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Volumn 41, Issue 30, 2002, Pages 9718-9726
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Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics
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Author keywords
[No Author keywords available]
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Indexed keywords
SUBSTRATE SPECIFICITY;
AMINO ACIDS;
BIOSYNTHESIS;
CRYSTAL STRUCTURE;
ENZYMES;
GENES;
GENETIC ENGINEERING;
MUTAGENESIS;
POLYPEPTIDES;
AMINO ACID;
ASPARAGINE;
ASPARTIC ACID;
GLUTAMIC ACID;
GLUTAMINE;
HEPTAPEPTIDE;
HISTIDINE;
ISOLEUCINE;
LYSINE;
MUTANT PROTEIN;
PEPTIDE SYNTHASE;
PHENYLALANINE;
POLYPEPTIDE ANTIBIOTIC AGENT;
RECOMBINANT PROTEIN;
SURFACTIN;
SYNTHETASE;
VALINE;
AMINO ACID SEQUENCE;
ARTICLE;
BACILLUS SUBTILIS;
BINDING SITE;
CATALYSIS;
CHEMICAL ANALYSIS;
CODON;
CONTROLLED STUDY;
CRYSTAL STRUCTURE;
DRUG DESIGN;
ENZYME SPECIFICITY;
GENE CLUSTER;
MOLECULAR RECOGNITION;
NONHUMAN;
PRIORITY JOURNAL;
PROTEIN DOMAIN;
SEQUENCE HOMOLOGY;
SITE DIRECTED MUTAGENESIS;
ANTI-BACTERIAL AGENTS;
BASE SEQUENCE;
DNA PRIMERS;
DRUG DESIGN;
ELECTROPHORESIS, POLYACRYLAMIDE GEL;
PEPTIDE SYNTHASES;
PEPTIDES;
SUBSTRATE SPECIFICITY;
BACILLUS SUBTILIS;
POSIBACTERIA;
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EID: 0037199494
PISSN: 00062960
EISSN: None
Source Type: Journal
DOI: 10.1021/bi0259406 Document Type: Article |
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Times cited : (134)
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References (31)
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