IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

Journal of Immunology

Volumn 169, Issue 7, 2002, Pages 3600-3605

  Strengeil, Mari ^a   Sareneva, Timo ^a   Foster, Don ^a   Julkunen, Ilkka ^a   Matikainen, Sampsa ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; CYTOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 21; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 9 RECEPTOR; RNA; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NATURAL KILLER CELL; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL;

EID: 0036784616     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.7.3600     Document Type: Article

References (46)

1. Parrish-Novak, J., S. R. Dillon, A. Nelson, A. Hammond, C. Sprecher, J. A. Gross, J. Johnston, K. Madden, W. Xu, J. West, et al. 2000. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408:57.
2. Asac, H., C. Okuyama, S. Kumaki, N. Ishii, S. Tsuchiya. D. Foster, and K. Sugamura. 2001. The common γ-chain is an indispensable subunit of the IL-21 receptor complex. J. Immunol. 167:1.
3. Ozaki, K., K. Kikly, D. Michalovich, P. R. Young, and W. J. Leonard. 2000. Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain. Proc. Natl. Acad. Sci. USA 97:11439.
4. Nishimura, H., M. Tagaya, H. Tsunobuchi, H. Suzuki, I. Nakashima, and Y. Yoshikai. 2001. Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant. Infect. Immun. 2:1226.
5. Moretta, L., M. C. Mingari, D. Pende, C. Bottino, R. Biassoni, and A. Moretta. 1996. The molecular basis of natural killer (NK) cell recognition and function. J. Clin. Immunol. 16:243.
6. Matikainen, S., A. Paananen, M. Miettinen, M. Kurimoto, T. Timonen, I. Julkunen, and T. Sareneva. 2001. IFN-α and IL-18 synergistically enhance IFN-γ production in human NK cells: differential regulation of Stat4 activation and IFN-γ gene expression by IFN-α and IL-12. Eur. J. Immunol. 31:2236.
7. crk21. J. Immunol. 165:1307.
8. Biron, C. A., K. B. Nguyen, G. C. Pien, L. P. Cousens, and T. P. Salazar-Mather. 1999. Natural killer cells in antiviral defence: function and regulation by innate cytokines. Annu. Rev. Immunol. 17:189.
9. Le Page, C., P. Genin, M. G. Baines, and J. Hiscott. 2000. Interferon activation and innate immunity. Rev. Immunogenet. 2:374.
10. Guidotti, L. G., and F. V. Chisari. 2001. Noncytolytic control of viral infections by the innate and adaptive immune response. Annu. Rev. Immunol. 19:65.
11. Trinchieri, G. 1998. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv. Immunol. 70:83.
12. Matikainen, S., T. Sareneva, T. Ronni, A. Lehtonen, P. Koskinen, and I. Julkunen. 1999. Interferon-α activates multiple STAT proteins and up-regulates proliferation-associated IL-2Rα, c-myc, and pim-1 genes in human T cells. Blood 93:1980.
13. Sareneva. T., J. Pirhonen, K. Cantell, N. Kalkkinen. and I. Julkunen. 1994. Role of N-glycosylation in the synthesis, dimerization and secretion of human interferon-γ. Biochem. J. 303:831.
14. Sareneva, T., I. Julkunen, and S. Matikainen. 2000. IFN-α and IL-12 induce IL-18 receptor gene expression in human NK and T cells. J. Immunol. 165:1933.
15. Born, T. L., E. Thomassen, T. A. Bird, and J. E. Sims. 1998. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J. Biol. Chem. 273:29445.
16. Bonnert, T. P., K. E. Garka, P. Parnet, G. Sonoda, J. R. Testa, and J. E. Sims, 1997. The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. FEBS Lett. 402:81.
17. Andrews. N. C., and D. V. Faller. 1991. A rapid micropreparation techniques for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
18. Matikainen, S., T. Ronni, M. Hurme, R. Pine, and I. Julkunen. 1996. Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells. Blood 88:114.
19. Szabo, S., S. T. Kim, X. Zhang, C. G. Fathman, and L. H. Glimcher. 2000. A novel transcription factor. T-bet, directs Th1 lineage commitment. Cell 17:655.
20. Rogge, L., L. Barberis-Maino, M. Biffi, N. Passini, D. H. Presky, U. Gubler, and F. Sinigaglia. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:825.
