Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE

Structure

Volumn 10, Issue 3, 2002, Pages 301-310

  Bruner, Steven D ^a   Weber, Thomas ^b   Kohli, Rahul M ^a   Schwarzer, Dirk ^b   Marahiel, Mohamed A ^b   Walsh, Christopher T ^a   Stubbs, Milton T ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Antibiotic biosynthesis; Cyclic peptide formation; Nonribosomal peptide synthesis; Surfactant; Thioesterase; X ray crystal structure

Indexed keywords

CARRIER PROTEIN; ENZYME; HEPTAPEPTIDE; HYDROLASE; LACTONE DERIVATIVE; LIPOPEPTIDE; SURFACTIN; THIOL ESTER HYDROLASE;

ACYLATION; ARTICLE; BINDING SITE; CATALYSIS; CYCLIZATION; DEACYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PANTETHEINE; PEPTIDE SYNTHASES; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT;

ILEX COOKII;

EID: 0036120595     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(02)00716-5     Document Type: Article

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