Cicaprost and the type IV phosphodiesterase inhibitor, rolipram, synergize in suppression of tumor necrosis factor-α synthesis

European Journal of Pharmacology

Volumn 299, Issue 1-3, 1996, Pages 229-233

  Greten, Tim F ^a   Sinha, Bhanu ^a   Haslberger, Christiane ^a   Eigler, Andreas ^a   Endres, Stefan ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Cicaprost; Prostaglandin E2; Rolipram; TNF (tumor nccrosis factor )

Indexed keywords

CICAPROST; LIPOPOLYSACCHARIDE; MESSENGER RNA; PHOSPHODIESTERASE INHIBITOR; PROSTACYCLIN DERIVATIVE; PROSTAGLANDIN E2; ROLIPRAM; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BIOSYNTHESIS; BLOOD; CONTROLLED STUDY; DRUG POTENTIATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; MONONUCLEAR CELL; NORMAL HUMAN; NORTHERN BLOTTING; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; STAPHYLOCOCCUS EPIDERMIDIS; VOLUNTEER;

EID: 0029866945     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00867-5     Document Type: Article

References (15)

1. Crutchley, D.J., L.B. Conanan and B.G. Que, 1994, Effects of prostacyclin analogs on the synthesis of tissue factor, tumor necrosis factor-α and interleukin-1β in human monocytic THP-1 cells, J. Pharmacol. Exp. Ther. 271, 446.
2. Eisenhut, T., B. Sinha, E. Gröttrup-Wolfers, J. Semmler, W. Siess and S. Endres, 1993, Prostacyclin analogs suppress the synthesis of tumor necrosis factor-α in LPS-stimulated human peripheral blood mononuclear cells, Immunopharmacology 26, 259.
3. Elliott, M.J., R.N. Maini, M. Feldmann, J.R. Kalden, C. Antoni, J.S. Smolen, B. Leeb, F.C. Breedveld, J.D. Macfarlane, H. Bijl and J.N. Woody, 1994, Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor a (cA2) versus placebo in rheumatoid arthritis, Lancet 344, 1105.
4. Endres, S., H.J. Fülle, B. Sinha, D. Stoll, C.A. Dinarello, R. Gerzer and P.C. Weber, 1991, Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-α and interleukin-1β by human mononuclear cells, Immunology 72, 56.
5. Greten, T.F., A. Eigler, B. Sinha, J. Moeller and S. Endres, 1995, The specific type IV phosphodiesterase inhibitor rolipram differentially regulates the proinflammatory mediators TNF-α and nitric oxide, Int. J. Immunopharmacol. 17, 605.
6. Hildebrand, M., T. Staks and B. Nieuweboer, 1990, Pharmakokinetics and pharmacodynamics of cicaprost in healthy volunteers after oral administration of 5 to 20 μg, Eur. J. Clin. Pharmacol. 39, 149.
7. Krause, W., G. Kühne and N. Sauerbrey, 1990, Pharmacokinetics of (+)-rolipram and (-)-rolipram in healthy volunteers, Eur. J. Clin. Pharmacol. 38, 71.
8. Nerad, L.D., J.K. Griffiths, J.W.M. Van der Meer, S. Endres, D.D. Poutsiaka, G.T. Keusch, M. Bennish, M.A. Salam, C.A. Dinarello and J.G. Cannon, 1992, Interleukin-1β (IL-1β), IL-1 receptor antagonist, and TNF-α production in whole blood, J. Leukocyte Biol. 52, 200.
9. Prabhakar, U., D. Lipshutz, J. O'Leary Bartus, M.J. Slivjak, E.F. Smith, J.C. Lee and K. Esser, 1994, Characterization of cAMP-dependent inhibition of LPS-induced TNF-α production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor, Int. J. Immunopharmacol. 16, 805.
10. Sambrook, J., E.F. Fritsch and T. Maniatis, 1989, Molecular Cloning (Cold Spring Harbor Laboratory Press, Cold Spring Harbor).
11. Semmler, J., H. Wachtel and S. Endres, 1993, The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells, Int. J. Immunopharmacol. 15, 409.
12. Sinha, B., J. Semmler, T. Eisenhut, A. Eigler and S. Endres, 1995, Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids, Eur. J. Immunol. 25, 147.
13. Thompson, W.J., 1991, Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function, Pharmacol. Ther. 51, 13.
14. Tracey, K.J. and A. Cerami, 1994, Tumor necrosis factor: a pleiotropic cytokine and therapeutic target, Annu. Rev. Med. 45, 491.
15. Wakabayashi, G., J.A. Gelfand, W.K. Jung, R.J. Connolly, J.F. Burke and C.A. Dinarello, 1991, Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli, J. Clin. Invest. 87, 1925.