Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2

Journal of Immunology

Volumn 166, Issue 3, 2001, Pages 1723-1729

  Martino, A ^a   Holmes IV, J H ^a   Lord, J D ^a   Moon, J J ^a   Nelson, B H ^a  

^a BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CD8 ANTIGEN; CYCLIN D2; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; LUCIFERASE; PROTEIN SHC; STAT5 PROTEIN; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; B LYMPHOBLAST; CELL CYCLE; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION REGULATION; GENE INDUCTION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REPORTER GENE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0035253352     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.3.1723     Document Type: Article

References (51)

1. Recent advances in the understanding of interleukine-2 signal transduction
2. Biology of the interleukin-2 receptor
3. An associated molecule, p64 with IL-2 receptor β chain: Its possible involvement in the formation of the functional intermediate IL-2 receptor complex
4. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
5. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2
6. Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line
7. Different interleukin 2 receptor β-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation
8. The IL-2 receptor promotes proliferation, bcl-2 and bcl-x induction, but not cell viability through the adapter molecule Shc
9. Evidence for a role for the phosphotyrosine binding domain of Shc in interleukin-2 signaling
10. Analysis of interleukin-2 dependent signal transduction through the Shc/Grb2 adaptor pathway
11. Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes
12. Transcriptional regulation by extracellular signals: Mechanisms and specificity
13. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
14. The role of phosphotyrosine phosphatases in haematopoietic cell signal transduction
15. Cloning of p97/Gab2, the major SHP-2 binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
16. IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98 kDa protein associated with SHP-2, phosphatidylinositol 3-kinase, and Grb2
17. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
18. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
19. s6K integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes
20. Interleukin 2 activates Stat5 transcriptional factor (mammary gland factor) and specific gene expression in T lymphocytes
21. Identification and purification of human stat proteins activated in response to interleukin-2
22. Cytokines and JAK-STAT signaling
23. The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the transactivation domain of Stat5
24. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: Role of Stat5 in proliferation
25. Stat5 is required for IL-2 induced cell cycle progression of peripheral T cells
26. An IL-2 response element in the human IL-2 receptor α chain promoter is a composite element that binds Stat5, Elf-1, HMG-1(Y), and GATA family protein
27. Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene
28. Interferon-α activates multiple STAT proteins and upregulates proliferation-associated IL-2Rα, c-myc, and pim-1 genes in human T cells
29. Transcriptional regulation of the cyclin D1 promoter by STAT5: Its involvement in cytokine dependent growth of hematopoietic cells
30. WAF1/Cip1 by Stat5
31. 1 cyclins in primary T cells is not blocked by rapamycin or cyclosporin A
32. 1 phase in primary human T lymphocytes
33. Cyclin D expression is controlled posttranscriptionally via a phosphatidylinosital 3-kinase/Akt dependent pathway
34. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
35. Functional analysis of the human cyclin D2 and cyclin D3 promoters
36. Distinct regions of the human granulocyte-colony-stimulating factor receptor are required for proliferation and gene induction
37. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis
38. Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms
39. Naturally occurring dominant negative variants of Stat5
40. Association of STATs with relatives and friends
41. Transcription factor activity of STAT proteins: Structural requirements and regulation by phosphorylation and interacting proteins
42. Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3
43. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation
44. Functional association of Nmi with Stat5 and Stat1 in IL-2 and 1FNγ-mediated signaling
45. The enhanceosome and transcriptional synergy
46. Cofactor requirements for transcriptional activation by Sp1
47. Chromatin, TAFs, and a novel multiprotein co-activator are required for synergistic activation by Sp1 and SREBP-1 α in vitro
48. Induction of Sp1 activation by prolactin and interleukin-2 in Nb2 T-cells: Differential association of Sp1-DNA complexes with Stats
49. Stat1 depends on transcriptional synergy with Sp1
50. Growth/cell cycle regulation of Sp1 phosphorylation
51. Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor