메뉴 건너뛰기




Volumn 202, Issue , 2004, Pages 67-83

Cytokines and immunodeficiency diseases: Critical roles of the γc-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR G; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 7; INTERLEUKIN 9; UNCLASSIFIED DRUG;

EID: 9644295710     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0105-2896.2004.00203.x     Document Type: Review
Times cited : (332)

References (226)
  • 1
    • 0030888122 scopus 로고    scopus 로고
    • Naturally occurring primary deficiencies of the immune system
    • Fischer A, et al. Naturally occurring primary deficiencies of the immune system. Annu Rev Immunol 1997;15:93-124.
    • (1997) Annu Rev Immunol , vol.15 , pp. 93-124
    • Fischer, A.1
  • 2
    • 0035752146 scopus 로고    scopus 로고
    • Cytokines and immunodeficiency diseases
    • Leonard WJ. Cytokines and immunodeficiency diseases. Nat Rev Immunol 2001;1:200-208.
    • (2001) Nat Rev Immunol , vol.1 , pp. 200-208
    • Leonard, W.J.1
  • 3
    • 0036246445 scopus 로고    scopus 로고
    • Primary cellular immunodeficiencies
    • Buckley RH. Primary cellular immunodeficiencies. J Allergy Clin Immunol 2002;109:747-757.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 747-757
    • Buckley, R.H.1
  • 4
    • 2542461255 scopus 로고    scopus 로고
    • Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution
    • Buckley RH. Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Annu Rev Immunol 2004;22:625-655.
    • (2004) Annu Rev Immunol , vol.22 , pp. 625-655
    • Buckley, R.H.1
  • 5
    • 0036464666 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival
    • Myers LA, Patel DD, Puck JM, Buckley RH. Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival. Blood 2002;99:872-878.
    • (2002) Blood , vol.99 , pp. 872-878
    • Myers, L.A.1    Patel, D.D.2    Puck, J.M.3    Buckley, R.H.4
  • 6
    • 0842327458 scopus 로고    scopus 로고
    • Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: Huge review
    • Kalman L, et al. Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: huge review. Genet Med 2004;6:16-26.
    • (2004) Genet Med , vol.6 , pp. 16-26
    • Kalman, L.1
  • 7
    • 0029126218 scopus 로고
    • Adenosine deaminase deficiency: Molecular basis and recent developments
    • Hirschhorn R. Adenosine deaminase deficiency: molecular basis and recent developments. Clin Immunol Immunopathol 1995;76:S219-S227.
    • (1995) Clin Immunol Immunopathol , vol.76
    • Hirschhorn, R.1
  • 8
    • 0021833639 scopus 로고
    • Epstein-Barr virus-associated B-cell proliferations of diverse clonal origins after bone marrow transplantation in a 12-year-old patient with severe combined immunodeficiency
    • Shearer WT, et al. Epstein-Barr virus-associated B-cell proliferations of diverse clonal origins after bone marrow transplantation in a 12-year-old patient with severe combined immunodeficiency. N Engl J Med 1985;312:1151-1159.
    • (1985) N Engl J Med , vol.312 , pp. 1151-1159
    • Shearer, W.T.1
  • 9
    • 0023442485 scopus 로고
    • Close linkage of the locus for X chromosome-linked severe combined immunodeficiency to polymorphic DNA markers in Xq11-q13
    • de Saint Basile G, et al. Close linkage of the locus for X chromosome-linked severe combined immunodeficiency to polymorphic DNA markers in Xq11-q13. Proc Natl Acad Sci USA 1987;84:7576-7579.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7576-7579
    • De Saint Basile, G.1
  • 10
    • 0027403374 scopus 로고
    • Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans
    • Noguchi M, et al. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 1993;73:147-157.
    • (1993) Cell , vol.73 , pp. 147-157
    • Noguchi, M.1
  • 11
    • 0025599933 scopus 로고
    • Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes
    • Chatila T, et al. Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes. Proc Natl Acad Sci USA 1990;87:10033-10037.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 10033-10037
    • Chatila, T.1
  • 12
    • 0025297840 scopus 로고
    • Severe combined immunodeficiency due to a specific defect in the production of interleukin-2
    • Weinberg K, Parkman R. Severe combined immunodeficiency due to a specific defect in the production of interleukin-2. N Engl J Med 1990;322:1718-1723.
    • (1990) N Engl J Med , vol.322 , pp. 1718-1723
    • Weinberg, K.1    Parkman, R.2
  • 13
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 1991;15:621-624.
    • (1991) Nature , vol.15 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 14
    • 0027731604 scopus 로고
    • Sharing of interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4
    • Kondo M, et al. Sharing of interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4. Science 1993;262:1874-1877.
    • (1993) Science , vol.262 , pp. 1874-1877
    • Kondo, M.1
  • 15
    • 0027751556 scopus 로고
    • Interleukin-2 receptor gamma chain: A functional component of the interleukin-7 receptor
    • Noguchi M, et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science 1993;262:1877-1880.
    • (1993) Science , vol.262 , pp. 1877-1880
    • Noguchi, M.1
  • 16
    • 0027787877 scopus 로고
    • Interleukin-2 receptor γ chain: A functional component of the interleukin-4 receptor
    • Russell SM, et al. Interleukin-2 receptor γ chain: a functional component of the interleukin-4 receptor. Science 1993;262:1880-1883.
    • (1993) Science , vol.262 , pp. 1880-1883
    • Russell, S.M.1
  • 17
    • 0028171065 scopus 로고
    • Interaction of IL-2Rβ and γc chains with Jak1 and Jak3. Implications for XSCID and XCID
    • Russell SM, et al. Interaction of IL-2Rβ and γc chains with Jak1 and Jak3. Implications for XSCID and XCID. Science 1994;266:1042-1045.
    • (1994) Science , vol.266 , pp. 1042-1045
    • Russell, S.M.1
  • 18
    • 0028221433 scopus 로고
    • Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
    • Giri JG, et al. Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 1994;13:2822-2830.
    • (1994) EMBO J , vol.13 , pp. 2822-2830
    • Giri, J.G.1
  • 19
    • 0028814556 scopus 로고
    • Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex
    • Kimura Y, et al. Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex. Int Immunol 1995;7:115-120.
    • (1995) Int Immunol , vol.7 , pp. 115-120
    • Kimura, Y.1
  • 20
    • 0035400054 scopus 로고    scopus 로고
    • Cutting edge: The common gamma-chain is an indispensable subunit of the IL-21 receptor complex
    • Asao H, et al. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol 2001;167:1-5.
    • (2001) J Immunol , vol.167 , pp. 1-5
    • Asao, H.1
  • 21
    • 0037159687 scopus 로고    scopus 로고
    • A critical role for IL-21 in regulating immunoglobulin production
    • Ozaki K, et al. A critical role for IL-21 in regulating immunoglobulin production. Science 2002;298:1630-1634.
    • (2002) Science , vol.298 , pp. 1630-1634
    • Ozaki, K.1
  • 22
    • 0037119351 scopus 로고    scopus 로고
    • Cytokine and cytokine receptor pleiotropy and redundancy
    • Ozaki K, Leonard WJ. Cytokine and cytokine receptor pleiotropy and redundancy. J Biol Chem 2002;277:29355-29358.
    • (2002) J Biol Chem , vol.277 , pp. 29355-29358
    • Ozaki, K.1    Leonard, W.J.2
  • 23
    • 0028925778 scopus 로고
    • Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain
    • Cao X, et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 1995;2:223-238.
    • (1995) Immunity , vol.2 , pp. 223-238
    • Cao, X.1
  • 24
    • 0028878330 scopus 로고
    • Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain
    • Disanto JP, Muller W, Guy-Grand D, Fischer A, Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain. Proc Natl Acad Sci USA 1995;92:377-381.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 377-381
    • Disanto, J.P.1    Muller, W.2    Guy-Grand, D.3    Fischer, A.4    Rajewsky, K.5
  • 25
    • 0028840706 scopus 로고
    • Defective lymphoid development in mice lacking Jak3
    • Nosaka T, et al. Defective lymphoid development in mice lacking Jak3. Science 1995;270:800-802.
    • (1995) Science , vol.270 , pp. 800-802
    • Nosaka, T.1
  • 26
    • 0029550822 scopus 로고
    • Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
    • Park SY, et al. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 1995;3:771-782.
    • (1995) Immunity , vol.3 , pp. 771-782
    • Park, S.Y.1
  • 27
    • 0034979957 scopus 로고    scopus 로고
    • Impaired interferon gamma-mediated immunity and susceptibility to mycobacterial infection in childhood
    • Remus N, et al. Impaired interferon gamma-mediated immunity and susceptibility to mycobacterial infection in childhood. Pediatr Res 2001;50:8-13.
