Role of mitochondrial amyloid-β in Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 20, Issue SUPPL.2, 2010, Pages

  Chen, John Xi ^a   Yan, Shirley Shidu ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Columbia University ^*  (United States)

Author keywords

Alzheimer's disease; amyloid; cyclophilin; mitochondria; toxicity

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALCOHOL DEHYDROGENASE; AMYLOID BETA PROTEIN; AMYLOID BINDING ALCOHOL DEHYDROGENASE; CYCLOPHILIN D; CYTOCHROME C OXIDASE; PROTEINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOIDOSIS; BRAIN; CELL FUNCTION; CELL PROTECTION; CONFOCAL MICROSCOPY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; IMAGE ANALYSIS; IMMUNOELECTRON MICROSCOPY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REVIEW;

EID: 77956201762     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-100357     Document Type: Review

References (106)

1. Hardy J (1997) Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 20, 154-159.
2. Sisodia SS, St George-Hyslop PH (2002) gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the prese-nilins fit in? Nat Rev Neurosci 3, 281-290.
3. George-Hyslop PS, Rossor M (2001) Alzheimer's disease. Unravelling the disease process. Lancet 358 Suppl, S1.
4. D'Andrea MR, Nagele RG, Wang HY, Peterson PA, Lee DH (2001) Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease. Histopathology 38, 120-134.
5. Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, Greenfield JP, Haroutunian V, Buxbaum JD, Xu H, Greengard P, Relkin NR (2000) Intraneuronal Abeta42 accumulation in human brain. Am J Pathol 156, 15-20.
6. Martin LJ, Pardo CA, Cork LC, Price DL (1994) Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex. Am J Pathol 145, 1358-1381.
7. Martin BL, Schrader-Fischer G, Busciglio J, Duke M, Pa-ganetti P, Yankner BA (1995) Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein. J Biol Chem 270, 26727-26730.
8. Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L (1999) Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci U S A 96, 3228-3233.
9. Li QX, Maynard C, Cappai R, McLean CA, Cherny RA, Lynch T, Culvenor JG, Trevaskis J, Tanner JE, Bailey KA, Czech C, Bush AI, Beyreuther K, Masters CL (1999) Intra-cellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice. J Neurochem 72, 2479-2487.
10. Wirths O, Multhaup G, Czech C, Blanchard V, Moussaoui S, Tremp G, Pradier L, Beyreuther K, Bayer TA (2001) In-traneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett 306, 116-120.
11. Reddy PH, Beal MF (2008) Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 14, 45-53.
12. Takuma K, Yao J, Huang J, Xu H, Chen X, Luddy J, Tril-lat AC, Stern DM, Arancio O, Yan SS (2005) ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction. FASEB J 19, 597-598.
13. Caspersen C, Wang N, Yao J, Sosunov A, Chen X, Lustbader JW, Xu HW, Stern D, McKhann G, Yan SD (2005) Mitochon-drial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J 19, 2040-2041.
14. Manczak M, Anekonda TS, Henson E, Park BS, Quinn J, Reddy PH (2006) Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet 15, 1437-1449.
15. Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF, Walker DG, Kuppusamy P, Zewier ZL, Arancio O, Stern D, Yan SS, Wu H (2004) ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304, 448-452.
16. Reddy PH (2006) Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease. J Neurochem 96, 1-13.
17. Shukkur EA, Shimohata A, Akagi T, Yu W, Yamaguchi M, Murayama M, Chui D, Takeuchi T, Amano K, Subramhanya KH, Hashikawa T, Sago H, Epstein CJ, Takashima A, Ya-makawa K (2006) Mitochondrial dysfunction and tau hyper-phosphorylation in Ts1Cje, a mouse model for Down syndrome. Hum Mol Genet 15, 2752-2762.
18. Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, At-wood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shi-mohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Pe-tersen RB, Perry G, Smith MA (2001) Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 21, 3017-3023.
19. Lin MT, Beal MF (2006) Alzheimer's APP mangles mitochondria. Nat Med 12, 1241-1243.
20. Devi L, Prabhu BM, Galati DF, Avadhani NG, Anan-datheerthavarada HK (2006) Accumulation of amyloid precursor protein in the mitochondrial import channels ofhuman Alzheimer's disease brain is associated with mitochondrial dysfunction. J Neurosci 26, 9057-9068.
21. Hansson Petersen CA, Alikhani N, Behbahani H, Wiehager B, Pavlov PF, Alafuzoff I, Leinonen V, Ito A, Winblad B, Glaser E, Ankarcrona M (2008) The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci U SA 105, 13145-13150.
22. Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brin-ton RD (2009) Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 106, 1467014675.
23. Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y, Wang C, Zhang H, Molkentin JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, Yan SD (2008) Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med 14, 1097-1105.
24. Du H, Guo L, Zhang W, Rydzewska M, Yan S (2009) Cy-clophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model. Neurobiol Aging, in press.
25. Du H, Yan SS (2009) Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta. Biochim Biophys Acta 1802, 198-204.
26. Crouch PJ, Blake R, Duce JA, Ciccotosto GD, Li QX, Barn-ham KJ, Curtain CC, Cherny RA, Cappai R, Dyrks T, Masters CL, Trounce IA (2005) Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42. J Neurosci 25, 672-679.
27. Yamaguchi H, Yamazaki T, Ishiguro K, Shoji M, Nakazato Y, Hirai S (1992) Ultrastructural localization of Alzheimer amyloid beta/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes. Acta Neuropathol 85, 15-22.
28. Mungarro-Menchaca X, Ferrera P, Moran J, Arias C (2002) beta-Amyloid peptide induces ultrastructural changes in synaptosomes and potentiates mitochondrial dysfunction in the presence ofryanodine. J Neurosci Res 68, 89-96.
29. Swerdlow RH (2009) The neurodegenerative mitochondri-opathies. J Alzheimers Dis 17, 737-751.
30. Beal MF (2004) Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coen-zyme Q10 as a potential treatment. J Bioenerg Biomembr 36, 381-386.
31. Blass JP (2000) The mitochondrial spiral. An adequate cause of dementia in the Alzheimer's syndrome. Ann N YAcad Sci 924, 170-183.
32. Chen X, Stern D, Yan SD (2006) Mitochondrial dysfunction and Alzheimer's disease. Curr Alzheimer Res 3, 515-520.
33. Maurer I, Zierz S, Moller HJ (2000) A selective defect of cytochrome c oxidase is present in brain ofAlzheimer disease patients. Neurobiol Aging 21, 455-462.
34. Cottrell DA, Blakely EL, Johnson MA, Ince PG, Turnbull DM (2001) Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD. Neurology 57, 260-264.
35. Cottrell DA, Borthwick GM, Johnson MA, Ince PG, Turn-bull DM (2002) The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease. Neuropathol Appl Neurobiol 28, 390-396.
36. de la Monte SM, Luong T, Neely TR, Robinson D, Wands JR (2000) Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease. Lab Invest 80, 1323-1335.
37. Mutisya EM, Bowling AC, Beal MF (1994) Cortical cy-tochrome oxidase activity is reduced in Alzheimer's disease. J Neurochem 63, 2179-2184.
38. Parker WD, Jr., Parks J, Filley CM, Kleinschmidt-DeMasters BK (1994) Electron transport chain defects in Alzheimer's disease brain. Neurology 44, 1090-1096.
39. Parker WD, Jr., Mahr NJ, Filley CM, Parks JK, Hughes D, Young DA, Cullum CM (1994) Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. Neurology 44, 1086-1090.
40. Parker WD, Jr. (1991) Cytochrome oxidase deficiency in Alzheimer's disease. Ann N Y Acad Sci 640, 59-64.
41. Valla J, Berndt JD, Gonzalez-Lima F (2001) Energy hy-pometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration. J Neurosci 21, 4923-4930.
