New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1

Journal of Biological Chemistry

Volumn 274, Issue 52, 1999, Pages 37391-37399

  Silakowski, Barbara ^a   Schairer, Hans Ulrich ^b   Ehret, Heidi ^b   Kunze, Brigitte ^a   Weinig, Stefan ^a   Nordsiek, Gabriele ^a   Brandt, Petra ^a   Blöcker, Helmut ^a   Höfle, Gerhard ^a   Beyer, Stefan ^a   Müller, Rolf ^a,c  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; MYXOTHIAZOL; POLYKETIDE SYNTHASE;

ARTICLE; BACTERIAL METABOLISM; GENE EXPRESSION; GENETIC ANALYSIS; MOLECULAR CLONING; MYXOCOCCALES; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

AMINO ACID SEQUENCE; CLONING, MOLECULAR; GENES, BACTERIAL; METHACRYLATES; METHYLTRANSFERASES; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MULTIGENE FAMILY; PEPTIDE SYNTHASES; PLASMIDS; STIGMATELLA; THIAZOLES;

BACTERIA (MICROORGANISMS); MYXOCOCCALES; STIGMATELLA AURANTIACA;

EID: 0033601178     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.52.37391     Document Type: Article

References (69)

1. Reichenbach, H. (1993) in Myxobacteria II (Dworkin, M., and Kaiser, D., eds) pp. 13-62, American Society for Microbiology, Washington, D. C.
2. Reichenbach, H., and Dworkin, M. (1992) in The Procaryotes (Balows, A., Trüper, H. G., Dworkin, M., Harder, W., and Schleifer, K.-H., eds) 2nd Ed., pp. 3416-3478, Springer Verlag, New York
3. Dworkin, M. (1996) Microbiol. Rev. 60, 70-102
4. Reichenbach, H., and Höfle, G. (1999) in Drug Discovery from Nature (Grabley, S., and Thiericke, R., eds) pp. 149-179, Springer Verlag, Berlin
5. Reichenbach, H., and Höfle, G. (1993) in Myxobacteria II (Dworkin, M., and Kaiser, D., eds) pp. 347-397, American Society for Microbiology, Washington, D. C.
6. Gerth, K., Irschik, H., Reichenbach, H., and Trowitzsch, W. (1980) J. Antibiot. 33, 1474-1479
7. Kunze, B., Kemmer, T., Höfle, G., and Reichenbach, H. (1984) J. Antibiot. 37, 454-461
8. Gerth, K., Jansen, R., Reifenstahl, G., Höfle, G., Irschik, H., Kunze, B., Reichenbach, H., and Thierbach, G. (1983) J. Antibiot. 36, 1150-1156
9. Gerth, K., Bedorf, N., Höfle, G., Irschik, H., and Reichenbach, H. (1996) J. Antibiot. 49, 560-563
10. Bollag, D. M., McQueney, P. A., Zhu, J., Hensens, O., Koupal, L., Liesch, J., Goetz, M., Lazarides, E., and Woods, C. M. (1995) Cancer Res. 55, 2325-2333
11. Mühlradt, P. F., and Sasse, F. (1997) Cancer Res. 57, 3344-3346
12. Nicolaou, K., Roschangar, F., and Vourloumis, D. (1998) Angew. Chem. 110, 2120-2153
13. Trowitzsch-Kienast, W., Wray, V., Gerth, K., Reichenbach, H., and Höfle, G. (1986) Liebigs Ann. Chem. 93-98
14. Konz, D., Klens, A., Schorgendorfer, K., and Marahiel, M. A. (1997) Chem. Biol. 4, 927-937
15. Gehring, A., Mori, I., Perry, R. D., and Walsh, C. T. (1998) Biochemistry 37, 11637-11650
16. Gehring, A. M., DeMoll, E., Fetherston, J. D., Mori, I., Mayhew, G. f., Blattner, F. R., Walsh, C. T., and Perry, R. D. (1998) Chem. Biol. 5, 573-586
17. Quadri, L. E. N., Sello, J., Keating, T. A., Weinreb, P. H., and Walsh, C. T. (1998) Chem. Biol. 5, 631-645
18. Chen, S., von Bamberg, D., Hale, V., Brauer, M., Hardt, B., Müller, R., Floss, H. G., Reynolds, K. A., and Leistner, E. (1999) Eur. J. Biochem. 261, 98-107