    • (2001) Pediatr Res , vol.50 , pp. 8-13
    • Remus, N.1
  • 28
    • 0030455878 scopus 로고    scopus 로고
    • Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guerin infection
    • Jouanguy E, et al. Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guerin infection. N Engl J Med 1996;335:1956-1961.
    • (1996) N Engl J Med , vol.335 , pp. 1956-1961
    • Jouanguy, E.1
  • 29
    • 0030467174 scopus 로고    scopus 로고
    • A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection
    • Newport MJ, et al. A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. N Engl J Med 1996;335:1941-1949.
    • (1996) N Engl J Med , vol.335 , pp. 1941-1949
    • Newport, M.J.1
  • 30
    • 0033967256 scopus 로고    scopus 로고
    • Partial interferon-gamma receptor signaling chain deficiency in a patient with bacille Calmette-Guerin and Mycobacterium abscessus infection
    • Doffinger R, et al. Partial interferon-gamma receptor signaling chain deficiency in a patient with bacille Calmette-Guerin and Mycobacterium abscessus infection. J Infect Dis 2000;181:379-384.
    • (2000) J Infect Dis , vol.181 , pp. 379-384
    • Doffinger, R.1
  • 31
    • 0035854542 scopus 로고    scopus 로고
    • Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation
    • Dupuis S, et al. Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation. Science 2001;293:300-303.
    • (2001) Science , vol.293 , pp. 300-303
    • Dupuis, S.1
  • 32
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: Biological implications
    • Leonard WJ, O'Shea JJ. Jaks and STATs: biological implications. Annu Rev Immunol 1998;16:293-322.
    • (1998) Annu Rev Immunol , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 34
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat Rev Immunol 2002;2:933-944.
    • (2002) Nat Rev Immunol , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 35
    • 18244428735 scopus 로고    scopus 로고
    • Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
    • Altare F, et al. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 1998;280:1432-1435.
    • (1998) Science , vol.280 , pp. 1432-1435
    • Altare, F.1
  • 36
    • 0032535370 scopus 로고    scopus 로고
    • Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection
    • Altare F, et al. Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection. J Clin Invest 1998;102:2035-2040.
    • (1998) J Clin Invest , vol.102 , pp. 2035-2040
    • Altare, F.1
  • 37
    • 0032577295 scopus 로고    scopus 로고
    • Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients
    • de Jong R, et al. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 1998;280:1435-1438.
    • (1998) Science , vol.280 , pp. 1435-1438
    • De Jong, R.1
  • 38
    • 0026684134 scopus 로고
    • Cloning of the gamma chain of the human IL-2 receptor
    • Takeshita T, et al. Cloning of the gamma chain of the human IL-2 receptor. Science 1992;257:379-382.
    • (1992) Science , vol.257 , pp. 379-382
    • Takeshita, T.1
  • 39
    • 0020409664 scopus 로고
    • A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor
    • Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC. A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature 1982;300:267-269.
    • (1982) Nature , vol.300 , pp. 267-269
    • Leonard, W.J.1    Depper, J.M.2    Uchiyama, T.3    Smith, K.A.4    Waldmann, T.A.5    Greene, W.C.6
  • 40
    • 0021193219 scopus 로고
    • Molecular cloning and expression of cDNAs for the human interleukin-2 receptor
    • Leonard WJ, et al. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 1984;311:626-631.
    • (1984) Nature , vol.311 , pp. 626-631
    • Leonard, W.J.1
  • 41
    • 0021123385 scopus 로고
    • Molecular cloning of cDNA encoding human interleukin-2 receptor
    • Nikaido T, et al. Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature 1984;311:631-635.
    • (1984) Nature , vol.311 , pp. 631-635
    • Nikaido, T.1
  • 42
    • 0021707413 scopus 로고
    • Cloning, sequence and expression of human interleukin-2 receptor
    • Cosman D, et al. Cloning, sequence and expression of human interleukin-2 receptor. Nature 1984;312:768-771.
    • (1984) Nature , vol.312 , pp. 768-771
    • Cosman, D.1
  • 43
    • 0023010578 scopus 로고
    • Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions
    • Sharon M, Klausner RD, Cullen BR, Chizzonite R, Leonard WJ. Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science 1986;234:859-863.
    • (1986) Science , vol.234 , pp. 859-863
    • Sharon, M.1    Klausner, R.D.2    Cullen, B.R.3    Chizzonite, R.4    Leonard, W.J.5
  • 44
    • 0023230069 scopus 로고
    • The IL-2 receptor beta chain (p70): Role in mediating signals for LAK, NK, and proliferative activities
    • Siegel JP, Sharon M, Smith PL, Leonard WJ. The IL-2 receptor beta chain (p70): role in mediating signals for LAK, NK, and proliferative activities. Science 1987;238:75-78.
    • (1987) Science , vol.238 , pp. 75-78
    • Siegel, J.P.1    Sharon, M.2    Smith, P.L.3    Leonard, W.J.4
  • 45
    • 0023280191 scopus 로고
    • The p75 peptide is the receptor for interleukin 2 expressed on large granular lymphocytes and is responsible for the interleukin 2 activation of these cells
    • Tsudo M, et al. The p75 peptide is the receptor for interleukin 2 expressed on large granular lymphocytes and is responsible for the interleukin 2 activation of these cells. Proc Natl Acad Sci USA 1987;84:5394-5398.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 5394-5398
    • Tsudo, M.1
  • 46
    • 0024403321 scopus 로고
    • Interleukin-2 receptor beta chain gene: Generation of three receptor forms by cloned human alpha and beta chain cDNA's
    • Hatakeyama M, et al. Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Science 1989;244:551-556.
    • (1989) Science , vol.244 , pp. 551-556
    • Hatakeyama, M.1
  • 47
    • 0029962080 scopus 로고    scopus 로고
    • The interleukin-2 receptor gamma chain: Its role in the multiple cytokine receptor complexes and T cell development in XSCID
    • Sugamura K, et al. The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol 1996;14:179-205.
    • (1996) Annu Rev Immunol , vol.14 , pp. 179-205
    • Sugamura, K.1
  • 48
    • 0029924265 scopus 로고    scopus 로고
    • The molecular basis of X-linked severe combined immunodeficiency: Defective cytokine receptor signaling
    • Leonard WJ. The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. Annu Rev Med 1996;47:229-239.
    • (1996) Annu Rev Med , vol.47 , pp. 229-239
    • Leonard, W.J.1
  • 49
    • 0031410650 scopus 로고    scopus 로고
    • Signaling from the IL-2 receptor to the nucleus
    • Lin JX, Leonard WJ. Signaling from the IL-2 receptor to the nucleus. Cytokine Growth Factor Rev 1997;8:313-332.
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 313-332
    • Lin, J.X.1    Leonard, W.J.2
  • 50
    • 0023225411 scopus 로고
    • A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors
    • Dukovich M, et al. A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors. Nature 1987;327:518-522.
    • (1987) Nature , vol.327 , pp. 518-522
    • Dukovich, M.1
  • 51
    • 84942877339 scopus 로고    scopus 로고
    • Interleukin-2
    • Thomson A, Lotze MT, eds. New York: Academic Press
    • Lin JX, Leonard WJ. Interleukin-2. In: Thomson A, Lotze MT, eds. The Cytokine Handbook. New York: Academic Press, 2003: 167-199.
    • (2003) The Cytokine Handbook , pp. 167-199
    • Lin, J.X.1    Leonard, W.J.2
  • 53
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993;75:253-261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 54
    • 0029414785 scopus 로고
    • Interleukin-2 deficient mice: A new model to study autoimmunity and self-tolerance
    • Horak I, Lohler J, Ma A, Smith KA. Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance. Immunol Rev 1995;148:35-44.
    • (1995) Immunol Rev , vol.148 , pp. 35-44
    • Horak, I.1    Lohler, J.2    Ma, A.3    Smith, K.A.4
  • 55
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995;3:521-530.
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 56
    • 0030903027 scopus 로고    scopus 로고
    • Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor
    • Sharfe N, Dadi HK, Shahar M, Roifman CM. Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor. Proc Natl Acad Sci USA 1997;94:3168-3171.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3168-3171
    • Sharfe, N.1    Dadi, H.K.2    Shahar, M.3    Roifman, C.M.4
  • 57
    • 0032502801 scopus 로고    scopus 로고
    • Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
    • Van Parijs L, Abbas AK. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 1998;280:243-248.
    • (1998) Science , vol.280 , pp. 243-248
    • Van Parijs, L.1    Abbas, A.K.2
  • 58
    • 0033007321 scopus 로고    scopus 로고
    • Mature T lymphocyte apoptosis - Immune regulation in a dynamic and unpredictable antigenic environment
    • Lenardo M, et al. Mature T lymphocyte apoptosis - immune regulation in a dynamic and unpredictable antigenic environment. Annu Rev Immunol 1999;17:221-253.
