Multimodular biocatalysts for natural product assembly

Naturwissenschaften

Volumn 88, Issue 3, 2001, Pages 93-101

  Schwarzer, Dirk ^a   Marahiel, Mohamed A ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CYCLOSPORIN; EPOTHILONE B; ERYTHROMYCIN; IMMUNOSUPPRESSIVE AGENT; ISOPENICILLIN N; MYCOBACTIN T; MYOTHIAZOL; NATURAL PRODUCT; PENICILLIN DERIVATIVE; POLYKETIDE; RAPAMYCIN; SURFACTIN; TACROLIMUS; TYROCIDINE; UNCLASSIFIED DRUG; VANCOMYCIN; YERSINIABACTIN;

BIOSYNTHESIS; CATALYSIS; CATALYST; CHEMICAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVITY; NONHUMAN; PEPTIDE SYNTHESIS; REVIEW; RIBOSOME;

ANTI-BACTERIAL AGENTS; BIOLOGICAL FACTORS; CATALYSIS; IMMUNOSUPPRESSIVE AGENTS; MULTIENZYME COMPLEXES; PEPTIDE SYNTHASES; PEPTIDES;

EID: 0035023450     PISSN: 00281042     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001140100211     Document Type: Review

References (50)

1. Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis
2. The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
3. Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S
4. Sequence and analysis of the genetic locus responsible for surfactin synthesis in Bacillus subtilis
5. Expression of an active adenylate-forming domain of peptide synthetases corresponding to acyl-CoA-synthetases
6. Dipeptide formation on engineered hybrid peptide synthetases
7. An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003
8. Aminoacyl-SNACs as small-molecule substrates for the condensation domains of nonribosomal peptide synthetases
9. Iron acquisition in plague: Modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis
10. The activation of amino acids for biosynthesis of gramicidin S
11. Characterization of the syringomycin synthetase gene cluster: A link between prokaryotic and eukaryotic peptide synthetases
12. Molecular characterization of the enniatin synthetase gene encoding a multifunctional enzyme catalysing N-methyldepsipeptide formation in Fusarium scirpi
13. Vancomycin resistance in enterococci: Reprogramming of the D-ala-D-Ala ligases in bacterial peptidoglycan biosynthesis
14. Genetic contributions to understanding polyketide synthases
15. Manipulation of modular polyketide synthases
16. Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis
17. Selectivity of the yersiniabactin synthetase adenylation domain in the two-step process of amino acid activation and transfer to a holocarrier protein domain
18. Harnessing the biosynthetic potential of modular polyketide synthases
19. The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin-nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus
20. A new enzyme superfamily - The phosphopantetheinyl transferases
21. Modular peptide synthetases involved in nonribosomal peptide synthesis
22. The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
23. The tyrocidine biosynthesis operon of Bacillus brevis: Complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
24. Design and application of multimodular peptide synthetases
25. Construction of hybrid peptide synthetases by module and domain fusions
26. The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase
27. Assembly of aryl-capped siderophores by modular peptide synthetases and polyketide synthases
28. Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin
29. Assembly of the Pseudomonas aeruginosa nonribosomal peptide siderophore pyochelin: In vitro reconstitution of aryl-4, 2-bisthiazoline synthetase activity from PchD, PchE, and PchF
30. Entire nucleotide sequence for Bacillus brevis Nagano Grs2 gene encoding gramicidin S synthetase 2: A multifunctional peptide synthetase
31. Construction and in vitro analysis of a new bi-modular polypeptide synthetase for synthesis of N-methylated acyl peptides
32. Genetic evidence for a role of thioesterase domains, integrated in or associated with peptide synthetases, in non-ribosomal peptide biosynthesis in Bacillus subtilis
33. Targeted alteration of the substrate specificity of peptide synthetases by rational module swapping
34. The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin
35. New lessons for combinatorial biosynthesis from myxobacteria: The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1
36. Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA
37. Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase
38. Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains
39. Peptide bond formation in nonribosomal peptide biosynthesis: Catalytic role of the condensation domain
40. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
41. The multiple carrier model of nonribosomal peptide biosynthesis at modular multienzymatic templates
42. Epimerization of the D-valine portion in the biosynthesis of actinomycin D
43. Tandem heterocyclization activity of the multidomain 230 kDa HMWP2 subunit of Yersinia pestis yersiniabactin synthetase: Interaction of the 1-1382 and 1383-2035 fragments
44. Cloning and heterologous expression of the epothilone gene cluster
45. Cell-free synthesis of gramicidin S
46. Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase
47. Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes
48. Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic
49. The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilo-base open reading frame
50. Complete nucleotide sequence of the tycA gene coding the tyrocidine synthetase 1 from Bacillus brevis