-
1
-
-
77956910736
-
Acyl-CoA carboxylase
-
ed. PD Boyer. New York: Academic
-
Alberts A, Vagelos PR. 1972. Acyl-CoA carboxylase. In The Enzymes, ed. PD Boyer, pp. 37-82. New York: Academic
-
(1972)
The Enzymes
, pp. 37-82
-
-
Alberts, A.1
Vagelos, P.R.2
-
2
-
-
0042626159
-
Structure of gramicidin A in a lipid bilayer environment determined using molecular dynamics simulations and solid-state NMR data
-
Allen TW, Andersen OS, Roux B. 2003. Structure of gramicidin A in a lipid bilayer environment determined using molecular dynamics simulations and solid-state NMR data. J. Am. Chem. Soc. 125:9868-77
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 9868-9877
-
-
Allen, T.W.1
Andersen, O.S.2
Roux, B.3
-
3
-
-
0028943591
-
Amide exchange rates in Escherichia coli acyl carrier protein: Correlation with protein structure and dynamics
-
Andrec M, Hill RB, Prestegard JH. 1995. Amide exchange rates in Escherichia coli acyl carrier protein: correlation with protein structure and dynamics. Protein Sci. 4:983-93
-
(1995)
Protein Sci.
, vol.4
, pp. 983-993
-
-
Andrec, M.1
Hill, R.B.2
Prestegard, J.H.3
-
4
-
-
0030962189
-
Structural and functional considerations of the aminoacylation reaction
-
Arnez JG, Moras D. 1997. Structural and functional considerations of the aminoacylation reaction. Trends Biochem. Sci. 22:203-6
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 203-206
-
-
Arnez, J.G.1
Moras, D.2
-
5
-
-
0033574774
-
Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis
-
Belshaw PJ, Walsh CT, Stachelhaus T. 1999. Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis. Science 284:486-89
-
(1999)
Science
, vol.284
, pp. 486-489
-
-
Belshaw, P.J.1
Walsh, C.T.2
Stachelhaus, T.3
-
6
-
-
0036161991
-
Mutational analysis of the C-domain in nonribosomal peptide synthesis
-
Bergendahl V, Linne U, Marahiel MA. 2002. Mutational analysis of the C-domain in nonribosomal peptide synthesis. Eur. J. Biochem. 269:620-29
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 620-629
-
-
Bergendahl, V.1
Linne, U.2
Marahiel, M.A.3
-
7
-
-
0028058149
-
Molecular and biochemical analyses of fatty acid transport, metabolism, and gene regulation in Escherichia coli
-
Black PN, DiRusso CC. 1994. Molecular and biochemical analyses of fatty acid transport, metabolism, and gene regulation in Escherichia coli. Biochim. Biophys. Acta. 1210:123-45
-
(1994)
Biochim. Biophys. Acta
, vol.1210
, pp. 123-145
-
-
Black, P.N.1
DiRusso, C.C.2
-
8
-
-
0036120595
-
Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE
-
Bruner SD, Weber T, Kohli RM, Schwarzer D, Marahiel MA, et al. 2002. Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure 10:301-10
-
(2002)
Structure
, vol.10
, pp. 301-310
-
-
Bruner, S.D.1
Weber, T.2
Kohli, R.M.3
Schwarzer, D.4
Marahiel, M.A.5
-
10
-
-
0033485280
-
The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
-
Cane DE, Walsh CT. 1999. The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases. Chem. Biol. 6:R319-25
-
(1999)
Chem. Biol.
, vol.6
-
-
Cane, D.E.1
Walsh, C.T.2
-
11
-
-
0032475992
-
Harnessing the biosynthetic code: Combinations, permutations, and mutations
-
Cane DE, Walsh CT, Khosla C. 1998. Harnessing the biosynthetic code: combinations, permutations, and mutations. Science 282:63-68
-
(1998)
Science
, vol.282
, pp. 63-68
-
-
Cane, D.E.1
Walsh, C.T.2
Khosla, C.3
-
12
-
-
0029116455
-
Transposon mutagenesis and cloning of the genes encoding the enzymes of fengycin biosynthesis in Bacillus subtilis
-
Chen CL, Chang LK, Chang YS, Liu ST, Tschen JS. 1995. Transposon mutagenesis and cloning of the genes encoding the enzymes of fengycin biosynthesis in Bacillus subtilis. Mol. Gen. Genet. 248:121-25
-
(1995)
Mol. Gen. Genet.
, vol.248
, pp. 121-125
-
-
Chen, C.L.1
Chang, L.K.2
Chang, Y.S.3
Liu, S.T.4
Tschen, J.S.5
-
13
-
-
0034837369
-
Epothilone biosynthesis: Assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit
-
Chen H, O'Connor S, Cane DE, Walsh CT. 2001. Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. Chem. Biol. 8:899-912
-
(2001)
Chem. Biol.
, vol.8
, pp. 899-912
-
-
Chen, H.1
O'Connor, S.2
Cane, D.E.3
Walsh, C.T.4
-
14
-
-
0034675957
-
Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: An essential enzyme in bacterial fatty acid biosynthesis
-
Chirgadze NY, Briggs SL, McAllister KA, Fischl AS, Zhao G. 2000. Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis. EMBO J. 19:5281-87
-
(2000)
EMBO J.
, vol.19
, pp. 5281-5287
-
-
Chirgadze, N.Y.1
Briggs, S.L.2
McAllister, K.A.3
Fischl, A.S.4
Zhao, G.5
-
15
-
-
0030584662
-
Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes
-
Conti E, Franks NP, Brick P. 1996. Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. Structure 4:287-98
-
(1996)
Structure
, vol.4
, pp. 287-298
-
-
Conti, E.1
Franks, N.P.2
Brick, P.3
-
16
-
-
0030756031
-
Structural basis for the activation of phenylalanine in the nonribosomal biosynthesis of gramicidin S
-
Conti E, Stachelhaus T, Marahiel MA, Brick P. 1997. Structural basis for the activation of phenylalanine in the nonribosomal biosynthesis of gramicidin S. EMBO J. 16:4174-83
-
(1997)
EMBO J.
, vol.16
, pp. 4174-4183
-
-
Conti, E.1
Stachelhaus, T.2
Marahiel, M.A.3
Brick, P.4
-
17
-
-
0019588236
-
Pyochelin: Novel structure of an iron-chelating growth promotor for Pseudomonas aeruginosa
-
Cox CD. 1981. Pyochelin: novel structure of an iron-chelating growth promotor for Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 78:4256-60
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 4256-4260
-
-
Cox, C.D.1
-
18
-
-
0024404842
-
Genetics and molecular biology of siderophore-mediated iron transport in bacteria
-
Crosa JH. 1989. Genetics and molecular biology of siderophore-mediated iron transport in bacteria. Microbiol. Rev. 53:517-30
-
(1989)
Microbiol. Rev.
, vol.53
, pp. 517-530
-
-
Crosa, J.H.1
-
19
-
-
0036280341
-
Genetics and assembly line enzymology of siderophore biosynthesis in bacteria
-
Crosa JH, Walsh CT. 2002. Genetics and assembly line enzymology of siderophore biosynthesis in bacteria. Microbiol. Mol. Biol. Rev. 66:223-49
-
(2002)
Microbiol. Mol. Biol. Rev.
, vol.66
, pp. 223-249
-
-
Crosa, J.H.1
Walsh, C.T.2
-
20
-
-
0030972114
-
Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3 (2)
-
Crump MP, Crosby J, Dempsey CE, Parkinson JA, Murray M, et al. 1997. Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3 (2). Biochemistry 36:6000-8
-
(1997)
Biochemistry
, vol.36
, pp. 6000-6008
-
-
Crump, M.P.1
Crosby, J.2
Dempsey, C.E.3
Parkinson, J.A.4
Murray, M.5
-
21
-
-
0015819138
-
Inhibition of fatty acid synthesis by the antibiotic cerulenin, specific inactivation of β-ketoacyl-acyl carrier protein synthase
-
D'Agnolo G, Rosenfeld IS, Awaya J, Omura S, Vagelos PR. 1973. Inhibition of fatty acid synthesis by the antibiotic cerulenin, specific inactivation of β-ketoacyl-acyl carrier protein synthase. Biochim. Biophys. Acta. 326:155-56
-
(1973)
Biochim. Biophys. Acta
, vol.326
, pp. 155-156
-
-
D'Agnolo, G.1
Rosenfeld, I.S.2
Awaya, J.3
Omura, S.4
Vagelos, P.R.5
-
22
-
-
0016734774
-
Multiple forms of β-ketoacyl-acyl carrier protein synthase in Escherichia coli
-
D'Agnolo G, Rosenfeld IS, Vagelos PR. 1975. Multiple forms of β-ketoacyl-acyl carrier protein synthase in Escherichia coli. J. Biol. Chem. 250:5289-94
-
(1975)
J. Biol. Chem.
, vol.250
, pp. 5289-5294
-
-
D'Agnolo, G.1
Rosenfeld, I.S.2
Vagelos, P.R.3
-
23
-
-
0034651317
-
The 1.8 Å crystal structure and active-site architecture of β-ketoacyl-acyl carrier protein synthase III (FabH) from Escherichia coli
-
Davies C, Heath RJ, White SW, Rock CO. 2000. The 1.8 Å crystal structure and active-site architecture of β-ketoacyl-acyl carrier protein synthase III (FabH) from Escherichia coli. Structure 8:185-95
-
(2000)
Structure
, vol.8
, pp. 185-195
-
-
Davies, C.1
Heath, R.J.2
White, S.W.3
Rock, C.O.4
-
24
-
-
0029997792
-
The D-alanyl carrier protein in Lactobacillus casei: Cloning, sequencing, and expression of dltC
-
Debabov DV, Heaton MP, Zhang Q, Stewart KD, Lambalot RH, Neuhaus FC. 1996. The D-alanyl carrier protein in Lactobacillus casei: cloning, sequencing, and expression of dltC. J. Bacteriol. 178:3869-76
-
(1996)
J. Bacteriol.
, vol.178
, pp. 3869-3876
-
-
Debabov, D.V.1
Heaton, M.P.2
Zhang, Q.3
Stewart, K.D.4
Lambalot, R.H.5
Neuhaus, F.C.6
-
25
-
-
0028896569
-
Expression of an active adenylate-forming domain of peptide synthetases corresponding to acyl-CoA-synthetases
-
Dieckmann R, Lee YO, vanLiempt H, von Döhren H, Kleinkauf H. 1995. Expression of an active adenylate-forming domain of peptide synthetases corresponding to acyl-CoA-synthetases. FEBS Lett. 357:212-16
-
(1995)
FEBS Lett.
