Transgenic expression of intraneuronal Aβ42 but not Aβ40 leads to cellular Aβ lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology

Journal of Neuroscience

Volumn 32, Issue 4, 2012, Pages 1273-1283

  Abramowski, Dorothee ^a   Rabe, Sabine ^a   Upadhaya, Ajeet Rijal ^b   Reichwald, Julia ^a   Danner, Simone ^a   Staab, Dieter ^a   Capetillo Zarate, Estibaliz ^c   Yamaguchi, Haruyasu ^d   Saido, Takaomi C ^e   Wiederhold, Karl Heinz ^a   Thal, Dietmar Rudolf ^b   Staufenbiel, Matthias ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF ULM   (Germany)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d GUNMA UNIVERSITY   (Japan)

^e RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN [1-40]; AMYLOID BETA PROTEIN [1-42]; UNCLASSIFIED DRUG;

AGE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ATROPHY; CONTROLLED STUDY; DENDRITE; ELECTRON MICROSCOPY; FEMALE; FUNCTIONAL DISEASE; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; LYSOSOME; MALE; MOTOR DYSFUNCTION; MOUSE; NERVE CELL LESION; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; ROTAROD TEST; STEREOLOGY; TRANSGENIC MOUSE; WESTERN BLOTTING; WHITE MATTER;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR MEMBRANES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE DEGENERATION; NEURONS; PEPTIDE FRAGMENTS; RATS;

EID: 84856296092     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4586-11.2012     Document Type: Article

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