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Volumn 17, Issue 6, 1997, Pages 431-447

Advances in the understanding of cytokine signal transduction: The role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency

Author keywords

Cytokines; Immunodeficiency; Immunoregulation; Jaks; Signal transruction; STATs

Indexed keywords

CYTOKINE; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH HORMONE; MONOPHENOL MONOOXYGENASE; PROLACTIN; THROMBOPOIETIN;

EID: 0031440585     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027388508570     Document Type: Article
Times cited : (46)

References (215)
  • 1
    • 0028887623 scopus 로고
    • Cytokines and their receptor complexes
    • Davies DR, Wlodawer A: Cytokines and their receptor complexes. FASEB J 9:50-56, 1995
    • (1995) FASEB J , vol.9 , pp. 50-56
    • Davies, D.R.1    Wlodawer, A.2
  • 2
    • 0025102756 scopus 로고
    • Haemopoietic receptors and helical cytokines
    • Bazan JF: Haemopoietic receptors and helical cytokines. Immunol Today 11:350-354, 1990
    • (1990) Immunol Today , vol.11 , pp. 350-354
    • Bazan, J.F.1
  • 3
    • 0027232919 scopus 로고
    • The hematopoietin receptor superfamily
    • Cosman D: The hematopoietin receptor superfamily. Cytokine 5:95-106, 1993
    • (1993) Cytokine , vol.5 , pp. 95-106
    • Cosman, D.1
  • 4
    • 0028946686 scopus 로고
    • Signaling mechanisms through cytokine receptors that share signal transducing receptor components
    • Taga T, Kishimoto T: Signaling mechanisms through cytokine receptors that share signal transducing receptor components. Curr Opin Immunol 7:17-23, 1995
    • (1995) Curr Opin Immunol , vol.7 , pp. 17-23
    • Taga, T.1    Kishimoto, T.2
  • 5
    • 0029924265 scopus 로고    scopus 로고
    • The molecular basis of X-linked severe combined immunodeficiency: Defective cytokine receptor signaling
    • Leonard WJ: The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. Annu Rev Med 47:229-239, 1996
    • (1996) Annu Rev Med , vol.47 , pp. 229-239
    • Leonard, W.J.1
  • 9
    • 0030047514 scopus 로고    scopus 로고
    • Interleukin-15 up-regulates interleukin-2 receptor alpha chain but down-regulates its own high-affinity binding sites on human T and B cells
    • Kumaki S, Armitage R, Ahdieh M, Park L, Cosman D: Interleukin-15 up-regulates interleukin-2 receptor alpha chain but down-regulates its own high-affinity binding sites on human T and B cells. Eur J Immunol 26:1235-1239, 1996
    • (1996) Eur J Immunol , vol.26 , pp. 1235-1239
    • Kumaki, S.1    Armitage, R.2    Ahdieh, M.3    Park, L.4    Cosman, D.5
  • 10
    • 0029946063 scopus 로고    scopus 로고
    • IL-15: A pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels
    • Tagaya Y, Bamford RN, DeFilippis AP, Waldmann TA: IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity 4:329-336, 1996
    • (1996) Immunity , vol.4 , pp. 329-336
    • Tagaya, Y.1    Bamford, R.N.2    DeFilippis, A.P.3    Waldmann, T.A.4
  • 11
    • 0029811474 scopus 로고    scopus 로고
    • Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells
    • Tagaya Y, Burton JD, Miyamoto Y, Waldmann TA: Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells. EMBO J 15:4928-4939, 1996
    • (1996) EMBO J , vol.15 , pp. 4928-4939
    • Tagaya, Y.1    Burton, J.D.2    Miyamoto, Y.3    Waldmann, T.A.4
  • 12
    • 0027274890 scopus 로고
    • Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction
    • Zurawski SM, Vega FJ, Huyghe B, Zurawski G: Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J 12: 2663-2670, 1993
    • (1993) EMBO J , vol.12 , pp. 2663-2670
    • Zurawski, S.M.1    Vega, F.J.2    Huyghe, B.3    Zurawski, G.4
  • 13
    • 0029867119 scopus 로고    scopus 로고
    • IL-4 and IL-13 receptors: Are they one and the same?
    • Callard RE, Matthews DJ, Hibbert L: IL-4 and IL-13 receptors: Are they one and the same? Immunol Today 17:108-110, 1996
    • (1996) Immunol Today , vol.17 , pp. 108-110
    • Callard, R.E.1    Matthews, D.J.2    Hibbert, L.3
  • 14
    • 0030068217 scopus 로고    scopus 로고
    • Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor
    • Hilton DJ, Zhang JG, Metcalf D, Alexander WS, Nicola NA, Willson TA: Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc Natl Acad Sci USA 93:497-501, 1996
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 497-501
    • Hilton, D.J.1    Zhang, J.G.2    Metcalf, D.3    Alexander, W.S.4    Nicola, N.A.5    Willson, T.A.6
  • 15
    • 0029927153 scopus 로고    scopus 로고
    • Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain
    • Caput D, Laurent P, Kaghad M, Lelias JM, Lefort S, Vita N, Ferrara P: Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. J Biol Chem 271:16921-16926, 1996
    • (1996) J Biol Chem , vol.271 , pp. 16921-16926
    • Caput, D.1    Laurent, P.2    Kaghad, M.3    Lelias, J.M.4    Lefort, S.5    Vita, N.6    Ferrara, P.7
  • 16
    • 10544246077 scopus 로고    scopus 로고
    • cDNA cloning and characterization of the human interleukin 13 receptor alpha chain
    • Aman MJ, Tayebi N, Obiri NI, Puri RK, Modi WS, Leonard WJ: cDNA cloning and characterization of the human interleukin 13 receptor alpha chain. J Biol Chem 271:29265-29270, 1996
    • (1996) J Biol Chem , vol.271 , pp. 29265-29270
    • Aman, M.J.1    Tayebi, N.2    Obiri, N.I.3    Puri, R.K.4    Modi, W.S.5    Leonard, W.J.6
  • 17
    • 0030889207 scopus 로고    scopus 로고
    • The IFN-gamma receptor: A paradigm for cytokine receptor signaling
    • Bach EA, Aguet M, Schreiber RD: The IFN-gamma receptor: A paradigm for cytokine receptor signaling. Annu Rev Immunol 15:563-593, 1997
    • (1997) Annu Rev Immunol , vol.15 , pp. 563-593
    • Bach, E.A.1    Aguet, M.2    Schreiber, R.D.3
  • 18
    • 0028892869 scopus 로고
    • Cloning and characterization of a mouse IL-12 receptor-beta component
    • Chua AO, Wilkinson VL, Presky DH, Gubler U: Cloning and characterization of a mouse IL-12 receptor-beta component. J Immunol 155:4286-4294, 1995
    • (1995) J Immunol , vol.155 , pp. 4286-4294
