Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degeneration

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 12, 2014, Pages 2517-2527

  Du, Heng ^a   Guo, Lan ^a   Wu, Xiaoping ^b   Sosunov, Alexander A ^b   McKhann, Guy M ^b   Chen, John Xi ^c   Yan, Shirley ShiDu ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b Department of Neurosurgery Physicians and Surgeons College of Columbia University ^*  (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Alzheimer's disease; Amyloid beta; Mitochondrial permeability transition; Oxidative stress; PKA CREB signaling; Synaptic alteration

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTIOXIDANT; CATALASE; CREB1 PROTEIN, MOUSE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOPHILIN; CYCLOPHILIN D; PROBUCOL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL; CELL CULTURE; DRUG EFFECTS; GENETICS; IMMUNOBLOTTING; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; NERVE CELL; OXIDATIVE STRESS; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIOXIDANTS; CATALASE; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOPHILINS; IMMUNOBLOTTING; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIA; NEURONS; OXIDATIVE STRESS; PATCH-CLAMP TECHNIQUES; PROBUCOL; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; SYNAPTIC TRANSMISSION;

EID: 84914153002     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2013.03.004     Document Type: Article

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