42. Ren Y, Xu HW, Davey F, Taylor M, Aiton J, Coote P, Fang F, Yao J, Chen D, Chen JX, Yan SD, Gunn-Moore FJ (2008) En-dophilin I expression is increased in the brains of Alzheimer disease patients. J Biol Chem 283, 5685-5691.
43. Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brin-ton RD (2009) Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 106, 1467014675.
44. Crouch PJ, Harding SM, White AR, Camakaris J, Bush AI, Masters CL (2008) Mechanisms of A beta mediated neurode-generation in Alzheimer's disease. Int J Biochem Cell Biol 40, 181-198.
45. Anandatheerthavarada HK, Biswas G, Robin MA, Avadhani NG (2003) Mitochondrial targeting and a novel transmem-brane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol 161, 41-54.
46. Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X (2009) Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29, 9090-9103.
47. Mori C, Spooner ET, Wisniewsk KE, Wisniewski TM, Ya-maguch H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA (2002) Intraneuronal Abeta42 accumulation in Down syndrome brain. Amyloid 9, 88-102.
48. Glabe C (2001) Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease. J Mol Neurosci 17, 137-145.
49. Hartmann T, Bieger SC, Bruhl B, Tienari PJ, Ida N, All-sop D, Roberts GW, Masters CL, Dotti CG, Unsickr K, Beyreuther K (1997) Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med 3, 1016-1020.
50. Cook DG, Forman MS, Sung JC, Leight S, Kolson DL, Iwat-subo T, Lee VM, Doms RW (1997) Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nat Med 3, 1021-1023.
51. Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H (1999) Endoplas-mic reticulum and trans-Golgi network generate distinct populations ofAlzheimer beta-amyloid peptides. Proc Natl Acad Sci U S A 96, 742-747.
52. Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKhann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K, Yan SS (2009) RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction. Proc Natl Acad Sci USA 106, 20021-20026.
53. El Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD (1996) Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature 382, 716-719.
54. Fujiwara T, Oda K, Yokota S, Takatsuki A, Ikehara Y (1988) Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum. J Biol Chem 263, 18545-18552.
55. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE (1997) Metabolic reduction in the posterior cingu-late cortex in very early Alzheimer's disease. Ann Neurol 42, 85-94.
56. Chen X, Stern, D, Yan SD (2007) Cellular targets of amyloid beta peptide: potential roles in neuronal cell stress and tox-icity. In Neurobiology of Alzheimer's disease, Dawbarn D, Allen S, Eds. Oxford University Press, Oxford, pp. 227-243.
57. Chen X, Yan SD (2006) Mitochondrial Abeta: a potential cause of metabolic dysfunction in Alzheimer's disease. IUBMB Life 58, 686-694.
58. Cardoso SM, Santana I, Swerdlow RH, Oliveira CR (2004) Mitochondria dysfunction ofAlzheimer's disease cybrids enhances Abeta toxicity. J Neurochem 89, 1417-1426.
59. Cardoso SM, Santos S, Swerdlow RH, Oliveira CR (2001) Functional mitochondria are required for amyloid beta-mediated neurotoxicity. FASEB J 15, 1439-1441.
60. Crompton M (2004) Mitochondria and aging: a role for the permeability transition? Aging Cell 3, 3-6.
61. Halestrap AP, McStay GP, Clarke SJ (2002) The permeability transition pore complex: another view. Biochimie 84, 153166.
62. Halestrap A (2005) Biochemistry: a pore way to die. Nature 434, 578-579.
63. Zamzami N, Larochette N, Kroemer G (2005) Mitochondrial permeability transition in apoptosis and necrosis. Cell Death Differ 12 Suppl2, 1478-1480.
64. Crompton M, Barksby E, Johnson N, Capano M (2002) Mi-tochondrial intermembrane junctional complexes and their involvement in cell death. Biochimie 84, 143-152.