    • Chua, A.O.1    Wilkinson, V.L.2    Presky, D.H.3    Gubler, U.4
  • 20
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo SJ, Dighe AS, Gubler U, Murphy KM: Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 185:817-824, 1997
    • (1997) J Exp Med , vol.185 , pp. 817-824
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 21
    • 0028179006 scopus 로고
    • Lymphocyte responses and cytokines
    • Paul WE, Seder RA: Lymphocyte responses and cytokines. Cell 76:241-251, 1994
    • (1994) Cell , vol.76 , pp. 241-251
    • Paul, W.E.1    Seder, R.A.2
  • 22
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 383:787-793, 1996
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 24
    • 0027400726 scopus 로고
    • Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    • Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA: Multiple defects of immune cell function in mice with disrupted interferon-gamma genes, Science 259:1739-1742, 1993
    • (1993) Science , vol.259 , pp. 1739-1742
    • Dalton, D.K.1    Pitts-Meek, S.2    Keshav, S.3    Figari, I.S.4    Bradley, A.5    Stewart, T.A.6
  • 28
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kuhn R, Rajewsky K, Muller W: Generation and analysis of interleukin-4 deficient mice. Science 254:707-710, 1991
    • (1991) Science , vol.254 , pp. 707-710
    • Kuhn, R.1    Rajewsky, K.2    Muller, W.3
  • 30
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W: Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263-274, 1993
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 31
    • 0028929565 scopus 로고
    • Lymphopenia in interleukin (IL)-7 gene-deleted mice identities IL-7 as a nonredundant cytokine
    • von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, Murray R: Lymphopenia in interleukin (IL)-7 gene-deleted mice identities IL-7 as a nonredundant cytokine. J Exp Med 181:1519-1526, 1995
    • (1995) J Exp Med , vol.181 , pp. 1519-1526
    • Von Freeden-Jeffry, U.1    Vieira, P.2    Lucian, L.A.3    McNeil, T.4    Burdach, S.E.5    Murray, R.6
  • 33
    • 0030018826 scopus 로고    scopus 로고
    • Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells
    • He YW, Malek TR: Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells. J Exp Med 184:289-293, 1996
    • (1996) J Exp Med , vol.184 , pp. 289-293
    • He, Y.W.1    Malek, T.R.2
  • 35
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I: Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253-261, 1993
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 36
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW: Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521-530, 1995
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 38
    • 0030903027 scopus 로고    scopus 로고
    • Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor
    • Sharfe N, Dadi HK, Shahar M, Roifman CM: Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor. Proc Natl Acad Sci USA 94:3168-3171, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3168-3171
    • Sharfe, N.1    Dadi, H.K.2    Shahar, M.3    Roifman, C.M.4
  • 39
    • 0026081302 scopus 로고
    • Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase
    • Wilks AF, Harpur AG, Kurban RR, Ralph SJ, Zurcher G, Ziemiecki A: Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol Cell Biol 11:2057-2065, 1991
    • (1991) Mol Cell Biol , vol.11 , pp. 2057-2065
    • Wilks, A.F.1    Harpur, A.G.2    Kurban, R.R.3    Ralph, S.J.4    Zurcher, G.5    Ziemiecki, A.6
  • 43
    • 0026632288 scopus 로고
    • A protein tyrosine kinase in the Interferon alpha/beta signaling pathway
    • Velazquez L, Fellous M, Stark GR, Pellegrini S: A protein tyrosine kinase in the Interferon alpha/beta signaling pathway. Cell 70:313-322, 1992
    • (1992) Cell , vol.70 , pp. 313-322
    • Velazquez, L.1    Fellous, M.2    Stark, G.R.3    Pellegrini, S.4
  • 45
    • 0028244396 scopus 로고
    • Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
    • Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, Ihle JN: Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153-157, 1994
    • (1994) Nature , vol.370 , pp. 153-157
    • Witthuhn, B.A.1    Silvennoinen, O.2    Miura, O.3    Lai, K.S.4    Cwik, C.5    Liu, E.T.6    Ihle, J.N.7
  • 46
    • 0029865748 scopus 로고    scopus 로고
    • Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells
    • Gurniak CB, Berg LJ: Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells. Blood 87:3151-3160, 1996
    • (1996) Blood , vol.87 , pp. 3151-3160
    • Gurniak, C.B.1    Berg, L.J.2
  • 47
    • 0028268381 scopus 로고
    • Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases
    • Takahashi T, Shirasawa T: Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases. FEBS Lett 342:124-128, 1994
    • (1994) FEBS Lett , vol.342 , pp. 124-128
    • Takahashi, T.1    Shirasawa, T.2
  • 48
    • 0028206119 scopus 로고
    • JAK3: A novel JAK kinase associated with terminal differentiation of hematopoietic cells
    • Rane SG, Reddy EP: JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells. Oncogene 9:2415-2423, 1994
    • (1994) Oncogene , vol.9 , pp. 2415-2423
    • Rane, S.G.1    Reddy, E.P.2
  • 49
    • 0028955102 scopus 로고
    • Regulation of JAK3 expression in human monocytes: Phosphorylation in response to interleukins 2, 4, and 7
    • Musso T, Johnston JA, Linnekin D, Varesio L, Rowe TK, O'Shea JJ, McVicar DW: Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7. J Exp Med 181:1425-1431, 1995
    • (1995) J Exp Med , vol.181 , pp. 1425-1431
    • Musso, T.1    Johnston, J.A.2    Linnekin, D.3    Varesio, L.4    Rowe, T.K.5    O'Shea, J.J.6    McVicar, D.W.7
  • 51
    • 17544376062 scopus 로고    scopus 로고
    • Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells
    • Verbsky JW, Bach EA, Fang YF, Yang L, Randolph DA, Fields LE: Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells. J Biol Chem 271:13976-13980, 1996
    • (1996) J Biol Chem , vol.271 , pp. 13976-13980
    • Verbsky, J.W.1    Bach, E.A.2    Fang, Y.F.3    Yang, L.4    Randolph, D.A.5    Fields, L.E.6
  • 52
    • 0028823396 scopus 로고
    • A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells
    • Lai KS, Jin Y, Graham DK, Witthuhn BA, Ihle JN, Liu ET: A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells. J Biol Chem 270: 25028-25036, 1995
    • (1995) J Biol Chem , vol.270 , pp. 25028-25036
    • Lai, K.S.1    Jin, Y.2    Graham, D.K.3    Witthuhn, B.A.4    Ihle, J.N.5    Liu, E.T.6
  • 55
    • 0029906485 scopus 로고    scopus 로고
    • Structural organization and chromosomal mapping of JAK3 locus
    • Kumar A, Toscani A, Rane S, Reddy EP: Structural organization and chromosomal mapping of JAK3 locus. Oncogene 13:2009-2014, 1996
    • (1996) Oncogene , vol.13 , pp. 2009-2014
    • Kumar, A.1    Toscani, A.2    Rane, S.3    Reddy, E.P.4
  • 56
    • 0029011115 scopus 로고
    • The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colonystimulating factor receptor beta c chain
    • Zhao Y, Wagner F, Frank SJ, Kraft AS: The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colonystimulating factor receptor beta c chain. J Biol Chem 270:13814-13818, 1995
    • (1995) J Biol Chem , vol.270 , pp. 13814-13818
    • Zhao, Y.1    Wagner, F.2    Frank, S.J.3    Kraft, A.S.4
  • 62
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JEJ, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421, 1994
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.J.1    Kerr, I.M.2    Stark, G.R.3
  • 63
    • 0029069145 scopus 로고
    • Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
    • Schindler C, Darnell JEJ: Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64: 621-651, 1995
    • (1995) Annu Rev Biochem , vol.64 , pp. 621-651
    • Schindler, C.1    Darnell, J.E.J.2
  • 64
    • 0028845212 scopus 로고
    • Cytokine receptor signalling
    • Ihle JN: Cytokine receptor signalling. Nature 377:591-594, 1995
    • (1995) Nature , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 66
    • 0029896604 scopus 로고    scopus 로고
    • In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction
    • Candotti F, Oakes SA, Johnston JA, Notarangelo LD, O'Shea JJ, Blaese RM: In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction. J Exp Med 183:2687-2692, 1996
    • (1996) J Exp Med , vol.183 , pp. 2687-2692
    • Candotti, F.1    Oakes, S.A.2    Johnston, J.A.3    Notarangelo, L.D.4    O'Shea, J.J.5    Blaese, R.M.6
  • 69
    • 0027327484 scopus 로고
    • JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    • Witthuhn BA, Quelle FW, Silvennoinen O, Yi T, Tang B, Miura O. Ihle JN: JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin, Cell 74:227-236, 1993
    • (1993) Cell , vol.74 , pp. 227-236
    • Witthuhn, B.A.1    Quelle, F.W.2    Silvennoinen, O.3    Yi, T.4    Tang, B.5    Miura, O.6    Ihle, J.N.7
  • 71
    • 0028180569 scopus 로고
    • JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region
    • Quelle FW, Sato N, Witthuhn BA, Inhorn RC, Eder M, Miyajima A, Griffin JD, Ihle JN: JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol 14:4335-4341, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 4335-4341
    • Quelle, F.W.1    Sato, N.2    Witthuhn, B.A.3    Inhorn, R.C.4    Eder, M.5    Miyajima, A.6    Griffin, J.D.7    Ihle, J.N.8
  • 77
    • 0028299340 scopus 로고
    • The human interferon alpha/beta receptor: Characterization and molecular cloning
    • Novick D, Cohen B, Rubinstein M: The human interferon alpha/beta receptor: Characterization and molecular cloning. Cell 77:391-400, 1994
    • (1994) Cell , vol.77 , pp. 391-400
    • Novick, D.1    Cohen, B.2    Rubinstein, M.3
  • 78
    • 0028605245 scopus 로고
    • Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta
    • Abramovich C, Shulman LM, Ratovitski E, Harroch S, Tovey M, Eid P, Revel M: Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta. EMBO J 13:5871-5877, 1994
    • (1994) EMBO J , vol.13 , pp. 5871-5877
    • Abramovich, C.1    Shulman, L.M.2    Ratovitski, E.3    Harroch, S.4    Tovey, M.5    Eid, P.6    Revel, M.7
  • 79
    • 0029149376 scopus 로고
    • The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors
    • Sakatsume M, Igarashi K, Winestock KD, Garotta G, Larner AC, Finbloom DS: The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. J Biol Chem 270:17528-17534, 1995
    • (1995) J Biol Chem , vol.270 , pp. 17528-17534
    • Sakatsume, M.1    Igarashi, K.2    Winestock, K.D.3    Garotta, G.4    Larner, A.C.5    Finbloom, D.S.6
  • 82
    • 0026598960 scopus 로고
    • Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
    • de Vos AM, Ultsch M, Kossiakoff AA: Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex. Science 255:306-312, 1992
    • (1992) Science , vol.255 , pp. 306-312
    • De Vos, A.M.1    Ultsch, M.2    Kossiakoff, A.A.3
  • 84
    • 0026326555 scopus 로고
    • An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: A cytokine receptor superfamily oncogene
    • Longmore GD, Lodish HF: An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: A cytokine receptor superfamily oncogene. Cell 67:1089-1102, 1991
    • (1991) Cell , vol.67 , pp. 1089-1102
    • Longmore, G.D.1    Lodish, H.F.2
  • 86
    • 0028286628 scopus 로고
    • Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation
    • Nelson BH, Lord JD, Greenberg PD: Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation. Nature 369:333-336, 1994
    • (1994) Nature , vol.369 , pp. 333-336
    • Nelson, B.H.1    Lord, J.D.2    Greenberg, P.D.3
  • 88
    • 0028859279 scopus 로고
    • Protein modules and signalling networks
    • Pawson T: Protein modules and signalling networks. Nature 373:573-580, 1995
    • (1995) Nature , vol.373 , pp. 573-580
    • Pawson, T.1
  • 89
    • 0026723419 scopus 로고
    • A transcription factor with SH2 and SH3 domains is directly activated by an Interferon alpha-induced cytoplasmic protein tyrosine kinase(s)
    • Fu XY: A transcription factor with SH2 and SH3 domains is directly activated by an Interferon alpha-induced cytoplasmic protein tyrosine kinase(s). Cell 70:323-335, 1992
    • (1992) Cell , vol.70 , pp. 323-335