, vol.357
, pp. 212-216
-
-
Dieckmann, R.1
Lee, Y.O.2
VanLiempt, H.3
Von Döhren, H.4
Kleinkauf, H.5
-
26
-
-
0034125798
-
Dipeptide formation on engineered hybrid peptide synthetases
-
Doekel S, Marahiel MA. 2000. Dipeptide formation on engineered hybrid peptide synthetases. Chem. Biol. 7:373-84
-
(2000)
Chem. Biol.
, vol.7
, pp. 373-384
-
-
Doekel, S.1
Marahiel, M.A.2
-
27
-
-
0033603539
-
Phylogenetic classification and the universal tree
-
Doolittle WF. 1999. Phylogenetic classification and the universal tree. Science 284:2124-28
-
(1999)
Science
, vol.284
, pp. 2124-2128
-
-
Doolittle, W.F.1
-
28
-
-
0043244862
-
BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation
-
Du L, Chen M, Zhang Y, Shen B. 2003. BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation. Biochemistry 42:9731-49
-
(2003)
Biochemistry
, vol.42
, pp. 9731-9749
-
-
Du, L.1
Chen, M.2
Zhang, Y.3
Shen, B.4
-
29
-
-
0033835373
-
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC 15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
-
Du L, Sanchez C, Chen M, Edwards DJ, Shen B. 2000. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC 15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase. Chem. Biol. 7:623-42
-
(2000)
Chem. Biol.
, vol.7
, pp. 623-642
-
-
Du, L.1
Sanchez, C.2
Chen, M.3
Edwards, D.J.4
Shen, B.5
-
30
-
-
0345305853
-
Construction of hybrid peptide synthetases for the production of alpha-L-aspartyl-L-phenylalanine, a precursor for the high-intensity sweetener aspartame
-
Duerfahrt T, Doekel S, Sonke T, Quaedflieg PJLM, Marahiel MA. 2003. Construction of hybrid peptide synthetases for the production of alpha-L-aspartyl-L-phenylalanine, a precursor for the high-intensity sweetener aspartame. Eur. J. Biochem. 270:4555-63
-
(2003)
Eur. J. Biochem.
, vol.270
, pp. 4555-4563
-
-
Duerfahrt, T.1
Doekel, S.2
Sonke, T.3
Quaedflieg, P.J.L.M.4
Marahiel, M.A.5
-
31
-
-
1542380023
-
Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis
-
Duerfahrt T, Eppelmann K, Müller R, Marahiel MA. 2004. Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis. Chem. Biol. 11:261-71
-
(2004)
Chem. Biol.
, vol.11
, pp. 261-271
-
-
Duerfahrt, T.1
Eppelmann, K.2
Müller, R.3
Marahiel, M.A.4
-
32
-
-
0033545834
-
Lysine biosynthesis in Saccharomycescerevisiae: Mechanism of α-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5
-
Ehmann DE, Gehring AM, Walsh CT. 1999. Lysine biosynthesis in Saccharomycescerevisiae: mechanism of α-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5. Biochemistry 38:6171-77
-
(1999)
Biochemistry
, vol.38
, pp. 6171-6177
-
-
Ehmann, D.E.1
Gehring, A.M.2
Walsh, C.T.3
-
33
-
-
0034646227
-
The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: Sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates
-
Ehmann DE, Shaw-Reid CA, Losey HC, Walsh CT. 2000. The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates. Proc. Natl. Acad. Sci. USA 97:2509-14
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 2509-2514
-
-
Ehmann, D.E.1
Shaw-Reid, C.A.2
Losey, H.C.3
Walsh, C.T.4
-
34
-
-
0037199494
-
Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics
-
Eppelmann K, Stachelhaus T, Marahiel MA. 2002. Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics. Biochemistry 41:9718-26
-
(2002)
Biochemistry
, vol.41
, pp. 9718-9726
-
-
Eppelmann, K.1
Stachelhaus, T.2
Marahiel, M.A.3
-
35
-
-
0025158208
-
Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs
-
Eriani G, Delarue M, Poch O, Gangloff J, Moras D. 1990. Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs. Nature 347:203-6
-
(1990)
Nature
, vol.347
, pp. 203-206
-
-
Eriani, G.1
Delarue, M.2
Poch, O.3
Gangloff, J.4
Moras, D.5
-
36
-
-
0036007872
-
Marine natural products
-
Faulkner DJ. 2002. Marine natural products. Nat. Prod. Rep. 19:1-48
-
(2002)
Nat. Prod. Rep.
, vol.19
, pp. 1-48
-
-
Faulkner, D.J.1
-
37
-
-
0034111426
-
A novel function of yeast fatty acid synthase. Subunit α is capable of self-pantetheinylation
-
Fichtischerer F, Wellein C, Mittag M, Schweizer E. 2000. A novel function of yeast fatty acid synthase. Subunit α is capable of self-pantetheinylation. Eur. J. Biochem. 267:2666-71
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 2666-2671
-
-
Fichtischerer, F.1
Wellein, C.2
Mittag, M.3
Schweizer, E.4
-
38
-
-
0038457084
-
Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus
-
Findlow SC, Winsor C, Simpson TJ, Crosby J, Crump MP. 2003. Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus. Biochemistry 42:8423-33
-
(2003)
Biochemistry
, vol.42
, pp. 8423-8433
-
-
Findlow, S.C.1
Winsor, C.2
Simpson, T.J.3
Crosby, J.4
Crump, M.P.5
-
39
-
-
0141795294
-
Amino acyl-adenylate substrate analogues for the inhibition of adenylation domains of non-ribosomal peptide synthetases
-
Finking R, Neumüller A, Solsbacher J, Konz D, Kretzschmar G, et al. 2003. Amino acyl-adenylate substrate analogues for the inhibition of adenylation domains of non-ribosomal peptide synthetases. ChemBiol. Chem. 4:903-6
-
(2003)
ChemBiol. Chem.
, vol.4
, pp. 903-906
-
-
Finking, R.1
Neumüller, A.2
Solsbacher, J.3
Konz, D.4
Kretzschmar, G.5
-
40
-
-
0348087044
-
Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore metabolism in Pseudomonas aeruginosa
-
Finking R, Solsbacher J, Konz D, Schobert M, Schäfer A, et al. 2002. Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore metabolism in Pseudomonas aeruginosa. J. Biol. Chem. 277:50293-302
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50293-50302
-
-
Finking, R.1
Solsbacher, J.2
Konz, D.3
Schobert, M.4
Schäfer, A.5
-
41
-
-
0035929665
-
Site-directed mutagenesis of acyl carrier protein reveals amino acid residues involved in ACP structure and acyl-ACP synthetase activity
-
Flaman AS, Chen JM, Van Iderstine SC, Byers DM. 2001. Site-directed mutagenesis of acyl carrier protein reveals amino acid residues involved in ACP structure and acyl-ACP synthetase activity. J. Biol. Chem. 276:35934-39
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 35934-35939
-
-
Flaman, A.S.1
Chen, J.M.2
Van Iderstine, S.C.3
Byers, D.M.4
-
42
-
-
0033955033
-
Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli
-
Flugel RS, Hwangbo Y, Lambalot RH, Cronan JE Jr, Walsh CT. 2000. Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli. J. Biol. Chem. 275:959-68
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 959-968
-
-
Flugel, R.S.1
Hwangbo, Y.2
Lambalot, R.H.3
Cronan Jr., J.E.4
Walsh, C.T.5
-
43
-
-
0031784872
-
Structural basis for the inhibition of firefly luciferase by a general anesthetic
-
Franks NP, Jenkins A, Conti E, Lieb WR, Brick P. 1998. Structural basis for the inhibition of firefly luciferase by a general anesthetic. Biophys. J. 75:2205-11
-
(1998)
Biophys. J.
, vol.75
, pp. 2205-2211
-
-
Franks, N.P.1
Jenkins, A.2
Conti, E.3
Lieb, W.R.4
Brick, P.5
-
44
-
-
0347384092
-
Antibiotic optimization via in vitro glycorandomization
-
Fu X, Albermann C, Jiang J, Liao J, Zhang C, Thorson JS. 2003. Antibiotic optimization via in vitro glycorandomization. Nat. Biotechnol. 21:1467-69
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 1467-1469
-
-
Fu, X.1
Albermann, C.2
Jiang, J.3
Liao, J.4
Zhang, C.5
Thorson, J.S.6
-
45
-
-
0019275308
-
Structural, enzymatic, and genetic studies of β-ketoacyl-acyl carrier protein synthase I and II of Escherichia coli
-
Garwin JL, Klages AL, Cronan JE Jr. 1980. Structural, enzymatic, and genetic studies of β-ketoacyl-acyl carrier protein synthase I and II of Escherichia coli. J. Biol. Chem. 255:11949-56
-
(1980)
J. Biol. Chem.
, vol.255
, pp. 11949-11956
-
-
Garwin, J.L.1
Klages, A.L.2
Cronan Jr., J.E.3
-
46
-
-
0030738431
-
Enterobactin biosynthesis in Escherichia coli: Isochorismate lyase (EntB) is a bifunctional enzyme that is phosphopantetheinylated by EntD and then acylated by EntE using ATP and 2,3-dihydroxybenzoate
-
Gehring AM, Bradley KA, Walsh CT. 1997. Enterobactin biosynthesis in Escherichia coli: Isochorismate lyase (EntB) is a bifunctional enzyme that is phosphopantetheinylated by EntD and then acylated by EntE using ATP and 2,3-dihydroxybenzoate. Biochemistry 36:8495-503
-
(1997)
Biochemistry
, vol.36
, pp. 8495-8503
-
-
Gehring, A.M.1
Bradley, K.A.2
Walsh, C.T.3
-
47
-
-
0032193282
-
Iron acquisition in plague: Modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis
-
Gehring AM, DeMoll E, Fetherston JD, Mori I, Mayhew GF, et al. 1998. Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis. Chem. Biol. 5:573-86
-
(1998)
Chem. Biol.