    • (1999) Annu Rev Immunol , vol.17 , pp. 221-253
    • Lenardo, M.1
  • 59
    • 0345059209 scopus 로고    scopus 로고
    • An inherited disorder of lymphocyte apoptosis: The autoimmune lymphoproliferative syndrome
    • Straus SE, Sneller M, Lenardo MJ, Puck JM, Strober W. An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome. Ann Intern Med 1999;130:591-601.
    • (1999) Ann Intern Med , vol.130 , pp. 591-601
    • Straus, S.E.1    Sneller, M.2    Lenardo, M.J.3    Puck, J.M.4    Strober, W.5
  • 60
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis
    • Lenardo MJ. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature 1991;353:858-861.
    • (1991) Nature , vol.353 , pp. 858-861
    • Lenardo, M.J.1
  • 61
    • 0031569514 scopus 로고    scopus 로고
    • Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor
    • Van Parijs L, Biuckians A, Ibragimov A, Alt FW, Willerford DM, Abbas AK. Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor. J Immunol 1997;158:3738-3745.
    • (1997) J Immunol , vol.158 , pp. 3738-3745
    • Van Parijs, L.1    Biuckians, A.2    Ibragimov, A.3    Alt, F.W.4    Willerford, D.M.5    Abbas, A.K.6
  • 62
    • 17544398702 scopus 로고    scopus 로고
    • Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
    • Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 1998;8:615-623.
    • (1998) Immunity , vol.8 , pp. 615-623
    • Refaeli, Y.1    Van Parijs, L.2    London, C.A.3    Tschopp, J.4    Abbas, A.K.5
  • 63
    • 0033199317 scopus 로고    scopus 로고
    • Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
    • Van Parijs L, Refaeli Y, Lord JD, Nelson BH, Abbas AK, Baltimore D. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 1999;11:281-288.
    • (1999) Immunity , vol.11 , pp. 281-288
    • Van Parijs, L.1    Refaeli, Y.2    Lord, J.D.3    Nelson, B.H.4    Abbas, A.K.5    Baltimore, D.6
  • 64
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: Key controllers of immunologic self-tolerance
    • Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000;101:455-458.
    • (2000) Cell , vol.101 , pp. 455-458
    • Sakaguchi, S.1
  • 65
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity
    • Shevach EM. Regulatory T cells in autoimmmunity. Annu Rev Immunol 2000;18:423-449.
    • (2000) Annu Rev Immunol , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 66
    • 0036857530 scopus 로고    scopus 로고
    • The role of suppressor T cells in regulation of immune responses
    • McHugh RS, Shevach EM. The role of suppressor T cells in regulation of immune responses. J Allergy Clin Immunol 2002;110:693-702.
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 693-702
    • McHugh, R.S.1    Shevach, E.M.2
  • 67
    • 0348047537 scopus 로고    scopus 로고
    • The main function of IL-2 is to promote the development of T regulatory cells
    • Malek TR. The main function of IL-2 is to promote the development of T regulatory cells. J Leukoc Biol 2003;74:961-965.
    • (2003) J Leukoc Biol , vol.74 , pp. 961-965
    • Malek, T.R.1
  • 68
    • 7144259082 scopus 로고    scopus 로고
    • Regulatory CD4 T cells: Expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
    • Papiernik M, de Moraes ML, Pontoux C, Vasseur F, Penit C. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 1998;10:371-378.
    • (1998) Int Immunol , vol.10 , pp. 371-378
    • Papiernik, M.1    De Moraes, M.L.2    Pontoux, C.3    Vasseur, F.4    Penit, C.5
  • 69
    • 0036839102 scopus 로고    scopus 로고
    • Homeostasis of peripheral CD4+ T cells. IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    • Almeida AR, Legrand N, Papiernik M, Freitas AA. Homeostasis of peripheral CD4+ T cells. IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 2002;169:4850-4860.
    • (2002) J Immunol , vol.169 , pp. 4850-4860
    • Almeida, A.R.1    Legrand, N.2    Papiernik, M.3    Freitas, A.A.4
  • 71
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • Malek TR, Yu A, Vincek V, Scibelli P, Kong L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002;17:167-178.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 72
    • 0141920630 scopus 로고    scopus 로고
    • Essential role for STAT5 signaling in CD25+CD4+ regulatory T cell homeostasis and the maintenance of self-tolerance
    • Antov A, Yang L, Vig M, Baltimore D, Van Parijs L. Essential role for STAT5 signaling in CD25+CD4+ regulatory T cell homeostasis and the maintenance of self-tolerance. J Immunol 2003;171:3435-3441.
    • (2003) J Immunol , vol.171 , pp. 3435-3441
    • Antov, A.1    Yang, L.2    Vig, M.3    Baltimore, D.4    Van Parijs, L.5
  • 73
  • 74
    • 1642398043 scopus 로고    scopus 로고
    • Interleukin 2 plays a central role in Th2 differentiation
    • Cote-Sierra J, et al. Interleukin 2 plays a central role in Th2 differentiation. Proc Natl Acad Sci USA 2004;101:3880-3885.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3880-3885
    • Cote-Sierra, J.1
  • 75
    • 0033118752 scopus 로고    scopus 로고
    • The role of cytokine receptor signaling in lymphocyte development
    • Baird AM, Gerstein RM, Berg LJ. The role of cytokine receptor signaling in lymphocyte development. Curr Opin Immunol 1999;11:157-166.
    • (1999) Curr Opin Immunol , vol.11 , pp. 157-166
    • Baird, A.M.1    Gerstein, R.M.2    Berg, L.J.3
  • 77
    • 0036624721 scopus 로고    scopus 로고
    • Interleukin-7: From bench to clinic
    • Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood 2002;99:3892-3904.
    • (2002) Blood , vol.99 , pp. 3892-3904
    • Fry, T.J.1    Mackall, C.L.2
  • 78
    • 0027209141 scopus 로고
    • Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody
    • Grabstein KH, et al. Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J Exp Med 1993;178:257-264.
    • (1993) J Exp Med , vol.178 , pp. 257-264
    • Grabstein, K.H.1
  • 79
    • 0027988545 scopus 로고
    • Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    • Peschon JJ, et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 1994;180:1955-1960.
    • (1994) J Exp Med , vol.180 , pp. 1955-1960
    • Peschon, J.J.1
  • 80
    • 0028929565 scopus 로고
    • Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
    • von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 1995;181:1519-1526.
    • (1995) J Exp Med , vol.181 , pp. 1519-1526
    • Von Freeden-Jeffry, U.1    Vieira, P.2    Lucian, L.A.3    McNeil, T.4    Burdach, S.E.5    Murray, R.6
  • 81
    • 0031740732 scopus 로고    scopus 로고
    • Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency
    • Fuel A, Ziegler SF, Buckley RH, Leonard WJ. Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Nat Genet 1998;20:394-397.
    • (1998) Nat Genet , vol.20 , pp. 394-397
    • Fuel, A.1    Ziegler, S.F.2    Buckley, R.H.3    Leonard, W.J.4
  • 82
    • 0024282606 scopus 로고
    • Stimulation of B-cell progenitors by cloned murine interleukin-7
    • Namen AE, et al. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 1988;333:571-573.
    • (1988) Nature , vol.333 , pp. 571-573
    • Namen, A.E.1
  • 83
    • 0026531928 scopus 로고
    • Interleukin-7 expression during mouse thymus development
    • Wiles MV, Ruiz P, Imhof BA. Interleukin-7 expression during mouse thymus development. Eur J Immunol 1992;22:1037-1042.
    • (1992) Eur J Immunol , vol.22 , pp. 1037-1042
    • Wiles, M.V.1    Ruiz, P.2    Imhof, B.A.3
  • 84
    • 0029150219 scopus 로고
    • Vascular cell adhesion molecule 1-positive reticular cells express interleukin-7 and stem cell factor in the bone marrow
    • Funk PE, Stephan RP, Witte PL. Vascular cell adhesion molecule 1-positive reticular cells express interleukin-7 and stem cell factor in the bone marrow. Blood 1995;86:2661-2671.
    • (1995) Blood , vol.86 , pp. 2661-2671
    • Funk, P.E.1    Stephan, R.P.2    Witte, P.L.3
  • 85
    • 0026027238 scopus 로고
    • Development of lymphocytes in interleukin 7-transgenic mice
    • Samaridis J, et al. Development of lymphocytes in interleukin 7-transgenic mice. Eur J Immunol 1991;21:453-460.