    • Fu, X.Y.1
  • 90
    • 0026686488 scopus 로고
    • The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction
    • Fu XY, Schindler C, Improta T, Aebersold R, Darnell JEJ: The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci USA 89:7840-7843, 1992
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7840-7843
    • Fu, X.Y.1    Schindler, C.2    Improta, T.3    Aebersold, R.4    Darnell, J.E.J.5
  • 91
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong Z, Wen Z, Darnell JEJ: Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264:95-98, 1994
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.J.3
  • 92
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K, Sudo T, Naruto M, Kishimoto T: Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77:63-71, 1994
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3    Wang, X.J.4    Wei, S.5    Matsusaka, T.6    Yoshida, K.7    Sudo, T.8    Naruto, M.9    Kishimoto, T.10
  • 93
    • 0028284762 scopus 로고
    • Stat3 and Stat4: Members of the family of signal transducers and activators of transcription
    • Zhong Z, Wen Z, Darnell JEJ: Stat3 and Stat4: Members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci USA 91:4806-4810, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4806-4810
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.J.3
  • 95
    • 0028217452 scopus 로고
    • Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
    • published erratum appears in EMBO J 14(4):854-855, 1995
    • Wakao H, Gouilleux F, Groner B: Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response [published erratum appears in EMBO J 14(4):854-855, 1995]. EMBO J 13:2182-2191, 1994
    • (1994) EMBO J , vol.13 , pp. 2182-2191
    • Wakao, H.1    Gouilleux, F.2    Groner, B.3
  • 96
    • 0028964916 scopus 로고
    • Identification and purification of human Stat proteins activated in response to interleukin-2
    • Hou J, Schindler U, Henzel WJ, Wong SC, McKnight SL: Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity 2:321-329, 1995
    • (1995) Immunity , vol.2 , pp. 321-329
    • Hou, J.1    Schindler, U.2    Henzel, W.J.3    Wong, S.C.4    McKnight, S.L.5
  • 97
    • 0028963550 scopus 로고
    • Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs
    • Mui AL, Wakao H. O'Farrell AM, Harada N, Miyajima A: Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J 14:1166-1175, 1995
    • (1995) EMBO J , vol.14 , pp. 1166-1175
    • Mui, A.L.1    Wakao, H.2    O'Farrell, A.M.3    Harada, N.4    Miyajima, A.5
  • 99
    • 0029115640 scopus 로고
    • Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue
    • Liu X, Robinson GW, Gouilleux F, Groner B, Hennighausen L: Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci USA 92:8831-8835, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8831-8835
    • Liu, X.1    Robinson, G.W.2    Gouilleux, F.3    Groner, B.4    Hennighausen, L.5
  • 100
    • 15844386904 scopus 로고    scopus 로고
    • Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells
    • Lin JX, Mietz J, Modi WS, John S, Leonard WJ: Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. J Biol Chem 271:10738-10744, 1996
    • (1996) J Biol Chem , vol.271 , pp. 10738-10744
    • Lin, J.X.1    Mietz, J.2    Modi, W.S.3    John, S.4    Leonard, W.J.5
  • 103
    • 0028979707 scopus 로고
    • Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process
    • Greenlund AC, Morales MO, Viviano BL, Yan H, Krolewski J, Schreiber RD: Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process. Immunity 2:677-687, 1995
    • (1995) Immunity , vol.2 , pp. 677-687
    • Greenlund, A.C.1    Morales, M.O.2    Viviano, B.L.3    Yan, H.4    Krolewski, J.5    Schreiber, R.D.6
  • 104
    • 0029001660 scopus 로고
    • Components of a Stat recognition code: Evidence for two layers of molecular selectivity
    • Schindler U, Wu P, Rothe M, Brasseur M, McKnight SL: Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity 2:689-697, 1995
    • (1995) Immunity , vol.2 , pp. 689-697
    • Schindler, U.1    Wu, P.2    Rothe, M.3    Brasseur, M.4    McKnight, S.L.5
  • 105
    • 0028962572 scopus 로고
    • The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
    • Lin JX, Migone TS, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, et al.: The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331-339, 1995
    • (1995) Immunity , vol.2 , pp. 331-339
    • Lin, J.X.1    Migone, T.S.2    Tsang, M.3    Friedmann, M.4    Weatherbee, J.A.5    Zhou, L.6    Yamauchi, A.7    Bloom, E.T.8    Mietz, J.9    John, S.10
  • 107
    • 0028943484 scopus 로고
    • Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
    • Jacobson NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JEJ, Murphy KM: Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med 181:1755-1762, 1995
    • (1995) J Exp Med , vol.181 , pp. 1755-1762
    • Jacobson, N.G.1    Szabo, S.J.2    Weber-Nordt, R.M.3    Zhong, Z.4    Schreiber, R.D.5    Darnell, J.E.J.6    Murphy, K.M.7
  • 108
    • 0030469719 scopus 로고    scopus 로고
    • Activation of STAT4 by IL-12 and IFN-alpha: Evidence for the involvement of ligand-induced tyrosine and serine phosphorylation
    • Cho SS, Bacon CM, Sudarshan C, Rees RC, Finbloom D, Pine R, O'Shea JJ: Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J Immunol 157:4781-4789, 1996
    • (1996) J Immunol , vol.157 , pp. 4781-4789
    • Cho, S.S.1    Bacon, C.M.2    Sudarshan, C.3    Rees, R.C.4    Finbloom, D.5    Pine, R.6    O'Shea, J.J.7
  • 109
    • 0029858447 scopus 로고    scopus 로고
    • Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency
    • Johnston JA, Bacon CM, Riedy MC, O'Shea JJ: Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency. J Leukoc Biol 60:441-452, 1996
    • (1996) J Leukoc Biol , vol.60 , pp. 441-452
    • Johnston, J.A.1    Bacon, C.M.2    Riedy, M.C.3    O'Shea, J.J.4
  • 110
    • 0029793368 scopus 로고    scopus 로고
    • Stats and cytokine specificity
    • Leonard WJ: Stats and cytokine specificity. Nature Med 2:968-969, 1996
    • (1996) Nature Med , vol.2 , pp. 968-969