19. Gaisser, S., and Hughes, C. (1997) Mol. Gen. Genet. 253, 415-427
20. Schwecke, T., Aparicio, J. F., Molnar, I., König, A., Khaw, L. E., Haydock, S. F., Oliynyke, M., Caffrey, P., Cortes, J., Lester, J. B., Bohm, G. A., Staunton, J., and Leadlay, P. F. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7839-7843
21. Paitan, Y., Alon, G., Orr, E., Ron, E. Z., and Rosenberg, E. (1999) J. Mol. Biol. 286, 465-474
22. Beyer, S., Kunze, B., Silakowski, B., and Müller, H. (1999) Biochim. Biophys. Acta 1445, 185-195
23. Schupp, T., Toupet, C., Cluzel, B., Neff, S., Hill, S., Beck, J. J., and Ligon, J. M. (1995) J. Bacteriol. 177, 3673-3679
24. Pospiech, A., Cluzel, B., Bietenhader, J., and Schupp, T. (1995) Microbiology 141, 1793-1803
25. Cane, D. E. (ed) (1997) Chem. Rev. 97, 2463-2706
26. Lambalot, R. H., Gehring, A. M., Flugel, R. S., Zuber, P., LaCelle, M., Marahiel, M. A., Reid, R., Khosla, C., and Walsh, C. T. (1996) Chem. Biol. 3, 923-936
27. Walsh, C. T., Gehring, A. M., Weinreb, P. H., Quadri, L. E., and Flugel, R. S. (1997) Curr. Opin. Chem. Biol. 1, 309-15
28. Silakowski, B., Pospiech, A., Neumann, B., and Schairer, H. U. (1996) J. Bacteriol. 178, 6706-6713
29. Silakowski, B., Ehret, H., and Schairer, H. U. (1998) J. Bacteriol. 180, 1241-1247
30. Quails, G. T., Stephens, K., and White, D. (1978) Dev. Biol. 66, 270-274
31. Neumann, B., Pospiech, A., and Schairer, H. U. (1992) Trends Genet. 8, 332-333
32. Bonfield, J. K., Smith, K., and Staden, R. (1995) Nucleic Acids Res. 23, 4992-4999
33. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory Press, New York
34. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680
35. Shimkets, L. (1993) in Myxobacteria II (Dworkin, M., and Kaiser, D., eds) pp. 85-108, American Society for Microbiology, Washington, D. C.
36. Quadri, L. E., Weinreb, P. H., Lei, M., Nakano, M. M., Zuber, P., and Walsh, C. T. (1998) Biochemistry 37, 1585-1595
37. Gokhale, R. S., Tsuji, S. Y., Cane, D. E., and Khosla, C. (1999) Science 284, 482-485
38. Donadino, S., Staver, M. J., McAlpine, J. B., Swanson, S. J., and Katz, L. (1991) Science 252, 675-679
39. August, P. R., Tang, L., Yoon, Y. J., Ning, S., Müller, R., Yu, T. W., Taylor, M., Hoffmann, D., Kim, C. G., Zhang, X., Hutchinson, C. R., and Floss, H. G. (1998) Chem. Biol. 5, 69-79
40. Stachelhaus, T., and Marahiel, M. A. (1995) J. Biol. Chem. 270, 6163-6169
41. Konz, D., and Marahiel, M. A. (1999) Chem. Biol. 6, R39-48
42. Kleinkauf, H., and von Döhren, H. (1997) in Bio/Technology: Products of Secondary Metabolism (Rehm, H.-J., and Reed, G., general eds.; Kleinkauf, H., and von Döhren, H., volume eds.) 2nd Ed., Vol. 7, pp. 277-322, VCH Verlagsgesellschaft mbH, Weinheim, Germany
43. Purwantini, E., and Daniels, L. (1998) J. Bacteriol. 180, 2212-2219
44. Schneider, A., and Marahiel, M. A. (1998) Arch. Microbiol. 169, 404-10
45. Katz, L., and Donadio, S. (1993) Annu. Rev. Microbiol. 47, 875-912
46. Molnar, I., Aparicio, J. F., Haydock, S. F., Khaw, L. E., Schwecke, T., Konig, A., Staunton, J., and Leadlay, P. F. (1996) Gene (Amst.) 169, 1-7