, vol.5
, pp. 573-586
-
-
Gehring, A.M.1
DeMoll, E.2
Fetherston, J.D.3
Mori, I.4
Mayhew, G.F.5
-
48
-
-
0030936547
-
Ability of Streptomyces spp. acyl carrier proteins and coenzyme A analogs to serve as substrates in vitro for E. coli holo-ACP synthase
-
Gehring AM, Lambalot RH, Vogel KW, Drueckhammer DG, Walsh CT. 1997. Ability of Streptomyces spp. acyl carrier proteins and coenzyme A analogs to serve as substrates in vitro for E. coli holo-ACP synthase. Chem. Biol. 4:17-24
-
(1997)
Chem. Biol.
, vol.4
, pp. 17-24
-
-
Gehring, A.M.1
Lambalot, R.H.2
Vogel, K.W.3
Drueckhammer, D.G.4
Walsh, C.T.5
-
49
-
-
0032544193
-
The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis
-
Gehring AM, Mori I, Perry RD, Walsh CT. 1998. The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis. Biochemistry 37:11637-50. Erratum. 1998. Biochemistry 37:17104
-
(1998)
Biochemistry
, vol.37
, pp. 11637-11650
-
-
Gehring, A.M.1
Mori, I.2
Perry, R.D.3
Walsh, C.T.4
-
50
-
-
0032400509
-
Erratum
-
Gehring AM, Mori I, Perry RD, Walsh CT. 1998. The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis. Biochemistry 37:11637-50. Erratum. 1998. Biochemistry 37:17104
-
(1998)
Biochemistry
, vol.37
, pp. 17104
-
-
-
51
-
-
0032562142
-
Reconstitution and characterization of the Escherichia coli enterobactin synthetase from EntB, EntE, and EntF
-
Gehring AM, Mori I, Walsh CT. 1998. Reconstitution and characterization of the Escherichia coli enterobactin synthetase from EntB, EntE, and EntF. Biochemistry 37:2648-59
-
(1998)
Biochemistry
, vol.37
, pp. 2648-2659
-
-
Gehring, A.M.1
Mori, I.2
Walsh, C.T.3
-
53
-
-
0036037587
-
Enniatin synthetase is a monomer with extended structure: Evidence for an intramolecular reaction mechanism
-
Glinski M, Urbanke C, Hornbogen T, Zocher R. 2002. Enniatin synthetase is a monomer with extended structure: evidence for an intramolecular reaction mechanism. Arch. Mircrobiol. 178:267-73
-
(2002)
Arch. Mircrobiol.
, vol.178
, pp. 267-273
-
-
Glinski, M.1
Urbanke, C.2
Hornbogen, T.3
Zocher, R.4
-
54
-
-
0028226896
-
Analysis of core sequences in the D-Phe activating domain of the multifunctional peptide synthetase TycA by site-directed mutagenesis
-
Gocht M, Marahiel MA. 1994. Analysis of core sequences in the D-Phe activating domain of the multifunctional peptide synthetase TycA by site-directed mutagenesis. J. Bacteriol. 176:2654-62
-
(1994)
J. Bacteriol.
, vol.176
, pp. 2654-2662
-
-
Gocht, M.1
Marahiel, M.A.2
-
55
-
-
0032562129
-
Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase
-
Gokhale RS, Lau J, Cane DE, Khosla C. 1998. Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase. Biochemistry 37:2524-28
-
(1998)
Biochemistry
, vol.37
, pp. 2524-2528
-
-
Gokhale, R.S.1
Lau, J.2
Cane, D.E.3
Khosla, C.4
-
56
-
-
0033574768
-
Dissecting and exploiting intermodular communication in polyketide synthases
-
Gokhale RS, Tsuji SY, Cane DE, Khosla C. 1999. Dissecting and exploiting intermodular communication in polyketide synthases. Science 284:482-85
-
(1999)
Science
, vol.284
, pp. 482-485
-
-
Gokhale, R.S.1
Tsuji, S.Y.2
Cane, D.E.3
Khosla, C.4
-
58
-
-
0016285541
-
Acetyl coenzyme A carboxylase system of Escherichia coli. Purification and properties of the biotin carboxylase, carboxyl-transferase, and carboxyl carrier protein components
-
Guchhait RB, Polakis SE, Dimroth P, Stoll E, Moss J, Lane MD. 1974. Acetyl coenzyme A carboxylase system of Escherichia coli. Purification and properties of the biotin carboxylase, carboxyl-transferase, and carboxyl carrier protein components. J. Biol. Chem. 249:6633-45
-
(1974)
J. Biol. Chem.
, vol.249
, pp. 6633-6645
-
-
Guchhait, R.B.1
Polakis, S.E.2
Dimroth, P.3
Stoll, E.4
Moss, J.5
Lane, M.D.6
-
59
-
-
0032484013
-
Characterization of the syringomycin synthetase gene cluster. A link between prokaryotic and eukaryotic peptide synthetases
-
Guenzi E, Galli G, Grgurina I, Gross DC, Grandi G. 1998. Characterization of the syringomycin synthetase gene cluster. A link between prokaryotic and eukaryotic peptide synthetases. J. Biol. Chem. 273:32857-63
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32857-32863
-
-
Guenzi, E.1
Galli, G.2
Grgurina, I.3
Gross, D.C.4
Grandi, G.5
-
60
-
-
0032486407
-
Coordinate transcription and physical linkage of domains in surfactin synthetase are not essential for proper assembly and activity of the multienzyme complex
-
Guenzi E, Galli G, Grgurina I, Pace E, Ferranti P, Grandi G. 1998. Coordinate transcription and physical linkage of domains in surfactin synthetase are not essential for proper assembly and activity of the multienzyme complex. J. Biol. Chem. 273:14403-10
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14403-14410
-
-
Guenzi, E.1
Galli, G.2
Grgurina, I.3
Pace, E.4
Ferranti, P.5
Grandi, G.6
-
61
-
-
0016351434
-
Mutants of Escherichia coli with temperature-sensitive malonyl coenzyme A-acyl carrier protein transacylase
-
Harder M, Ladenson RC, Schimmel SD, Silbert DF. 1974. Mutants of Escherichia coli with temperature-sensitive malonyl coenzyme A-acyl carrier protein transacylase. J. Biol. Chem. 249:7468-75
-
(1974)
J. Biol. Chem.
, vol.249
, pp. 7468-7475
-
-
Harder, M.1
Ladenson, R.C.2
Schimmel, S.D.3
Silbert, D.F.4
-
62
-
-
0033636188
-
The txtAB genes of the plant pathogen Streptomyces acidiscabies encode a peptide synthetase required for phytotoxin thaxtomin A production and pathogenicity
-
Healy FG, Wach M, Krasnoff SB, Gibson DM, Loria R. 2000. The txtAB genes of the plant pathogen Streptomyces acidiscabies encode a peptide synthetase required for phytotoxin thaxtomin A production and pathogenicity. Mol. Microbiol. 38:794-804
-
(2000)
Mol. Microbiol.
, vol.38
, pp. 794-804
-
-
Healy, F.G.1
Wach, M.2
Krasnoff, S.B.3
Gibson, D.M.4
Loria, R.5
-
63
-
-
0037469129
-
Dimeric structure of the six-domain VibF subunit of vibriobactin synthetase: Mutant domain activity regain and ultracentrifugation studies
-
Hillson NJ, Walsh CT. 2003. Dimeric structure of the six-domain VibF subunit of vibriobactin synthetase: mutant domain activity regain and ultracentrifugation studies. Biochemistry 42:766-75
-
(2003)
Biochemistry
, vol.42
, pp. 766-775
-
-
Hillson, N.J.1
Walsh, C.T.2
-
64
-
-
0028272082
-
Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis
-
Hoffmann K, Schneider-Scherzer E, Kleinkauf H, Zocher R. 1994. Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis. J. Biol. Chem. 269:12710-14
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 12710-12714
-
-
Hoffmann, K.1
Schneider-Scherzer, E.2
Kleinkauf, H.3
Zocher, R.4
-
65
-
-
0023813070
-
Three-dimensional structure of acyl carrier protein determined by NMR pseudoenergy and distance geometry calculations
-
Holak TA, Kearsley SK, Kim Y, Prestegard JH. 1988. Three-dimensional structure of acyl carrier protein determined by NMR pseudoenergy and distance geometry calculations. Biochemistry 27:6135-42
-
(1988)
Biochemistry
, vol.27
, pp. 6135-6142
-
-
Holak, T.A.1
Kearsley, S.K.2
Kim, Y.3
Prestegard, J.H.4
-
66
-
-
0001747786
-
Genetic contributions to understanding polyketide synthases
-
Hopwood DA. 1997. Genetic contributions to understanding polyketide synthases. Chem. Rev. 97:2465-97
-
(1997)
Chem. Rev.
, vol.97
, pp. 2465-2497
-
-
Hopwood, D.A.1
-
67
-
-
0024470350
-
Molecular cloning and nucleotide sequence of the gramicidin S synthetase 1 gene
-
Hori K, Yamamoto Y, Minetoki T, Kurotsu T, Kanda M, et al. 1989. Molecular cloning and nucleotide sequence of the gramicidin S synthetase 1 gene. J. Biochem. 106:639-45
-
(1989)
J. Biochem.
, vol.106
, pp. 639-645
-
-
Hori, K.1
Yamamoto, Y.2
Minetoki, T.3
Kurotsu, T.4
Kanda, M.5
-
69
-
-
0000991019
-
Biosynthesis of coenzymes and prosthetic groups
-
ed. FC Neidhard. New York: ASM Press
-
Jackowski S. 1996. Biosynthesis of coenzymes and prosthetic groups. In E. coli and Salmonella. Cellular and Molecular Biology, ed. FC Neidhard, pp. 687-94. New York: ASM Press
-
(1996)
E. coli and Salmonella. Cellular and Molecular Biology
, pp. 687-694
-
-
Jackowski, S.1
-
70
-
-
0037330531
-
Engineering of an active animal fatty acid synthase dimer with only one competent subunit
-
Joshi AK, Rangan VS, Witkowski A, Smith S. 2003. Engineering of an active animal fatty acid synthase dimer with only one competent subunit. Chem. Biol. 10:169-73
-
(2003)
Chem. Biol.