    • Leonard, W.J.1
  • 111
    • 0030046753 scopus 로고    scopus 로고
    • STATs: Signal transducers and activators of transcription
    • Ihle JN: STATs: signal transducers and activators of transcription. Cell 84:331-334, 1996
    • (1996) Cell , vol.84 , pp. 331-334
    • Ihle, J.N.1
  • 113
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell JEJ: Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241-250, 1995
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell, J.E.J.3
  • 114
    • 0029091195 scopus 로고
    • STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase
    • Boulton TG, Zhong Z, Wen Z, Darnell JEJ, Stahl N, Yancopoulos GD: STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc Natl Acad Sci USA 92:6915-6919, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6915-6919
    • Boulton, T.G.1    Zhong, Z.2    Wen, Z.3    Darnell, J.E.J.4    Stahl, N.5    Yancopoulos, G.D.6
  • 115
    • 0028942656 scopus 로고
    • Requirement of serine phosphorylation for formation of STAT-promoter complexes
    • Zhang X, Blenis J, Li HC, Schindler C, Chen-Kiang S: Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 267:1990-1994, 1995
    • (1995) Science , vol.267 , pp. 1990-1994
    • Zhang, X.1    Blenis, J.2    Li, H.C.3    Schindler, C.4    Chen-Kiang, S.5
  • 116
    • 0029133702 scopus 로고
    • Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins
    • David M, Petricoin ER, Benjamin C, Pine R, Weber MJ, Larner AC: Requirement for MAP kinase (ERK2) activity in interferon alpha-and interferon beta-stimulated gene expression through STAT proteins [see comments]. Science 269:1721-1723, 1995
    • (1995) Science , vol.269 , pp. 1721-1723
    • David, M.1    Petricoin, E.R.2    Benjamin, C.3    Pine, R.4    Weber, M.J.5    Larner, A.C.6
  • 122
    • 0029739627 scopus 로고    scopus 로고
    • Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
    • Xu X, Sun YL, Hoey T: Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 273:794-797, 1996
    • (1996) Science , vol.273 , pp. 794-797
    • Xu, X.1    Sun, Y.L.2    Hoey, T.3
  • 123
    • 0030962017 scopus 로고    scopus 로고
    • The state of STATs: Recent developments in the study of signal transduction to the nucleus
    • Horvath CM, Darnell JE: The state of STATs: Recent developments in the study of signal transduction to the nucleus. Curr Opin Cell Biol 9:233-239, 1997
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 233-239
    • Horvath, C.M.1    Darnell, J.E.2
  • 124
    • 0029909271 scopus 로고    scopus 로고
    • Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex
    • Horvath CM, Stark GR, Kerr IM, Darnell JEJ: Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol Cell Biol 16:6957-6964, 1996
    • (1996) Mol Cell Biol , vol.16 , pp. 6957-6964
    • Horvath, C.M.1    Stark, G.R.2    Kerr, I.M.3    Darnell, J.E.J.4
  • 126
    • 0029075875 scopus 로고
    • Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3
    • Schaefer TS, Sanders LK, Nathans D: Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. Proc Natl Acad Sci USA 92:9097-9101, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9097-9101
    • Schaefer, T.S.1    Sanders, L.K.2    Nathans, D.3
  • 127
    • 0029851231 scopus 로고    scopus 로고
    • Functional interactions between Stat5 and the glucocorticoid receptor
    • Stocklin E, Wissler M, Gouilleux F, Groner B: Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383:726-728, 1996
    • (1996) Nature , vol.383 , pp. 726-728
    • Stocklin, E.1    Wissler, M.2    Gouilleux, F.3    Groner, B.4
  • 128
    • 0028958849 scopus 로고
    • Mouse interleukin-2 receptor alpha gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements
    • Sperisen P, Wang SM, Soldaini E, Pla M, Rusterholz C, Bucher P, Corthesy P, Reichenbach P, Nabholz M: Mouse interleukin-2 receptor alpha gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements. J Biol Chem 270:10743-10753, 1995
    • (1995) J Biol Chem , vol.270 , pp. 10743-10753
    • Sperisen, P.1    Wang, S.M.2    Soldaini, E.3    Pla, M.4    Rusterholz, C.5    Bucher, P.6    Corthesy, P.7    Reichenbach, P.8    Nabholz, M.9
  • 129
    • 0029853971 scopus 로고    scopus 로고
    • An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATa family protein
    • John S, Robbins CM, Leonard WJ: An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein. EMBO J 15:5627-5635, 1996
    • (1996) EMBO J , vol.15 , pp. 5627-5635
    • John, S.1    Robbins, C.M.2    Leonard, W.J.3
  • 130
    • 0029909493 scopus 로고    scopus 로고
    • Flf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene
    • Lecine P, Algarte M, Rameil P, Beadling C, Bucher P, Nabholz M. Imbert J: Flf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene. Mol Cell Biol 16:6829-6840, 1996
    • (1996) Mol Cell Biol , vol.16 , pp. 6829-6840
    • Lecine, P.1    Algarte, M.2    Rameil, P.3    Beadling, C.4    Bucher, P.5    Nabholz, M.6    Imbert, J.7
  • 131
    • 0030945179 scopus 로고    scopus 로고
    • Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling
    • Li X, Leung S, Kerr IM, Stark GR: Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol Cell Biol 17:2048-2056, 1997
    • (1997) Mol Cell Biol , vol.17 , pp. 2048-2056
    • Li, X.1    Leung, S.2    Kerr, I.M.3    Stark, G.R.4
  • 132
    • 0029972194 scopus 로고    scopus 로고
    • The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase
    • Haspel RL, Salditt-Georgieff M, Darnell JEJ: The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. EMBO J 15:6262-6268, 1996
    • (1996) EMBO J , vol.15 , pp. 6262-6268
    • Haspel, R.L.1    Salditt-Georgieff, M.2    Darnell, J.E.J.3
  • 133
    • 0029742102 scopus 로고    scopus 로고
    • Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1
    • Shuai K, Liao J, Song MM: Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1. Mol Cell Biol 16:4932-4941, 1996
    • (1996) Mol Cell Biol , vol.16 , pp. 4932-4941
    • Shuai, K.1    Liao, J.2    Song, M.M.3
  • 134
    • 0000413462 scopus 로고    scopus 로고
    • Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proleasome pathway
    • Kim TK, Maniatis T: Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proleasome pathway. Science 273:1717-1719, 1996
    • (1996) Science , vol.273 , pp. 1717-1719
    • Kim, T.K.1    Maniatis, T.2
  • 136
    • 0029655458 scopus 로고    scopus 로고
    • The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein
    • Horvath CM, Darnell JEJ: The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein. J Virol 70:647-650, 1996
    • (1996) J Virol , vol.70 , pp. 647-650
    • Horvath, C.M.1    Darnell, J.E.J.2
  • 137
    • 0030793345 scopus 로고    scopus 로고
    • Functionally distinct isoforms of STAT5 are generated by protein processing
    • Azam M, Lee C, Strehlow I, Schindler C: Functionally distinct isoforms of STAT5 are generated by protein processing. Immunity 6:691-701, 1997
    • (1997) Immunity , vol.6 , pp. 691-701
    • Azam, M.1    Lee, C.2    Strehlow, I.3    Schindler, C.4
  • 138
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression and germinal center formation by BCL-6
    • Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM: Control of inflammation, cytokine expression and germinal center formation by BCL-6. Science 276:589-592, 1997
    • (1997) Science , vol.276 , pp. 589-592
    • Dent, A.L.1    Shaffer, A.L.2    Yu, X.3    Allman, D.4    Staudt, L.M.5
  • 142
    • 0027957316 scopus 로고
    • Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila
    • Binari R, Perrimon N: Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes Dev 8:300-312, 1994
    • (1994) Genes Dev , vol.8 , pp. 300-312
    • Binari, R.1    Perrimon, N.2
  • 143
    • 0028938172 scopus 로고
    • An amino acid substitution in the Drosophila hopTum-1 Jak kinase causes leukemia-like hematopoietic defects
    • Luo H, Hanratty WP, Dearolf CR: An amino acid substitution in the Drosophila hopTum-1 Jak kinase causes leukemia-like hematopoietic defects. EMBO J 14:1412-1420, 1995
    • (1995) EMBO J , vol.14 , pp. 1412-1420
    • Luo, H.1    Hanratty, W.P.2    Dearolf, C.R.3
  • 144
    • 0031105579 scopus 로고    scopus 로고
    • The JAK-STAT pathway in Drosophila
    • Hou XS, Perrimon N: The JAK-STAT pathway in Drosophila. Trends Genet 13:105-110, 1997
    • (1997) Trends Genet , vol.13 , pp. 105-110
    • Hou, X.S.1    Perrimon, N.2
  • 145
    • 0030040691 scopus 로고    scopus 로고
    • Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs
    • Hou XS, Melnick MB, Perrimon N: Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Cell 84:411-419, 1996
    • (1996) Cell , vol.84 , pp. 411-419
    • Hou, X.S.1    Melnick, M.B.2    Perrimon, N.3
  • 146
    • 0001514956 scopus 로고    scopus 로고
    • Identification of a Stat gene that functions in Drosophila development
    • Van R, Small S, Desplan C, Dearolf CR, Damell JEJ: Identification of a Stat gene that functions in Drosophila development. Cell 84:421-430, 1996
    • (1996) Cell , vol.84 , pp. 421-430
    • Van, R.1    Small, S.2    Desplan, C.3    Dearolf, C.R.4    Damell, J.E.J.5
  • 147
  • 150
    • 0029924265 scopus 로고    scopus 로고
    • The molecular basis of X-linked severe combined immunodeficiency: Detective cytokine receptor signaling
    • Leonard WJ: The molecular basis of X-linked severe combined immunodeficiency: detective cytokine receptor signaling. Annu Rev Med 47:229-239, 1996
    • (1996) Annu Rev Med , vol.47 , pp. 229-239
    • Leonard, W.J.1
  • 153
    • 0027731604 scopus 로고
    • Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4
    • Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, Sugamura K: Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science 262:1874-1877, 1993
    • (1993) Science , vol.262 , pp. 1874-1877
    • Kondo, M.1    Takeshita, T.2    Ishii, N.3    Nakamura, M.4    Watanabe, S.5    Arai, K.6    Sugamura, K.7
  • 159
    • 0011867811 scopus 로고
    • Primary immunodeficiency diseases: Report of a WHO scientific group
    • WHO Scientific Group: Primary immunodeficiency diseases: Report of a WHO scientific group. Clin Exp Immunol 99:1-24, 1995
    • (1995) Clin Exp Immunol , vol.99 , pp. 1-24
  • 160
    • 0030296468 scopus 로고    scopus 로고
    • IL2RGbase: A database of gamma c-chain defects causing human X-SCID
    • Puck JM: IL2RGbase: A database of gamma c-chain defects causing human X-SCID. Immunol Today 17:507-511, 1996
    • (1996) Immunol Today , vol.17 , pp. 507-511
    • Puck, J.M.1
  • 161
    • 0029161486 scopus 로고
    • Two mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiency
    • Pepper AE, Buckley RH, Small TN, Puck JM: Two mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiency. Am J Hum Genet 57:564-571, 1995
    • (1995) Am J Hum Genet , vol.57 , pp. 564-571
    • Pepper, A.E.1    Buckley, R.H.2    Small, T.N.3    Puck, J.M.4
  • 162
    • 0029102233 scopus 로고
    • Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis
    • Clark PA, Lester T, Genet S, Jones AM, Hendriks R, Levinsky RJ, Kinnon C: Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis. Hum Genet 96:427-432, 1995
    • (1995) Hum Genet , vol.96 , pp. 427-432
    • Clark, P.A.1    Lester, T.2    Genet, S.3    Jones, A.M.4    Hendriks, R.5    Levinsky, R.J.6    Kinnon, C.7
  • 163
    • 0029794558 scopus 로고    scopus 로고
    • T-lymphocyte differentiation and proliferation in the absence of the cytoplasmic tail of the common cytokine receptor gamma c chain in a severe combined immune deficiency X1 patient
    • Morelon E, Dautry-Varsat A, Le Deist F, Hacein-Bay S, Fischer A, de Saint Basile G: T-lymphocyte differentiation and proliferation in the absence of the cytoplasmic tail of the common cytokine receptor gamma c chain in a severe combined immune deficiency X1 patient. Blood 88:1708-1717, 1996
    • (1996) Blood , vol.88 , pp. 1708-1717
    • Morelon, E.1    Dautry-Varsat, A.2    Le Deist, F.3    Hacein-Bay, S.4    Fischer, A.5    De Saint Basile, G.6
  • 165
    • 0028087777 scopus 로고
    • Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells
    • DiSanto JP, Rieux-Laucat F, Dautry-Varsat A, Fischer A, de Saint Basile G: Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells. Proc Natl Acad Sci USA 91:9466-9470, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9466-9470
    • DiSanto, J.P.1    Rieux-Laucat, F.2    Dautry-Varsat, A.3    Fischer, A.4    De Saint Basile, G.5
  • 166
    • 0023188706 scopus 로고
    • Carrier detection in X-linked severe combined immunodeficiency based on patterns of X chromosome inactivation
    • Puck JM, Nussbaum RL, Conley ME: Carrier detection in X-linked severe combined immunodeficiency based on patterns of X chromosome inactivation. J Clin Invest 79:1395-1400, 1987
    • (1987) J Clin Invest , vol.79 , pp. 1395-1400
    • Puck, J.M.1    Nussbaum, R.L.2    Conley, M.E.3
  • 169
    • 0028878330 scopus 로고
    • Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain
    • DiSanto JP, Muller W, Guy-Grand D, Fischer A, Rajewsky K: Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci USA 92:377-381, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 377-381
    • DiSanto, J.P.1    Muller, W.2    Guy-Grand, D.3    Fischer, A.4    Rajewsky, K.5
  • 170
    • 0028799457 scopus 로고
    • Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
    • Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ: Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270:794-797, 1995
    • (1995) Science , vol.270 , pp. 794-797
    • Thomis, D.C.1    Gurniak, C.B.2    Tivol, E.3    Sharpe, A.H.4    Berg, L.J.5
  • 174
  • 175
    • 0029866741 scopus 로고    scopus 로고
    • Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene
    • Taylor N, Uribe L, Smith S, Jahn T, Kohn DB, Weinberg K: Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene. Blood 87:3103-3107, 1996
    • (1996) Blood , vol.87 , pp. 3103-3107
    • Taylor, N.1    Uribe, L.2    Smith, S.3    Jahn, T.4    Kohn, D.B.5    Weinberg, K.6
  • 177
    • 0028797453 scopus 로고
    • Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-I5
    • Matthews DJ, Clark PA, Herbert J, Morgan G, Armitage RJ, Kinnon C, Minty A, Grabstein KH, Caput D, Ferrara P, et al.: Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-I5. Blood 85:38-42, 1995
    • (1995) Blood , vol.85 , pp. 38-42
    • Matthews, D.J.1    Clark, P.A.2    Herbert, J.3    Morgan, G.4    Armitage, R.J.5    Kinnon, C.6    Minty, A.7    Grabstein, K.H.8    Caput, D.9    Ferrara, P.10
  • 178
    • 0029834119 scopus 로고    scopus 로고
    • Interleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor alpha subunit
    • Lai SY, Molden J, Liu KD, Puck JM, White MD, Goldsmith MA: Interleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor alpha subunit. EMBO J 15:4506-4514, 1996
    • (1996) EMBO J , vol.15 , pp. 4506-4514
    • Lai, S.Y.1    Molden, J.2    Liu, K.D.3    Puck, J.M.4    White, M.D.5    Goldsmith, M.A.6
  • 180
    • 0030915682 scopus 로고    scopus 로고
    • Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain
    • Fujiwara H, Hanissian SH, Tsytsykova A, Geha RS: Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci USA 94:5866-5871, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5866-5871
    • Fujiwara, H.1    Hanissian, S.H.2    Tsytsykova, A.3    Geha, R.S.4
  • 181
    • 0031041301 scopus 로고    scopus 로고
    • The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis
    • Nakajima H, Shores EW, Noguchi M, Leonard WJ: The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis. J Exp Med 185:189-195, 1997
    • (1997) J Exp Med , vol.185 , pp. 189-195
    • Nakajima, H.1    Shores, E.W.2    Noguchi, M.3    Leonard, W.J.4
  • 182
    • 1842291572 scopus 로고    scopus 로고
    • Crucial role of Jak3 in negative selection of self-reactive T cells
    • Saijo K, Park SY, Ishida Y, Arase H, Saito T: Crucial role of Jak3 in negative selection of self-reactive T cells. J Exp Med 185:351-356, 1997
    • (1997) J Exp Med , vol.185 , pp. 351-356
    • Saijo, K.1    Park, S.Y.2    Ishida, Y.3    Arase, H.4    Saito, T.5
  • 183
    • 0031054442 scopus 로고    scopus 로고
    • Peripheral expression of Jak3 is required to maintain T lymphocyte function
    • Thomis DC, Berg LJ: Peripheral expression of Jak3 is required to maintain T lymphocyte function. J Exp Med 185:197-206, 1997
    • (1997) J Exp Med , vol.185 , pp. 197-206
    • Thomis, D.C.1    Berg, L.J.2
  • 184
    • 0028029813 scopus 로고
    • Activation of JAK kinases and STAT proteins by interleukin-2 and Interferon alpha, but not the T cell antigen receptor, in human T lymphocytes
    • Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, Cantrell DA: Activation of JAK kinases and STAT proteins by interleukin-2 and Interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. EMBO J 13:5605-5615, 1994
    • (1994) EMBO J , vol.13 , pp. 5605-5615
    • Beadling, C.1    Guschin, D.2    Witthuhn, B.A.3    Ziemiecki, A.4    Ihle, J.N.5    Kerr, I.M.6    Cantrell, D.A.7
  • 185
    • 0030917141 scopus 로고    scopus 로고
    • Jak3 Is Associated with CD40 and is critical for CD40 induction of gene expression in B cells
    • Hanissian SH, Geha RS: Jak3 Is Associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity 6:379-387, 1997
    • (1997) Immunity , vol.6 , pp. 379-387
    • Hanissian, S.H.1    Geha, R.S.2
  • 186
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durhin JE, Hackenmiller R, Simon MC, Levy DE: Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443-450, 1996
    • (1996) Cell , vol.84 , pp. 443-450
    • Durhin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 188
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan MH, Sun YL, Hoey T, Grushy MJ: Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174-177, 1996
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.L.2    Hoey, T.3    Grushy, M.J.4
  • 190
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required tor mediating responses to IL-4 and for development of Th2 cells
    • Kaplan MH, Schindler U, Smiley ST, Grushy MJ: Stat6 is required tor mediating responses to IL-4 and for development of Th2 cells. Immunity 4:313-319, 1996