    • (1991) Eur J Immunol , vol.21 , pp. 453-460
    • Samaridis, J.1
  • 86
    • 0028924203 scopus 로고
    • Lymphoproliferative disorders in IL-7 transgenic mice: Expansion of immature B cells which retain macrophage potential
    • Fisher AG, Burdet C, Bunce C, Merkenschlager M, Ceredig R. Lymphoproliferative disorders in IL-7 transgenic mice: expansion of immature B cells which retain macrophage potential. Int Immunol 1995;7:415-423.
    • (1995) Int Immunol , vol.7 , pp. 415-423
    • Fisher, A.G.1    Burdet, C.2    Bunce, C.3    Merkenschlager, M.4    Ceredig, R.5
  • 87
    • 0029856131 scopus 로고    scopus 로고
    • Prelymphomatous B cell hyperplasia in the bone marrow of interleukin-7 transgenic mice: Precursor B cell dynamics, microenvironmental organization and osteolysis
    • Valenzona HO, Pointer R, Ceredig R, Osmond DG. Prelymphomatous B cell hyperplasia in the bone marrow of interleukin-7 transgenic mice: precursor B cell dynamics, microenvironmental organization and osteolysis. Exp Hematol 1996;24:1521-1529.
    • (1996) Exp Hematol , vol.24 , pp. 1521-1529
    • Valenzona, H.O.1    Pointer, R.2    Ceredig, R.3    Osmond, D.G.4
  • 88
    • 0034968595 scopus 로고    scopus 로고
    • Control of chromatin accessibility for V(D)J recombination by interleukin-7
    • Huang J, Muegge K. Control of chromatin accessibility for V(D)J recombination by interleukin-7. J Leukoc Biol 2001;69:907-911.
    • (2001) J Leukoc Biol , vol.69 , pp. 907-911
    • Huang, J.1    Muegge, K.2
  • 89
    • 2242434790 scopus 로고
    • Nonrandom X chromosome inactivation in B cells from carriers of X chromosome-linked severe combined immunodeficiency
    • Conley ME, Lavoie A, Briggs C, Brown P, Guerra C, Puck JM. Nonrandom X chromosome inactivation in B cells from carriers of X chromosome-linked severe combined immunodeficiency. Proc Natl Acad Sci USA 1988;85:3090-3094.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3090-3094
    • Conley, M.E.1    Lavoie, A.2    Briggs, C.3    Brown, P.4    Guerra, C.5    Puck, J.M.6
  • 90
    • 0035471754 scopus 로고    scopus 로고
    • Interleukin-7: Master regulator of peripheral T-cell homeostasis?
    • Fry TJ, Mackall CL. Interleukin-7: master regulator of peripheral T-cell homeostasis? Trends Immunol 2001;22:564-571.
    • (2001) Trends Immunol , vol.22 , pp. 564-571
    • Fry, T.J.1    Mackall, C.L.2
  • 91
    • 0036672918 scopus 로고    scopus 로고
    • Maintaining the norm: T-cell homeostasis
    • Jameson SC. Maintaining the norm: T-cell homeostasis. Nat Rev Immunol 2002;2:547-556.
    • (2002) Nat Rev Immunol , vol.2 , pp. 547-556
    • Jameson, S.C.1
  • 92
    • 0038655228 scopus 로고    scopus 로고
    • Cytokine control of memory T-cell development and survival
    • Schluns KS, Lefrancois L. Cytokine control of memory T-cell development and survival. Nat Rev Immunol 2003;3:269-279.
    • (2003) Nat Rev Immunol , vol.3 , pp. 269-279
    • Schluns, K.S.1    Lefrancois, L.2
  • 93
    • 0037460105 scopus 로고    scopus 로고
    • Cytokines and T cell homeostasis
    • Sprent J, Surh CD. Cytokines and T cell homeostasis. Immunol Lett 2003;85: 145-149.
    • (2003) Immunol Lett , vol.85 , pp. 145-149
    • Sprent, J.1    Surh, C.D.2
  • 94
    • 17444433046 scopus 로고    scopus 로고
    • Homeostatic control of T-cell generation in neonates
    • Schonland SO, et al. Homeostatic control of T-cell generation in neonates. Blood 2003;102:1428-1434.
    • (2003) Blood , vol.102 , pp. 1428-1434
    • Schonland, S.O.1
  • 96
    • 0034332403 scopus 로고    scopus 로고
    • Interleukin-7 mediates the homeostasis of naive and memory CDS T cells in vivo
    • Schluns KS, Kieper WC, Jameson SC, Lefrancois L. Interleukin-7 mediates the homeostasis of naive and memory CDS T cells in vivo. Nat Immunol 2000;1:426-432.
    • (2000) Nat Immunol , vol.1 , pp. 426-432
    • Schluns, K.S.1    Kieper, W.C.2    Jameson, S.C.3    Lefrancois, L.4
  • 97
    • 0035902513 scopus 로고    scopus 로고
    • IL-7 is critical for homeostatic proliferation and survival of naive T cells
    • Tan JT, et al. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci USA 2001;98:8732-8737.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8732-8737
    • Tan, J.T.1
  • 98
    • 0038487052 scopus 로고    scopus 로고
    • Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells
    • Seddon B, Tomlinson P, Zamoyska R. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol 2003;4:680-686.
    • (2003) Nat Immunol , vol.4 , pp. 680-686
    • Seddon, B.1    Tomlinson, P.2    Zamoyska, R.3
  • 99
    • 0037124328 scopus 로고    scopus 로고
    • Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells
    • Kieper WC, et al. Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med 2002;195:1533-1539.
    • (2002) J Exp Med , vol.195 , pp. 1533-1539
    • Kieper, W.C.1
  • 100
    • 0037124366 scopus 로고    scopus 로고
    • Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells
    • Tan JT, Ernst B, Kieper WC, LeRoy E, Sprent J, Surh CD. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med 2002;195:1523-1532.
    • (2002) J Exp Med , vol.195 , pp. 1523-1532
    • Tan, J.T.1    Ernst, B.2    Kieper, W.C.3    LeRoy, E.4    Sprent, J.5    Surh, C.D.6
  • 101
    • 0036890419 scopus 로고    scopus 로고
    • Interleukin-15 and the regulation of lymphoid homeostasis
    • Lodolce J, et al. Interleukin-15 and the regulation of lymphoid homeostasis. Mol Immunol 2002;39:537-544.
    • (2002) Mol Immunol , vol.39 , pp. 537-544
    • Lodolce, J.1
  • 102
    • 0037109077 scopus 로고    scopus 로고
    • IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes
    • Xue HH, et al. IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes. Proc Natl Acad Sci USA 2002;99:13759-13764.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13759-13764
    • Xue, H.H.1
  • 103
    • 0033696860 scopus 로고    scopus 로고
    • IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development
    • Townsend JM, Fallon GP, Matthews JD, Smith P, John EH, McKenzie NA. IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development. Immunity 2000;13:573-583.
    • (2000) Immunity , vol.13 , pp. 573-583
    • Townsend, J.M.1    Fallon, G.P.2    Matthews, J.D.3    Smith, P.4    John, E.H.5    McKenzie, N.A.6
  • 104
    • 0028293650 scopus 로고
    • Thymic lymphomas in interleukin 9 transgenic mice
    • Renauld JC, et al. Thymic lymphomas in interleukin 9 transgenic mice. Oncogene 1994;9:1327-1332.
    • (1994) Oncogene , vol.9 , pp. 1327-1332
    • Renauld, J.C.1
  • 105
    • 0028276796 scopus 로고
    • A lymphokine, provisionally desinated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells
    • Burton JD, et al. A lymphokine, provisionally desinated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 1994;91:4935-4939.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4935-4939
    • Burton, J.D.1
  • 106
    • 0028179054 scopus 로고
    • Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
    • Grabstein KH, et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 1994;264:965-968.
    • (1994) Science , vol.264 , pp. 965-968
    • Grabstein, K.H.1
  • 107
    • 0029006450 scopus 로고
    • IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2
    • Giri JG, Anderson DM, Kumaki S, Park LS, Grabstein KH, Cosman D. IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2. J Leukoc Biol 1995;57:763-766.
    • (1995) J Leukoc Biol , vol.57 , pp. 763-766
    • Giri, J.G.1    Anderson, D.M.2    Kumaki, S.3    Park, L.S.4    Grabstein, K.H.5    Cosman, D.6
  • 108
    • 0035102242 scopus 로고    scopus 로고
    • Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy
    • Waldmann TA, Dubois S, Tagaya Y. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity 2001;14:105-110.
    • (2001) Immunity , vol.14 , pp. 105-110
    • Waldmann, T.A.1    Dubois, S.2    Tagaya, Y.3
  • 109
    • 0031051547 scopus 로고    scopus 로고
    • Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain
    • Suzuki H, Duncan GS, Takimoto H, Mak TW. Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain. J Exp Med 1997;185:499-505.