47. Höfle, G., and Reichenbach, H. (1995) in Sekundärmetabolismus bei Mikroorganismen (Kuhn, W., and Fiedler, H. P., eds) pp. 61-78, Attempo Verlag, Tübingen, Germany
48. Haydock, S., Aparicio, J. F., Molnar, I., Schwecke, T., König, A., Marsden, A. F. A., Galloway, I. S., Staunton, J., and Leadlay, P. F. (1995) FEMS Lett. 374, 246-248
49. Kakavas, S. J., Katz, L., and Stassi, D. (1997) J. Bacteriol. 179, 7515-7522
50. Hafner, E. W., Holley, B. W., Holdom, K. S., Lee, S. E., Wax, H. G., Beck, D., McArthur, H. A., and Wernau, W. C. (1991) J. Antibiot. 44, 349-356
51. Denoya, C. D., Fedechko, R. W., Hafner, E. W., McArthur, H. A., Morgenstern, M. R., Skinner, D. D., Stutzman-Engwall, K., Wax, R. G., and Wernau, W. C. (1995) J. Bacteriol. 177, 3504-3511
52. Downard, J., and Toal, D. (1995) Mol. Microbiol. 16, 171-175
53. Downard, J., V, R. S., and Kil, K. S. (1993) J. Bacteriol. 175, 7762-7770
54. Ikeda, H., and Omura, S. (1997) in Polyketide and Nonribosomal Polypeptide Biosynthesis (Cane, D. A., ed) Vol. 7, pp. 2591-2609, American Chemical Society, Columbus, OH
55. Marsden, A. F., Wilkinson, B., Cortes, J., Dunster, N. J., Staunton, J., and Leadlay, P. F. (1998) Science 279, 199-202
56. Gehring, A. M., DeMoll, E., Fetherston, J. D., Mori, I., Mayhew, G. F., Blattner, F. R., Walsh, C. T., and Perry, R. D. (1998) Chem. Biol. 5, 573-586
57. Roy, R. S., Gehring, A. M., Milne, J. C., Belshaw, P. J., and Walsh, C. T. (1999) Nat. Prod. Rep. 16, 249-263
58. Kennedy, J., Auclair, K., Kendrew, S. G., Park, C., Vederas, J. C., and Hutchinson, C. R. (1999) Science 284, 1368-1372
59. Hendrickson, L., Davis, C. R., Roach, C., Nguyen, D. K., Aldrich, T., McAda, P. C., and Reeves, C. D. (1999) Chem. Biol. 8, 429-439
60. Kolattokudy, P. E., Fernandes, N. D., Azad, A. K., Fitzmaurice, A. M., and Sirakova, T. D. (1997) Mol. Microbiol. 24, 263-270
61. Cole, S. T., Broach, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., III, Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M. A., Rajandream, M.-A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, S., Sulston, J. E., Taylor, K., Whitehead, S., and Barrell, B. G. (1998) Nature 393, 537-544
62. Mocek, U., Knaggs, A. R., Tsuchiya, R., Nguyen, T., Beale, J. M., and Floss, H. G. (1993) J. Am. Chem. Soc. 115, 7557-7568
63. Schoof, L., Veelaert, D., Vanden Broeck, J., and De Loof, A. (1997) Peptides 18, 145-156
64. Kulathila, R., Merkler, K. A., and Merkler, D. J. (1999) Nat. Prod. Rep. 16, 145-154
65. Merkler, D. J., Glufke, U., Ritenour-Rodgers, K. J., Baumgart, L., DeBlassio, J. L., Merkler, K. A., and Vederas, J. C. (1999) J. Am. Chem. Soc. 121, 4904-4905
66. Silakowski, B. (1997) Fruchtkörper-Bilding beim Myxobakterium Stigmatella aurantiaca: Die Gene fbfA und fbfB. Ph.D. thesis, Universität Heidelberg, Heidelberg
67. Yanisch-Perron, C., Vieira, J., and Messing, J. (1985) Gene (Amst.) 33, 103-119
68. Cortes, J., Haydock, S. F., Roberts, G. A., Bevitt, D. J., and Leadlay, P. F. (1990) Nature 348, 176-178
69. Xue, Y., Zhao, L., Liu, H.-W., and Sherman, D. H. (1998) Proc. Natl. Acad. Sci. 95, 12111-12116