The basis for IL-2-induced IL-2 receptor α chain gene regulation: Importance of two widely separated IL-2 response elements

Immunity

Volumn 15, Issue 1, 2001, Pages 159-172

  Kim, Hyoung Pyo ^a   Kelly, John ^a   Leonard, Warren J ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2 RECEPTOR; PROTEIN STAT 5A; STAT5B PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL GROWTH; DNA RESPONSIVE ELEMENT; GENE CONTROL; HUMAN; INTRON; NONHUMAN; POSITIVE REGULATORY REGION III; POSITIVE REGULATORY REGION IV; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; TRANSCRIPTION INITIATION;

EID: 0034897188     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00167-4     Document Type: Article

References (43)

1. HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene
2. The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-α gene and type 1 HIV
3. A conserved IL-2 responsive enhancer in the IL-2R alpha gene
4. High-mobility-group chromosomal proteins: Architectural components that facilitate chromatin function
5. Regulation of the human interleukin-2 receptor α chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I
6. Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes
7. Simian virus 40-mediated cis induction of the Xenopus beta-globin DNase I hypersensitive site
8. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity
9. Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: Potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins
10. An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein
11. The significance of tetramerization in promoter recruitment by Stat5
12. A model for chromatin opening: Stimulation of topoisomerase II and restriction enzyme cleavage of chromatin by distamycin
13. Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene
14. A conformational study of the sequence specific binding of HMG-I (Y) with the bovine interleukin-2 cDNA
15. HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor
16. Signaling from the IL-2 receptor to the nucleus
17. Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene
18. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
19. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
20. CREB regulates MHC class II expression in a CIITA-dependent manner
21. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
22. An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction
23. Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signalling
24. Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation
25. Changes in superhelicity are introduced into closed circular DNA by binding of high mobility group protein I/Y
26. A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene
27. Interaction of high mobility group-I (Y) nonhistone proteins with nucleosome core particles
28. Cell cycle regulation and functions of HMG-I(Y)
29. Substrate structure influences binding of the non-histone protein HMG-I(Y) to free nucleosomal DNA
30. Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product
31. Rapid detection of octamer binding proteins with `mini-extracts', prepared from a small number of cells
32. Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor
33. Mouse interleukin-2 receptor alpha gene expression. Delimitation of cis-acting regulatory elements in transgenic mice and by mapping of DNase-I hypersensitive sites
34. Efficient infection of monkey cells with DNA of simian virus 40
35. Mouse interleukin-2 receptor alpha gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements
36. Virus induction of human IFN β gene expression requires the assembly of an enhanceosome
37. Clustal W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
38. The same target sequences are differentially important for activation of the interleukin 2 receptor alpha-chain gene in two distinct T-cell lines
39. The multi-subunit interleukin-2 receptor
40. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
41. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
42. SAR-dependent mobilization of histone H1 by HMG-I/Y in vitro: HMG-I/Y is enriched in H1-depleted chromatin