The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

Journal of Biological Chemistry

Volumn 277, Issue 49, 2002, Pages 47954-47963

  Saharinen, Pipsa ^a,b   Silvennoinen, Olli ^a,b,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF TAMPERE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; ENZYMES;

CYTOKINE-INDUCIBLE ACTIVATION;

BIOCHEMISTRY;

CHIMERIC PROTEIN; CYTOKINE; CYTOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 2; JAK2 TYROSINE KINASE; JAK3 TYROSINE KINASE; JANUS KINASE; PROTEIN TYROSINE KINASE; STAT5 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; COS CELLS; CYTOKINES; DNA; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMMUNOBLOTTING; JANUS KINASE 2; JANUS KINASE 3; LIGANDS; LUCIFERASES; MICE; MILK PROTEINS; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFECTION;

ANIMALIA; JANUS;

EID: 0037033012     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205156200     Document Type: Article

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