Distinct gene expression profiles of human type 1 and type 2 T helper cells

Genome Biology

Volumn 2, Issue 7, 2001, Pages

  Hamalainen, Heli ^a   Zhou, Hua ^b   Chou, William ^b   Hashizume, Hideki ^b   Heller, Renu ^b   Lahesmaa, Riitta ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b ROCHE BIOSCIENCE   (United States)

Author keywords

Change Threshold; Fibroblast Growth Factor Receptor; Helper Cell; Oligonucleotide Array; Reverse Transcription Polymerase Chain Reaction

Indexed keywords

CD4 ANTIGEN; CYTOKINE; CYTOKINE RECEPTOR; RNA;

ARTICLE; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; METHODOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TH1 CELL; TH2 CELL;

ANTIGENS, CD4; CYTOKINES; GENE EXPRESSION PROFILING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CYTOKINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SENSITIVITY AND SPECIFICITY; TH1 CELLS; TH2 CELLS;

EID: 0035224492     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2001-2-7-research0022     Document Type: Article

References (57)

1. Romagnani S: Lymphokine production by human T cells in disease states. Annu Rev Immunol. 1994, 12: 227-257. DOI: 10.1146/annurev.iy.12.040194.001303
2. + T cells. Annu Rev Immunol. 1994, 12: 635-673. DOI: 10.1146/annurev.iy.12.040194.003223
3. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature. 1996, 383: 787-793. DOI: 10.1038/383787a0
4. Marshall A, Hodgson J: DNA chips: an array of possibilities. Nat Biotechnol. 1998, 16: 27-31. DOI: 10.1038/nbt0198-27
5. Duggan DJ, Bittner M, Chen Y, Meltzer P, Trent JM: Expression profiling using cDNA microarrays. Nat Genet. 1999, 21: 10-14. DOI: 10.1038/4434
6. Der SD, Zhou A, Williams BR, Silverman RH: Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci USA. 1998, 95: 15623-15628. DOI: 10.1073/pnas.95.26.15623
7. Iwata M, Vieira J, Byrne M, Horton H, Torok-Storb B: Interleukin-1 (IL-1) inhibits growth of cytomegalovirus in human marrow stromal cells: inhibition is reversed upon removal of IL-1. Blood. 1999, 94: 572-578.
8. Zhu H, Cong JP, Mamtora G, Gingeras T, Shenk T: Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays. Proc Natl Acad Sci USA. 1998, 95: 14470-14475. DOI: 10.1073/pnas.95.24.14470
9. Geiss GK, Bumgarner RE, An MC, Agy MB, van't Wout AB, Hammersmark E, Carter VS, Upchurch D, Mullins JI, Katze MG: Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays. Virology. 2000, 266: 8-16. 10.1006/viro.1999.0044. DOI: 10.1006/viro.1999.0044
10. Heller RA, Schena M, Chai A, Shalon D, Bedilion T, Gilmore J, Woolley DE, Davis RW: Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci USA. 1997, 94: 2150-2155. DOI: 10.1073/pnas.94.6.2150
11. Kaminski N, Allard JD, Pittet JF, Zuo F, Griffiths MJ, Morris D, Huang X, Sheppar D, Heller RA: Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc Natl Acad Sci USA. 2000, 97: 1778-1783. DOI: 10.1073/pnas.97.4.1778
12. Amundson SA, Bittner M, Chen Y, Trent J, Meltzer P, Fornace AJ: Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene. 1999, 18: 3666-3672. 10.1038/sj/onc/1202676. DOI: 10.1038/sj.onc.1202676
13. Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, et al: Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999, 286: 531-537. 10.1126/science.286.5439.531. DOI: 10.1126/science.286.5439.531
14. Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, et al: Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000, 403: 503-511. 10.1038/35000501. DOI: 10.1038/35000501
15. Rogge L, Bianchi E, Biffi M, Bono E, Chang SY, Alexander H, Santini C, Ferrari G, Sinigaglia L, Seiler M, et al: Transcript imaging of the development of human T helper cells using oligonucleotide arrays. Nat Genet. 2000, 25: 96-101. 10.1038/75671. DOI: 10.1038/75671
16. Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H, Brown EL: Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol. 1996, 14: 1675-1680. DOI: 10.1038/nbt1296-1675