21. John, S., C. M. Robbins, W. J. Leonard. 1996. An IL-2 response element in the human IL-2 receptor α chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and GATA family protein. EMBO J. 15:5627.
22. Lécine, P., M. Algarté, P. Rameil, C. Beadling, P. Bucher, M. Nabholz, and J. Imbert. 1996. Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene. Mol. Cell. Biol. 16:6829.
23. Schnare, M., A. C. Holt, K. Takeda, S. Akira, and R. Medzhitov. 2000. Recognition of CpG DNA is mediated by signaling pathways dependent of the adaptor protein MyD88. Curr. Biol. 21:1139.
24. Kawai, T., O. Adachi, T. Ogawa, K. Takeda, and S. Akira. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11:115.
25. Ehret, G. B., P. Reichenbach, U. Schindler, C. M. Horvath, S. Fritz, M. Nabholz, and P. Bucher. 2001. DNA binding specificity of different STAT proteins. J. Biol. Chem. 276:6675.
26. Chakir, H., A. A. Camilucci, L. G. Filion, and J. R. Webb. 2000. Differentiation of murine NK cells into distinct subsets based on variable expression of the IL-12R β2 subunit. J. Immunol. 165:4985.
27. Dunne, J., S. Synch, C. O'Farrelly, S. Todryk, J. E. Hegarty, C. Feighery, and D. G. Doherty. 2001. Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15. J. Immunol. 167, 3129.
28. Waldmann, T. A., S. Dubois, and Y. Tagaya. 2001. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity 14:105.
29. Kennedy, M. K., M. Glaccum, and S. N. Brown. 2000. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191, 771.
30. Lodolce, J. P., D. L. Boone, S. Chai, R. E. Swain, T. Dassopoulos, S. Trettin, and A. Ma. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9:669.
31. + T cells. J. Exp. Med. 193:219.
32. Farrar, M. A., and R. D. Schreiber. 1993. The molecular cell biology of interferon-γ and its receptor. Annu. Rev. Immunol. 11:571.
33. Schindler, H., M. B. Lutz, M. Röllinghoff, and C. Bogdan. 2001. The production of IFN-γ by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4. J. Immunol. 166:3075.
34. Sareneva, T., S. Matikainen, M. Kurimoto, and I. Julkunen. 1998. Influenza A virus-induced IFN-α/β and IL-18 synergistically enhance IFN-γ gene expression in human T cells. J. Immunol. 160:6032.
35. + T lymphocytes. J. Immunol. 160:3642.
36. Pien, G. C., A. R. Satoskar, K. Takeda, S. Akira, and C. A. Biron. 2000. Selective IL-18 requirements for induction of compartmental IFN-γ responses during viral infection. J. Immunol. 165:4787.
37. Nakanishi. K., T. Yoshimoto, H. Tsutsui, and H. Okamura. 2001. Interleukin-18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol. 19:423.
38. Medzhitov, R., P. Preston-Hurlburt, E. Kopp, A. Stadlen, C. Chen, S, Ghosh, and C. A. Janeway, Jr. 1998. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2:253.
39. Adachi, O., T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, M Sakagami, K Nakanishi, and S. Akira. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9:143.
40. HI lineage commitment and IFN-γ production in CD4 and CD8 T cell. Science 295:338.
41. Mullen, A. C., F. A. High, A. S. Hutchins, H. W. Lee, A. V. Villarino, D. M. Livingston, A. L. Kung, N. Cereb, T. P. Yao, S. Y. Yang, and S. L. Reiner. 2001. Role of T-bet in commitment of ThI cells before IL-12-dependent selection. Science 8:1907.
42. Lighvani, A. A., D. M. Frucht, D. Jankovic, H. Yamane. J. Aliberti, B. D. Hissong, B. V. Nguyen, M. Gadina, A. Sher, W. E. Paul, and J. J. O'Shea. 2001. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 26:15137.
43. c-dependent network? Curr. Biol. 11:R175.
44. Johnston, J. A., C. M. Bacon, D. S. Finbloom, R. C. Rees, D. Kaplan, K. Shibuya, J. R. Ortaldo, S. Gupta, Y. Q. Chen, J. D. Giri, and J. J. O'Shea. 1995. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc. Natl. Acad. Sci. USA 92:8705.
45. Yu, C. R., H. A. Young, and J. R. Ortaldo. 1998. Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells. J. Leukocyte Biol. 64:245.
46. Kim, H., J. Kelly, and W. J. Leonard. 2001. The basis for IL-2-induced IL-2 receptor α chain gene regulation: importance of two widely separated IL-2 response elements. Immunity 15:159.