, vol.10
, pp. 169-173
-
-
Joshi, A.K.1
Rangan, V.S.2
Witkowski, A.3
Smith, S.4
-
71
-
-
0031050460
-
Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro
-
Joshi AK, Witkowski A, Smith S. 1997. Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro. Biochemistry 36:2316-22
-
(1997)
Biochemistry
, vol.36
, pp. 2316-2322
-
-
Joshi, A.K.1
Witkowski, A.2
Smith, S.3
-
72
-
-
0042858246
-
Cloning, expression and characterization of a human 4′- phosphopantetheinyl transferase with broad substrate specificity
-
Joshi AK, Zhang L, Rangan VS, Smith S. 2003. Cloning, expression and characterization of a human 4′-phosphopantetheinyl transferase with broad substrate specificity. J. Biol. Chem. 278:33142-49
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 33142-33149
-
-
Joshi, A.K.1
Zhang, L.2
Rangan, V.S.3
Smith, S.4
-
73
-
-
0029797581
-
Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase
-
Kao CM, Pieper R, Cane DE, Khosla C. 1996. Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase. Biochemistry 35:12363-68
-
(1996)
Biochemistry
, vol.35
, pp. 12363-12368
-
-
Kao, C.M.1
Pieper, R.2
Cane, D.E.3
Khosla, C.4
-
74
-
-
0242668745
-
A new redox-cofactor vitamin for mammals
-
Kasahara T, Tadafumi K. 2003. A new redox-cofactor vitamin for mammals. Nature 422:832
-
(2003)
Nature
, vol.422
, pp. 832
-
-
Kasahara, T.1
Tadafumi, K.2
-
75
-
-
0001436716
-
Manipulation of modular polyketide synthases
-
Katz L. 1997. Manipulation of modular polyketide synthases. Chem. Rev. 97:2557-76
-
(1997)
Chem. Rev.
, vol.97
, pp. 2557-2576
-
-
Katz, L.1
-
76
-
-
0034687759
-
Reconstitution and characterization of the Vibrio cholerae vibriobactin synthetase from VibB, VibE, VibF, and VibH
-
Keating TA, Marshall CG, Walsh CT. 2000. Reconstitution and characterization of the Vibrio cholerae vibriobactin synthetase from VibB, VibE, VibF, and VibH. Biochemistry 39:15522-30
-
(2000)
Biochemistry
, vol.39
, pp. 15522-15530
-
-
Keating, T.A.1
Marshall, C.G.2
Walsh, C.T.3
-
77
-
-
0034687767
-
Vibriobactin biosynthesis in Vibrio cholerae: VibH is an amide synthase homologous to nonribosomal peptide synthetase condensation domains
-
Keating TA, Marshall CG, Walsh CT. 2000. Vibriobactin biosynthesis in Vibrio cholerae: VibH is an amide synthase homologous to nonribosomal peptide synthetase condensation domains. Biochemistry 39:15513-21
-
(2000)
Biochemistry
, vol.39
, pp. 15513-15521
-
-
Keating, T.A.1
Marshall, C.G.2
Walsh, C.T.3
-
78
-
-
0036295033
-
The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains
-
Keating TA, Marshall CG, Walsh CT, Keating AE. 2002. The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains. Nat. Struct. Biol. 9:522-26
-
(2002)
Nat. Struct. Biol.
, vol.9
, pp. 522-526
-
-
Keating, T.A.1
Marshall, C.G.2
Walsh, C.T.3
Keating, A.E.4
-
79
-
-
0034712679
-
Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of yersiniabactin synthetase
-
Keating TA, Miller DA, Walsh CT. 2000. Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of yersiniabactin synthetase. Biochemistry 39:4729-39
-
(2000)
Biochemistry
, vol.39
, pp. 4729-4739
-
-
Keating, T.A.1
Miller, D.A.2
Walsh, C.T.3
-
80
-
-
0032829915
-
Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis
-
Keating TA, Walsh CT. 1999. Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis. Curr. Opin. Chem. Biol. 3:598-606
-
(1999)
Curr. Opin. Chem. Biol.
, vol.3
, pp. 598-606
-
-
Keating, T.A.1
Walsh, C.T.2
-
81
-
-
1542350231
-
The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 56 catalytic domains
-
Kessler N, Schuhmann H, Morneweg S, Linne U, Marahiel MA. 2004. The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 56 catalytic domains. J. Biol. Chem. 279:7413-19
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7413-7419
-
-
Kessler, N.1
Schuhmann, H.2
Morneweg, S.3
Linne, U.4
Marahiel, M.A.5
-
82
-
-
0038112130
-
The npgA/cfwA gene encodes a putative 4′-phosphopantetheinyl transferase which is essential for penicillin biosynthesis in Aspergillus nidulans
-
Keszenman-Pereyra D, Lawrence S, Twfieg ME, Price J, Turner G. 2003. The npgA/cfwA gene encodes a putative 4′-phosphopantetheinyl transferase which is essential for penicillin biosynthesis in Aspergillus nidulans. Curr. Genet. 43:186-90
-
(2003)
Curr. Genet.
, vol.43
, pp. 186-190
-
-
Keszenman-Pereyra, D.1
Lawrence, S.2
Twfieg, M.E.3
Price, J.4
Turner, G.5
-
83
-
-
0035912883
-
Generality of peptide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide synthetases
-
Kohli RM, Trauger JW, Schwarzer D, Marahiel MA, Walsh CT. 2001. Generality of peptide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide synthetases. Biochemistry 40:7099-108
-
(2001)
Biochemistry
, vol.40
, pp. 7099-7108
-
-
Kohli, R.M.1
Trauger, J.W.2
Schwarzer, D.3
Marahiel, M.A.4
Walsh, C.T.5
-
84
-
-
0024437776
-
Gramicidin S biosynthesis operon containing the structural genes grsA and grsB has an open reading frame encoding a protein homologous to fatty acid thioesterases
-
Kratzschmar J, Krause M, Marahiel MA. 1989. Gramicidin S biosynthesis operon containing the structural genes grsA and grsB has an open reading frame encoding a protein homologous to fatty acid thioesterases. J. Bacteriol. 171:5422-29
-
(1989)
J. Bacteriol.
, vol.171
, pp. 5422-5429
-
-
Kratzschmar, J.1
Krause, M.2
Marahiel, M.A.3
-
85
-
-
0030294470
-
A new enzyme superfamily: The phosphopantetheinyl transferases
-
Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, et al. 1996. A new enzyme superfamily: the phosphopantetheinyl transferases. Chem. Biol. 3:923-36
-
(1996)
Chem. Biol.
, vol.3
, pp. 923-936
-
-
Lambalot, R.H.1
Gehring, A.M.2
Flugel, R.S.3
Zuber, P.4
LaCelle, M.5
-
86
-
-
0028882690
-
Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase
-
Lambalot RH, Walsh CT. 1995. Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase. J. Biol. Chem. 270:24658-61
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 24658-24661
-
-
Lambalot, R.H.1
Walsh, C.T.2
-
87
-
-
0031419005
-
Holo-[acyl-carrier-protein] synthase of Escherichia coli
-
Lambalot RH, Walsh CT 1997. Holo-[acyl-carrier-protein] synthase of Escherichia coli. Methods Enzymol. 279:254-62
-
(1997)
Methods Enzymol.
, vol.279
, pp. 254-262
-
-
Lambalot, R.H.1
Walsh, C.T.2
-
88
-
-
0037472114
-
Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein
-
Li Q, Khosla C, Puglisi JD, Liu CW. 2003. Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein. Biochemistry 42:4648-57
-
(2003)
Biochemistry
, vol.42
, pp. 4648-4657
-
-
Li, Q.1
Khosla, C.2
Puglisi, J.D.3
Liu, C.W.4
-
89
-
-
0035951102
-
Portability of epimerization domain and role of peptidyl carrier protein on epimerization activity in nonribosomal peptide synthetases
-
Linne U, Doekel S, Marahiel MA. 2001. Portability of epimerization domain and role of peptidyl carrier protein on epimerization activity in nonribosomal peptide synthetases. Biochemistry 40:15824-34
-
(2001)
Biochemistry
, vol.40
, pp. 15824-15834
-
-
Linne, U.1
Doekel, S.2
Marahiel, M.A.3
-
90
-
-
0034730091
-
Control of directionality in nonribosomal peptide synthesis: Role of the condensation domain in preventing misinitiation and timing of epimerization
-
Linne U, Marahiel MA. 2000. Control of directionality in nonribosomal peptide synthesis: role of the condensation domain in preventing misinitiation and timing of epimerization. Biochemistry 39:10439-47
-
(2000)
Biochemistry
, vol.39
, pp. 10439-10447
-
-
Linne, U.1
Marahiel, M.A.2
-
91
-
-
0037995374
-
Systematic and quantitative analysis of protein-protein recognition between nonribosomal peptide synthetases investigated in the tyrocidine biosynthetic template
-
Linne U, Stein DB, Mootz HD, Marahiel MA. 2003. Systematic and quantitative analysis of protein-protein recognition between nonribosomal peptide synthetases investigated in the tyrocidine biosynthetic template. Biochemistry 42:5114-24
-
(2003)
Biochemistry
, vol.42
, pp. 5114-5124
-
-
Linne, U.1
Stein, D.B.2
Mootz, H.D.3
Marahiel, M.A.4
-
92
-
-
0037162408
-
Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: Kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B
-
Luo L, Kohli RM, Onishi M, Linne U, Marahiel MA, Walsh CT. 2002. Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B. Biochemistry 41:9184-96
-
(2002)
Biochemistry
, vol.41
, pp. 9184-9196
-
-
Luo, L.1
Kohli, R.M.2
Onishi, M.3
Linne, U.4
Marahiel, M.A.5
Walsh, C.T.6
-
93
-
-
0031215148
-
Protein templates for the biosynthesis of peptide antibiotics
-
Marahiel MA. 1997. Protein templates for the biosynthesis of peptide antibiotics. Chem. Biol. 4:561-67
-
(1997)
Chem. Biol.