65. Halestrap AP (2006) Calcium, mitochondria and reperfusion injury: a pore way to die. Biochem Soc Trans 34, 232-237.
66. Bernardi P, Krauskopf A, Basso E, Petronilli V, Blachly-Dyson E, Di Lisa F, Forte MA (2006) The mitochondrial permeability transition from in vitro artifact to disease target. Febs J 273, 2077-2099.
67. Crompton M, Virji S, Ward JM (1998) Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore. Eur J Biochem 258, 729-735.
68. Halestrap AP, Woodfield KY, Connern CP (1997) Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J Biol Chem 272, 3346-3354.
69. Connern CP, Halestrap AP (1994) Recruitment of mitochon-drial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel. Biochem J 302 (Pt 2), 321-324.
70. Andreeva L, Heads R, Green CJ (1999) Cyclophilins and their possible role in the stress response. IntJExp Pathol 80, 305-315.
71. Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, Robbins J, Molkentin JD (2005) Loss of cy-clophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434, 658-662.
72. Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL (1998) The overexpression of Bax produces cell death upon induction ofthe mitochondrial permeability transition. J Biol Chem 273, 7770-7775.
73. Liu X, Kim CN, Yang J, Jemmerson R, Wang X (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86, 147-157.
74. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413.
75. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Brenner C, Larochette N, Prevost MC, Alzari PM, Kroemer G (1999) Mitochondrial release of caspase-2 and -9 during the apop-totic process. J Exp Med 189, 381-394.
76. Adrain C, Creagh EM, Martin SJ (2001) Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J 20, 6627-6636.
77. Li LY, Luo X, Wang X (2001) Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412, 95-99.
78. Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, Inohara H, Kubo T, Tsujimoto Y (2005) Cy-clophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 434, 652-658.
79. Basso E, Fante L, Fowlkes J, Petronilli V, Forte MA, Bernardi P (2005) Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. J Biol Chem 280, 18558-18561.
80. Schinzel AC, Takeuchi O, Huang Z, Fisher JK, Zhou Z, Rubens J, Hetz C, Danial NN, Moskowitz MA, Korsmeyer SJ (2005) Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. ProcNatl Acad Sci U SA 102, 1200512010.
81. Eliseev RA, Filippov G, Velos J, VanWinkle B, Goldman A, Rosier RN, Gunter TE (2007) Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition. Neurobiol Aging 28, 1532-1542.
82. Hajnoczky G, Hoek JB (2007) Cell signaling. Mitochondrial longevity pathways. Science 315, 607-609.
83. Yan SD, Fu J, Soto C, Chen X, Zhu H, Al-Mohanna F, Colli-son K, Zhu A, Stern E, Saido T, Tohyama M, Ogawa S, Roher A, Stern D (1997) An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. Nature 389, 689-695.
84. Yan SD, Shi Y, Zhu A, Fu J, Zhu H, Zhu Y, Gibson L, Stern E, Collison K, Al-Mohanna F, Ogawa S, Roher A, Clarke SG, Stern DM (1999) Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxi-city. J Biol Chem 274, 2145-2156.
85. Powell AJ, Read JA, Banfield MJ, Gunn-Moore F, Yan SD, Lustbader J, Stern AR, Stern DM, Brady RL (2000) Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD). J Mol Biol 303, 311-327.
86. Du Yan S, Zhu Y, Stern ED, Hwang YC, Hori O, Ogawa S, Frosch MP, Connolly ES, Jr., McTaggert R, Pinsky DJ, Clarke S, Stern DM, Ramasamy R (2000) Amyloid beta -peptide-binding alcohol dehydrogenase is a component of the cellular response to nutritional stress. J Biol Chem 275, 27100-27109.
87. Kobayashi A, Jiang LL, Hashimoto T (1996) Two mitochon-drial 3-hydroxyacyl-CoA dehydrogenases in bovine liver. J Biochem 119, 775-782.
88. Furuta S, Kobayashi A, Miyazawa S, Hashimoto T (1997) Cloning and expression of cDNA for a newly identified isozyme of bovine liver 3-hydroxyacyl-CoA dehydrogenase and its import into mitochondria. Biochim Biophys Acta 1350, 317-324.