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grushy, M.J.4
  • 193
    • 0030587813 scopus 로고    scopus 로고
    • Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice
    • Takeda K, Kamanaka M, Tanaka T, Kishimoto T, Akira S: Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol 157:3220-3222, 1996
    • (1996) J Immunol , vol.157 , pp. 3220-3222
    • Takeda, K.1    Kamanaka, M.2    Tanaka, T.3    Kishimoto, T.4    Akira, S.5
  • 197
    • 0027253701 scopus 로고
    • The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus
    • Hanratty WP, Dearolf CR: The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus. Mol Gen Genet 238:33-37, 1993
    • (1993) Mol Gen Genet , vol.238 , pp. 33-37
    • Hanratty, W.P.1    Dearolf, C.R.2
  • 198
    • 0029031668 scopus 로고
    • Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects
    • Harrison HA, Binari R, Nahreini TS, Gilman M, Perrimon N: Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J 14:2857-2865, 1995
    • (1995) EMBO J , vol.14 , pp. 2857-2865
    • Harrison, H.A.1    Binari, R.2    Nahreini, T.S.3    Gilman, M.4    Perrimon, N.5
  • 201
    • 0029834676 scopus 로고    scopus 로고
    • Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome
    • Zhang Q, Nowak I, Vonderheid EC, Rook AH, Kadin ME. Nowell PC, Shaw LM, Wasik MA: Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc Natl Acad Sci USA 93:9148-9153, 1996
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9148-9153
    • Zhang, Q.1    Nowak, I.2    Vonderheid, E.C.3    Rook, A.H.4    Kadin, M.E.5    Nowell, P.C.6    Shaw, L.M.7    Wasik, M.A.8
  • 202
    • 0028817880 scopus 로고
    • Jak-STAT signaling induced by the v-abl oncogene
    • Danial NN, Pernis A, Rothman PB: Jak-STAT signaling induced by the v-abl oncogene. Science 269:1875-1877, 1995
    • (1995) Science , vol.269 , pp. 1875-1877
    • Danial, N.N.1    Pernis, A.2    Rothman, P.B.3
  • 204
    • 0029916933 scopus 로고    scopus 로고
    • Activation and association of Stat3 with Src in v-Src-transformed cell lines
    • Cao X, Tay A, Guy GR, Tan YH: Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol Cell Biol 16:1595-1603, 1996
    • (1996) Mol Cell Biol , vol.16 , pp. 1595-1603
    • Cao, X.1    Tay, A.2    Guy, G.R.3    Tan, Y.H.4
  • 205
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, Jove R: Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81-83, 1995
    • (1995) Science , vol.269 , pp. 81-83
    • Yu, C.L.1    Meyer, D.J.2    Campbell, G.S.3    Larner, A.C.4    Carter-Su, C.5    Schwartz, J.6    Jove, R.7
  • 206
    • 0030200982 scopus 로고    scopus 로고
    • Distinct tumorigenic potential of abl and raf in B cell neoplasia: Abl activates the IL-6 signaling pathway
    • Hilbert DM, Migone TS, Kopf M, Leonard WJ, Rudikoff S: Distinct tumorigenic potential of abl and raf in B cell neoplasia: abl activates the IL-6 signaling pathway. Immunity 5:81-89, 1996
    • (1996) Immunity , vol.5 , pp. 81-89
    • Hilbert, D.M.1    Migone, T.S.2    Kopf, M.3    Leonard, W.J.4    Rudikoff, S.5
  • 207
    • 0028915936 scopus 로고
    • Induction of sequence-specific DNA-binding factors by erythropoietin and the spleen focus-forming virus
    • Ohashi T, Masuda M, Ruscetti SK: Induction of sequence-specific DNA-binding factors by erythropoietin and the spleen focus-forming virus. Blood 85:1454-1462, 1995
    • (1995) Blood , vol.85 , pp. 1454-1462
    • Ohashi, T.1    Masuda, M.2    Ruscetti, S.K.3
  • 208
    • 0029863169 scopus 로고    scopus 로고
    • Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl
    • Carlesso N, Frank DA, Griffin JD: Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J Exp Med 183:811-820, 1996
    • (1996) J Exp Med , vol.183 , pp. 811-820
    • Carlesso, N.1    Frank, D.A.2    Griffin, J.D.3
  • 209
    • 0000506439 scopus 로고    scopus 로고
    • P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members
    • Ilaria RLJ, Van Etten RA: P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem 271:31704-31710, 1996
    • (1996) J Biol Chem , vol.271 , pp. 31704-31710
    • Ilaria, R.L.J.1    Van Etten, R.A.2
  • 210
    • 0029810923 scopus 로고    scopus 로고
    • Constitutive activation of STATS by the BCR-ABL oncogene in chronic myelogenous leukemia
    • Shuai K, Halpern J, ten Hoeve J, Rao X, Sawyers CL: Constitutive activation of STATS by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 13:247-254, 1996
    • (1996) Oncogene , vol.13 , pp. 247-254
    • Shuai, K.1    Halpern, J.2    Ten Hoeve, J.3    Rao, X.4    Sawyers, C.L.5
  • 212
    • 0029784886 scopus 로고    scopus 로고
    • Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
    • Weber-Nordt RM, Egen C, Wehinger J, Ludwig W, Gouilleux-Gruart V, Mertelsmann R, Finke J: Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood 88:809-816, 1996
    • (1996) Blood , vol.88 , pp. 809-816
    • Weber-Nordt, R.M.1    Egen, C.2    Wehinger, J.3    Ludwig, W.4    Gouilleux-Gruart, V.5    Mertelsmann, R.6    Finke, J.7
  • 213
    • 0030003920 scopus 로고    scopus 로고
    • Lack of constitutive activation of Janus kinases and signal transduction and activation of transcription factors in Philadelphia chromosome-positive acute lymphoblastic leukemia
    • Kanwar VS, Witthuhn B, Campana D, Ihle JN: Lack of constitutive activation of Janus kinases and signal transduction and activation of transcription factors in Philadelphia chromosome-positive acute lymphoblastic leukemia [letter]. Blood 87:4911-4912, 1996
    • (1996) Blood , vol.87 , pp. 4911-4912
    • Kanwar, V.S.1    Witthuhn, B.2    Campana, D.3    Ihle, J.N.4
  • 214
    • 0028919560 scopus 로고
    • Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency
    • Schmalstieg FC, Leonard WJ, Noguchi M, Berg M, Rudloff HE, Denney RM: Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency. J Clin Invest 95:1169-1173, 1995
    • (1995) J Clin Invest , vol.95 , pp. 1169-1173
    • Schmalstieg, F.C.1    Leonard, W.J.2    Noguchi, M.3    Berg, M.4    Rudloff, H.E.5    Denney, R.M.6


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