, vol.4
, pp. 561-567
-
-
Marahiel, M.A.1
-
94
-
-
9444278428
-
Modular peptide synthetases involved in nonribosomal peptide synthesis
-
Marahiel MA, Stachelhaus T, Mootz HD. 1997. Modular peptide synthetases involved in nonribosomal peptide synthesis. Chem. Rev. 97:2651-74
-
(1997)
Chem. Rev.
, vol.97
, pp. 2651-2674
-
-
Marahiel, M.A.1
Stachelhaus, T.2
Mootz, H.D.3
-
95
-
-
0028863835
-
The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase of fatty acid synthesis
-
Marini P, Li S-J, Gardiol D, Cronan JE Jr, de Mendoza D. 1995. The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase of fatty acid synthesis. J. Bacteriol. 177:7003-6
-
(1995)
J. Bacteriol.
, vol.177
, pp. 7003-7006
-
-
Marini, P.1
Li, S.-J.2
Gardiol, D.3
Cronan Jr., J.E.4
De Mendoza, D.5
-
96
-
-
0036863098
-
Mechanistic diversity and regulation of type II fatty acid synthesis
-
Marrakchi H, Zhang Y-M, Rock CO. 2002. Mechanistic diversity and regulation of type II fatty acid synthesis. Biochem. Soc. Trans. 30:1050-55
-
(2002)
Biochem. Soc. Trans.
, vol.30
, pp. 1050-1055
-
-
Marrakchi, H.1
Zhang, Y.-M.2
Rock, C.O.3
-
97
-
-
0037039287
-
Catalytic mapping of the vibriobactin biosynthetic enzyme VibF
-
Marshall CG, Hillson NJ, Walsh CT. 2002. Catalytic mapping of the vibriobactin biosynthetic enzyme VibF. Biochemistry 41:244-50
-
(2002)
Biochemistry
, vol.41
, pp. 244-250
-
-
Marshall, C.G.1
Hillson, N.J.2
Walsh, C.T.3
-
98
-
-
0037126024
-
Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases
-
May JJ, Keßler N, Marahiel MA, Stubbs MT. 2002. Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases. Proc. Natl. Acad. Sci. USA 99:12120-25
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 12120-12125
-
-
May, J.J.1
Keßler, N.2
Marahiel, M.A.3
Stubbs, M.T.4
-
99
-
-
0035831486
-
The dhb operon of Bacillus subtilis encodes the biosynthetic template for the catecholic siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin
-
May JJ, Wendrich TM, Marahiel MA. 2001. The dhb operon of Bacillus subtilis encodes the biosynthetic template for the catecholic siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin. J. Biol. Chem. 276:7209-17
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7209-7217
-
-
May, J.J.1
Wendrich, T.M.2
Marahiel, M.A.3
-
100
-
-
0034613261
-
Biochemical and molecular analyses of the Streptococcus pneumoniae acyl carrier protein synthase, an enzyme essential for fatty acid biosynthesis
-
McAllister KA, Peery RB, Meier TI, Fischl AS, Zhao G. 2000. Biochemical and molecular analyses of the Streptococcus pneumoniae acyl carrier protein synthase, an enzyme essential for fatty acid biosynthesis. J. Biol. Chem. 275:30864-72
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 30864-30872
-
-
McAllister, K.A.1
Peery, R.B.2
Meier, T.I.3
Fischl, A.S.4
Zhao, G.5
-
101
-
-
0036009334
-
Yersiniabactin synthetase. A four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis
-
Miller DA, Luo L, Hillson N, Keating TA, Walsh CT. 2002. Yersiniabactin synthetase. A four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis. Chem. Biol. 9:333-44
-
(2002)
Chem. Biol.
, vol.9
, pp. 333-344
-
-
Miller, D.A.1
Luo, L.2
Hillson, N.3
Keating, T.A.4
Walsh, C.T.5
-
102
-
-
0035339908
-
Yersiniabactin synthetase: Probing the recognition of carrier protein domains by the catalytic heterocyclization domains, Cy1 and Cy2, in the chain-initiating HWMP2 subunit
-
Miller DA, Walsh CT. 2001. Yersiniabactin synthetase: probing the recognition of carrier protein domains by the catalytic heterocyclization domains, Cy1 and Cy2, in the chain-initiating HWMP2 subunit. Biochemistry 40:5313-21
-
(2001)
Biochemistry
, vol.40
, pp. 5313-5321
-
-
Miller, D.A.1
Walsh, C.T.2
-
104
-
-
0037053388
-
Recognition of hybrid peptidyl carrier proteins/acyl carrier proteins in nonribosomal peptide synthetase modules by the 4′-phosphopantetheinyl transferases AcpS and Sfp
-
Mofid MR, Finking R, Marahiel MA. 2002. Recognition of hybrid peptidyl carrier proteins/acyl carrier proteins in nonribosomal peptide synthetase modules by the 4′-phosphopantetheinyl transferases AcpS and Sfp. J. Biol. Chem. 277:17023-31
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 17023-17031
-
-
Mofid, M.R.1
Finking, R.2
Marahiel, M.A.3
-
105
-
-
1842531416
-
Structure-based mutational analysis of the 4′-phosphopantetheinyl transferases Sfp from Bacillus subtilis: Carrier protein recognition and reaction mechanism
-
Mofid MR, Finking R, Marahiel MA. 2004. Structure-based mutational analysis of the 4′-phosphopantetheinyl transferases Sfp from Bacillus subtilis: carrier protein recognition and reaction mechanism. Biochemistry 43:4128-36
-
(2004)
Biochemistry
, vol.43
, pp. 4128-4136
-
-
Mofid, M.R.1
Finking, R.2
Marahiel, M.A.3
-
106
-
-
0033135983
-
Crystallization and preliminary crystallographic studies of Sfp: A phosphopantetheinyl transferase of modular peptide synthetases
-
Mofid MR, Marahiel MA, Ficner R, Reuter K. 1999. Crystallization and preliminary crystallographic studies of Sfp: a phosphopantetheinyl transferase of modular peptide synthetases. Acta. Crystallogr. D 55:1098-100
-
(1999)
Acta. Crystallogr. D
, vol.55
, pp. 1098-1100
-
-
Mofid, M.R.1
Marahiel, M.A.2
Ficner, R.3
Reuter, K.4
-
107
-
-
0035813125
-
4′-Phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis
-
Mootz HD, Finking R, Marahiel MA. 2001. 4′-Phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis. J. Biol. Chem. 276:37289-98
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37289-37298
-
-
Mootz, H.D.1
Finking, R.2
Marahiel, M.A.3
-
108
-
-
0037130634
-
Decreasing the ring-size of a nonribosomal peptide antibiotic by in frame module deletion in the biosynthetic genes
-
Mootz HD, Kessler N, Linne U, Eppelmann K, Schwarzer D, Marahiel MA. 2002. Decreasing the ring-size of a nonribosomal peptide antibiotic by in frame module deletion in the biosynthetic genes. J. Am. Chem. Soc. 124:10980-81
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 10980-10981
-
-
Mootz, H.D.1
Kessler, N.2
Linne, U.3
Eppelmann, K.4
Schwarzer, D.5
Marahiel, M.A.6
-
109
-
-
0030669091
-
The tyrocidine biosynthesis operon of Bacillus brevis: Complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
-
Mootz HD, Marahiel MA. 1997. The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains. J. Bacteriol. 179:6843-50
-
(1997)
J. Bacteriol.
, vol.179
, pp. 6843-6850
-
-
Mootz, H.D.1
Marahiel, M.A.2
-
110
-
-
0037118621
-
Functional characterization of 4′-phosphopantetheinyl transferase genes of bacterial and fungal origin by complementation of Saccharomyces cerevisiae Lys5
-
Mootz HD, Schörgendorfer K, Marahiel MA. 2002. Functional characterization of 4′-phosphopantetheinyl transferase genes of bacterial and fungal origin by complementation of Saccharomyces cerevisiae Lys5. FEMS Microbiol. Lett. 213:51-57
-
(2002)
FEMS Microbiol. Lett.
, vol.213
, pp. 51-57
-
-
Mootz, H.D.1
Schörgendorfer, K.2
Marahiel, M.A.3
-
111
-
-
0034705130
-
Construction of hybrid peptide synthetases by module and domain fusions
-
Mootz HD, Schwarzer D, Marahiel MA. 2000. Construction of hybrid peptide synthetases by module and domain fusions. Proc. Natl. Acad. Sci. USA 97:5848-53
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5848-5853
-
-
Mootz, H.D.1
Schwarzer, D.2
Marahiel, M.A.3
-
112
-
-
0036905773
-
Ways of assembling complex natural products on modular nonribosomal peptide synthetases
-
Mootz HD, Schwarzer D, Marahiel MA. 2002. Ways of assembling complex natural products on modular nonribosomal peptide synthetases. ChemBioChem. 3:490-504
-
(2002)
ChemBioChem.
, vol.3
, pp. 490-504
-
-
Mootz, H.D.1
Schwarzer, D.2
Marahiel, M.A.3
-
113
-
-
0026520361
-
Isolation and characterization of sfp: A gene that functions in the production of the lipopeptide biosurfactant, surfactin, in Bacillus subtilis
-
Nakano MM, Corbell N, Besson J, Zuber P. 1992. Isolation and characterization of sfp: a gene that functions in the production of the lipopeptide biosurfactant, surfactin, in Bacillus subtilis. Mol. Gen. Genet. 232:313-21
-
(1992)
Mol. Gen. Genet.
, vol.232
, pp. 313-321
-
-
Nakano, M.M.1
Corbell, N.2
Besson, J.3
Zuber, P.4
-
114
-
-
0034614460
-
Expression and assay of an N-methyltransferase involved in the biosynthesis of a vancomycin group antibiotic
-
O'Brien DP, Kirkpatrick PN, O'Brien WW, Staroske T, Richardson TI, et al. 2000. Expression and assay of an N-methyltransferase involved in the biosynthesis of a vancomycin group antibiotic. Chem. Com. 103-4.