89. He XY, Schulz H, Yang SY (1998) A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease. J Biol Chem 273, 10741-10746.
90. Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH (1999) Mutagenesis identifies new signals for beta-amyloid precursor protein en-docytosis, turnover, and the generation ofsecreted fragments, including Abeta42. J Biol Chem 274, 18851-18856.
91. TorrojaL, Ortuno-SahagunD, Ferrus A, HammerleB, Barbas JA (1998) scully, an essential gene ofDrosophila, is homologous to mammalian mitochondrial type II L-3-hydroxyacyl-CoA dehydrogenase/amyloid-beta peptide-binding protein. J Cell Biol 141, 1009-1017.
92. Ofman R, Ruiter JP, Feenstra M, Duran M, Poll-The BT, Zschocke J, Ensenauer R, Lehnert W, Sass JO, Sperl W, Wanders RJ (2003) 2-Methyl-3- hydroxybutyryl-CoA dehydroge-nase deficiency is caused by mutations in the HADH2 gene. Am J Hum Genet 72, 1300-1307.
93. Yan Y, Liu Y, Sorci M, Belfort G, Lustbader JW, Yan SS, Wang C (2007) Surface plasmon resonance and nuclear magnetic resonance studies of ABAD-Abeta interaction. Biochemistry 46, 1724-1731.
94. Oppermann UC, Salim S, Tjernberg LO, Terenius L, Jornvall H (1999) Binding of amyloid beta-peptide to mitochondri-al hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease. FEBS Lett 451, 238-242.
95. Milton NG, Mayor NP, Rawlinson J (2001) Identification of amyloid-beta binding sites using an antisense peptide approach. Neuroreport 12, 2561-2566.
96. Shuli S, Yongmei Z, Zhiwei Z, Zhijuan J (2001) beta-Amyloid and its binding protein in the hippocampus of diabetic mice: effect of APP17 peptide. Neuroreport 12, 33173319.
97. He XY, Wen GY, Merz G, Lin D, Yang YZ, Mehta P, Schulz H, Yang SY (2002) Abundant type 10 17 beta-hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease model. Brain Res Mol Brain Res 99, 46-53.
98. Wen GY, Yang SY, Kaczmarski W, He XY, Pappas KS (2002) Presence of hydroxysteroid dehydrogenase type 10 in amyloid plaques (APs) of Hsiao's APP-Sw transgenic mouse brains, but absence in APs of Alzheimer's disease brains. BrainRes 954, 115-122.
99. Chen JX, Yan SD (2007) Amyloid-beta-induced mitochon-drial dysfunction. J Alzheimers Dis 12, 177-184.
100. Sheehan JP, Swerdlow RH, Miller SW, Davis RE, Parks JK, Parker WD, Tuttle JB (1997) Calcium homeostasis and reactive oxygen species production in cells transformed by mito-chondriafrom individuals with sporadic Alzheimer's disease. J Neurosci 17, 4612-4622.
101. Bosetti F, Brizzi F, Barogi S, Mancuso M, Siciliano G, Tendi EA, Murri L, Rapoport SI, Solaini G (2002) Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease. Neurobiol Aging 23, 371-376.
102. Davis RE, Miller S, Herrnstadt C, Ghosh SS, Fahy E, Shinobu LA, Galasko D, Thal LJ, Beal MF, Howell N, Parker WD, Jr. (1997) Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc Natl Acad Sci USA 94, 4526-4531.
103. Humphries KM, Szweda LI (1998) Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydroge-nase: reaction of lipoic acid with 4-hydroxy-2-nonenal. Biochemistry 37, 15835-15841.
104. Floyd RA, Hensley K (2002) Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 23, 795-807.
105. Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA (2002) Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron 33, 677-688.
106. Yao J, Taylor M, Davey F, Ren Y, Aiton J, Coote P, Fang F, Chen JX, Yan SD, Gunn-Moore FJ (2007) Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model. Mol Cell Neurosci 35, 377-382.