    • (1997) J Exp Med , vol.185 , pp. 499-505
    • Suzuki, H.1    Duncan, G.S.2    Takimoto, H.3    Mak, T.W.4
  • 110
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce JP, et al. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 1998;9:669-676.
    • (1998) Immunity , vol.9 , pp. 669-676
    • Lodolce, J.P.1
  • 111
    • 0034610970 scopus 로고    scopus 로고
    • Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    • Kennedy MK, et al. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 2000;191:771-780.
    • (2000) J Exp Med , vol.191 , pp. 771-780
    • Kennedy, M.K.1
  • 112
    • 0037093844 scopus 로고    scopus 로고
    • Cutting edge: Requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells
    • Schluns KS, Williams K, Ma A, Zheng XX, Lefrancois L. Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol 2002;168:4827-4831.
    • (2002) J Immunol , vol.168 , pp. 4827-4831
    • Schluns, K.S.1    Williams, K.2    Ma, A.3    Zheng, X.X.4    Lefrancois, L.5
  • 113
    • 0037124341 scopus 로고    scopus 로고
    • Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells
    • Becker TC, et al. Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J Exp Med 2002;195:1541-1548.
    • (2002) J Exp Med , vol.195 , pp. 1541-1548
    • Becker, T.C.1
  • 114
    • 0034633683 scopus 로고    scopus 로고
    • IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice
    • Marks-Konczalik J, et al. IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proc Natl Acad Sci USA 2000;97:11445-11450.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11445-11450
    • Marks-Konczalik, J.1
  • 115
    • 0035862325 scopus 로고    scopus 로고
    • Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8(+) T Cells
    • Fehniger TA, et al. Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8(+) T Cells. J Exp Med 2001;193:219-232.
    • (2001) J Exp Med , vol.193 , pp. 219-232
    • Fehniger, T.A.1
  • 117
    • 0033504733 scopus 로고    scopus 로고
    • Molecular basis of T-cell differentiation
    • Flavell RA, et al. Molecular basis of T-cell differentiation. Cold Spring Harb Symp Quant Biol 1999;64:563-571.
    • (1999) Cold Spring Harb Symp Quant Biol , vol.64 , pp. 563-571
    • Flavell, R.A.1
  • 118
    • 0034571173 scopus 로고    scopus 로고
    • The molecular basis of T helper 1 and T helper 2 cell differentiation
    • O'Garra A, Arai N. The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol 2000;10:542-550.
    • (2000) Trends Cell Biol , vol.10 , pp. 542-550
    • O'Garra, A.1    Arai, N.2
  • 119
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kuhn R, Rajewsky K, Muller W. Generation and analysis of interleukin-4 deficient mice. Science 1991;254:707-710.
    • (1991) Science , vol.254 , pp. 707-710
    • Kuhn, R.1    Rajewsky, K.2    Muller, W.3
  • 120
    • 0030931043 scopus 로고    scopus 로고
    • An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice
    • Noben-Trauth N, Shultz LD, Brombacher F, Urban JF Jr, Gu H, Paul WE. An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci USA 1997;94:10838-10843.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10838-10843
    • Noben-Trauth, N.1    Shultz, L.D.2    Brombacher, F.3    Urban Jr., J.F.4    Gu, H.5    Paul, W.E.6
  • 121
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996;4:313-319.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 122
    • 15844374279 scopus 로고    scopus 로고
    • Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
    • Shimoda K, et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996;380:630-633.
    • (1996) Nature , vol.380 , pp. 630-633
    • Shimoda, K.1
  • 123
    • 15844404509 scopus 로고    scopus 로고
    • Essential role of Stat6 in IL-4 signalling
    • Takeda K, et al. Essential role of Stat6 in IL-4 signalling. Nature 1996;380:627-630.
    • (1996) Nature , vol.380 , pp. 627-630
    • Takeda, K.1
  • 124
    • 0037775352 scopus 로고    scopus 로고
    • IL-13 effector functions
    • Wynn TA. IL-13 effector functions. Annu Rev Immunol 2003;21:425-456.
    • (2003) Annu Rev Immunol , vol.21 , pp. 425-456
    • Wynn, T.A.1
  • 126
  • 127
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000;408:57-63.
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1
  • 128
    • 18344394955 scopus 로고    scopus 로고
    • IL-21 limits NK cell responses and promotes antigen-specific T cell activation: A mediator of the transition from innate to adaptive immunity
    • Kasaian MT, et al. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 2002;16:559-569.
    • (2002) Immunity , vol.16 , pp. 559-569
    • Kasaian, M.T.1
  • 129
    • 0037037544 scopus 로고    scopus 로고
    • Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells
    • Wurster AL, et al. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med 2002;196:969-977.
    • (2002) J Exp Med , vol.196 , pp. 969-977
    • Wurster, A.L.1
  • 130
    • 0036784616 scopus 로고    scopus 로고
    • IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
    • Strengell M, Sareneva T, Foster D, Julkunen I, Matikainen S. IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J Immunol 2002;169:3600-3605.
    • (2002) J Immunol , vol.169 , pp. 3600-3605
    • Strengell, M.1    Sareneva, T.2    Foster, D.3    Julkunen, I.4    Matikainen, S.5
  • 131
    • 0031440585 scopus 로고    scopus 로고
    • Advances in the understanding of cytokine signal transduction: The role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency
    • O'Shea JJ, Notarangelo LD, Johnston JA, Candotti F. Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency. J Clin Immunol 1997;17:431-447.
    • (1997) J Clin Immunol , vol.17 , pp. 431-447
    • O'Shea, J.J.1    Notarangelo, L.D.2    Johnston, J.A.3    Candotti, F.4
  • 132
    • 3242742473 scopus 로고    scopus 로고
    • Type 1 cytokines and interferons and their receptors
    • Paul WE, ed. Philadelphia: Lippincott Williams & Wilkins
    • Leonard WJ. Type 1 cytokines and interferons and their receptors. In: Paul WE, ed. Fundamental Immunology. Philadelphia: Lippincott Williams & Wilkins, 2003: 701-747.
    • (2003) Fundamental Immunology , pp. 701-747
    • Leonard, W.J.1
  • 133
    • 0028114542 scopus 로고
    • Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor
    • Boussiotis VA, et al. Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science 1994;266:1039-1042.
    • (1994) Science , vol.266 , pp. 1039-1042
    • Boussiotis, V.A.1
  • 134
    • 0027993022 scopus 로고
    • Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
    • Miyazaki T, et al. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 1994;266:1045-1047.
    • (1994) Science , vol.266 , pp. 1045-1047
    • Miyazaki, T.1
  • 135
    • 0032562772 scopus 로고    scopus 로고
    • Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta
    • Zhu MH, Berry JA, Russell SM, Leonard WJ. Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta. J Biol Chem 1998;273:10719-10725.
    • (1998) J Biol Chem , vol.273 , pp. 10719-10725
    • Zhu, M.H.1    Berry, J.A.2    Russell, S.M.3    Leonard, W.J.4
  • 136
    • 0028857954 scopus 로고
    • Mutation of Jak3 in a patient with SCID. Essential role of Jak3 in lymphoid development
    • Russell SM, et al. Mutation of Jak3 in a patient with SCID. Essential role of Jak3 in lymphoid development. Science 1995;270:797-799.
    • (1995) Science , vol.270 , pp. 797-799
    • Russell, S.M.1
  • 137
    • 0029164841 scopus 로고
    • Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
    • Macchi P, et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995;377:65-68.
    • (1995) Nature , vol.377 , pp. 65-68
    • Macchi, P.1
  • 138
    • 0032076183 scopus 로고    scopus 로고
    • Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
    • Rodig SJ, et al. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 1998;93:373-383.
    • (1998) Cell , vol.93 , pp. 373-383
    • Rodig, S.J.1
  • 139
    • 0036233585 scopus 로고    scopus 로고
    • Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
    • O'Shea JJ, Gadina M, Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 2002;109:S121-S131.
    • (2002) Cell , vol.109
    • O'Shea, J.J.1    Gadina, M.2    Schreiber, R.D.3
  • 140
    • 0034501027 scopus 로고    scopus 로고
    • Of genes and phenotypes: The immunological and molecular spectrum of combined immune deficiency. Defects of the gamma (c)-JAK3 signaling pathway as a model
    • Notarangelo LD, et al. Of genes and phenotypes: the immunological and molecular spectrum of combined immune deficiency. Defects of the gamma (c)-JAK3 signaling pathway as a model. Immunol Rev 2000;178:39-48.
