PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease

Brain

Volumn 140, Issue 12, 2017, Pages 3233-3251

  Du, Fang ^a   Yu, Qing ^a   Yan, Shijun ^a   Hu, Gang ^a   Lue, Lih Fen ^b   Walker, Douglas G ^b   Wu, Long ^a   Yan, Shi Fang ^a   Tieu, Kim ^c   Yan, Shirley Shidu ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

^c FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

autophagy; A ; mitochondrial dysfunction; PINK1; synaptic injury

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYTOCHROME C OXIDASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN INDUCED PUTATIVE KINASE 1; UNCLASSIFIED DRUG; APP PROTEIN, HUMAN; CELL RECEPTOR; EYE PROTEIN; NDP52 PROTEIN, MOUSE; NERVE PROTEIN; OPTN PROTEIN, MOUSE; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; COGNITION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; FEMALE; GENOTYPE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL PLASTICITY; NEURO-2A CELL LINE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; AGED; ANIMAL; BRAIN; GENE THERAPY; GENETICS; METABOLISM; MIDDLE AGED; MITOCHONDRION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AUTOPHAGY; BRAIN; EYE PROTEINS; FEMALE; GENETIC THERAPY; HIPPOCAMPUS; HUMANS; MALE; MICE, TRANSGENIC; MIDDLE AGED; MITOCHONDRIA; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; PROTEIN KINASES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION;

EID: 85038264234     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awx258     Document Type: Article

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