Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by the type 4 phosphodiesterase (PDE-4) inhibitor, denbufylline

British Journal of Pharmacology

Volumn 119, Issue 3, 1996, Pages 463-470

  Hadley, A J ^a   Kumari, M ^a,c   Cover, P O ^a   Osborne, J ^b   Poyser, R ^b   Flack, J D ^b,d   Buckingham, J C ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d Zenyth Therapeutics Limited Australia   (Australia)

Author keywords

ACTH; Denbufylline; HPA axis; Signal transduction; Type 4 phosphodiesterase

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP; DENBUFYLLINE; FORSKOLIN; PHOSPHODIESTERASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG MECHANISM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0029841172     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15695.x     Document Type: Article

References (51)

1. AGUILERA, G., HARWOOD, J.P., WILSON, J.X., MORELL, J., BROWN, J.H. & CATT, K.J. (1983). Mechanisms of action of corticotropin-releasing factor and other regulators of corticotropin release in rat pituitary cells. J. Biol. Chem., 258, 8039-8045.
2. AL-DUJAILI, E.A.S., WILLIAMS, B.C. & EDWARDS, C.R.,W. (1981). The development and application of a direct radioimmunoassay for corticosterone. Steroids, 37, 157-176.
3. ANAND-SRIVASTAVA, M.B., CONTIN, M. & GUTKOWSKA, J. (1989). Adenosine regulates the release of adrenocorticotrophic hormone (ACTH) from cultured pituitary cells. Mol. Cell. Biochem., 89, 21-28.
4. ARIMURA, A., SAITO, T. & SCHALLY, A.V. (1967). Assays for corticotropin releasing factor (CRF) using rats treated with morphine, chlorpromazine, dexamethasone and nembutal. Endocrinology, 81, 235-245.
5. BEAVO, J.A. (1988). Multiple isozymes of cyclic nucleotide phosphodiesterase. Adv. Second Messenger Phosphorylation Res., 22, 1-30.
6. BEAVO, J.A. & REIFSNYDER, D.H. (1990). Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol. Sci., 11, 150-155.
7. BENTLEY, J.K. & BEAVO, J.A. (1992). Regulation and function of cyclic nucleotides. Curr. Opin. Cell. Biol., 4, 233-240.
8. BOLGER, G., MICHAELI, T., MARTINS, T., JOHN, T.S., STEINER, B., RODGERS, L., RIGGS, S., WIGLER, M. & FERGUSON, K. (1993). A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol. Cell. Biol., 13, 6558-6571.
9. BUCKINGHAM, J.C. (1984). Inhibition of corticotrophin releasing factor secretion in the pentobarbitone-morphine treated rat. Eur. J. Pharmacol., 98, 211-221.
10. BUCKINGHAM, J.C., CHRISTIAN, H., GILLIES, G.E., PHILIP, J.G. & TAYLOR, A.D. (1996). The hypothalamo-pituitary immune axis. In The Physiology of Immunity. ed. Kendall, M.D. & Marsh, J.M., New York: CRC Press (in press).
11. BUCKINGHAM, J.C. & HODGES, J.R. (1977). The use of corticotrophin production by adenohypophysial tissue in vitro for the detection and estimation of potential corticotrophin releasing factors. J. Endocrinol., 72, 187-193.
12. BUCKINGHAM, J.C. LOXLEY, H.D. & SMITH T. (1992). The control of ACTH secretion. In Comprehensive Endocrinology: The Adrenal Cortex (Second Edition) ed. James, V.H.T. pp. 131-158. New York: Raven Press.
13. CHNEIWEISS, H., CORDIER, J. & GLOWINSKI, J. (1991). Cyclic AMP accumulation induces a rapid desensitization of the cyclic AMP-dependent protein kinase in mouse striatal neurons. J. Neurochem., 51, 1708-1715.
14. CONTI, M. JR, S-L. C., MONACO, L., REPASKE, D.R. & SWINNEN, J.V. (1991). Hormonal regulation of cyclic nucleotide phosphodiesterases. Endocrine Reviews, 12, 218-234.
15. DEPASQUALE, A., COSTA, G., TROVATO, A. & CESEVANI, R. (1979). Effect of prostaglandins on the increased corticosterone output induced by caffeine in the rat. Prostaglandins Med., 3, 97-103.
16. EMANUEL, R.L., GIRARD, D.M., THULL, D.C. & MAJZOUB, J.A. (1990). Second messengers involved in the regulation of corticotropin-releasing hormone mRNA and peptide in cultured rat fetal hypothalamic primary cultures. Endocrinology, 126, 3016-3021.