    • (2000) Immunol Rev , vol.178 , pp. 39-48
    • Notarangelo, L.D.1
  • 141
    • 0030062769 scopus 로고    scopus 로고
    • Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state
    • Briscoe J, et al. Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state. EMBOJ 1996;15:799-809.
    • (1996) EMBO J , vol.15 , pp. 799-809
    • Briscoe, J.1
  • 142
    • 0029786754 scopus 로고    scopus 로고
    • Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase
    • Gauzzi MC, Velazquez L, McKendry R, Mogensen KE, Fellous M, Pellegrini S. Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J Biol Chem 1996;271:20494-20500.
    • (1996) J Biol Chem , vol.271 , pp. 20494-20500
    • Gauzzi, M.C.1    Velazquez, L.2    McKendry, R.3    Mogensen, K.E.4    Fellous, M.5    Pellegrini, S.6
  • 143
    • 0033965488 scopus 로고    scopus 로고
    • Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: Evidence for interactions between the kinase and pseudokinase domains
    • Chen M, et al. Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains. Mol Cell Biol 2000;20:947-956.
    • (2000) Mol Cell Biol , vol.20 , pp. 947-956
    • Chen, M.1
  • 144
    • 0034949188 scopus 로고    scopus 로고
    • Novel CD28-responsive enhancer activated by CREB/ATF and AP-1 families in the human interleukin-2 receptor alpha-chain locus
    • Yeh JH, et al. Novel CD28-responsive enhancer activated by CREB/ATF and AP-1 families in the human interleukin-2 receptor alpha-chain locus. Mol Cell Biol 2001;21:4515-4527.
    • (2001) Mol Cell Biol , vol.21 , pp. 4515-4527
    • Yeh, J.H.1
  • 145
    • 0037033012 scopus 로고    scopus 로고
    • The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
    • Saharinen P, Silvennoinen O. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem 2002;277:47954-47963.
    • (2002) J Biol Chem , vol.277 , pp. 47954-47963
    • Saharinen, P.1    Silvennoinen, O.2
  • 146
    • 0031017533 scopus 로고    scopus 로고
    • Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways
    • Luo H, et al. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol Cell Biol 1997;17:1562-1571.
    • (1997) Mol Cell Biol , vol.17 , pp. 1562-1571
    • Luo, H.1
  • 147
    • 0028097219 scopus 로고
    • Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase
    • Frank SJ, Gilliland G, Kraft AS, Arnold CS. Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase. Endocrinology 1994;135:2228-2239.
    • (1994) Endocrinology , vol.135 , pp. 2228-2239
    • Frank, S.J.1    Gilliland, G.2    Kraft, A.S.3    Arnold, C.S.4
  • 148
    • 0029024882 scopus 로고
    • Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor
    • Frank SJ, et al. Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor. J Biol Chem 1995;270:14776-14785.
    • (1995) J Biol Chem , vol.270 , pp. 14776-14785
    • Frank, S.J.1
  • 149
    • 0029011115 scopus 로고
    • The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain
    • Zhao Y, Wagner F, Frank SJ, Kraft AS. The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain. J Biol Chem 1995;270:13814-13818.
    • (1995) J Biol Chem , vol.270 , pp. 13814-13818
    • Zhao, Y.1    Wagner, F.2    Frank, S.J.3    Kraft, A.S.4
  • 150
    • 0031009816 scopus 로고    scopus 로고
    • The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals
    • Chen M, et al. The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals. Proc Natl Acad Sci USA 1997;94:6910-6915.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6910-6915
    • Chen, M.1
  • 151
    • 0033559793 scopus 로고    scopus 로고
    • Autosomal SCID caused by a point mutation in the N-terminus of Jak3: Mapping of the Jak3-receptor interaction domain
    • Cacalano NA, et al. Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain. EMBO J 1999;18:1549-1558.
    • (1999) EMBO J , vol.18 , pp. 1549-1558
    • Cacalano, N.A.1
  • 152
    • 1542343959 scopus 로고    scopus 로고
    • Janus kinase 3 (JAK3) deficiency: Clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation
    • Roberts JL, et al. Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation. Blood 2004;103:2009-2018.
    • (2004) Blood , vol.103 , pp. 2009-2018
    • Roberts, J.L.1
  • 153
    • 18244393495 scopus 로고    scopus 로고
    • Unexpected effects of PERM domain mutations on catalytic activity of Jak3: Structural implication for Janus kinases
    • Zhou YJ, et al. Unexpected effects of PERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol Cell 2001;8:959-969.
    • (2001) Mol Cell , vol.8 , pp. 959-969
    • Zhou, Y.J.1
  • 155
    • 0037007207 scopus 로고    scopus 로고
    • Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha
    • McBride KM, Banninger G, McDonald C, Reich NC. Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha. EMBO J 2002;21:1754-1763.
    • (2002) EMBO J , vol.21 , pp. 1754-1763
    • McBride, K.M.1    Banninger, G.2    McDonald, C.3    Reich, N.C.4
  • 156
    • 33750216805 scopus 로고    scopus 로고
    • Mechanisms and biological consequences of STAT signaling by cytokines that share the common cytokine receptor γ chain, γc
    • Sehgal PB, Levy D, Hirano T, eds. Boston: Kluwer Academic
    • Lin JX, Leonard WJ. Mechanisms and biological consequences of STAT signaling by cytokines that share the common cytokine receptor γ chain, γc. In: Sehgal PB, Levy D, Hirano T, eds. Signal Transducers and Activators of Transcription (STATs): Activation and Biology. Boston: Kluwer Academic, 2003.
    • (2003) Signal Transducers and Activators of Transcription (STATs): Activation and Biology
    • Lin, J.X.1    Leonard, W.J.2
  • 157
    • 0035367819 scopus 로고    scopus 로고
    • Signaling by type I and II cytokine receptors: Ten years after
    • Gadina M, et al. Signaling by type I and II cytokine receptors: ten years after. Curr Opin Immunol 2001;13:363-373.
    • (2001) Curr Opin Immunol , vol.13 , pp. 363-373
    • Gadina, M.1
  • 159
    • 0030833570 scopus 로고    scopus 로고
    • Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
    • Udy GB, et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci USA 1997;94:7239-7244.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7239-7244
    • Udy, G.B.1
  • 160
    • 0000943469 scopus 로고    scopus 로고
    • Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
    • Teglund S, et al. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 1998;93:841-850.
    • (1998) Cell , vol.93 , pp. 841-850
    • Teglund, S.1
  • 161
    • 0031433362 scopus 로고    scopus 로고
    • An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction
    • Nakajima H, et al. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction. Immunity 1997;7:691-701.
    • (1997) Immunity , vol.7 , pp. 691-701
    • Nakajima, H.1
  • 162
    • 0031774896 scopus 로고    scopus 로고
    • Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity
    • Imada K, et al. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J Exp Med 1998;188:2067-2074.
    • (1998) J Exp Med , vol.188 , pp. 2067-2074
    • Imada, K.1
  • 163
    • 0033082138 scopus 로고    scopus 로고
    • Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
    • Moriggl R, et al. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 1999;10:249-259.
    • (1999) Immunity , vol.10 , pp. 249-259
    • Moriggl, R.1
  • 164
    • 0029124056 scopus 로고
    • Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain
    • Goldsmith MA, et al. Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain. J Biol Chem 1995;270:21729-21737.
    • (1995) J Biol Chem , vol.270 , pp. 21729-21737
    • Goldsmith, M.A.1
  • 165
    • 0028962572 scopus 로고
    • The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
    • Lin JX, et al. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 1995;2:331-339.
    • (1995) Immunity , vol.2 , pp. 331-339
    • Lin, J.X.1
  • 166
    • 0029875230 scopus 로고    scopus 로고
    • Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation
    • Friedmann MC, Migone TS, Russell SM, Leonard WJ. Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc Natl Acad Sci USA 1996;93:2077-2082.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2077-2082
    • Friedmann, M.C.1    Migone, T.S.2    Russell, S.M.3    Leonard, W.J.4
  • 167
    • 0031836964 scopus 로고    scopus 로고
    • Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation
    • Onishi M, et al. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol 1998;18:3871-3879.
    • (1998) Mol Cell Biol , vol.18 , pp. 3871-3879
    • Onishi, M.1
  • 168
    • 0029005549 scopus 로고
    • Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
    • Migone TS, et al. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 1995;269:79-81.
    • (1995) Science , vol.269 , pp. 79-81
    • Migone, T.S.1
  • 169
    • 0037062489 scopus 로고    scopus 로고
    • Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice
    • Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H. Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. Proc Natl Acad Sci USA 2002;99:8253-8258.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8253-8258
    • Tsuruyama, T.1    Nakamura, T.2    Jin, G.3    Ozeki, M.4    Yamada, Y.5    Hiai, H.6
  • 170
    • 0038152914 scopus 로고    scopus 로고
    • Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma
    • Kelly JA, et al. Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma. J Exp Med 2003;198:79-89.
