The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase

Chemistry and Biology

Volumn 7, Issue 8, 2000, Pages 623-642

  Du, Liangcheng ^a   Sánchez, César ^a   Chen, Mei ^a   Edwards, Daniel J ^a   Shen, Ben ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biosynthesis; Bleomycin; Nonribosomal peptide synthetase; Polyketide synthase; Streptomyces verticillus

Indexed keywords

BIOSYNTHESIS; BLEOMYCIN; BLM GENE; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYMIC CONVERSION; GENE CLUSTER; GENE FUNCTION; GENETIC STRAIN; METABOLITE; NONRIBOSOMAL PEPTIDE SYNTHETASE COMPLEX; POLYKETIDE SYNTHASE; STREPTOMYCES LIVIDANS; STREPTOMYCES VERTICILLUS;

AMINO ACID SEQUENCE; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CLONING, MOLECULAR; CONSERVED SEQUENCE; GENES, BACTERIAL; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; MULTIGENE FAMILY; OLIGOSACCHARIDES; OPEN READING FRAMES; PEPTIDE SYNTHASES; RESTRICTION MAPPING; SEQUENCE ALIGNMENT; STREPTOMYCES; SUBSTRATE SPECIFICITY;

STREPTOMYCES LIVIDANS; STREPTOMYCES VERTICILLUS;

EID: 0033835373     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00011-9     Document Type: Article

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