17. GARSIDE, D.A. & HARVEY, P.W. (1992). Endocrine toxicology of the male reproductive system. In Endocrine Toxicology, ed. Atterwill, C.K. & Flack, J.D., pp. 285-312, Cambridge: University Press.
18. GIGUÈRE, V. & LABRIE, F. (1982). Vasopressin potentiates cyclic AMP accumulation and ACTH release induced by corticotrophin-releasing factor in rat anterior pituitary cells in culture. Endocrinology, 111, 1752-1753.
19. HADLEY, A.J., FLACK, J.D. & BUCKINGHAM, J.C. (1990). A role for adenosine receptors in the regulation of ACTH and LH secretion. J. Endocrinol., 127, 50.
20. HADLEY, A.J., FLACK, J.D. & BUCKINGHAM, J.C. (1993). Effects of selective phosphodiesterase inhibitors on the release of ACTH and LH from the rat anterior pituitary gland in vitro. Pharmacol. Communications, 3, 283-295.
21. HILLHOUSE, E.W. & MILTON, N.G.N. (1989). Effects of acetylcholine and 5-hydroxytryptamine on the secretion of corticotrophin-releasing factor and arginine vasopressin from the rat hypothalamus in vitro. J. Endocrinol., 122, 713-718.
22. KEUHL, F.A., ZANETTI, M.E. SODERMAN, D.D., MILLER, D.K. & HAM, E.A. (1987). Cyclic AMP-dependent regulation of lipid mediators in white cells- a unifying concept for explaining the efficacy of theophylline in asthma. Am. Rev. Resp. Dis., 136, 210-231.
23. KOCH, B. & LUTZ-BUCHER, B. (1995). Multifactorial regulation of pituitary adenylate cyclase-activating polypeptide (PACAP)-induced production of cyclic AMP in AtT-20 corticotrophs: major involvement of rolipram-sensitive and insensitive phosphodiesterases. Mol. Cell. Endocrinol., 112, 27-34.
24. KUMARI, M., COVER, P.O., POYSER, R. & BUCKINGHAM, J.C. (1994a). Activation of the hypothalamo-pituitary-adrenal (HPA) axis by type IV phosphodiesterase inhibitors. J. Endocrinol., 143 (suppl)., 037.
25. KUMARI, M., COVER, P.O., POYSER, R. & BUCKINGHAM, J.C. (1994b). Neuroendocrine reposes to rolipram, denbufylline and 1,3-dicyclopropylmethyl-8-xanthine (BRL 61063) in the rat. Br. J. Pharmacol., 112, 163P.
26. LABRIE, F., GAGNE, B. & LEFEVRE G. (1982a). Corticotropin-releasing factor stimulates adenylate cyclase activity in the anterior pituitary gland. Life Sci., 31, 1117-1121.
27. LABRIE, F. VIELLEUX, R. LEFEVRE, G., COY, D.H., SUERIAS-DIAZ, J. & SCHALLY, A.V. (1982b). CRF stimulates accumulation of adenosine 3′5-monophosphate in rat pituitary corticotrophs. Science, 216, 1007-1008.
28. LOUGHNEY, K. & FERGUSON, K.M. (1994). The human cyclic nucleotide phosphodiesterases. In Methylxanthines and Phosphodiesterase Inhibitors in the Treatment of Airways Disease, ed. Costello, J.F. & Piper, P.J. pp. 61-100. The Parthenon Publishing Group, Lancaster: U.K.
29. LOXLEY, H.D., COWELL, A.M., FLOWER, R.J. & BUCKINGHAM, J.C. (1993a). Modulation of the hypothalamo-pituitary adrenocortical responses to cytokines in the rat by lipocortin 1 and glucocorticoids: a role for lipocortin 1 in the feedback inhibition of CRF-41 release? Neuroendocrinology, 57, 801-814.
30. LOXLEY, H.D., COWELL, A.M., FLOWER, R.J. & BUCKINGHAM, J.C. (1993b). Effects of lipocortin 1 and dexamethasone on the secretion of corticotrophin releasing factors in the rat: in vitro and in vivo studies. J. Neuroendocrinology., 5, 51-61.
31. MICHEALI, T., BLOOM, T.J., MARTINS, T., LOUGHNEY, K., FERGUSON, K., RIGGS, M., RODGERS, L., BEAVO, J.A. & WIGLER, M. (1993). Isolation and characterisation of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. J. Biol. Chem., 268, 12925-12932.
32. NEGRO-VILAR, A., SANCHO-FRANCO, F., KWAITKOWSKI, M. & SAMSON, W.K. (1979). Failure to detect immunoassayable arginine vasopressin in mammalian pineals. Brain Res. Bull., 4, 789-792.