    • (2003) J Exp Med , vol.198 , pp. 79-89
    • Kelly, J.A.1
  • 171
    • 0029853971 scopus 로고    scopus 로고
    • An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I (Y) and a GATA family protein
    • John S, Robbins CM, Leonard WJ. An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I (Y) and a GATA family protein. EMBO J 1996;15:5627-5635.
    • (1996) EMBO J , vol.15 , pp. 5627-5635
    • John, S.1    Robbins, C.M.2    Leonard, W.J.3
  • 172
    • 0034897188 scopus 로고    scopus 로고
    • The basis for IL-2-induced IL-2 receptor a chain gene regulation: Importance of two widely separated IL-2 response elements
    • Kim HP, Kelly J, Leonard WJ. The basis for IL-2-induced IL-2 receptor a chain gene regulation: importance of two widely separated IL-2 response elements. Immunity 2001;15:159-172.
    • (2001) Immunity , vol.15 , pp. 159-172
    • Kim, H.P.1    Kelly, J.2    Leonard, W.J.3
  • 173
    • 0033199236 scopus 로고    scopus 로고
    • STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells
    • Nosaka T, Kawashima T, Misawa K, Ikuta K, Mui AL, Kitamura T. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J 1999;18:4754-4765.
    • (1999) EMBO J , vol.18 , pp. 4754-4765
    • Nosaka, T.1    Kawashima, T.2    Misawa, K.3    Ikuta, K.4    Mui, A.L.5    Kitamura, T.6
  • 174
    • 0033560095 scopus 로고    scopus 로고
    • Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells
    • Matikainen S, Sareneva T, Ronni T, Lehtonen A, Koskinen PJ, Julkunen I. Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells. Blood 1999;93:1980-1991.
    • (1999) Blood , vol.93 , pp. 1980-1991
    • Matikainen, S.1    Sareneva, T.2    Ronni, T.3    Lehtonen, A.4    Koskinen, P.J.5    Julkunen, I.6
  • 175
    • 0033106168 scopus 로고    scopus 로고
    • Transcriptional regulation of the cyclin D1 promoter by STAT5: Its involvement in cytokine-dependent growth of hematopoietic cells
    • Matsumura I, et al. Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J 1999;18:1367-1377.
    • (1999) EMBO J , vol.18 , pp. 1367-1377
    • Matsumura, I.1
  • 176
    • 0035253352 scopus 로고    scopus 로고
    • Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2
    • Martino A, Holmes JHT, Lord JD, Moon JJ, Nelson BH. Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2. J Immunol 2001;166:1723-1729.
    • (2001) J Immunol , vol.166 , pp. 1723-1729
    • Martino, A.1    Holmes, J.H.T.2    Lord, J.D.3    Moon, J.J.4    Nelson, B.H.5
  • 177
    • 0344064893 scopus 로고    scopus 로고
    • Stat5 activation plays a critical role in Th2 differentiation
    • Zhu J, Cote-Sierra J, Guo L, Paul WE. Stat5 activation plays a critical role in Th2 differentiation. Immunity 2003;19:739-748.
    • (2003) Immunity , vol.19 , pp. 739-748
    • Zhu, J.1    Cote-Sierra, J.2    Guo, L.3    Paul, W.E.4
  • 178
    • 0142219240 scopus 로고    scopus 로고
    • Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation
    • Blaeser F, et al. Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. JExp Med 2003;198:1189-1200.
    • (2003) JExp Med , vol.198 , pp. 1189-1200
    • Blaeser, F.1
  • 179
    • 0029115522 scopus 로고
    • Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
    • Johnston JA, et al. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc Natl Acad Sci USA 1995;92:8705-8709.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8705-8709
    • Johnston, J.A.1
  • 180
    • 0033520477 scopus 로고    scopus 로고
    • Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9
    • Demoulin JB, Van Roost E, Stevens M, Groner B, Renauld JC. Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. J Biol Chem 1999;274:25855-25861.
    • (1999) J Biol Chem , vol.274 , pp. 25855-25861
    • Demoulin, J.B.1    Van Roost, E.2    Stevens, M.3    Groner, B.4    Renauld, J.C.5
  • 181
    • 0037514399 scopus 로고    scopus 로고
    • IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells
    • Strengell M, et al. IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells. J Immunol 2003;170:5464-5469.
    • (2003) J Immunol , vol.170 , pp. 5464-5469
    • Strengell, M.1
  • 182
    • 0030935260 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
    • Takeda K, et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci USA 1997;94:3801-3804.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3801-3804
    • Takeda, K.1
  • 183
    • 0034657958 scopus 로고    scopus 로고
    • Roles of STAT3 defined by tissue-specific gene targeting
    • Akira S. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene 2000;19:2607-2611.
    • (2000) Oncogene , vol.19 , pp. 2607-2611
    • Akira, S.1
  • 184
    • 0031758022 scopus 로고    scopus 로고
    • Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes
    • Akaishi H, et al. Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes. Int Immunol 1998;10:1747-1751.
    • (1998) Int Immunol , vol.10 , pp. 1747-1751
    • Akaishi, H.1
  • 185
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat 1 gene results in compromised innate immunity to viral disease
    • Durbin JE, Hackenmiller R, Simon MC, Levy DE. Targeted disruption of the mouse Stat 1 gene results in compromised innate immunity to viral disease. Cell 1996;84:443-450.
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 186
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • Meraz MA, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996;84:431-442.
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1
  • 187
    • 0036200194 scopus 로고    scopus 로고
    • Protein kinase B (Akt) regulation and function in T lymphocytes
    • Cantrell D. Protein kinase B (Akt) regulation and function in T lymphocytes. Semin Immunol 2002;14:19-26.
    • (2002) Semin Immunol , vol.14 , pp. 19-26
    • Cantrell, D.1
  • 188
    • 0030890933 scopus 로고    scopus 로고
    • Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
    • Ahmed NN, Grimes HL, Bellacosa A, Chan TO, Tsichlis PN. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc Natl Acad Sci USA 1997;94:3627-3632.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3627-3632
    • Ahmed, N.N.1    Grimes, H.L.2    Bellacosa, A.3    Chan, T.O.4    Tsichlis, P.N.5
  • 189
    • 0037080219 scopus 로고    scopus 로고
    • IL-2 and related cytokines can promote T cell survival by activating AKT
    • Kelly E, Won A, Refaeli Y, Van Parijs L. IL-2 and related cytokines can promote T cell survival by activating AKT. J Immunol 2002;168:597-603.
    • (2002) J Immunol , vol.168 , pp. 597-603
    • Kelly, E.1    Won, A.2    Refaeli, Y.3    Van Parijs, L.4
  • 190
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1
  • 191
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev 1999;13:2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 192
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96:857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1
  • 193
    • 0037094096 scopus 로고    scopus 로고
    • The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2
    • Stahl M, et al. The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol 2002;168:5024-5031.
    • (2002) J Immunol , vol.168 , pp. 5024-5031
    • Stahl, M.1
  • 194
    • 0031433335 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
    • Brennan P, Babbage JW, Burgering BM, Groner B, Reif K, Cantrell DA. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 1997;7:679-689.
    • (1997) Immunity , vol.7 , pp. 679-689
    • Brennan, P.1    Babbage, J.W.2    Burgering, B.M.3    Groner, B.4    Reif, K.5    Cantrell, D.A.6
  • 195
    • 0029983731 scopus 로고    scopus 로고
    • The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis
    • Corcoran AE, Smart FM, Cowling RJ, Crompton T, Owen MJ, Venkitaraman AR. The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. EMBO J 1996;15:1924-1932.
    • (1996) EMBO J , vol.15 , pp. 1924-1932
    • Corcoran, A.E.1    Smart, F.M.2    Cowling, R.J.3    Crompton, T.4    Owen, M.J.5    Venkitaraman, A.R.6
  • 196
    • 0033136288 scopus 로고    scopus 로고
    • Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors
    • Pallard C, Stegmann AP, van Kleffens T, Smart F, Venkitaraman A, Spits H. Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity 1999;10:525-535.
    • (1999) Immunity , vol.10 , pp. 525-535
    • Pallard, C.1    Stegmann, A.P.2    Van Kleffens, T.3    Smart, F.4    Venkitaraman, A.5    Spits, H.6
  • 197
    • 0035971435 scopus 로고    scopus 로고
    • Signal transduction by MAP kinases in T lymphocytes
    • Rincon M, Flavell RA, Davis RJ. Signal transduction by MAP kinases in T lymphocytes. Oncogene 2001;20:2490-2497.