17. Wodicka L, Dong H, Mittmann M, Ho MH, Lockhart DJ: Genome-wide expression monitoring in Saccharomyces cerevisiae. Nat Biotechnol. 1997, 15: 1359-1367. DOI: 10.1038/nbt1297-1359
18. Heller RA, Allard J, Zuo F, Lock C, Wilson S, Klonowski P, Gmuender H, van Hart H, Booth R: Gene chips and microarrays: applications in disease profiles, drug target discovery, drug action and toxicity. In Secondary Gene Chips and Microarrays: Applications in Disease Profiles, Drug Target Discovery, Drug Action and Toxicity. Edited by Schena M. New York: Oxford University Press,. 1999, 187-202.
19. Heid CA, Stevens J, Livak KJ, Williams PM: Real time quantitative PCR. Genome Res. 1996, 6: 986-994. DOI: 10.1101/gr.6.10.986
20. Hamalainen H, Meissner S, Lahesmaa R: Signaling lymphocytic activation molecule (SLAM) is differentially expressed in human Th1 and Th2 cells. J Immunol Methods. 2000, 242: 9-19. DOI: 10.1016/S0022-1759(00)00200-3
21. Teague TK, Hildeman D, Kedl RM, Mitchell T, Rees W, Schaefer BC, Bender J, Kappler J, Marrack P: Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc Natl Acad Sci USA. 1999, 96: 12691-12696. DOI: 10.1073/pnas.96.22.12691
22. Shanafelt MC, Yssel H, Soderberg C, Steinman L, Adelman DC, Peltz G, Lahesmaa R: CD45 isoforms on human CD4+ T-cell subsets. J Allergy Clin Immunol. 1996, 98: 433-440. DOI: 10.1016/S0091-6749(96)70168-9
23. Rogge L, Barberis-Maino L, Biffi M, Passini N, Presky DH, Gubler U, Sinigaglia F: Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med. 1997, 185: 825-831. DOI: 10.1084/jem.185.5.825
24. Groux H, Sornasse T, Cottrez F, de Vries JE, Coffman RL, Roncarolo MG, Yssel H: Induction of human T helper cell type 1 differentiation results in loss of IFN-gamma receptor beta-chain expression. J Immunol. 1997, 158: 5627-5631.
25. Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, Sinigaglia F: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med. 1998, 187: 129-134. DOI: 10.1084/jem.187.1.129
26. Imai T, Nagira M, Takagi S, Kakizaki M, Nishimura M, Wang J, Gray PW, Matsushima K, Yoshie O: Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol. 1999, 11: 81-88. DOI: 10.1093/intimm/11.1.81
27. Glimcher LH, Murphy KM: Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 2000, 14: 1693-1711.
28. Ho IC, Hodge MR, Rooney JW, Glimcher LH: The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell. 1996, 85: 973-983. DOI: 10.1016/S0092-8674(00)81299-4
29. Zheng W, Flavell RA: The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 1997, 89: 587-596. DOI: 10.1016/S0092-8674(00)80240-8
30. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000, 100: 655-669. DOI: 10.1016/S0092-8674(00)80702-3
31. Romagnani S: Biology of human TH1 and TH2 cells. J Clin Immunol. 1995, 15: 121-129. DOI: 10.1007/BF01543103
32. Agarwal S, Rao A: Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity. 1998, 9: 765-775. DOI: 10.1016/S1074-7613(00)80642-1
33. Kelly BL, Locksley RM: Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns. J Immunol. 2000, 165: 2982-2986. DOI: 10.4049/jimmunol.165.6.2982
34. Bacher M, Metz CN, Calandra T, Mayer K, Chesney J, Lohoff M, Gemsa D, Donnelly T, Bucala R: An essential regulatory role for macrophage migration inhibitory factor in T-cell activation. Proc Natl Acad Sci USA. 1996, 93: 7849-7854. DOI: 10.1073/pnas.93.15.7849
35. Baggiolini M, Dewald B, Moser B: Human chemokines: an update. Annu Rev Immunol. 1997, 15: 675-705. DOI: 10.1146/annurev.immunol.15.1.675
36. Schrum S, Probst P, Fleischer B, Zipfel PF: Synthesis of the CC-chemokines MIP-1alpha, MIP-1beta, and RANTES is associated with a type 1 immune response. J Immunol. 1996, 157: 3598-3604.
37. Siveke JT, Hamann A: T helper 1 and T helper 2 cells respond differentially to chemokines. J Immunol. 1998, 160: 550-554.