-
(2000)
Chem. Com.
, pp. 103-104
-
-
O'Brien, D.P.1
Kirkpatrick, P.N.2
O'Brien, W.W.3
Staroske, T.4
Richardson, T.I.5
-
115
-
-
0038403669
-
Insights into the decoding mechanism from recent ribosome structures
-
Ogle JM, Carter AP, Ramakrishnan V. 2003. Insights into the decoding mechanism from recent ribosome structures. Trends Biochem. Sci. 28:259-66
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 259-266
-
-
Ogle, J.M.1
Carter, A.P.2
Ramakrishnan, V.3
-
116
-
-
0034662753
-
Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites
-
Parris KD, Lin L, Tam A, Mathew R, Hixon J, et al. 2000. Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites. Struct. Fold. Des. 8:883-95
-
(2000)
Struct. Fold. Des.
, vol.8
, pp. 883-895
-
-
Parris, K.D.1
Lin, L.2
Tam, A.3
Mathew, R.4
Hixon, J.5
-
117
-
-
0042318441
-
Epimerization of an L-cysteinyl to a D-cysteinyl residue during thiazoline ring formation in siderophore chain elongation by pyochelin synthetase from Pseudomonas aeruginosa
-
Patel HM, Tao J, Walsh CT. 2003. Epimerization of an L-cysteinyl to a D-cysteinyl residue during thiazoline ring formation in siderophore chain elongation by pyochelin synthetase from Pseudomonas aeruginosa. Biochemistry 42:10514-27
-
(2003)
Biochemistry
, vol.42
, pp. 10514-10527
-
-
Patel, H.M.1
Tao, J.2
Walsh, C.T.3
-
118
-
-
0035979338
-
In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: Characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities
-
Patel HM, Walsh CT. 2001. In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities. Biochemistry 40:9023-31
-
(2001)
Biochemistry
, vol.40
, pp. 9023-9031
-
-
Patel, H.M.1
Walsh, C.T.2
-
120
-
-
0019416792
-
A mutant of Escherichia coli conditionally defective in the synthesis of holo-[acyl carrier protein]
-
Polacco ML, Cronan JE Jr. 1981. A mutant of Escherichia coli conditionally defective in the synthesis of holo-[acyl carrier protein]. J. Biol. Chem. 256:5750-54
-
(1981)
J. Biol. Chem.
, vol.256
, pp. 5750-5754
-
-
Polacco, M.L.1
Cronan Jr., J.E.2
-
121
-
-
0035716604
-
Identification of the α-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LysS gene
-
Praphanphoj V, Sacksteder KA, Gould SJ, Thomas GH, Geraghty MT. 2001. Identification of the α-aminoadipic semialdehyde dehydrogenase- phosphopantetheinyl transferase gene, the human ortholog of the yeast LysS gene. Mol. Gen. Metab. 72:336-42
-
(2001)
Mol. Gen. Metab.
, vol.72
, pp. 336-342
-
-
Praphanphoj, V.1
Sacksteder, K.A.2
Gould, S.J.3
Thomas, G.H.4
Geraghty, M.T.5
-
122
-
-
0033539471
-
Assembly of the Pseudomonasaeruginosa nonribosomal peptide siderophore pyochelin: In vitro reconstitution of aryl-4, 2-bisthiazoline synthetase activity from PchD, PchE, and PchF
-
Quadri LE, Keating TA, Patel HM, Walsh CT. 1999. Assembly of the Pseudomonasaeruginosa nonribosomal peptide siderophore pyochelin: in vitro reconstitution of aryl-4, 2-bisthiazoline synthetase activity from PchD, PchE, and PchF. Biochemistry 38:14941-54
-
(1999)
Biochemistry
, vol.38
, pp. 14941-14954
-
-
Quadri, L.E.1
Keating, T.A.2
Patel, H.M.3
Walsh, C.T.4
-
123
-
-
0032501971
-
Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases
-
Quadri LE, Weinreb PH, Lei M, Nakano MM, Zuber P, Walsh CT. 1998. Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases. Biochemistry 37:1585-95
-
(1998)
Biochemistry
, vol.37
, pp. 1585-1595
-
-
Quadri, L.E.1
Weinreb, P.H.2
Lei, M.3
Nakano, M.M.4
Zuber, P.5
Walsh, C.T.6
-
124
-
-
0035845638
-
Mapping of the functional topology of the animal fatty acid synthase by mutant complementation in vitro
-
Rangan VS, Joshi AK, Smith S. 2001. Mapping of the functional topology of the animal fatty acid synthase by mutant complementation in vitro. Biochemistry 40:10792-99
-
(2001)
Biochemistry
, vol.40
, pp. 10792-10799
-
-
Rangan, V.S.1
Joshi, A.K.2
Smith, S.3
-
125
-
-
0030911617
-
Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA: acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue
-
Rangan VS, Smith S. 1997. Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue. J. Biol. Chem. 272:11975-78
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11975-11978
-
-
Rangan, V.S.1
Smith, S.2
-
126
-
-
0035151726
-
Essential PchG-dependent reduction in pyochelin biosynthesis of Pseudomonas aeruginosa
-
Reimmann C,Patel HM, Serino L, Barone M, Walsh CT, Haas D. 2001. Essential PchG-dependent reduction in pyochelin biosynthesis of Pseudomonas aeruginosa. J. Bacteriol. 183:813-20
-
(2001)
J. Bacteriol.
, vol.183
, pp. 813-820
-
-
Reimmann, C.1
Patel, H.M.2
Serino, L.3
Barone, M.4
Walsh, C.T.5
Haas, D.6
-
127
-
-
0033485259
-
Crystal structure of the surfactin synthetase-activating enzyme Sfp: A prototype of the 4′-phosphopantetheinyl transferase superfamily
-
Reuter K, Mofid MR, Marahiel MA, Ficner R. 1999. Crystal structure of the surfactin synthetase-activating enzyme Sfp: a prototype of the 4′-phosphopantetheinyl transferase superfamily. EMBO J. 18:6823-31
-
(1999)
EMBO J.
, vol.18
, pp. 6823-6831
-
-
Reuter, K.1
Mofid, M.R.2
Marahiel, M.A.3
Ficner, R.4
-
128
-
-
0142071737
-
Ebony: A novel nonribosomal peptide synthetase for β-alanine conjugation with biogenic amines in Drosophila
-
Richardt A, Kemme T, Wagner S, Schwarzer D, Marahiel MA, Hovemann BT. 2003. Ebony: a novel nonribosomal peptide synthetase for β-alanine conjugation with biogenic amines in Drosophila. J. Biol. Chem. 278:41160-66
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 41160-41166
-
-
Richardt, A.1
Kemme, T.2
Wagner, S.3
Schwarzer, D.4
Marahiel, M.A.5
Hovemann, B.T.6
-
129
-
-
0030581109
-
Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis
-
Rock CO, Cronan JE. 1996. Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis. Biochim. Biophys. Acta 1302:1-16
-
(1996)
Biochim. Biophys. Acta
, vol.1302
, pp. 1-16
-
-
Rock, C.O.1
Cronan, J.E.2
-
130
-
-
0033926435
-
Genes encoding synthetases of cyclic depsipeptides, anabaenopeptilides, in Anabaena strain 90
-
Rouhiainen L, Paulin L, Suomalainen S, Hyytiainen H, Buikema W, et al. 2000. Genes encoding synthetases of cyclic depsipeptides, anabaenopeptilides, in Anabaena strain 90. Mol. Microblol. 37:156-67
-
(2000)
Mol. Microblol.
, vol.37
, pp. 156-167
-
-
Rouhiainen, L.1
Paulin, L.2
Suomalainen, S.3
Hyytiainen, H.4
Buikema, W.5
-
131
-
-
0028049440
-
Entire nucleotide sequence for Bacillus brevis Nagano Grs2 gene encoding gramicidin S synthetase 2: A multifunctional peptide synthetase
-
Saito F, Hori K, Kanda M, Kurotsu T, Saito Y. 1994. Entire nucleotide sequence for Bacillus brevis Nagano Grs2 gene encoding gramicidin S synthetase 2: a multifunctional peptide synthetase. J. Biochem. 116:357-67
-
(1994)
J. Biochem.
, vol.116
, pp. 357-367
-
-
Saito, F.1
Hori, K.2
Kanda, M.3
Kurotsu, T.4
Saito, Y.5
-
134
-
-
0026766758
-
Cyclosporin synthetase is a 1.4 MDa multienzyme polypeptide. Re-evaluation of the molecular mass of various peptide synthetases
-
Schmidt B, Riesner D, Lawen A, Kleinkauf H. 1992. Cyclosporin synthetase is a 1.4 MDa multienzyme polypeptide. Re-evaluation of the molecular mass of various peptide synthetases. FEBS Lett. 307:355-60
-
(1992)
FEBS Lett.
, vol.307
, pp. 355-360
-
-
Schmidt, B.1
Riesner, D.2
Lawen, A.3
Kleinkauf, H.4
-
135
-
-
1642496906
-
The challenge of multidrug resistance: Actual strategies in the development of novel antibacterials
-
Schmidt FR. 2004. The challenge of multidrug resistance: actual strategies in the development of novel antibacterials. Appl. Microbiol. Biotechnol. 63(4):335-43
-
(2004)
Appl. Microbiol. Biotechnol.
, vol.63
, Issue.4
, pp. 335-343
-
-
Schmidt, F.R.1
-
136
-
-
0031943369
-
Genetic evidence for a role of thioesterase domains, integrated in or associated with peptide synthetases, in non-ribosomal peptide biosynthesis in Bacillus subtilis
-
Schneider A, Marahiel MA. 1998. Genetic evidence for a role of thioesterase domains, integrated in or associated with peptide synthetases, in non-ribosomal peptide biosynthesis in Bacillus subtilis. Arch. Microbiol. 169:404-10
-
(1998)
Arch. Microbiol.