    • (2001) Oncogene , vol.20 , pp. 2490-2497
    • Rincon, M.1    Flavell, R.A.2    Davis, R.J.3
  • 199
    • 0038578688 scopus 로고    scopus 로고
    • GTPases and T cell activation
    • Cantrell DA. GTPases and T cell activation. Immunol Rev 2003;192:122-130.
    • (2003) Immunol Rev , vol.192 , pp. 122-130
    • Cantrell, D.A.1
  • 200
    • 0036359608 scopus 로고    scopus 로고
    • Transgenic analysis of thymocyte signal transduction
    • Cantrell DA. Transgenic analysis of thymocyte signal transduction. Nat Rev Immunol 2002;2:20-27.
    • (2002) Nat Rev Immunol , vol.2 , pp. 20-27
    • Cantrell, D.A.1
  • 201
    • 17144458301 scopus 로고    scopus 로고
    • Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
    • Pages G, et al. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 1999;286:1374-1377.
    • (1999) Science , vol.286 , pp. 1374-1377
    • Pages, G.1
  • 203
    • 0042432047 scopus 로고    scopus 로고
    • Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1
    • Layer K, et al. Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. Immunity 2003;19:243-255.
    • (2003) Immunity , vol.19 , pp. 243-255
    • Layer, K.1
  • 204
    • 0028299984 scopus 로고
    • In search of cytokine-response genes
    • Beadling C, Smith KA. In search of cytokine-response genes. Immunol Today 1994;15:197-199.
    • (1994) Immunol Today , vol.15 , pp. 197-199
    • Beadling, C.1    Smith, K.A.2
  • 205
    • 0043247592 scopus 로고    scopus 로고
    • DNA array analysis of interleukin-2-regulated immediate/early genes
    • Beadling C, Smith KA. DNA array analysis of interleukin-2-regulated immediate/early genes. Med Immunol 2002;1:2.
    • (2002) Med Immunol , vol.1 , pp. 2
    • Beadling, C.1    Smith, K.A.2
  • 206
    • 0037197925 scopus 로고    scopus 로고
    • IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
    • Liu K, Catalfamo M, Li Y, Henkart PA, Weng NP. IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc Natl Acad Sci USA 2002;99:6192-6197.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6192-6197
    • Liu, K.1    Catalfamo, M.2    Li, Y.3    Henkart, P.A.4    Weng, N.P.5
  • 207
    • 0038813748 scopus 로고    scopus 로고
    • Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling
    • Kovanen PE, et al. Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling. J Biol Chem 2003;278:5205-5213.
    • (2003) J Biol Chem , vol.278 , pp. 5205-5213
    • Kovanen, P.E.1
  • 208
    • 0034075845 scopus 로고    scopus 로고
    • Transcript imaging of the development of human T helper cells using oligonucleotide arrays
    • Rogge L, et al. Transcript imaging of the development of human T helper cells using oligonucleotide arrays. Nat Genet 2000;25:96-101.
    • (2000) Nat Genet , vol.25 , pp. 96-101
    • Rogge, L.1
  • 210
    • 0035884779 scopus 로고    scopus 로고
    • Gene microarrays reveal extensive differential gene expression in both CD4(+) and CD8(+) type 1 and type 2 T cells
    • Chtanova T, Kemp RA, Sutherland AP, Ronchese F, Mackay CR. Gene microarrays reveal extensive differential gene expression in both CD4(+) and CD8(+) type 1 and type 2 T cells. J Immunol 2001;167:3057-3063.
    • (2001) J Immunol , vol.167 , pp. 3057-3063
    • Chtanova, T.1    Kemp, R.A.2    Sutherland, A.P.3    Ronchese, F.4    Mackay, C.R.5
  • 211
    • 1542327676 scopus 로고    scopus 로고
    • Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation
    • Lu B, Zagouras P, Fischer JE, Lu J, Li B, Flavell RA. Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation. Proc Natl Acad Sci USA 2004;101:3023-3028.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3023-3028
    • Lu, B.1    Zagouras, P.2    Fischer, J.E.3    Lu, J.4    Li, B.5    Flavell, R.A.6
  • 212
    • 0037015038 scopus 로고    scopus 로고
    • Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation
    • Diehn M, et al. Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci USA 2002;99:11796-11801.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11796-11801
    • Diehn, M.1
  • 213
    • 0037015055 scopus 로고    scopus 로고
    • Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors
    • Riley JL, et al. Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc Natl Acad Sci USA 2002;99:11790-11795.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11790-11795
    • Riley, J.L.1
  • 214
    • 0036467533 scopus 로고    scopus 로고
    • Cutting edge: STAT6 serves as a positive and negative regulator of gene expression in IL-4-stimulated B lymphocytes
    • Schroder AJ, Pavlidis P, Arimura A, Capece D, Rothman PB. Cutting edge: STAT6 serves as a positive and negative regulator of gene expression in IL-4-stimulated B lymphocytes. J Immunol 2002;168:996-1000.
    • (2002) J Immunol , vol.168 , pp. 996-1000
    • Schroder, A.J.1    Pavlidis, P.2    Arimura, A.3    Capece, D.4    Rothman, P.B.5
  • 216
    • 0346121599 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling and immunity
    • Kubo M, Kanada T, Yoshimura A. Suppressors of cytokine signaling and immunity. Nat Immun 2003;4:1169-1176.
    • (2003) Nat Immun , vol.4 , pp. 1169-1176
    • Kubo, M.1    Kanada, T.2    Yoshimura, A.3
  • 217
    • 0347093460 scopus 로고    scopus 로고
    • Inhibitors of cytokine signal transduction
    • Wormald S, Hilton DJ. Inhibitors of cytokine signal transduction. J Biol Chem 2004;279:821-824.
    • (2004) J Biol Chem , vol.279 , pp. 821-824
    • Wormald, S.1    Hilton, D.J.2
  • 218
    • 0033520326 scopus 로고    scopus 로고
    • SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
    • Alexander WS, et al. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 1999;98:597-608.
    • (1999) Cell , vol.98 , pp. 597-608
    • Alexander, W.S.1
  • 219
    • 0344394485 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes
    • Ilangumaran S, et al. Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes. Blood 2003;102:4115-4122.
    • (2003) Blood , vol.102 , pp. 4115-4122
    • Ilangumaran, S.1
  • 220
    • 0042931134 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling I regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes
    • Ilangumaran S, Ramanathan S, La Rose J, Poussier P, Rottapel R. Suppressor of cytokine signaling I regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes. J Immunol 2003;171:2435-2445.
    • (2003) J Immunol , vol.171 , pp. 2435-2445
    • Ilangumaran, S.1    Ramanathan, S.2    La Rose, J.3    Poussier, P.4    Rottapel, R.5
  • 221
    • 1442335020 scopus 로고    scopus 로고
    • A genome-wide survey of human tyrosine phosphatases
    • Bhaduri A, Sowdhamini R. A genome-wide survey of human tyrosine phosphatases. Protein Eng 2003;16:881-888.
    • (2003) Protein Eng , vol.16 , pp. 881-888
    • Bhaduri, A.1    Sowdhamini, R.2
  • 222
    • 0034096201 scopus 로고    scopus 로고
    • Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
    • Keyse SM. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr Opin Cell Biol 2000;12:186-192.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 186-192
    • Keyse, S.M.1
  • 223
    • 18244411938 scopus 로고    scopus 로고
    • Long-term immune reconstitution and outcome after HLA-nonidentical T-cell-depleted bone marrow transplantation for severe combined immunodeficiency: A European retrospective study of 116 patients
    • Haddad E, et al. Long-term immune reconstitution and outcome after HLA-nonidentical T-cell-depleted bone marrow transplantation for severe combined immunodeficiency: a European retrospective study of 116 patients. Blood 1998;91:3646-3653.
    • (1998) Blood , vol.91 , pp. 3646-3653
    • Haddad, E.1
  • 224
    • 0033580206 scopus 로고    scopus 로고
    • Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency
    • Buckley RH, et al. Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. N Engl J Med 1999;340:508-516.
    • (1999) N Engl J Med , vol.340 , pp. 508-516
    • Buckley, R.H.1
  • 225
    • 0037129435 scopus 로고    scopus 로고
    • Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy
    • Hacein-Bey-Abina S, et al. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med 2002;346:1185-1193.
    • (2002) N Engl J Med , vol.346 , pp. 1185-1193
    • Hacein-Bey-Abina, S.1
  • 226
    • 0037448352 scopus 로고    scopus 로고
    • A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
    • Hacein-Bey-Abina S, et al. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 2003;348:255-256.
    • (2003) N Engl J Med , vol.348 , pp. 255-256
    • Hacein-Bey-Abina, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.