitors on non-cholinergic bronchoconstriction in the anaesthetised guinea-pig, Inflamm. Res., 44, suppl. 3. S265.
12. HOLBROOK, M. & HUGHES, B. (1992). The effect of rolipram and SK&F 94120 on ozone induced bronchial hyperreactivity to inhaled histamine in guinea-pigs. Br. J. Pharmacol., 107, 254P.
13. HUGHES, B., GOZZARD, N. & HIGGS, G, (1992). Differential effects of phosphodiesterase isoenzyme inhibitors (PDEIs) in reversing induced tone in guinea-pig trachea. Br. J. Pharmacol., 105, 185P.
14. HUGHES, B., HOLBROOK, M., ALLEN, R., OWENS, R., PERRY, M., WARRELOW, G., HOWAT, D., BLOXHAM, D. & HIGGS, G. (1995). Suppression of antigen induced airway responses and bronchial hyperresponsiveness by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br. J. Pharmacol., 116, 6P.
15. HUGHES, B., HOWAT, D., LISLE, H., HOLBROOK, M., JAMES, T., GOZZARD, N., BLEASE, K., HUGHES, P., KINGABY, R., WARRELOW, G., ALEXANDER, R., HEAD, J., BOYD, E., EATON, M., PERRY, M., WALES, M., SMITH, B., OWENS, R., CATTERALL, C., LUMB, S., RUSSEL, A., ALLEN, R., MERRIMAN, M., BLOXHAM, D. & HIGGS, G. (1996). The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br. J. Pharmacol., 118, 1183-1191.
16. MURLAS, C.G., WILLIAMS, G.I., LANG, Z. & CHODIMELLA, V. (1990). Aerosolised neutral endopeptidase reverses the increased airway reactivity to substance P caused by ozone. Am. Rev. Respir. Dis., 141, A734.
17. NICHOLSON, C.D. & SHAHID, M. (1994). Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes - their potential utility in the therapy of asthma. Pulmonary Pharmacol., 7, 1-17.
18. QIAN, Y., GIRARD, V., MARTIN, C.A.E., MOLIMARD, M. & ADVENIER, C. (1994). Rolipram, but not siguazodan or zaprinast, inhibits the excitatory noncholinergic neurotransmission in guinea-pig bronchi. Eur. Respir. J., 7, 306-310.
19. QIAN, Y., NALINE, E., KARLSSON, J.-A., RAEBURN, D. & ADVENIER, C. (1993). Effects of rolipram and siguazodan on the human isolated bronchus and their interaction with isoprenaline and sodium nitroprusside. Br. J. Pharmacol., 109, 774-778.
20. RAEBURN, D., UNDERWOOD, S.L., LEWIS, S.A., WOODMAN, V.R., BATTRAM, C.H., TOMKINSON, A., SHARMA, S., JORDAN, R., SOUNESS, J.E., WEBBER, S.E. & KARLSSON, J.-A. (1994). Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type 4 inhibitor. Br. J. Pharmacol., 113, 1423-1431.
21. SCHWABE, U., MIYAKE, M., OHAJA, Y. & DALY, J.W. (1976). 4-(3-Cyclopentyloxy-4-methoxy)-2-pyrolidone (ZK 62711): A potent inhibitor of adenosine cyclic-3′ 5′-mono-phosphate phosphodiesterase in homogenates and tissue slices from rat brain. Mol. Pharmacol., 12, 900-910.
22. STRETTON, D. (1991). Non-adrenergic non-cholinergic neural control of the airways. Clin. Exp. Pharmacol. Physiol., 18, 675-684.
23. TORPHY, T.J., ZHOU, H.L., BURMAN, M. & HUANG, B.F. (1991). Role of cyclic nucleotide phosphodiesterase isozymes in intact canine trachealis. Mol. Pharmacol., 39, 376-384.
24. TURNER, C.R., ANDRESEN, C.J., SMITH, W.B & WATSON, J.W. (1994). Effects of rolipram on responses to acute and chronic antigen exposure in monkeys. Am. J. Crit. Care Med., 149, 1153-1159.
25. UNDERWOOD, D.C., KOTZER, C.J., BOCHOWICZ, S., OSBORN, R.R., LUTTMANN, M.A., HAY, D.W.P. & TORPHY, T.J. (1994). Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea-pigs. J. Pharmacol. Exp. Ther., 270, 250-259.
26. UNDERWOOD, D.C., OSBORN, R.R., NOVAK, L.B., MATHEWS, J.K., NEWSHOLME, S.J., UNDEM. B.J., HAND, J.M. & TORPHY, T.J. (1993). Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea-pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram. J. Pharmacol. Exp. Ther., 266, 306-313.
27. YEADON, M., WILKINSON, D., DARLEY-USMAR. V., O'LEARY, V.J. & PAYNE, A.N. (1992). Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs. Pulm. Pharmacol., 5, 39-50.