, vol.169
, pp. 404-410
-
-
Schneider, A.1
Marahiel, M.A.2
-
137
-
-
0042242569
-
Oxidase domains in epothilone and bleomycin biosynthesis: Thiazoline to thiazole oxidation during chain elongation
-
Schneider TL, Shen B, Walsh CT. 2003. Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation. Biochemistry 42:9722-30
-
(2003)
Biochemistry
, vol.42
, pp. 9722-9730
-
-
Schneider, T.L.1
Shen, B.2
Walsh, C.T.3
-
139
-
-
0035023450
-
Multimodular biocatalysts for natural product assembly
-
Schwarzer D, Marahiel MA. 2001. Multimodular biocatalysts for natural product assembly. Naturwissenschaften 88:93-101
-
(2001)
Naturwissenschaften
, vol.88
, pp. 93-101
-
-
Schwarzer, D.1
Marahiel, M.A.2
-
140
-
-
0037195068
-
Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases
-
Schwarzer D, Mootz HD, Linne U, Marahiel MA. 2002. Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases. Proc. Natl. Acad. Sci. USA 99:14083-88
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14083-14088
-
-
Schwarzer, D.1
Mootz, H.D.2
Linne, U.3
Marahiel, M.A.4
-
141
-
-
0033150199
-
Assembly line enzymology by multimodular nonribosomal peptide synthetases: The thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization
-
Shaw-Reid CA, Kelleher NL, Losey HC, Gehring AM, Berg C, Walsh CT. 1999. Assembly line enzymology by multimodular nonribosomal peptide synthetases: The thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization. Chem. Biol 6:385-400
-
(1999)
Chem. Biol.
, vol.6
, pp. 385-400
-
-
Shaw-Reid, C.A.1
Kelleher, N.L.2
Losey, H.C.3
Gehring, A.M.4
Berg, C.5
Walsh, C.T.6
-
142
-
-
0036753230
-
Evidence for a monomeric structure of nonribosomal peptide synthetases
-
Sieber SA, Linne U, Hillson NJ, Roche E, Walsh CT, Marahiel MA. 2002. Evidence for a monomeric structure of nonribosomal peptide synthetases. Chem. Biol. 9:997-1008
-
(2002)
Chem. Biol.
, vol.9
, pp. 997-1008
-
-
Sieber, S.A.1
Linne, U.2
Hillson, N.J.3
Roche, E.4
Walsh, C.T.5
Marahiel, M.A.6
-
143
-
-
0345097576
-
Learning from nature's drug factories: Nonribosomal synthesis of macrocyclic peptides
-
Sieber SA, Marahiel MA. 2003. Learning from nature's drug factories: nonribosomal synthesis of macrocyclic peptides. J. Bacteriol. 185:7036-43
-
(2003)
J. Bacteriol.
, vol.185
, pp. 7036-7043
-
-
Sieber, S.A.1
Marahiel, M.A.2
-
144
-
-
0842285878
-
Peptidyl thiophenols as substrates for nonribosomal peptide cyclases
-
Sieber SA, Tao J, Walsh CT, Marahiel MA. 2004. Peptidyl thiophenols as substrates for nonribosomal peptide cyclases. Angew. Chem. 43:493-98
-
(2004)
Angew. Chem.
, vol.43
, pp. 493-498
-
-
Sieber, S.A.1
Tao, J.2
Walsh, C.T.3
Marahiel, M.A.4
-
145
-
-
0042233828
-
Loading peptidyl-coenzyme A onto peptidyl carrier proteins: A novel approach in characterizing macrocyclization by thioesterase domains
-
Sieber SA, Walsh CT, Marahiel MA. 2003. Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains. J. Am. Chem. Soc. 125:10862-66
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 10862-10866
-
-
Sieber, S.A.1
Walsh, C.T.2
Marahiel, M.A.3
-
146
-
-
0033762192
-
The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sga15
-
Silakowski B, Kunze B, Nordsiek G, Blocker H, Hofle G, Muller R. 2000. The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sga15. Eur. J. Biochem. 267:6476-85
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 6476-6485
-
-
Silakowski, B.1
Kunze, B.2
Nordsiek, G.3
Blocker, H.4
Hofle, G.5
Muller, R.6
-
147
-
-
0033601178
-
New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1
-
Silakowski B, Schairer HU, Ehret H, Kunze B, Weinig S, et al. 1999. New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1. J. Biol. Chem. 274:37391-99
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37391-37399
-
-
Silakowski, B.1
Schairer, H.U.2
Ehret, H.3
Kunze, B.4
Weinig, S.5
-
148
-
-
0030292865
-
Biochemical characterization of peptidyl carrier protein (PCP), the thiolation domain of multifunctional peptide synthetases
-
Stachelhaus T, Hüser A, Marahiel MA. 1996. Biochemical characterization of peptidyl carrier protein (PCP), the thiolation domain of multifunctional peptide synthetases. Chem. Biol. 3:913-21
-
(1996)
Chem. Biol.
, vol.3
, pp. 913-921
-
-
Stachelhaus, T.1
Hüser, A.2
Marahiel, M.A.3
-
149
-
-
0028908601
-
Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA
-
Stachelhaus T, Marahiel MA. 1995. Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA. J. Biol. Chem. 270:6163-69
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 6163-6169
-
-
Stachelhaus, T.1
Marahiel, M.A.2
-
150
-
-
0032575648
-
Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain
-
Stachelhaus T, Mootz HD, Bergendahl V, Marahiel MA. 1998. Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain. J. Biol. Chem. 273:22773-81
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 22773-22781
-
-
Stachelhaus, T.1
Mootz, H.D.2
Bergendahl, V.3
Marahiel, M.A.4
-
151
-
-
0033179468
-
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
-
Stachelhaus T, Mootz HD, Marahiel MA. 1999. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem. Biol. 6:493-505
-
(1999)
Chem. Biol.
, vol.6
, pp. 493-505
-
-
Stachelhaus, T.1
Mootz, H.D.2
Marahiel, M.A.3
-
152
-
-
0029034197
-
Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains
-
Stachelhaus T, Schneider A, Marahiel MA. 1995. Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains. Science 269:69-72
-
(1995)
Science
, vol.269
, pp. 69-72
-
-
Stachelhaus, T.1
Schneider, A.2
Marahiel, M.A.3
-
153
-
-
0034673983
-
Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase
-
Stachelhaus T, Walsh CT. 2000. Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase. Biochemistry 39:5775-87
-
(2000)
Biochemistry
, vol.39
, pp. 5775-5787
-
-
Stachelhaus, T.1
Walsh, C.T.2
-
154
-
-
0030065324
-
Evidence for a double-helical structure for modular polyketide synthases
-
Staunton J, Caffrey P, Aparicio JF, Roberts GA, Bethell SS, Leadlay PF. 1996. Evidence for a double-helical structure for modular polyketide synthases. Nat. Struct. Biol. 3:188-92
-
(1996)
Nat. Struct. Biol.
, vol.3
, pp. 188-192
-
-
Staunton, J.1
Caffrey, P.2
Aparicio, J.F.3
Roberts, G.A.4
Bethell, S.S.5
Leadlay, P.F.6
-
155
-
-
0029978534
-
The multiple carrier model of nonribosomal peptide biosynthesis at modular multienzymatic templates
-
Stein T, Vater J, Kruft V, Otto A, Wittmann-Liebold B, et al. 1996. The multiple carrier model of nonribosomal peptide biosynthesis at modular multienzymatic templates. J. Biol. Chem. 271:15428-35
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 15428-15435
-
-
Stein, T.1
Vater, J.2
Kruft, V.3
Otto, A.4
Wittmann-Liebold, B.5
-
156
-
-
0033976983
-
Purification of the fengycin synthetase multienzyme system from Bacillus subtilis b213
-
Steller S, Vater J. 2000. Purification of the fengycin synthetase multienzyme system from Bacillus subtilis b213. J. Chromatogr. B Biomed. Sci. Appl. 737:267-75
-
(2000)
J. Chromatogr. B Biomed. Sci. Appl.
, vol.737
, pp. 267-275
-
-
Steller, S.1
Vater, J.2
-
157
-
-
0019888073
-
Animal fatty acid synthetase. A novel arrangement of the β-ketoacyl synthetase sites comprising domains of the two subunits
-
Stoops JK, Wakil SJ. 1981. Animal fatty acid synthetase. A novel arrangement of the β-ketoacyl synthetase sites comprising domains of the two subunits. J. Biol. Chem. 256:5128-33
-
(1981)
J. Biol. Chem.
, vol.256
, pp. 5128-5133
-
-
Stoops, J.K.1
Wakil, S.J.2
-
158
-
-
0020490493
-
Animal fatty acid synthetase. Identification of the residues comprising the novel arrangement of the β-ketoacyl synthetase site and their role in its cold inactivation
-
Stoops JK, Wakil SJ. 1982. Animal fatty acid synthetase. Identification of the residues comprising the novel arrangement of the β-ketoacyl synthetase site and their role in its cold inactivation. J. Biol. Chem. 257:3230-35
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 3230-3235
-
-
Stoops, J.K.1
Wakil, S.J.2
-
159
-
-
9244228715
-
-
ed. G Stoll, B Pfeiffer, J Guglielmi. Heidelberg/Berlin/New York: Spektrum Akad
-
Stryer L. 1995. Biochemie, vierte Auflage, der Fettstoffwechsel, ed. G Stoll, B Pfeiffer, J Guglielmi, pp. 635-37. Heidelberg/Berlin/New York: Spektrum Akad.
-
(1995)
Biochemie, Vierte Auflage, der Fettstoffwechsel
, pp. 635-637
-
-
Stryer, L.1
-
160
-
-
0030885954
-
Identification, isolation and biochemical characterization of a phosphopantetheine:protein transferase that activates the two type-I fatty acid synthases of Brevibacterium ammoniagenes
-
Stuible H-P, Meier S, Schweizer E. 1997. Identification, isolation and biochemical characterization of a phosphopantetheine:protein transferase that activates the two type-I fatty acid synthases of Brevibacterium ammoniagenes. Eur. J. Biochem. 248:481-87
-
(1997)
Eur. J. Biochem.
