Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model

Human Molecular Genetics

Volumn 24, Issue 18, 2015, Pages 5198-5210

  Fang, Du ^a   Wang, Yongfu ^a   Zhang, Zhihua ^a,b   Du, Heng ^a   Yan, Shiqiang ^c   Sun, Qinru ^a   Zhong, Changjia ^a   Wu, Long ^a   Vangavaragu, Jhansi Rani ^a   Yan, Shijun ^a   Hu, Gang ^a   Guo, Lan ^a   Rabinowitz, Molly ^c   Glaser, Elzbieta ^d   Arancio, Ottavio ^c   Sosunov, Alexander A ^e   McKhann, Guy M ^e   Chen, John Xi ^f   Yan, Shirley ShiDu ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b BEIJING NORMAL UNIVERSITY   (China)

^c NewYork Presbyterian Hospital   (United States)

^d STOCKHOLM UNIVERSITY   (Sweden)

^e Physicians and Surgeons College of Columbia University ^*  (United States)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; MITOCHONDRIAL ENZYME; PRESEQUENCE PROTEASE; PROTEINASE; UNCLASSIFIED DRUG; AUTACOID; SERINE PROTEINASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN MITOCHONDRION; CLEARANCE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE OVEREXPRESSION; IN VIVO STUDY; LEARNING; LONG TERM POTENTIATION; MALE; MEDIATOR RELEASE; MEMORY; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SYNAPTIC TRANSMISSION; ANIMAL; ANIMAL BEHAVIOR; CELL CULTURE; COGNITION; DISEASE MODEL; GENE EXPRESSION; GENETICS; METABOLISM; MITOCHONDRION; NERVE CELL; PATHOPHYSIOLOGY; PROTEINOSIS; SYNAPSE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BEHAVIOR, ANIMAL; CELLS, CULTURED; COGNITION; DISEASE MODELS, ANIMAL; GENE EXPRESSION; INFLAMMATION MEDIATORS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; NEURONS; OXIDATIVE STRESS; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEOLYSIS; SERINE ENDOPEPTIDASES; SYNAPSES;

EID: 84940642263     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv241     Document Type: Article

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