33. NICHOLSON, C.D., JACKMAN, S.A. & WILKE, R. (1989). The ability of denbufylline to inhibit cyclic nucleotide phosphodiesterase and its affinity for adenosine receptors and the adenosine reuptake site. Br. J. Pharmacol., 97, 889-897.
34. NICHOLSON, C.D. & SHALID, M. (1994). Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes their potential utility in the therapy of asthma. Pulm. Pharmacol., 7, 1-17.
35. NICHOLSON, S.A. (1987). The effect of caffeine on plasma corticosterone and pituitary adrenocorticotrophin (ACTH) release in the rat is antagonised by adenosine. J. Physiol., 39, 124P.
36. NICHOLSON, S.A. (1989). Stimulatory effect of caffeine on the hypothalamo-pituitary-adrenocortical axis in the rat. J. Endocrinol., 122, 535-543.
37. NIELSON, C.P., CROWLEY, J.J., CUSACK, B.J. & VESTAL, R.E. (1986). Therapeutic concentrations of theophylline and enprofylline potentiate catecholamine effects and inhibit leukocyte activation. J. Allergy Clin. Immunol., 78, 660-667.
38. REES, L.H., COOK, D.M., KENDALL, J.W., ALLEN, C.F., KRAMER, R.M., RATCLIFFE, J.G. & KNIGHT, R.A. (1971). A radioimmunoassay for rat plasma ACTH. Endocrinology, 89, 254-261.
39. REPASKE, D.R., SWINNEN, J.V., JR, S-L. C., VAN WICK, J.J. & CONTI, M. (1992). A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. J. Biol. Chem., 267, 18683-18688.
40. SCHWARTZ, J., FAMILIARI, M., WALLACE, C. & FUNDER, J.W. (1989). Dissociation of ACTH-secretory mechanisms in rat pituitary cells: Evidence that basal and vasopressin-stimulated secretion act via a mechanism distinct from that of corticotrophin releasing factor. J. Endocrinol., 1, 117-120.
41. SCHWARTZ, J., PHAM, T. & FUNDER, J.W. (1990). Chloroquine decreases adrenocorticotrophin-secretory response to corticotrophin releasing factor hut not to vasopressin in rat pituitary cells: Further evidence for differentially responsive subpopulations. J. Neuroendocrinol., 2, 25-28.
42. SEASHOLTZ, A.F., THOMPSON, R.C. & DOUGLAS, J.O. (1988). Identification of a cyclic adenosine monophosphate-responsive element in the rat corticotropin-releasing hormone gene. Mol. Endocrinol., 2, 1311-1319.
43. SETTE, C., IONA, S. & CONTI, M. (1994a). The short-term activation of a rolipram-sensitive, cAMP-specitic phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation. J. Biol. Chem., 269, 9245-9252.
44. SETTE, C., VICINI, E. & CONTI, M. (1994b). Modulation of cellular responses by hormones: a role of cAMP specific, rolipram-sensitive phosphodiesterases. Mol. Cell. Endocrinol., 100, 75-79.
45. SOBEL, D.O. (1985). Role of cyclic AMP in corticotropin releasing factor-mediated ACTH release. Peptides, 6, 591-595.
46. SPINDEL, E.R., ARNOLD, M., CUSACK, A.B. & WURTMAN, R.J. (1980a). Effects of caffeine on anterior pituitary and thyroid function in the rat. J. Pharmacol. Exp. Ther., 214, 58-62.
47. SPINDEL, E.R., GRIFFITH, I. & WURTMAN, R.J. (1983). Neuroendocrine effects of caffeine. II. Effects on thyrotropin and corticosterone secretion. J. Pharmacol. Exp. Ther., 225, 346-350.
48. SPINDEL, E.R., MCCALL, A.J. & WURTMAN, R.J. (1980b). Lack of endocrine effects of a low dose of caffeine in man. In Proceedings of the 3rd International Caffeine Workshop, International Life Sciences Institute. Washington, DC.
49. SPINDEL, E.R. & WURTMAN, R.J. (1984). Neuroendocrine effects of caffeine in rat and man. In Caffeine-Perspectives from Recent Research, ed. Dews, P.B. pp. 119-128. Berlin: Springer-Verlag.
50. SULLIVAN, P., BEKIR, S., JAFFAR, Z., PAGE, C., JEFFERY, P. & COSTELLO, J. (1994). The anti-inflammatory effects of low dose theophylline in atopic asthma. Lancet. 343, 1006-1008.
51. TODD, K. & LIGHTMAN, S.L. (1987). Vasopressin activation of phosphatidylmositol metabolism in rat anterior pituitary in vitro and its metabolism by changes in the hypothalamo-pituitary adrenal axis. Neuroendocrinology, 45, 212-218.