38. Loetscher P, Uguccioni M, Bordoli L, Baggiolini M, Moser B, Chizzolini C, Dayer JM: CCR5 is characteristic of Th1 lymphocytes. Nature. 1998, 391: 344-345. DOI: 10.1038/34814
39. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med. 1998, 187: 875-883. DOI: 10.1084/jem.187.6.875
40. Soares MV, Borthwick NJ, Maini MK, Janossy G, Salmon M, Akbar AN: IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire. J Immunol. 1998, 161: 5909-5917.
41. Marrack P, Kappler J, Mitchell T: Type 1 interferons keep activated T cells alive. J Exp Med. 1999, 189: 521-530. DOI: 10.1084/jem.189.3.521
42. Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly PA, Shah K, Ho S, Antonenko S, Liu YJ: The nature of the principal type 1 interferon-producing cells in human blood. Science. 1999, 284: 1835-1837. 10.1126/science.284.5421.1835. DOI: 10.1126/science.284.5421.1835
43. Zhao XM, Byrd VM, McKeehan WL, Reich MB, Miller GG, Thomas JW: Costimulation of human CD4+ T cells by fibroblast growth factor-1 (acidic fibroblast growth factor). J Immunol. 1995, 155: 3904-3911.
44. Swain SL, Huston G, Tonkonogy S, Weinberg A: Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J Immunol. 1991, 147: 2991-3000.
45. Heath VL, Murphy EE, Crain C, Tomlinson MG, O'Garra A: TGF-beta1 down-regulates Th2 development and results in decreased IL-4- induced STAT6 activation and GATA-3 expression. Eur J Immunol. 2000, 30: 2639-2649. 10.1002/1521-4141(200009)30:9<2639::AID-IMMU2639>3.3.CO;2-Z. DOI: 10.1002/1521-4141(200009)30:9<2639::AID-IMMU2639>3.0.CO;2-7
46. Gorelik L, Fields PE, Flavell RA: Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression. J Immunol. 2000, 165: 4773-4777. DOI: 10.4049/jimmunol.165.9.4773
47. Hansen G, McIntire JJ, Yeung VP, Berry G, Thorbecke GJ, Chen L, DeKruyff RH, Umetsu DT: CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation. J Clin Invest. 2000, 105: 61-70. DOI: 10.1172/JCI7589
48. Zhang X, Brunner T, Carter L, Dutton RW, Rogers P, Bradley L, Sato T, Reed JC, Green D, Swain SL: Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J Exp Med. 1997, 185: 1837-1849. DOI: 10.1084/jem.185.10.1837
49. Varadhachary AS, Perdow SN, Hu C, Ramanarayanan M, Salgame P: Differential ability of T cell subsets to undergo activation-induced cell death. Proc Natl Acad Sci USA. 1997, 94: 5778-5783. DOI: 10.1073/pnas.94.11.5778
50. Jayaraman S, Castro M, O'Sullivan M, Bragdon MJ, Holtzman MJ: Resistance to Fas-mediated T cell apoptosis in asthma. J Immunol. 1999, 162: 1717-1722.
51. Humphreys DT, Carver JA, Easterbrook-Smith SB, Wilson MR: Clusterin has chaperone-like activity similar to that of small heat shock proteins. J Biol Chem. 1999, 274: 6875-6881. DOI: 10.1074/jbc.274.11.6875
52. Humphreys D, Hochgrebe TT, Easterbrook-Smith SB, Tenniswood MP, Wilson MR: Effects of clusterin overexpression on TNFalpha- and TGFbeta-mediated death of L929 cells. Biochemistry. 1997, 36: 15233-15243. 10.1021/bi9703507. DOI: 10.1021/bi9703507
53. Harris DP, Haynes L, Sayles PC, Duso DK, Eaton SM, Lepak NM, Johnson LL, Swain SL, Lund FE: Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat Immunol. 2000, 1: 475-482. 10.1038/82717. DOI: 10.1038/82717
54. Yang LP, Byun DG, Demeure CE, Vezzio N, Delespesse G: Default development of cloned human naive CD4 T cells into interleukin-4- and interleukin-5- producing effector cells. Eur J Immunol. 1995, 25: 3517-3520. DOI: 10.1002/eji.1830251247
55. Lahesmaa R, Allsup A, Soderberg C, Jackman J, Findell P, Peltz G: Modulation of the Grb2-associated protein complex in human CD4+ T cells by receptor activation. J Immunol. 1995, 155: 3815-3822.
56. Lipshutz RJ, Fodor SP, Gingeras TR, Lockhart DJ: High density synthetic oligonucleotide arrays. Nat Genet. 1999, 21: 20-24. DOI: 10.1038/4447
57. Gibson UE, Heid CA, Williams PM: A novel method for real time quantitative RT-PCR. Genome Res. 1996, 6: 995-1001. DOI: 10.1101/gr.6.10.995