, vol.248
, pp. 481-487
-
-
Stuible, H.-P.1
Meier, S.2
Schweizer, E.3
-
161
-
-
0032575508
-
A novel phosphopantetheine:protein transferase activating yeast mitochondrial acyl carrier protein
-
Stuible H-P, Meier S, Wagner C, Hannappel W, Schweizer E. 1996. A novel phosphopantetheine:protein transferase activating yeast mitochondrial acyl carrier protein. J. Biol. Chem. 273:22334-39
-
(1996)
J. Biol. Chem.
, vol.273
, pp. 22334-22339
-
-
Stuible, H.-P.1
Meier, S.2
Wagner, C.3
Hannappel, W.4
Schweizer, E.5
-
162
-
-
0035793081
-
Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase
-
Suo Z, Tseng CC, Walsh CT. 2001. Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase. Proc. Natl. Acad. Sci. USA 98:99-104
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 99-104
-
-
Suo, Z.1
Tseng, C.C.2
Walsh, C.T.3
-
163
-
-
0344761973
-
Tandem heterocyclization activity of the multidomain 230 kDa HMWP2 subunit of Yersinia pestis yersiniabactin synthetase: Interaction of the 1-1382 and 1383-2035 fragments
-
Suo Z, Walsh CT, Miller DA. 1999. Tandem heterocyclization activity of the multidomain 230 kDa HMWP2 subunit of Yersinia pestis yersiniabactin synthetase: interaction of the 1-1382 and 1383-2035 fragments. Biochemistry 38:14023-35
-
(1999)
Biochemistry
, vol.38
, pp. 14023-14035
-
-
Suo, Z.1
Walsh, C.T.2
Miller, D.A.3
-
164
-
-
0026509083
-
Locating essential Escherichia coli genes by using mini-Tn10 transposons: The pdxJ operon
-
Takiff HE, Baker T, Copeland T, Chen SM, Court DL. 1992. Locating essential Escherichia coli genes by using mini-Tn10 transposons: the pdxJ operon. J. Bacteriol. 174:1544-53
-
(1992)
J. Bacteriol.
, vol.174
, pp. 1544-1553
-
-
Takiff, H.E.1
Baker, T.2
Copeland, T.3
Chen, S.M.4
Court, D.L.5
-
165
-
-
0034648798
-
Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase
-
Trauger JW, Kohli RM, Mootz HD, Marahiel MA, Walsh CT. 2000. Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase. Nature 407:215-18
-
(2000)
Nature
, vol.407
, pp. 215-218
-
-
Trauger, J.W.1
Kohli, R.M.2
Mootz, H.D.3
Marahiel, M.A.4
Walsh, C.T.5
-
166
-
-
0035912930
-
Cyclization of backbone-substituted peptides catalyzed by the thioesterase domain from the tyrocidine nonribosomal peptide synthetase
-
Trauger JW, Kohli RM, Walsh CT. 2001. Cyclization of backbone-substituted peptides catalyzed by the thioesterase domain from the tyrocidine nonribosomal peptide synthetase. Biochemistry 40:7092-98
-
(2001)
Biochemistry
, vol.40
, pp. 7092-7098
-
-
Trauger, J.W.1
Kohli, R.M.2
Walsh, C.T.3
-
167
-
-
0037069317
-
Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase
-
Tseng CC, Bruner SD, Kohli RM, Marahiel MA, Walsh CT, Sieber SA. 2002. Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase. Biochemistry 41:13350-59
-
(2002)
Biochemistry
, vol.41
, pp. 13350-13359
-
-
Tseng, C.C.1
Bruner, S.D.2
Kohli, R.M.3
Marahiel, M.A.4
Walsh, C.T.5
Sieber, S.A.6
-
168
-
-
0032874789
-
The genes degQ,pps, and lpa-8 (sfp) are responsible for conversion of Bacillus subtilis 168 to plipastatin production
-
Tsuge K, Ano T, Hirai M, Nakamura Y, Shoda M. 1999. The genes degQ,pps,
-
(1999)
Antimicrob. Agents Chemother.
, vol.43
, pp. 2183-2192
-
-
Tsuge, K.1
Ano, T.2
Hirai, M.3
Nakamura, Y.4
Shoda, M.5
-
169
-
-
0026926521
-
Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes
-
Turgay K, Krause M, Marahiel MA. 1992. Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes. Mol. Microbiol. 6:529-46
-
(1992)
Mol. Microbiol.
, vol.6
, pp. 529-546
-
-
Turgay, K.1
Krause, M.2
Marahiel, M.A.3
-
172
-
-
0034680167
-
Molecular mechanisms that confer antibacterial drug resistance
-
Walsh C. 2000. Molecular mechanisms that confer antibacterial drug resistance. Nature 406:775-81
-
(2000)
Nature
, vol.406
, pp. 775-781
-
-
Walsh, C.1
-
173
-
-
0035478654
-
Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines
-
Walsh CT, Chen H, Keating TA, Hubbard BK, Losey HC, et al. 2001. Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines. Curr. Opin. Chem. Biol. 5:525-34
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 525-534
-
-
Walsh, C.T.1
Chen, H.2
Keating, T.A.3
Hubbard, B.K.4
Losey, H.C.5
-
174
-
-
0031244337
-
Posttranslational modification of polyketide and nonribosomal peptide synthetases
-
Walsh CT, Gehring AM, Weinreb PH, Luis EN, Flugel RS. 1997. Posttranslational modification of polyketide and nonribosomal peptide synthetases. Curr. Opin. Chem. Biol. 1:309-15
-
(1997)
Curr. Opin. Chem. Biol.
, vol.1
, pp. 309-315
-
-
Walsh, C.T.1
Gehring, A.M.2
Weinreb, P.H.3
Luis, E.N.4
Flugel, R.S.5
-
175
-
-
0028284699
-
The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame
-
Weber G, Schorgendorfer K, Schneider-Scherzer E, Leitner E. 1994. The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr. Genet. 26:120-25
-
(1994)
Curr. Genet.
, vol.26
, pp. 120-125
-
-
Weber, G.1
Schorgendorfer, K.2
Schneider-Scherzer, E.3
Leitner, E.4
-
176
-
-
0034656331
-
Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases
-
Weber T, Baumgartner R, Renner C, Marahiel MA, Holak TA. 2000. Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases. Struct. Fold. Des. 8:407-18
-
(2000)
Struct. Fold. Des.
, vol.8
, pp. 407-418
-
-
Weber, T.1
Baumgartner, R.2
Renner, C.3
Marahiel, M.A.4
Holak, T.A.5
-
177
-
-
0035156443
-
Exploring the domain structure of modular nonribosomal peptide synthetases
-
Weber T, Marahiel MA. 2001. Exploring the domain structure of modular nonribosomal peptide synthetases. Structure 9:3-9
-
(2001)
Structure
, vol.9
, pp. 3-9
-
-
Weber, T.1
Marahiel, M.A.2
-
178
-
-
0142167587
-
Melithiazol biosynthesis: Further insights into myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases
-
Weinig S, Hecht H-J, Mahmud T, Müller R. 2003. Melithiazol biosynthesis: further insights into myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases. Chem. Biol. 10:939-52
-
(2003)
Chem. Biol.
, vol.10
, pp. 939-952
-
-
Weinig, S.1
Hecht, H.-J.2
Mahmud, T.3
Müller, R.4
-
179
-
-
0029816829
-
Fatty acid synthase: In vitro complementation of inactive mutants
-
Witkowski A, Joshi A, Smith S. 1996. Fatty acid synthase: in vitro complementation of inactive mutants. Biochemistry 40:10569-75
-
(1996)
Biochemistry
, vol.40
, pp. 10569-10575
-
-
Witkowski, A.1
Joshi, A.2
Smith, S.3
-
180
-
-
0037013187
-
The solution structure of acyl carrier protein from Mycobacterium tuberculosis
-
Wong HC, Liu G, Zhang Y-M, Rock CO, Zheng J. 2002. The solution structure of acyl carrier protein from Mycobacterium tuberculosis. J. Biol. Chem. 277:15874-80
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 15874-15880
-
-
Wong, H.C.1
Liu, G.2
Zhang, Y.-M.3
Rock, C.O.4
Zheng, J.5
-
181
-
-
0037117747
-
Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases
-
Wu N, Cane DE, Khosla C. 2002. Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases. Biochemistry 41:5056-66
-
(2002)
Biochemistry
, vol.41
, pp. 5056-5066
-
-
Wu, N.1
Cane, D.E.2
Khosla, C.3
-
182
-
-
0030729715
-
Cloning of a Vibrio cholerae vibriobactin gene cluster: Identification of genes required for early steps in siderophore biosynthesis
-
Wyckoff EE, Stoebner JA, Reed KE, Payne SM. 1997. Cloning of a Vibrio cholerae vibriobactin gene cluster: identification of genes required for early steps in siderophore biosynthesis. J. Bacteriol. 179:7055-62
-
(1997)
J. Bacteriol.
, vol.179
, pp. 7055-7062
-
-
Wyckoff, E.E.1
Stoebner, J.A.2
Reed, K.E.3
Payne, S.M.4
-
183
-
-
0034886054
-
Solution structure of B. subtilis acyl carrier protein
-
Xu GY, Tam A, Lin L, Hixon J, Fritz CC, Powers R. 2001. Solution structure of B. subtilis acyl carrier protein. Structure 9:277-87
-
(2001)
Structure
, vol.9
, pp. 277-287
-
-
Xu, G.Y.1
Tam, A.2
Lin, L.3
Hixon, J.4
Fritz, C.C.5
Powers, R.6
-
184
-
-
0035896547
-
Identification and analysis of the acyl carrier protein (ACP) docking site on β-ketoacyl-ACP synthase III
-
Zhang YM, Rao MS, Heath RJ, Price AC, Olson AJ, et al. 2001. Identification and analysis of the acyl carrier protein (ACP) docking site on β-ketoacyl-ACP synthase III. J. Biol. Chem. 276:8231-38
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8231-8238
-
-
Zhang, Y.M.1
Rao, M.S.2
Heath, R.J.3
Price, A.C.4
Olson, A.J.5
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