Protein kinase B (Akt) regulation and function in T lymphocytes

Seminars in Immunology

Volumn 14, Issue 1, 2002, Pages 19-26

  Cantrell, Doreen ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Antigen receptor; Chemokines; Interleukin 2; PKB; T lymphocytes

Indexed keywords

CD28 ANTIGEN; CHEMOKINE; CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE;

CELL CYCLE; CELL LINEAGE; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE INDUCTION; HUMAN; IMMUNE SYSTEM; IMMUNOREGULATION; NONHUMAN; REVIEW; T LYMPHOCYTE;

EID: 0036200194     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.2001.0338     Document Type: Article

References (73)

1. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
2. Akt is a direct target of the phosphatidylinositol 3-kinase
3. Akt activation by growth factors is a multiple-step process: The role of the PH domain
4. Protein-kinase-b (c-akt) - A multifunctional mediator of phosphatidylinositol 3-kinase activation
5. Akt signaling: Linking membrane events to life and death decisions
6. Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase
7. A negative role for phosphatidylinositol 3-kinase in T cell antigen receptor function
8. The T Cell antigen receptor activates phosphatidyl inositol 3-kinase regulated serine kinases protein kinase B (PKB) and ribosomal S6 kinase 1
9. Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B
10. Phosphoinositide 3-kinase: A key biochemical signal for cell migration in response to chemokines
11. Induction of NF-kappa B by the Akt PKB kinase
12. Mechanism of activation and function of protein-kinase-B
13. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Ba
14. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
15. Protein-kinase-b kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein-kinase-b
16. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
17. PDK1 aquires PDK2 activity in the presence of a synthetic peptide from the carboxy-terminus of PRK2
18. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B
19. Role of Phosphatidylinositol 3,4,5 triphosphate in regulating the activity and localisation of 3′phosphoinositide dependent protein kinase 1
20. Cellular signaling: Pivoting around PDK-1
21. Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation
22. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
23. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3
24. The dynamics of protein kinase B regulation during B cell antigen receptor engagement
25. Phosphoinositides 3-kinases: A conserved family of signal transducers
26. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
27. Phosphoinositide 3-kinase in T lymphocyte activation
28. Negative regulation of pkb/akt-dependent cell-survival by the tumor-suppressor pten
29. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
30. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
31. Phosphoinositide 3 kinase and T lymphocyte activation: Limitation of T leukaemic cell lines as signalling molecules
32. The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase
33. Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells
34. Lipid phosphatases in the immune system
35. Targeted disruption of Ship leads to hematopoietic perturbations lung pathology, and a shortened life-span
36. Deletion of SHIP of SHP-1 reveals two distinct pathways for inhibitory signaling
37. The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B-cell antigen receptor signaling
38. Regulation through inhibitory receptors - Lessons from natural-killer-cells
39. The inositol phosphatase SHIP inhibits Akt/PKB activation in B Cells
40. Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB
41. Supression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
42. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
43. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
44. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
45. Protection of Fas-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B
46. Direct control of the Forkhead transcription factor AFX by protein kinase B
47. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
48. Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1)
49. The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
50. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
51. Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX
52. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways
53. Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B
54. Expression of the pro-apoptotic bcl-2 family member bim is regulated by the forkhead transcription factor FKHR-L1
55. Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction
56. Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation
57. The proteins encoded by c-akt, and v-akt differ in post-translational modification, subcellular localization and oncogenic potential
58. Nuclear export of NFATc enhanced by glycogen synthase kinase-3
59. Calcium, calcineurin, and the control of transcription
60. Transcription factors of the nfat family - Regulation and function
61. Rac-1 regulates nuclear factor of activated T cells (NFAT) C1 nuclear translocation in response to Fcepsilon receptor type 1 stimulation of mast cells
62. Expressi on of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation
63. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFNg but not TH2 cytokines
64. Complex formation and cooperation of PKCθ and Akt1/PKBα in the NF-κB transactivation cascade in Jurkat T cells
65. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
66. p70S6k integrates PI 3-kinase and rapamycin regulated signals for E2F regulation in T lymphocytes
67. c-myb Transcription is activated by protein kinase b (pkb) following interleukin 2 stimulation of t cells and is required for pkb-mediated protection from apoptosis
68. Role of the forkhead transcription factor family member, FKHR, in thymocyte differentiation
69. Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo
70. Cytokine-induced protein kinase-B activation and Bad phosphorylation do not correlate with cell survival of haemopoetic cells
71. Dissociation of apoptosis from proliferation, protein kinase B activation, and Bad phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signalling
72. Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
73. The PI3K-PDK1 connection: More than just a road to PKB